JP5884205B2 - Effervescent skin external preparation - Google Patents

Description

  The present invention relates to an external preparation for skin.

  Conventionally, an external preparation for skin containing a synthetic or natural extract having a blood circulation promoting action on the skin has been used.

These extracts are not effective with a small amount of formulation, and because of the reason that the skin irritation is too great with a large amount of formulation, a proposal of a topical skin preparation containing carbon dioxide gas to promote blood circulation promotion Has been made. Many of these generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide-generating substance. As a dosage form of these external preparations for skin, there are those in which an acidic substance and a carbon dioxide generating substance are separated from each other from the viewpoint of maintaining the carbonation generating ability of the external preparation for a long period of time, and they are mixed and foamed at the time of use. Known (Patent Documents 1 and 2).
On the other hand, an external preparation for skin containing an acidic substance and a carbon dioxide generating substance and mixed with a viscous composition containing water and a thickener at the time of use is also known (Patent Document 3).

JP-A-63-310807 JP 05-229933 A WO99 / 24043

A foamable external preparation for skin containing an acidic substance and a carbon dioxide generating substance and mixed with a hydrated substance at the time of use has advantages such as easy handling when it is made into a single agent type.
However, conventionally, this type of external preparation for skin improves the feeling of use such as ease of mixing and application when mixed with a hydrous substance, and the skin's moist feeling, elasticity, brightness, etc. The state improvement effect was insufficient from the viewpoint of achieving both.

The present invention is a foamable skin external preparation having at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
As the polysaccharide or derivative thereof, at least one selected from cellulose derivatives and starch derivatives;
Alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or at least one kind selected from hydrophilic natural polymers which are tamarind gum (however, when cellulose derivative contains sodium carboxymethyl cellulose, alginic acid or a salt thereof is Excluding)
The present invention provides an effervescent skin external preparation that is mixed with a water-containing substance when the external skin preparation is used.

Further, the present invention is a foamable skin external preparation having at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
As polysaccharides or derivatives thereof, containing two or more kinds selected from hydrophilic natural polymers which are alginic acid or salts thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum,
The present invention provides an effervescent skin external preparation that is mixed with a water-containing substance when the external skin preparation is used.

Further, the present invention is a foamable skin external preparation having at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
As polysaccharides or derivatives thereof, containing two or more selected from cellulose derivatives and starch derivatives,
The present invention provides an effervescent skin external preparation that is mixed with a water-containing substance when the external skin preparation is used.

Further, the present invention is a foamable skin external preparation having at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
At least one polysaccharide or derivative thereof;
Containing an inorganic hydrophilic thickening compound, or at least one hydrophilic synthetic polymer that is an organic thickening agent,
The present invention provides an effervescent skin external preparation that is mixed with a water-containing substance when the external skin preparation is used.

  ADVANTAGE OF THE INVENTION According to this invention, a feeling of use is good and can provide the skin external preparation effective in skin condition improvement.

FIG. 1 is a graph showing the rate of change of L * value (whiteness) in Examples and Comparative Examples. FIG. 2 is a graph showing the rate of change of the stratum corneum moisture content in Examples and Comparative Examples. FIG. 3 is a graph showing the rate of change in elasticity in Examples and Comparative Examples. FIG. 4 is a graph showing the amount of foaming (volume increase rate of a mixture of a skin external preparation and a water-containing substance) in Examples and Comparative Examples. FIG. 5 is a graph showing the amount of generated carbon dioxide in Examples and Comparative Examples. FIG. 6 is a graph showing the rate of change of moisture transpiration in the examples. FIG. 7 is a graph showing the rate of change of the stratum corneum moisture content in another example. FIG. 8 is a graph showing the rate of change of the L * value in another example. FIG. 9 is a graph showing the rate of change of the stratum corneum moisture content in another example. FIG. 10 is a graph showing the rate of change in elasticity in another example. FIG. 11 is a graph showing the rate of change of moisture transpiration in another example.

  The skin external preparation of the present invention contains at least a solid acidic substance and a solid carbon dioxide generating substance that generates carbon dioxide by reacting with the acidic substance.

  The external preparation for skin of the present invention is used by a user when the external preparation for skin and a water-containing substance are mixed to cause foaming due to the generation of carbon dioxide gas and applied to the skin. Hereinafter, each component contained in the external preparation for skin and its production method will be described.

<Solid acidic substance>
The solid acidic substance used in the present invention may be either an inorganic acid or an organic acid, and one or more of these are used. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, acidic sodium hexametaphosphate, acidic potassium hexametaphosphate, acidic sodium pyrophosphate, acidic Examples include potassium pyrophosphate and sulfamic acid.

  Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid Acids, dicarboxylic acids such as terephthalic acid, acidic amino acids such as glutamic acid and aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid And oxyacids such as tropic acid, ascorbic acid and gluconic acid.

  Of these, citric acid, ascorbic acid, malic acid and succinic acid are preferred from the viewpoints of safety and solubility in water.

  The content of the solid acidic substance in the external preparation for skin of the present invention is preferably 1% by mass or more and 20% by mass or less, and more preferably 2% by mass or more and 18% by mass or less in the external preparation for skin. preferable.

<Solid carbon dioxide generator>
As the solid carbon dioxide gas generating substance that generates carbon dioxide by reacting with the acidic substance used in the present invention, various substances can be used without any particular limitation. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonate is preferably used, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The content of the carbon dioxide generating substance in the external preparation for skin of the present invention is preferably 1% by mass or more and 30% by mass or less, and more preferably 2% by mass or more and 25% by mass or less in the external preparation for skin. preferable.

<Polysaccharides or derivatives thereof>
Examples of polysaccharides or derivatives thereof used in the present invention include various types that can be used in the cosmetics and pharmaceutical fields. Specific examples of polysaccharides include xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, hyaluronic acid and its salts, chondroitin sulfate and its Hydrophilic natural polymers such as salts, curdlan, pectin, alginic acid and salts thereof, starch, dextrin, celluloses; starch derivatives such as carboxymethyl starch and salts thereof, acrylic acid grafted starch and salts thereof, hydroxypropyl cellulose and Derivatives thereof, hydroxyethylcellulose and derivatives thereof, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, and hydrocarbons having a hydrocarbon group such as stearyl group Derivatives of hydroxypropylmethylcellulose such as propylmethylcellulose, sulfonated cellulose derivatives, carboxymethylcellulose and derivatives thereof, and salts thereof, carboxymethylethylcellulose and salts thereof, cellulose acetate phthalate, O- [2-hydroxy-3- (trimethylammoni) chloride (E) cation] hydrophilic synthetic polymers such as cationized cellulose such as hydroxyethylcellulose (also referred to as “polyquaternium-10”), and cellulose derivatives such as ethylcellulose, chlorcarmellose and salts thereof. These can be used alone or in combination of two or more. As exemplified above, dextrin is not included in the starch derivative herein. Moreover, as said salts, sodium salt, potassium salt, calcium salt etc. are mentioned, for example. Examples of the hydroxypropyl cellulose derivative include hydroxypropyl cellulose acetate and hydroxypropyl cellulose propionate. Examples of the hydroxyethyl cellulose derivative include hydroxyethyl cellulose acetate, hydroxyethyl cellulose propionate, and polyquaternium-67. Examples of the derivatives of methyl cellulose include carboxymethyl cellulose acetate, carboxymethyl cellulose propionate, and methylamide cellulose gum.

  In addition, the polysaccharide or derivative thereof used in the present invention is highly soluble in water and / or dispersible, so that when the external preparation for skin of the present invention is mixed with a water-containing substance, it is uniform. It is preferable because it can dissolve or / and disperse in water, and can relieve the feeling of rough skin caused by the undissolved component. Here, whether water solubility or dispersibility is good is that, when water at about room temperature is added and stirred, the external preparation for skin is uniformly dissolved or dispersed in a short time, and no lumps are generated during dissolution, etc. It can be judged from.

  From the viewpoint of solubility and dispersibility in water described above, preferable examples of polysaccharides or derivatives thereof include, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, gum tragacanth, Examples include tamarind gum, agar, agarose, mannan, hyaluronic acid and salts thereof, curdlan, alginic acid and salts thereof, starch and derivatives thereof, dextrin, cellulose and cellulose derivatives.

Among the polysaccharides or derivatives thereof used in the present invention, only one type may be used, but it is preferable to use two or more types in combination. This is due to the following reason.
Many polysaccharides or derivatives thereof are dissolved or dispersed in water and exhibit a thickening effect. In addition, the addition of polysaccharides or derivatives thereof to the external preparation for skin enhances the stability of the external preparation for skin before use and storage, prevents the reaction between the acid and the carbon dioxide generating substance, There is also an advantage of preventing the occurrence. Among polysaccharides or derivatives thereof, those that contribute more to the thickening effect than stability during storage (hereinafter also referred to as A type polysaccharides or derivatives thereof) are more stable during storage than thickening effect. Since there is also a thing that contributes to a lot of properties (hereinafter referred to as B type polysaccharides or derivatives thereof), by combining both types of polysaccharides or derivatives thereof, a thickening effect and stability during storage Both can be improved. A type polysaccharides or derivatives thereof include xanthan gum, carrageenan, hyaluronic acid and cellulose and salts or derivatives thereof. B type polysaccharides or derivatives thereof are preferably starches or derivatives thereof and dextrins. Listed as sugars. By using the B-type polysaccharide or a derivative thereof, generation of carbon dioxide during storage of the external preparation for skin can be suppressed. In particular, it is preferable to use starch or a derivative thereof because generation of carbon dioxide gas is effectively suppressed, and long-term storage stability is further improved. In the present invention, when starch or a derivative thereof is used, the preferred amount of use can be 3% by mass or more, particularly 5% by mass or more, particularly 10% by mass or more in the external preparation for skin.
In the present invention, it is also preferable that there are many types of polysaccharides or derivatives thereof, for example, combinations of 3 or more types.

  Further, as is apparent from the comparison of Examples described later, for example, Examples 1 and 2, the present inventors have used a polysaccharide or a derivative thereof in combination of two or more, when only one is used. Compared with hydrated substances, the skin external preparation (mixture) has a high ability to retain carbon dioxide when mixed with water-containing substances, making it difficult for the mixture applied to the skin to drip, improving redness, improving elasticity, etc. We found that it was easy to use and that it improved usability including ease of application and removal. Furthermore, as is clear from Examples 6 to 10, it was found that these effects were higher in the presence of an extract containing a water-soluble protein and / or a natural surfactant, particularly saponin.

  In the present invention, the content of the polysaccharide or derivative thereof in the external preparation for skin is preferably 8% by mass or more and 50% by mass or less, and more preferably 11% by mass or more and 45% by mass or less. It is preferable that the content of the polysaccharide or the derivative thereof is 8% by mass or more and 50% by mass or less from the viewpoint of handling at the time of use, particularly from the viewpoint that it is easy to mix when mixed with a hydrous substance and is difficult to sag during use. If it is less than 8% by mass, it tends to sag during use, and if it exceeds 50% by mass, it is difficult to mix at the time of mixing, and also thickens immediately after mixing with a water-containing substance, making it difficult to apply to the site of use. Therefore, it is not preferable.

  In addition, when a polysaccharide of type A or a derivative thereof and a polysaccharide of type B or a derivative thereof are used in combination as a polysaccharide or a derivative thereof, the mass ratio of both is 100 mass of the polysaccharide of A or a derivative thereof. The B polysaccharide or derivative thereof is preferably 10 parts by mass or more and 1000 parts by mass or less, and more preferably 20 parts by mass or more and 800 parts by mass or less with respect to parts.

The present inventors further have a case where the external preparation for skin of the present invention contains two or more polysaccharides or derivatives thereof in any of the following (1) to (3): Further, the present inventors have found that the effect of the present invention “improving the skin condition” is remarkable.
(1) At least one selected from cellulose derivatives and starch derivatives and at least one selected from hydrophilic natural polymers such as alginic acid or salts thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum (however, as cellulose derivatives When containing sodium carboxymethylcellulose, excluding alginic acid and its salts).
(2) When containing two or more kinds selected from hydrophilic natural polymers which are alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum as a polysaccharide or a derivative thereof (3) a polysaccharide or When the derivative contains two or more selected from cellulose derivatives and starch derivatives.

  Hereinafter, the hydrophilic natural polymer which is alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum may be simply referred to as “specific hydrophilic natural polymer”.

First, the case of (1) will be described.
In the case of (1), as an aspect containing two or more polysaccharides or derivatives thereof, the following aspect (a) or (b) is “good feeling and improves skin condition” It is preferable from the viewpoint of enhancing the effects of the present invention more reliably.
(A) As cellulose derivatives, hydroxyethyl cellulose and derivatives thereof, carboxymethyl cellulose and derivatives thereof and salts thereof, hydroxypropyl methyl cellulose and derivatives thereof, sulfonated cellulose derivatives, carboxymethyl ethyl cellulose and salts thereof, cellulose acetate phthalate, cationized cellulose Or at least one selected from ethyl cellulose and croscarmellose and salts thereof, and / or
Contains starch derivatives.

(B) It contains at least one selected from hydroxypropylcellulose and derivatives thereof as the cellulose derivative and at least one selected from alginic acid and salts thereof, carrageenan, guar gum, xanthan gum and tamarind gum as the hydrophilic natural polymer.

In the case of (1), as a particularly preferred embodiment containing two or more polysaccharides or derivatives thereof, the following cases (a) to (c) are mentioned.
(A) The cellulose derivative contains at least one selected from hydroxypropylmethylcellulose and derivatives thereof and cationized cellulose; and / or starch derivatives include carboxymethyl starch and salts thereof, and acrylic acid grafted starch and salts thereof Containing at least one selected from
(A) Contains at least one selected from hydroxyethyl cellulose and derivatives thereof as a cellulose derivative and at least one selected from alginic acid and salts thereof, carrageenan, guar gum, locust bean gum, and tamarind gum as a hydrophilic natural polymer. .
(C) At least one selected from carboxymethylcellulose and derivatives thereof and salts thereof as the cellulose derivative, and at least one selected from carrageenan, guar gum, locust bean gum and tamarind gum as the hydrophilic natural polymer.

In the case of (1), a particularly preferred embodiment containing two or more polysaccharides or derivatives thereof includes a case of containing any of the following combinations as polysaccharides or derivatives thereof.
A combination of at least one selected from hydroxypropylmethylcellulose and derivatives thereof and at least one selected from alginic acid and salts thereof and xanthan gum;
A combination of cationized cellulose and tamarind gum;
A combination of starch derivative and tamarind gum;
A combination of at least one selected from hydroxyethyl cellulose and derivatives thereof and at least one selected from alginic acid and salts thereof and carrageenan;
A combination of at least one selected from carboxymethylcellulose and derivatives thereof and salts thereof and at least one selected from carrageenan and guar gum.

  When the cellulose derivative or starch derivative is combined with a specific hydrophilic natural polymer as in the case of (1) above, the amount of the specific hydrophilic natural polymer relative to 100 parts by mass of the cellulose derivative or starch derivative. Is preferably 1 part by mass or more and 10000 parts by mass or less from the viewpoint of more reliably obtaining the effects of the present invention. From this viewpoint, the amount of the specific hydrophilic natural polymer with respect to 100 parts by mass of the cellulose derivative or starch derivative is preferably 1 part by mass or more and 10000 parts by mass or less, and preferably 5 parts by mass or more and 5000 parts by mass or less. More preferably, it is 10 parts by mass or more and 1000 parts by mass or less. In addition, the quantity of a cellulose derivative or a starch derivative here is the total amount, when a skin external preparation contains a cellulose derivative and a starch derivative. The amount of the cellulose derivative, starch derivative, and hydrophilic natural polymer referred to here is specified when the external preparation for skin of the present invention contains a specific kind of cellulose derivative, starch derivative, or hydrophilic natural polymer. It can be the amount of seed cellulose derivatives, starch derivatives, hydrophilic natural polymers. Similarly, for the amounts of cellulose derivatives, starch derivatives and hydrophilic natural polymers described below, the external preparation for skin of the present invention contains specific types of cellulose derivatives, starch derivatives and hydrophilic natural polymers. In this case, the amount of the specific type of cellulose derivative, starch derivative, and hydrophilic natural polymer can be used.

  In both cases (1) and (2) to (4), the ratio of the total amount of the cellulose derivative, starch derivative and specific hydrophilic natural polymer in the external preparation for skin is 5% by mass or more. It is preferable that the effect of the present invention is high, and that it is 50% by mass or less ensures the amount of the acidic substance and the carbon dioxide generating substance, and the foamability of the external preparation for skin of the present invention is reduced. It is preferable from the viewpoint of preventing functionalities and ensuring functionality such as a feeling of use and an improvement in skin condition. From this viewpoint, the ratio of the total amount of cellulose derivative, starch derivative and specific hydrophilic natural polymer in the external preparation for skin is more preferably 10% by mass or more and 45% by mass or less, and more preferably 12% by mass or more and 45% by mass. % Or less is particularly preferable.

  Next, the case of (2) will be described. In the case of (2) above, the external preparation for skin comprises two or more kinds selected from hydrophilic natural polymers that are alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum as a polysaccharide or a derivative thereof. contains. In this case, from the viewpoint of making the effect of the present invention “good in use and improving the condition of the skin” even more remarkable, the combination of two or more of these specific hydrophilic natural polymers is as follows: (A) to (C) are particularly preferable.

(A) A combination of alginic acid or a salt thereof and at least one selected from carrageenan, guar gum, locust bean gum and tamarind gum.
(B) A combination of carrageenan and at least one selected from alginic acid and its salts, guar gum, xanthan gum and tamarind gum.
(C) A combination with two or more selected from guar gum, locust bean gum, xanthan gum and tamarind gum.

As the particularly preferred combination in the case of containing two or more specific hydrophilic natural polymers, any of the following (A) ′ to (C) ′ can be mentioned.
(A) 'A combination of alginic acid or a salt thereof and at least one selected from carrageenan and tamarind gum;
(B) 'A combination of carrageenan and at least one selected from xanthan gum and tamarind gum;
(C) 'A combination of tamarind gum and at least one selected from guar gum and xanthan gum.

  When the polysaccharide or derivative thereof contains two or more kinds selected from hydrophilic natural polymers such as alginic acid or salts thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum as in (2), Among them, the content of any one of the other to 100 parts by mass of 1 type is preferably 1 part by mass or more and 10000 parts by mass or less, more preferably 5 parts by mass or more and 5000 parts by mass or less. The amount is particularly preferably 1000 parts by mass or less.

In the case of (A), the content of at least one selected from carrageenan, guar gum, locust bean gum and tamarind gum is 1 to 10000 parts by mass with respect to 100 parts by mass of alginic acid or a salt thereof. Is more preferably 5 parts by mass or more and 5000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.
In the case of (B), the content of at least one selected from alginic acid and its salts, guar gum, xanthan gum and tamarind gum is preferably 1 part by mass or more and 10000 parts by mass or less with respect to 100 parts by mass of carrageenan. It is more preferably 5 parts by mass or more and 5000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.
In addition, "at least 1 type of content" here is the total amount, when there are 2 or more types.
In the case of (C), it is preferable that the total amount of the other three types with respect to 100 parts by mass selected from guar gum, locust bean gum, xanthan gum and tamarind gum is 1 part by mass or more and 10000 parts by mass or less. It is more preferably 5 parts by mass or more and 5000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.

  In the case of (2), the proportion of the total amount of the specific hydrophilic natural polymer in the external preparation for skin is preferably 5% by mass or more in order to enhance the effect of the present invention, and 50 The mass% or less ensures the amount of the acidic substance and carbon dioxide generating substance, prevents the foaming of the skin external preparation of the present invention from decreasing, and feels the use of the skin external preparation of the present invention and the skin. It is preferable from the viewpoint of ensuring functionality such as a state improvement effect. From this viewpoint, the ratio of the total amount of the specific hydrophilic natural polymer in the external preparation for skin is more preferably 10% by mass or more and 45% by mass or less, and more preferably 12% by mass or more and 45% by mass or less. Particularly preferred.

  Subsequently, (3) a case where two or more kinds selected from cellulose derivatives and starch derivatives are contained as polysaccharides or derivatives thereof will be described.

  In the case of (3), from the viewpoint of making the effects of the present invention even more remarkable, (b) a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives Or (b) a combination of two or more specific cellulose derivatives.

In the case of (a), for example, as a cellulose derivative, hydroxyethyl cellulose and its derivatives, hydroxypropyl methyl cellulose and its derivatives, sulfonated cellulose derivatives, carboxymethyl cellulose and its derivatives and salts thereof, carboxymethyl ethyl cellulose and its salts, acetic acid At least one selected from cellulose phthalate, cationized cellulose, ethyl cellulose and croscarmellose and salts thereof, and at least one selected from carboxymethyl starch and salts thereof and acrylic acid grafted starch and salts thereof as starch derivatives It is particularly preferable to contain them in combination.
In the case of (a), it is particularly preferable to use at least one selected from carboxymethyl cellulose and derivatives thereof and salts thereof as the cellulose derivative.

In the case of (b), for example, the following cases (X) or (Y) are preferable examples.
(X) The cellulose derivative contains at least one selected from hydroxypropylmethylcellulose and derivatives thereof, and at least one selected from hydroxyethylcellulose and derivatives thereof and cationized cellulose.
(Y) as the cellulose derivative, at least one selected from carboxymethylcellulose and derivatives thereof and salts thereof, hydroxyethylcellulose and derivatives thereof, hydroxypropylcellulose and derivatives thereof, sulfonated cellulose derivatives, carboxymethylethylcellulose and salts thereof, It contains at least one selected from cellulose acetate phthalate, cationized cellulose, ethyl cellulose and croscarmellose and salts thereof.

When the external preparation for skin contains two or more selected from cellulose derivatives and starch derivatives as polysaccharides or derivatives thereof as in (3), any one of them in addition to 100 parts by mass of one of these The amount is preferably 1 part by mass or more and 10000 parts by mass or less, more preferably 5 parts by mass or more and 5000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.
When the skin external preparation contains a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives, as in (A), the effect of the present invention becomes even more remarkable. From the viewpoint of, the starch derivative is preferably contained in an amount of 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5000 parts by mass or less, more preferably 10 parts by mass or more and 1000 parts by mass with respect to 100 parts by mass of the cellulose derivative. It is particularly preferable that the amount is not more than part by mass.

  The external preparation for skin is at least one selected from hydroxypropylmethylcellulose and its derivatives, and at least one selected from hydroxyethylcellulose and its derivatives and cationized cellulose, as in (X) in (B). When the seed (the latter) is contained, the latter total amount is preferably 1 part by mass or more and 10000 parts by mass or less, and preferably 5 parts by mass or more and 5000 parts by mass or less with respect to the former total amount of 100 parts by mass. More preferably, the amount is 10 parts by mass or more and 1000 parts by mass or less.

  In addition, as in (Y) in (B), the skin external preparation comprises at least one (the former) selected from carboxymethylcellulose and its derivatives and salts thereof as a cellulose derivative, hydroxyethylcellulose and its derivatives, hydroxy When containing at least one selected from propylcellulose and derivatives thereof, sulfonated cellulose derivatives, carboxymethylethylcellulose and salts thereof, cellulose acetate phthalate, cationized cellulose, ethylcellulose and croscarmellose and salts thereof (the latter) The total amount of the latter is preferably 1 part by mass or more and 10000 parts by mass or less, more preferably 5 parts by mass or more and 5000 parts by mass or less, more preferably 10 parts by mass or more with respect to 100 parts by mass of the former total amount. 100 And particularly preferably less parts by mass.

  In the case of (3), the proportion of the total amount of the cellulose derivative and starch derivative in the external preparation for skin is preferably 5% by mass or more in order to enhance the effect of the present invention, and 50% by mass or less. It is preferable from the viewpoint of ensuring functionality such as a feeling of use of the external preparation for skin of the present invention and an effect of improving the skin condition. In this respect, the proportion of the total amount of the cellulose derivative and the starch derivative in the external preparation for skin is more preferably 10% by mass to 45% by mass, and particularly preferably 12% by mass to 45% by mass. .

The external preparation for skin of the present invention that employs any one of the constitutions (1) to (3) below is used after use of the external preparation for skin compared to the case where a combination of conventional polysaccharides or derivatives thereof is adopted. Compared to before, the amount of moisture transpiration from the skin is suppressed. Alternatively, and / or after use of the external preparation for skin, whiteness, skin moisture content and / or elasticity are increased as compared to before use. As a result, the skin condition such as moist feeling, elasticity, brightness, redness, smoothness, and / or smoothness of the skin is improved.
In addition, the characteristics of the effect when the external preparation for skin of the present invention adopts any one of the following constitutions (1) to (3) is the feeling of use in addition to the above-mentioned effect of improving the skin condition. Is in the point that greatly improves. When the external preparation for skin of the present invention adopts the constitutions (1) to (3) below, it is easier to mix, dissolve, and apply compared to the case where a combination of conventional polysaccharides or derivatives thereof is adopted. It combines the characteristics required for an external preparation for skin to be foamed by mixing with a water-containing substance, such as ease, drip resistance, and / or ease of removal.
Furthermore, when the external preparation for skin of the present invention adopts the following constitutions (1) to (3), the smoothness of the foam, the fineness of the foam, the roughness of the foam, the elasticity of the foam, , High carbonic acid feeling, and / or high persistent carbonic acid feeling. For this reason, the usability of the skin external preparation of the present invention is greatly improved compared to the case where a combination of conventional polysaccharides or derivatives thereof is employed.
Moreover, in the external preparation for skin of the present invention having a high carbonic sense, the feeling of tightening the skin is also high.
By obtaining these effects, the external preparation for skin of the present invention adopts any one of the following constitutions (1) to (3), so that “use feeling is good and skin condition is improved” The effect becomes remarkable.
The effect of the present invention is obtained when the agent of the present invention contains a specific combination of the polysaccharides (1) to (3) or derivatives thereof together with a solid acidic substance and a solid carbon dioxide generating substance. Effect. Therefore, for example, one or both of the combinations of (1) to (3) are contained together with water to form a viscous composition, and this viscous composition is used as a solid acidic substance and / or a solid carbon dioxide generating substance. Can not be obtained depending on the agent mixed with.

  The external preparation for skin of the present invention more preferably contains a water-soluble protein. Here, the water-soluble protein is a protein obtained by concentrating, separating and purifying animal or plant protein, and means a protein having a property of being easily dispersed or dissolved in water or various liquids. When added in an amount of 5% by mass or more to water at 25 ° C. under 1 atm, it means that it can be uniformly dispersed or dissolved without causing lumps. Water-soluble proteins include protein hydrolysates. The hydrolyzate is preferably a product obtained by hydrolyzing proteins derived from various organisms such as animals and fish by alkali treatment or enzyme treatment. Specific examples of water-soluble proteins include casein, collagen, hydrolyzed collagen such as gelatin, albumin, elastin, keratin, sericin, and the like. These can be used alone or in combination of two or more. Especially, it is preferable that the skin external preparation of this invention contains albumin, collagen, and hydrolyzed collagen as water-soluble protein. The water-soluble protein also has a role as a foaming aid, and in particular has a function of increasing the strength of the bubbles and keeping the foam stable for a long period of time. For this reason, the addition of water-soluble protein contributes to the ease of adjusting the viscosity of the external preparation for skin, the improvement in solubility in water, and the increase in the amount of carbonic acid, and it is easy to improve the skin condition improving effect. The present inventors have found that the effect of this water-soluble protein becomes excellent by containing a polysaccharide or a derivative thereof, particularly, two or more kinds of polysaccharides or a derivative thereof.

  Moreover, although the skin external preparation of this invention may contain only 1 type of water-soluble protein, it is also preferable to contain 2 or more types of water-soluble protein. This is shown, for example, in a comparison between Examples 13 and 14 and Example 17 described later. As is clear from these examples, compared to the case where only albumin is contained as a water-soluble protein, the skin quality improving effect such as moist feeling and smoothness of the skin after use when containing collagen or hydrolyzed collagen together with albumin, The feeling of use of the mixture obtained by mixing the external preparation for skin with a water-containing substance is easily improved. In particular, when the foamable skin external preparation of the present invention contains hydrolyzed collagen, as will be apparent from Example 14 to be described later, the ease of application, the comfort when applied, and the appearance are easy to improve. As will be apparent from the comparison of Examples 18 and 19 described later, even when hydrolyzed collagen is used alone, the retention of carbon dioxide in the mixture of the skin external preparation and the water-containing substance and the skin condition after use of the skin external preparation Has the same or better effect than albumin in improving

  When the skin external preparation of the present invention contains a water-soluble protein, the water-soluble protein is preferably 0.01% by mass or more and 10% by mass or less, and 0.05% by mass or more and 8% by mass or less in the skin external preparation. It is more preferable that When the content is 0.01% by mass or more and 10% by mass or less, it is preferable because the strength of the bubbles containing the water-soluble protein is increased and the effect of keeping the foam stable for a long period of time can be easily obtained.

  In addition, when the skin external preparation contains a water-soluble protein, the content of the water-soluble protein is a polysaccharide or a derivative thereof from the viewpoint of further enhancing the holding power of carbon dioxide gas when the skin external preparation of the present invention is dissolved in water. The amount is preferably 0.1 parts by mass or more and more preferably 1 part by mass or more and 50 parts by mass or less with respect to 100 parts by mass.

  The skin external preparation of the present invention can contain various components other than the solid acidic substance, the solid carbon dioxide generating substance, polysaccharides or derivatives thereof, and water-soluble proteins, depending on applications and purposes. . Such components are further described below.

  The external preparation for skin of the present invention is preferable from the viewpoint of retaining foam generated by using a surfactant such as a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant. At this time, from the viewpoint of storage stability, the surfactant to be used is preferably a solution, solid, flake, granule, fine granule, or powder that does not contain water. It is preferable to use granules, fine granules, and powders. As the surfactant, a natural surfactant is preferable. Natural surfactants refer to animal and plant derived surfactants such as phospholipids such as lecithin, lanolin, cholesterol, saponin, sphingolipid, pectin, dipotassium glycyrrhizinate, plant-extracted amino acid surfactants, etc. Can be mentioned. The skin external preparation of the present invention preferably contains a natural surfactant in an amount of 0.001% by mass to 10% by mass, and more preferably 0.005% by mass to 8% by mass.

  Among the natural surfactants used in the present invention, among those listed above, phospholipid, saponin, pectin, glycyrrhizic acid or a salt thereof is preferable, and an extract containing saponin and / or glycyrrhizic acid or a salt thereof is contained. It is particularly preferable. Saponin is a glycoside widely distributed in plants, and is a generic name for a group of compounds that have steroids and triterpenoids as non-sugar parts. Depending on the type of aglycon (non-sugar part of glycosides), triterpenoid saponins, It can be roughly divided into steroidal saponins. A common property of saponins is that their aqueous solutions have high foaming properties.

  As described above, saponins are known to have foaming properties. The present inventors have added an extract containing this saponin in place of the water-soluble protein so that the water-soluble protein can be added. It has been found that, for example, the stability of the foam for a long time, the improvement of the feeling of use such as the sag and ease of mixing of the mixture, the improvement of the skin condition such as moistness and elasticity can be obtained. The topical skin preparation containing water-soluble protein may be difficult to use, for example, for allergic users, but an extract containing saponin can be used effectively as a substitute for this water-soluble protein. It is. Furthermore, since the addition of an extract containing saponin has an effect of increasing the amount of carbon dioxide generation, it can contribute to effectively promoting blood circulation in the skin. The inventors of the present invention include a polysaccharide or a derivative thereof, in particular, two or more polysaccharides or a derivative thereof, thereby improving the effect of adding an extract containing saponin, particularly an improvement in use feeling and skin condition. It has been found that the effects such as the above are excellent.

As the extract containing saponin used in the external preparation for skin of the present invention, it is preferable to use a plant-derived extract. As an example of a plant here, as a plant containing a triterpenoid saponin, soybean, loofah, azuki bean, green beans, spinach, sugar beet, grapes, pearl oyster, licorice, senega, kiraya, mukuroji, bonsai, ginseng, tea seeds, In addition, examples of the plant containing a steroidal saponin include a lily family plant, a yam family plant, a chimo (mother's mother), and a Bakumondou (barley winter).
The agent of the present invention preferably uses, as an extract containing saponin, an extract of any one or more of the above-mentioned various plants containing a triterpenoid saponin among these plants. Muclozi, soybean, licorice, loofah It is preferable to contain an extract of one or more kinds of plants selected from the above, and it is particularly preferable to contain an extract of Mukuroji. Here, mukuroji is a plant belonging to the genus Sapindaceae, and the genus Sapindus. mukurossi and S. delavayi etc. correspond.

  The plant parts that are the raw materials for the extract include whole plants, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots And tuberous root. In the present invention, when an extract of mukuroji is used as an extract containing saponin, it is preferably an extract of mukuroji fruit and / or peel, and particularly preferably an extract of peel.

  The extract can be used as a whole plant or the aforementioned part as it is or after being cut, crushed, pulverized or exploited, or dried or pulverized. These treatments can be used alone or in combination.

  Examples of the solvent used for extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, Examples thereof include organic solvents such as isopropyl acetate, ethyl ether, and acetone. These can be used alone or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, or a mixed solvent thereof, which is harmless to the human body, as the extraction solvent. The extraction may be performed at or below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. The extract may contain moisture as an extraction solvent. However, when the external preparation for skin of the present invention is a one-part skin external preparation, an acidic substance and a carbon dioxide generating substance react during storage to generate carbon dioxide. Therefore, an extraction solvent containing moisture can also be used because it does not substantially contain moisture unless it contains the amount of moisture necessary to do so.

  After the impurities are removed by filtration, the extract is contained in the external preparation for skin of the present invention as a solid such as powder. Examples of the solid method include a method in which the extract obtained by extraction with the above solvent is powdered by freeze drying or spray drying. Prior to making the extract into a solid form, further purification operations may be added within a range that does not impair the physiological action of saponin.

  From the viewpoint of further enhancing the above effect, when the external preparation for skin of the present invention contains an extract containing saponin, the content thereof may be 0.001% by mass to 10% by mass in the external preparation for skin. Preferably, it is 0.005 mass% or more and 8 mass% or less. It is preferable that the content of the extract is 0.001% by mass or more and 10% by mass or less from the viewpoint of coexistence of the long-term stability of the foam and the effect of improving the skin condition.

In addition, examples of glycyrrhizic acid and salts thereof as natural surfactants in the present invention include dipotassium glycyrrhizinate (GK2). As will be described later, glycyrrhizic acid and salts thereof also function as anti-inflammatory agents and whitening agents. In the present invention, when glycyrrhizic acid or a salt thereof is used as a natural surfactant (or anti-inflammatory agent, whitening agent), as will be apparent from the comparison of Examples 4 and 5 described later, In addition to being able to hold carbon dioxide for a long time in this mixture, the amount of carbon dioxide generated can be increased, the amount of moisture in the stratum corneum of the skin is increased, and the effect of improving the skin condition such as enhancement of redness is enhanced, It is possible to improve the feeling of use of the external preparation for skin. The preferable content of glycyrrhizic acid and its salt in the external preparation for skin of the present invention is the same as the preferable content of the anti-inflammatory agent described later.

  Furthermore, the external preparation for skin of the present invention preferably contains at least one selected from bactericides, anti-inflammatory agents and whitening agents.

  A bactericidal agent is a substance that has bactericidal, bacteriostatic or antibacterial action and does not cause problems with the skin when blended into a topical skin preparation. Examples thereof include salicylic acid and its salts or salicylic acid derivatives; erythromycin, clinda Antibiotics such as mycin, gentamicin, penicillin, chloramphenicol, tetracycline; benzoyl peroxide; nadifloxacin; ethanol; benzalkonium chloride; sulfur; parahydroxybenzoate esters; hinokitiol; triclosan; Examples thereof include chitin and chitosan derivatives. Furthermore, an extract having an antibacterial action can also be used as an antibacterial agent. Examples of such an extract include fennel, apricot, tea, rosehip, chamomile, orange, yarrow, turmeric, gardenia, clove, sage, and yukinoshita. , Clove, eucalyptus, cypress, cedar and other extracts. These can be used alone or in combination of two or more.

Of these fungicides, salicylic acid and salts thereof or salicylic acid derivatives are particularly preferably used, and salicylic acid is particularly preferably used. As is apparent from Examples to be described later, in the skin external preparation of the present invention, it is possible to improve the stratum corneum water content and elasticity of the skin after use and used fungicides such as salicylic acid.
From the viewpoint of further enhancing this effect, when the external preparation for skin of the present invention contains a bactericidal agent, the content thereof is preferably 0.001% by mass or more and 20% by mass or less in the external preparation for skin. More preferably, it is 0.005 mass% or more and 10 mass% or less.

  An anti-inflammatory agent is a substance having an action of suppressing inflammation, and examples thereof include glycyrrhizic acid and salts thereof described above as natural surfactants, and derivatives thereof. Examples of other anti-inflammatory agents include glycyrrhetinic acid and salts thereof, mefenamic acid and salts thereof, phenylbutazone, indomethacin, ibuprofenic acid and salts thereof, ketoprofen, allantoin, guaiazulene, and derivatives thereof, ε-aminocaproic acid, Zinc oxide, diclofenac sodium, proanthocyanidins and the like can be mentioned. Furthermore, an extract having an anti-inflammatory action or the like can be used as an anti-inflammatory agent. Examples of such an extract include a yukinoshita extract, a licorice extract, an aloe extract, a sicon extract, a salvia extract, and an arnica extract. And extracts of animals and plants such as chamomile extract, birch extract, hypericum extract, eucalyptus extract, peach leaf extract, pine bark extract, grape seed extract, bilberry extract and the like. These can be used alone or in combination of two or more.

Among these anti-inflammatory agents, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, and derivatives thereof are preferably used, and glycyrrhizic acid and its salts are particularly preferable for the reasons described above. It is preferable to use dipotassium (GK2). In the external preparation for skin of the present invention, when an anti-inflammatory agent is used, the effect of suppressing skin inflammation and preventing acne and rough skin can be obtained.
From the viewpoint of further enhancing such effects, when the skin external preparation of the present invention contains an anti-inflammatory agent, the content thereof is preferably 0.001% by mass or more and 20% by mass or less in the skin external preparation, More preferably, it is 0.005 mass% or more and 10 mass% or less.
When GK2 is used in the external preparation for skin of the present invention, as will be apparent from Example 7 described later, not only a high skin whiteness improvement effect is obtained, but also a high skin condition improvement such as an increase in stratum corneum moisture content and elasticity. An effect is obtained. Furthermore, the external preparation for skin using GK2 is excellent in usability such as ease of mixing and difficulty in dripping, as is apparent from the description of 16 and 7 described later.

  As the whitening agent, those having tyrosinase activity or those having an activity of decolorizing melanin pigment are mainly used. Examples thereof include L-cysteine and derivatives thereof, ascorbic acid and derivatives thereof, tranexamic acid derivatives, grabrizine, liquiritin, isoliquiritin, hydroquinone, arbutin, kojic acid, placenta, and the like. Moreover, said glycyrrhizic acid or salt, glycyrrhetinic acid and its salt, and derivatives thereof can also be used as a whitening agent. Furthermore, an extract having a whitening action can also be used as a whitening agent, and as such an extract, Sakuhakuhi extract, Toki extract, Ibukitorano extract, Keiketou extract, Clara extract, hawthorn extract, Examples include a white lily extract, a hop extract, and a rose extract. These can be used alone or in combination of two or more.

  Among these whitening agents, it is preferable to use one or more selected from arbutin, placenta, glycyrrhizic acid or a salt thereof, ascorbic acid and a derivative thereof.

Arbutin used in the present invention is a compound whose system name is also called 4- (β-D-glucopyranosyloxy) phenol.
When arbutin is used in the external preparation for skin of the present invention, as will be apparent from Example 10 described later, not only a high skin whiteness improvement effect is obtained, but also a high skin condition improvement effect such as a moist feeling and elasticity of the skin. can get. Furthermore, the external preparation for skin using arbutin is excellent in the feeling of use such as ease of application, pleasantness at the time of application, ease of removal, etc., as is apparent from the description of Examples 10 and 16 described later. ing.

  Placenta refers to animals, particularly preferably pigs, horses, cows, sheep, human placenta extracted from growth factors and other nutrients that promote cell division, nutrients extracted from fish ovarian membranes, plant embryos It is a collective term for the nutritional components extracted from the food. The skin external preparation of the present invention containing placenta has the effect that the amount of water transpiration tends to decrease after application, and the smoothness and smoothness are likely to increase after application, as will be apparent from the description of Example 15 described later. In the present invention, any placenta can be used, but an animal-derived placenta or a fish-derived placenta can be preferably used.

  From the viewpoint of further enhancing the above effect, when the skin external preparation of the present invention contains a whitening agent, the content thereof is preferably 0.001% by mass or more and 30% by mass or less in the skin external preparation, More preferably, it is 0.005 mass% or more and 20 mass% or less.

  In the external preparation for skin of the present invention, other active ingredients can be used in place of or in addition to the extract containing saponin, bactericide, anti-inflammatory agent, and whitening agent. Examples of such active ingredients include gold leaf, pearl powder (pearl), mud, charcoal, gypsum, enzymes, herbs, seaweed, yogurt, whey, alcohol, fermented products such as sake, straw, honey, propylene glycol, polyethylene glycol, sorbitol And moisturizing ingredients such as sodium lactate and sodium pyrrolipyrrolidone carboxylate, plant ingredients such as licorice, and vitamins. Of these, gold foil and pearl powder are particularly preferred. As will be apparent from the description of Example 11 to be described later, when a gold foil is used, the feeling of use at the time of application, good appearance, and the like are improved, and an effect of improving the skin condition is also obtained. Further, as will be apparent from the description of Example 12 described later, when pearl powder is used, an effect of improving the skin condition such as the brightness of the skin is obtained, and the usability is also improved.

  Pearl powder is a cultured or natural pearl that is a spherical or amorphous metabolite formed in the body of sea shells such as pearl oysters, black butterflies, white butterflies, mabe, and abalone, and freshwater shells such as squid butterflies. This is a powder obtained by sieving a powder that has been pulverized by a known method such as a ball mill, a jet mill, or a turbo mill. When the pearl powder is contained, the content thereof is preferably 0.0001% by mass or more and 10% by mass or less in the external preparation for skin. When gold foil is contained, the content thereof is preferably 0.0001% by mass or more and 10% by mass or less in the external preparation for skin.

  The foamable skin external preparation of the present invention includes, in addition, polysaccharides and derivatives thereof and thickeners other than water-soluble proteins; excipients, granulating agents; pH adjusting agents; fats and oils; fragrances; coloring agents; Antibacterial and antifungal agent; alcohol, polyhydric alcohol; inorganic salt; lubricant; solvent; one or more of components usually used in skin external preparations, such as animal and plant extracts.

  Examples of thickeners other than polysaccharides and derivatives thereof and water-soluble proteins include organic alcohols such as polyvinyl alcohol, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, Examples include hydrophilic synthetic polymers such as poloxamer (Pluronic (registered trademark)), polyvinylpyrrolidone, acrylic acid / alkyl methacrylate copolymers, and inorganic ones such as laponite, bentonite, smectite, etc. Examples thereof include hydrophilic thickening compounds such as clay minerals, silica and talc. The acrylic acid / alkyl methacrylate copolymer is a compounding component that functions as a polymer emulsifier. For example, an (acrylates / alkyl acrylate (C10-30)) crosspolymer can be used.

  As the excipient or granulating agent, for example, powders such as lactose, powdered sugar, xylitol, D-sorbitol, glucose (glucose), D-mannitol, fructose, sucrose, sucrose, urea, etc., without particular limitation, are used alone. Alternatively, two or more types can be used in combination. When such excipients and / or granulating agents are contained, the content thereof is preferably 10% by mass or more, and 20% by mass or more and 88% by mass or less in the external preparation for skin of the present invention. It is more preferable.

  In the skin external preparation of the present invention, the acidic substance, the carbon dioxide generating substance, the polysaccharide or a derivative thereof, the water-soluble protein, the natural surfactant, the fungicide, the anti-inflammatory agent, the whitening agent, The total content of other components other than the excipient or granulating agent is preferably 40% by mass or less, and more preferably 30% by mass or less.

The external preparation for skin of the present invention comprises (4) the above-mentioned inorganic hydrophilic thickening compound and organic thickening as a thickening agent other than the above-mentioned polysaccharide and its derivative and water-soluble protein in addition to the polysaccharide or its derivative. In the case of containing at least one selected from the above-mentioned hydrophilic synthetic polymers that are agents, as in the case of (1) to (3) in which two or more of the above-mentioned polysaccharides or derivatives thereof are combined, "The skin condition is improved," and the effect is remarkable.
The effect of the present invention is that the agent of the present invention contains a polysaccharide or a derivative thereof and the hydrophilic thickening compound or the hydrophilic synthetic polymer together with a solid acidic substance and a solid carbon dioxide generating substance. It is an effect obtained by doing. Therefore, the effect of the present invention is, for example, a viscosity containing any one or both of the combination of the polysaccharide (4) or a derivative thereof and the hydrophilic thickening compound or the hydrophilic synthetic polymer together with water. It is not possible to obtain a viscous composition by mixing it with a solid acidic substance and / or a solid carbon dioxide generating substance.

  In the present invention, (4) when a hydrophilic synthetic polymer that is an inorganic hydrophilic thickening compound or an organic thickening agent is contained, a preferred example of the polysaccharide or derivative thereof contained in the external preparation for skin is hydrophilic. Examples include natural polymers, cellulose derivatives, and starch derivatives. Examples of the hydrophilic natural polymer include alginic acid and its salts, carrageenan, locust bean gum, tamarind gum and guar gum.

  In particular, (4) polysaccharides or derivatives thereof include alginic acid and salts thereof, carrageenan, locust bean gum, tamarind gum, guar gum, ethyl cellulose, carboxymethyl cellulose and derivatives thereof, and salts thereof, hydroxyethyl cellulose and derivatives thereof, hydroxypropyl methylcellulose And derivatives thereof, sulfonated cellulose derivatives, carboxymethyl ethyl cellulose and salts thereof, cellulose acetate phthalate, cationized cellulose and croscarmellose and salts thereof, preferably alginic acid and salts thereof, carrageenan, Carboxymethylcellulose and its derivatives and their salts, guar gum, hydroxyethylcellulose and its derivatives and cations And particularly preferably at least one selected from cellulose.

  Moreover, in this invention, when it contains the hydrophilic synthetic polymer which is (4) said inorganic hydrophilic thickening compound or organic thickener, it is also preferable to use a xanthan gum as a polysaccharide or its derivative (s). In this case, it is particularly preferable to combine xanthan gum and talc.

  In the case of (4), when the skin external preparation of the present invention contains a specific hydrophilic natural polymer, cellulose derivative or starch derivative as a polysaccharide or a derivative thereof, the hydrophilic natural polymer, cellulose The amount of the hydrophilic synthetic polymer that is an inorganic hydrophilic thickening compound or organic thickener is preferably 1 part by mass or more and 10000 parts by mass or less with respect to 100 parts by mass of the derivative or starch derivative. More preferably, it is more than 5000 parts by mass and more preferably 10 parts by mass and less than 1000 parts by mass. Here, the amount of the specific hydrophilic natural polymer, cellulose derivative or starch derivative is the total amount of these if two or more of them are contained. Further, the amount of the hydrophilic thickening compound or the hydrophilic synthetic polymer is the total amount of these if two or more of them are contained. In addition, when a specific type of hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound, or hydrophilic synthetic polymer is contained, the above-mentioned hydrophilic natural polymer, cellulose derivative, starch The amount of the derivative, hydrophilic thickening compound and hydrophilic synthetic polymer may be the amount of the specific kind of hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound and hydrophilic synthetic polymer. Yes (the same applies below).

  In the external preparation for skin of the present invention, the total content of the specific hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound and hydrophilic synthetic polymer is 5% by mass or more and 50% by mass. It is preferably 10% by mass or more and 45% by mass or less, and more preferably 12% by mass or more and 45% by mass or less.

  The dosage form of the external preparation for skin of the present invention is usually solid, and examples thereof include powder, granules, fine granules, pellets, or combinations of two or more thereof. From the viewpoint of cost reduction during production and ease of dissolution during use, powder form is preferred.

  For example, when the external preparation for skin of the present invention is granulated, the entire preparation may be granulated, or a part thereof may be granulated. When a part is made granular, the acidic substance and / or the carbon dioxide generating substance may be made granular. In this case, the granule may contain other components (one or more of the various components described above, such as excipients, granulating agents, polysaccharides or derivatives thereof, water-soluble proteins, etc.). Components other than the acidic substance and the carbon dioxide generating substance may be granular.

  For example, in the case of obtaining granules of the solid acidic substance and / or the solid carbon dioxide generating substance by granulating a mixture of the acidic substance and / or the carbon dioxide generating substance and other components, Although there is no restriction | limiting in particular as content of another component, It is preferable to set it as less than 80 mass% in the said granule. When other components are present in a content exceeding 80% by mass, foaming properties are lowered, which is not preferable.

  The method for producing the granule is not limited to this example, and is a conventional method such as dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc. Can be manufactured according to

  For example, when a low melting point compound is used as a granulation agent as a matrix base, the acidic substance and / or the carbon dioxide generating substance and the necessary material are necessary for the low melting point granulating agent melted by heating in a container such as a beaker. Add other ingredients depending on the conditions and mix well. You may add an appropriate additive to this as needed. The mixture is further stirred while being cooled at room temperature, and left to solidify. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker to generate the acidic substance and / or the carbon dioxide gas. The substance and other components as necessary are dissolved or dispersed and mixed well, then heated in an oven or the like to remove the solvent and dried. When it is completely solidified, it is crushed and sieved to adjust the size of the granules, and then granulated.

  Examples of the shape of the solidified acidic substance or solid carbon dioxide gas generating substance as described above include, for example, an irregular shape, a planar shape, a polyhedral shape, a spherical shape, a drop shape, a fiber shape, a columnar shape, a fine powder shape, and the like. Can be used without any particular restrictions. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm are more preferable from the viewpoint of ease of handling and ease of mixing with water-containing substances. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

  In the present invention, the acidic substance and the carbon dioxide generating substance are contained in the same agent, and the acidic substance and the carbon dioxide generating substance are blended and coexist in the same agent so as not to physically contact each other. It is preferable. The coexistence means is not particularly limited and can be widely applied.

  When blending so that the acidic substance and the carbon dioxide generating substance do not come into physical contact with each other, for example, a coating layer is provided on either or both of the acidic substance and the carbon dioxide generating substance. Alternatively, either one or both of the acidic substance and the carbon dioxide generating substance may be encapsulated. In addition, a layer that does not contain the acidic substance and the carbon dioxide generating substance may be sandwiched between the acidic substance and the carbon dioxide generating substance so that they do not come into direct contact with each other, and compression molding may be performed.

  Hereinafter, the coexistence means of the acidic substance and the carbon dioxide generating substance in the same agent will be specifically described, but the invention is not limited thereto.

[Coat layer formation]
As a coating layer forming method, for example, a method of forming a coating layer in at least one of an acidic substance and a carbon dioxide generating substance may be used. By providing a coat layer, even if it coexists with the acidic substance, the carbon dioxide generating substance and other components in the same agent, there is no risk of unexpected carbon dioxide generation during its production or storage, so stability, It is preferable from the viewpoint of durability.

  A preferable coating agent for constituting the coating layer can be used without particular limitation as long as it has low reactivity with the acidic substance or the carbon dioxide generating substance. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Examples include copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropylcellulose, wheat starch, sucrose, lactose, and citrate. In particular, when an acidic substance such as citric acid is coated, it is preferable to employ a citrate such as calcium citrate. Moreover, you may form a coat layer using solid hydrocarbon wax, solid fats, etc. which melt | dissolve at temperature more than fixed by heating.

    The amount of the coating agent used for the acidic substance and / or carbon dioxide generating substance is preferably 1 to 20% (w / w), more preferably 1 to 10% (w / w) based on the acidic substance or carbon dioxide generating substance. w) About.

  The coating layer may be coated by any method as long as it is usually used for coating particles. For example, it may be coated at the same time as granulation by spray granulation or tumbling granulation, etc., and the powder or granulated product is coated with oil and fat, granulation coating, transport layer method, pan coating, rolling coating, fluid coating or You may coat | cover using methods, such as dry coating. When excessive heat or physical force is applied during coating, the acidic substance or the carbon dioxide generating substance is destroyed and the generated film is broken, and the surface of the acidic substance or the carbon dioxide generating substance is broken. Not only is it difficult to uniformly coat the lipid powder on the whole, but the acidic substance or the carbon dioxide generating substance leaks out on the surface and solidifies due to moisture absorption, or it may cause adverse effects on other components during compounding. The coating conditions must be such that the coating layer and the coating object are not destroyed.

[Encapsulation]
When an acidic substance and / or a carbon dioxide generating substance is encapsulated, a known method may be employed without any particular limitation.

  As the encapsulation method, a known method can be applied without any particular limitation. Examples of the encapsulation material include gelatin, starch, gum arabic, methylcellulose, acrylic acid ester, methacrylic acid ester, vinyl acetate, Polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acid, higher alcohol, and the like, and those formed with a multilayer of surfactants such as liposomes are included, but can be widely used without being limited thereto. For example, the basic structure of the capsule is a homopolymer or copolymer formed from one or more monomers selected from acrylic acid esters, methacrylic acid esters, vinyl acetate, and styrene, or the monomers and acrylic acid, methacrylic acid, divinyl A resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate is also preferable. In such a microcapsule, the contents and the polymer constituent monomer constituting the capsule shell are emulsified in a reaction solvent such as water, and polymerization of azobisisobutyronitrile, benzoyl peroxide, etc. is started. What is necessary is just to add an agent and to perform emulsion polymerization. As a surface active component used for such emulsification, for example, hexlite sold under the name of “Laponite XLG” can be suitably exemplified. The produced microcapsules are separated by means such as centrifugation, and washed if desired, whereby the microcapsules of the present invention can be produced.

[Compression molding]
As a compression molding method, a substance other than the acidic substance and the carbon dioxide generating substance (so that they do not directly contact between the first layer containing the acidic substance and the second layer containing the carbon dioxide generating substance ( For example, a method in which a third layer made of an excipient, a thickener, etc.) is sandwiched and compression molded may be employed. The compression-molded dosage form may be any dosage form as long as it is solid, such as a tablet, sphere, or plate. Here, the acidic substance to be used and the carbon dioxide generating substance may be used as they are, or the acidic substance in which a coating layer is provided by the above-described method on either one of the first layer and the second layer, or A carbon dioxide generating substance, the encapsulated acidic substance or the carbon dioxide generating substance may be used. The compression molding method is not particularly limited, and a known method can be applied.

The skin external preparation of the present invention may be ones excluding the following skin external preparations.
“At least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener, and is a one-part skin external preparation that does not contain water, In all the external preparations for skin, the thickener is contained in an amount of 12 to 45% by mass. The thickener is used in combination with albumin and other thickeners and mixed with a liquid containing moisture when the external preparation for skin is used. One-part skin external preparation ". Here, examples of the thickener include polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methylcellulose, sulfonated cellulose derivatives, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxy Other hydrophilic synthetic polymers such as methylcellulose, cationized cellulose, and pluronic, and other hydrophilic natural polymers such as starch, xanthan gum, sodium alginate, succinoglycan, carrageenan, guar gum, locust bean gum, and celluloses , Hydrophilic protein compounds such as chondroitin sulfate, casein, collagen, gelatin, albumin, laponite, bentonite, smect Hydrophilic thickening compound such as a hydrophilic clay minerals such sites are mentioned.

<Usage form of external preparation for skin>
In use, the external preparation for skin of the present invention causes foaming by mixing with a water-containing substance on the palm or in a container.
The external preparation for skin of the present invention may be used as a one-part type external preparation for skin, or may be used as a two-part type comprising a hydrous substance and a kit. When the external preparation for skin of the present invention is a one-pack type, as described above, the external preparation for skin is usually a solid composition, and more preferably in the form of a solid, granule, fine particle, or powder. Since it is easy to mix with a hydrous substance and foaming easily occurs, it is particularly preferable to be in the form of granules, fine granules, or powders. In addition, when the external preparation for skin of the present invention is a one-component type, it usually does not substantially contain water. Here, “substantially free of water” means that the acid substance and the carbon dioxide generating substance react during storage of the external preparation for skin and do not contain the amount of water necessary for generating carbon dioxide. . Specifically, the amount of water contained in the external preparation for skin of the present invention is 15% by mass or less, preferably 10% by mass or less, more preferably 8% by mass or less. When the external preparation for skin of the present invention is a two-pack type comprising a hydrous substance and a kit, the agent containing an acidic substance, a carbon dioxide generating substance and at least one polysaccharide is usually a solid composition, More preferably, it is in the form of a solid, granule, fine granule, powder, and since it is easy to mix with a hydrous substance and foaming easily occurs, it may be in the form of a granule, fine granule, powder. Particularly preferred. In addition, when the external preparation for skin of the present invention is of a two-pack type, the solid composition usually contains substantially no water. Here, “substantially free of water” means that the acid substance and the carbon dioxide generating substance react during storage of the external preparation for skin and do not contain the amount of water necessary for generating carbon dioxide. . Specifically, the amount of water contained in the external preparation for skin of the present invention is 15% by mass or less, preferably 10% by mass or less, more preferably 8% by mass or less. When the external preparation for skin of the present invention is a one-part type, the user usually prepares a water-containing substance for mixing with the external preparation for skin, and in the case of two-part type, as described above, the external preparation for skin of the present invention And the hydrous material constitute a kit. When the external preparation for skin is a one-pack type, a liquid containing water is often used as a water-containing substance. In the case of the two-component type, examples of the water-containing substance include a liquid containing water and a gel. As the hydrous substance, a liquid is preferable, a liquid having a low viscosity is more preferable, and a liquid having no viscosity is particularly preferable. It is preferable that the water-containing substance does not substantially contain the above thickener. Specifically, the content of the thickener in the water-containing substance is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, and 0.01% by mass or less. Is particularly preferred. In particular, when the external preparation for skin is a two-part type, it is more effective to mix the external preparation for skin with a liquid, particularly a liquid having a relatively low viscosity, compared with the case of mixing with a gel. Since it is played, it is preferable. When the external preparation for skin of the present invention is mixed with gel or a liquid having a relatively high viscosity, it is not preferable because the two agents are difficult to mix and it takes time to foam. Specifically, the water-containing material has a viscosity at 25 ° C. of preferably 50000 mPa · s or less, more preferably 30000 mPa · s or less, particularly preferably 10000 mPa · s or less, and further preferably 5000 mPa · s or less. . This viscosity can be measured with a viscometer used in the following examples. The water content in the hydrous material may be 10% by mass or more, and preferably 30% by mass or more. More preferably, it is 40 mass% or more, More preferably, it is 50 mass%, It is especially preferable that it is 70 mass% or more, Especially 80 mass% or more. When the water content is less than 10% by mass, carbon dioxide gas is hardly generated when the skin external preparation and the water-containing substance are mixed, and effects such as blood flow promotion during use cannot be obtained.
Here, a high lower limit such as 70% by mass or more and 80% by mass or more can be adopted for both the one-part type and the two-part type, but is particularly preferable in the case of the one-part type.

  When the external preparation for skin of the present invention is a one-pack type, it is characterized by being easy to handle at a lower cost than a two-pack type by being made into one. In the case of the one-drug type, the water-containing substance used in the present invention can be a liquid containing water that is usually used in cosmetics, pharmaceuticals, etc., or used in general households. The liquid containing water may be water itself. Specifically, in addition to tap water, distilled water, membrane filtered water, ion exchange water, deep ocean water, sake, wine and other alcoholic beverages, soy milk, drinking yogurt, acerola juice, sports beverages, carbonated water beverages, rice Notogi soup and so on. These may be used alone or in combination of two or more.

  In addition, when the external preparation for skin of the present invention and the hydrated substance are combined to form a two-pack type, the hydrated substance includes, as described above, a liquid or gel containing water, and the water and water mentioned above. In addition to liquids containing any of these, there may be mentioned those obtained by adding arbitrary components thereto. As this component, a known component contained in a liquid preparation for a two-part skin external preparation, for example, a moisturizer, a surfactant, a pH adjuster, a volatile alcohol, an oil or fat, a fragrance, an animal or plant extract, etc. Can do. For example, as a humectant, polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1 , 3-propanediol, sorbitol, polyglycerin derivatives and other polyhydric alcohols, polyoxyalkylene alkyl glucosides, sodium lactate, sodium pyrrolidonecarboxylate, almonds, avocado, altea, aloe, usvenia oyster, onionis, oats, licorice, quince seed, Clara (kujin), gardenia, grapefruit, watercress, gentiana, genus shoko, burdock, wheat, saishin, cactus, bonito, hawthorn, jiou Shimotake, ginger, mallow, mulberry, prickly-spotted caterpillar, cordyceps, mint, pearl barley, clam, rose, cypress, dandelion, grapes, prunes, loofah, bodaiju, hop, pine, quince, maronier, melissa, cornflower, lily, lily Plant extracts such as lavender, apple, rice and rice bran, black currant, Ibukitorano, Neubara, Ezoukogi, seaweed, etc., and one or more of these can be used.

  The amount of the water-containing substance to be used is not particularly limited and can be used in a wide range. For example, it is preferably added in an amount of 1 to 10 times by mass with respect to the external preparation for skin, and 2 to 5 times. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, dripping due to a decrease in viscosity of the external preparation for skin can be prevented by adding the liquid within 10 times the amount.

  The temperature of the hydrated substance to be used is not particularly limited, and a wide range can be used. However, it is particularly preferable to use the hydrated substance after cooling in advance because the action of the active ingredient of the external preparation for skin is enhanced. The usable temperature range is preferably water at about room temperature or tap water from the viewpoint of usability during application and user convenience.

  The method for preserving the external preparation for skin is not particularly limited as long as it is stored in a state where it blocks moisture and does not come into contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, but is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

According to the external preparation for skin of the present invention, as will be apparent from the description of Examples described later, the usability is good and an excellent skin condition improving effect is obtained. Examples of the feeling of use include, for example, ease of mixing a mixture of a skin external preparation and a water-containing substance into the skin, ease of application, ease of dripping, ease of removal, smoothness of foam, fineness of foam, Examples include a uniform feeling of foam (no powdery feeling), elasticity of foam, foam retention, carbonic acid feeling (irritant feeling), sustainability of carbonic acid feeling, and the like. Examples of the skin condition improving effect include moist feeling, elasticity, brightness, redness, smoothness, tension, whiteness, increase in stratum corneum moisture, and suppression of moisture evaporation. As will be apparent from Example 24 described later, according to the external preparation for skin of the present invention, it may be possible to obtain an effect of making wrinkles less noticeable.

<Uses of external preparations for skin>
The topical skin preparation of the present invention promotes an increase in the blood flow of the skin, and by taking advantage of the above effects, whitening, skin quality improvement, freckles improvement, skin rejuvenation, skin tightening, partial skin thinning, clean the skin , Make skin smooth, smooth skin, keep skin smooth, prevent rough skin, squeeze skin, moisturize skin, keep skin moisture and oil supplement, keep skin flexible, skin Protect skin, prevent dryness, soften skin, give skin elasticity, give skin gloss, smooth skin, prevent sunburn spots and freckles, dry wrinkles are inconspicuous Not only for cosmetics intended to do, but also for skin, tingling, prevention of ash, moyake, cracks, redheads, acne, oily skin, prevention of razor baldness, sunburn spots, freckles, sunburn, After snow Non-pharmaceutical for the purpose of preventing skin irritation, tightening the skin, cleaning the skin, preparing the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing the skin from drying out, etc. It can be suitably used for any pharmaceutical products such as products and medicines. The external preparation for skin of the present invention is preferably used as cosmetics and quasi drugs, and is preferably used as cosmetics such as emulsions, creams, packs, and peeling agents, and medicinal cosmetics. Of these, use as a pack agent is particularly preferable because it provides a good feeling of use and a high skin condition improving effect.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples. In the following examples and comparative examples, commercially available products were used unless otherwise specified.

<Examples 1-10, Comparative Examples 1-3>
Each component shown in Table 1 was blended and mixed in the composition shown in the same table, and the powdered skin external preparations of Examples 1 to 10 and the powdered skin external preparations of Comparative Examples 1 to 3 were produced. . The numerical value of the following Table 1 is a mass ratio (mass%) in a skin external preparation.

  According to the following [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3], the characteristics of the skin external preparations of the above Examples and Comparative Examples were evaluated.

[Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3]
(1) Sensory evaluation As subjects, three healthy women in their 20s to 30s were randomly selected. The inner side of the subject's forearm was washed with face wash and rested in the measurement room for 15 minutes. Subsequently, the powdery skin external preparation sample and water were mixed in a container at a ratio of 1: 3 (mass ratio) to obtain a mixture that was a foamy pack cosmetic. This mixture was applied to the 4 cm × 4 cm portion inside the forearm. Ten minutes after application, the mixture was removed from the forearm and the forearm was washed with water. After that, as an evaluation of the feeling of use, “easy to mix”, “easy to apply”, “difficult to sag” and “easy to remove”, and the condition of the skin after use, “moist feeling” ”,“ Skin elasticity ”,“ Skin brightness ”and“ Skin redness ”were surveyed. For each item, points were assigned to the 7 levels shown in Table 2, and after aggregation, the average value of 3 people was obtained. The results are shown in Table 3. In addition, about "sagging difficulty", after application | coating, it was highly evaluated so that the mixture did not sag easily from skin. In addition, the higher the moisture content of the skin, the higher the “water content”, and the higher the “skin redness”, the higher the skin redness.

  From the results of Table 3 above, in the external preparation for skin of each Example containing polysaccharides or derivatives thereof, feeling of use such as ease of mixing, ease of application, resistance to dripping, ease of removal, and moist feeling It can be seen that it is superior to Comparative Examples 1 to 3 in terms of both skin condition improvement effects such as elasticity, brightness and redness. Furthermore, it turns out that Example 2, 6-10 containing 2 or more types of polysaccharide or its derivative | guide_body has a higher effect of both the improvement of this usability | use_condition and the state of skin. Moreover, when it contains water-soluble protein like Example 3, 6, 8, 10, the feeling of use and the improvement of the state of skin become still higher, like Example 4, 5, 7, 9. It can be seen that, when an extract containing saponin, which is a natural surfactant, is contained instead of the water-soluble protein, these effects become higher than those of the water-soluble protein. Moreover, it turns out that the high effect is acquired in Example 3, 5-10 containing GK2, salicylic acid, or arbutin. For example, as is apparent from the comparison between Examples 4 and 5, by containing GK2 which is a natural surfactant (and anti-inflammatory agent and whitening agent), not only the effect of improving the condition such as redness of the skin is enhanced, but also the skin The usability of external preparations is also improved. From the above results, when using two types of polysaccharides or derivatives thereof as in Examples 2 to 5 compared to Example 1 using one type of polysaccharide or derivatives thereof, water-soluble proteins, natural surfactants are used. By using together, it turns out that a higher usability and the skin condition improvement effect can be acquired. Moreover, it turns out that both a usability | use_condition and a skin condition improvement effect improve further by using together polysaccharide or its 2 types or more and water-soluble protein or a natural surfactant like Examples 6-10. .

(2) Measurement of skin condition For the sensory evaluation of (1) above, the L * value, the stratum corneum moisture content, and the elasticity at the planned mixture application location inside the forearm before application of the mixture were measured with the following measuring devices. After the mixture was removed and washed with water, the L * value, the stratum corneum moisture content, and the elasticity of the portion where the mixture on the inner side of the forearm was applied were measured in the same manner. From the measured values obtained, the average value of three subjects was determined. The average value after using the external preparation for skin was divided by the average value before use, and the obtained value was defined as the rate of change. The change rate of the L * value (whiteness) is shown in FIG. 1, the change rate of the stratum corneum moisture content is shown in FIG. 2, and the change rate of elasticity is shown in FIG. In these figures, the higher the rate of change, the higher the evaluation.

-L * value: Measured with a color difference meter (CR-400 manufactured by Konica Minolta).
-Stratum corneum moisture content: Measured with a skin surface stratum corneum moisture measuring device SKICON-200EX (manufactured by IBI S Co., Ltd.). This skin surface stratum corneum moisture content measuring apparatus evaluates the skin conductance (electrical conductivity, unit: μS) as the moisture content of the stratum corneum .
Elasticity: Measured with a skin viscoelasticity measuring device Cutometer MPA580 (Courage + Khazaka).
These measurements were performed by standard methods described in the instructions provided with the instrument.

From the results shown in FIGS. 1 to 3, in each example, the rate of change equal to or higher than that of each comparative example is obtained for the L * value, the stratum corneum moisture content, and the elasticity of the skin after using the external preparation for skin. I understand that. In particular, inclusion of two or more polysaccharides or derivatives thereof, inclusion of water-soluble protein, inclusion of an extract containing saponin which is a natural surfactant, glycyrrhizinate which is a natural surfactant (inflammatory agent and whitening agent) It can be seen that the L * value, the stratum corneum moisture content, and the rate of change in elasticity increase due to one or more factors selected from the inclusion of the whitening agent, the whitening agent, or the fungicide. For example, it can be seen from the comparison between Examples 1 and 2 that the L * value, the stratum corneum moisture content, and the elasticity are improved when two or more polysaccharides or derivatives thereof are contained. Moreover, it turns out that L * value, a stratum corneum moisture content, and elasticity improve when a water-soluble protein and glycyrrhizinate are contained from the comparison of Examples 1 and 3. In addition, it can be seen from the comparison of Examples 1 and 4 that when the extract containing saponin is contained, the L * value, the stratum corneum moisture content, and the elasticity are improved. Moreover, it turns out that a stratum corneum moisture content improves from the comparison of Example 4 and 5 when glycyrrhizinate is contained. From the comparison of Examples 6 and 8 and the comparison of Examples 7 and 9, it can be seen that the moisture content and elasticity of the stratum corneum are improved when a bactericidal agent is contained. Moreover, it can be seen from Example 10 that L * value is improved when arbutin is contained as a whitening agent.

(3) Evaluation of external preparation for skin 27 mL of water was put into a bottle (225 mL) having a diameter of about 4.8 cm and a height of about 10.5 cm, and 9 g of powdered external preparation for skin was added thereto, and 20 times in 10 seconds. Stir. About the obtained mixture, the following <foaming amount> and <carbon dioxide generation amount> were evaluated.

<Amount of foaming>
The volume of the mixture after 1 minute, 10 minutes and 20 minutes after stirring was measured, and the volume increase rate (%) relative to the volume before stirring was determined. The result is shown in FIG.

<CO2 generation amount>
Carbon dioxide generated from the stirred mixture was collected by water displacement. The accumulated amount (mL) of collected carbon dioxide gas at each time point after 3, 5, 7, 10, 15, 20, and 30 minutes after stirring was measured. The result is shown in FIG.

From the results of FIG. 4, it can be seen that the external preparation for skin of each Example does not easily decrease the volume of the mixture even after a lapse of time, and a certain amount of carbon dioxide gas is retained in the mixture. This effect is selected from the inclusion of two or more polysaccharides or derivatives thereof, the inclusion of water-soluble protein, the inclusion of an extract containing saponin, the inclusion of glycyrrhizinate, and the inclusion of other whitening agents or fungicides. Increased by inclusion of an extract containing one or more factors, particularly water-soluble proteins or saponins, and inclusion of glycyrrhizinate. For example, it can be seen from the comparison of Examples 1 and 2 that when two or more polysaccharides or derivatives thereof are contained, the carbon dioxide retention in the resulting mixture is improved. From the comparison of Examples 1 and 3, it can be seen that the inclusion of water-soluble protein and glycyrrhizinate improves the carbon dioxide retention in the resulting mixture. In addition, it can be seen from the comparison between Examples 1 and 4 that when an extract containing saponin is contained, the carbon dioxide retention in the resulting mixture is improved. From the comparison of Examples 4 and 5, it can be seen that the inclusion of glycyrrhizinate improves the carbon dioxide retention in the resulting mixture.
On the other hand, in each comparative example, it is found that the bubbles of the mixture are not easily held, and the volume of the mixture after stirring is likely to decrease, that is, the amount of carbon dioxide gas that can be held in the mixture is small.

From the results of FIG. 5, in each example, carbon dioxide gas was generated relatively gently during the period from stirring to 5 minutes, and thereafter, although there is a gradual slope, carbon dioxide gas generation from the mixture was stopped. It turns out that it is continuing without. In particular, in Examples 2 to 10 containing an extract containing two or more polysaccharides or derivatives thereof, a water-soluble protein or saponin, glycyrrhizinate, or other whitening agents and bactericides, carbon dioxide is generated. It can be seen that tends to continue for a long time. For example, it can be seen from the comparison of Examples 1 and 3 that when water-soluble protein and glycyrrhizinate are contained, the amount of carbon dioxide generated is improved. Further, it can be seen from the comparison between Examples 1 and 4 that the amount of carbon dioxide generated is improved when an extract containing saponin is contained. Moreover, it turns out that the generation amount of a carbon dioxide gas improves when it contains glycyrrhizinate from the comparison of Example 4 and 5.
On the other hand, in each of Comparative Examples 1 to 3, although the carbon dioxide generation speed from stirring to 3 minutes later is high, it is understood that the subsequent generation stops or the amount of generated carbon dioxide itself is low. .

<Examples 11 to 17>
Each component was blended and mixed at the blending ratio shown in Table 4 below to produce a powdery external skin preparation. The numerical values in Table 4 are mass ratios (mass%) in the external preparation for skin.

[Evaluation of Examples 11 to 17]
<Sensory evaluation>
Three healthy women in their 20s to 30s were randomly selected as subjects different from the subjects who evaluated Examples 1 to 10 and Comparative Examples 1 to 3. Other than that, after using a powdery skin external preparation sample in the same manner as “(1) Sensory evaluation” in [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] above, A questionnaire was conducted on the evaluation items. For each item, using Example 17 as a reference (4.0 points), scores were assigned to the seven stages shown in Table 2 above, and after aggregation, the average value of three persons was obtained. The results are shown in Table 5 below. In addition, about the following "stimulation", it was highly evaluated so that there was a tingling feeling. In addition, the “stickiness of skin” was rated high enough to prevent stickiness.
Evaluation items: “Ease of application”, “Pleasantness at the time of application”, “Good appearance of the applied mixture”, “Hardness of dripping”, “Irritation (existence of tingling)”, “ Eight items of “Ease of mixture to spread”, “Difficult to stick to mixture”, “Ease of removal of mixture”, Skin condition after use, “Smoothness of skin”, “Smoothness of skin”, A total of 15 items including 7 items of “smooth skin feel”, “smooth skin feel”, “skin firmness”, “skin tightness” and “skin brightness”.

  From the results of Table 5 above, each active ingredient (including the second water-soluble protein is also included) in the composition of Example 17 containing an acidic substance, carbon dioxide generating substance, polysaccharide or derivative thereof, and one water-soluble protein. In Examples 11 to 16 to which) is added, it can be seen that both the feeling of use and the improvement of the skin condition are improved. In particular, it can be seen that when the external preparation for skin of Example 11 to which a gold foil is added is used, the feeling of use such as comfort at the time of application and good appearance is improved. Moreover, it turns out that the brightness of skin etc. improve when the skin external preparation of Example 12 which added the pearl powder was used. Further, it can be seen that when the skin external preparation of Example 13 to which collagen is added is used, moist feeling and smoothness are improved. In addition, when the external preparation for skin of Example 14 to which hydrolyzed collagen is added is used, the ease of application, comfort, appearance and the like are improved during use, and the skin feels smooth and smooth after use. It turns out that it improves. It can also be seen that the use of the skin external preparation of Example 15 with placenta improves the smoothness, smoothness and the like after use. It can be seen that when Example 16 with arbutin added was used, the ease of application, comfort, and spread during use improved, and the smoothness and brightness of the skin after use improved.

[Evaluation of Examples 14 to 17]
<Measurement of skin condition>
In <Sensory Evaluation> in the above [Evaluation of Examples 11 to 17], the amount of water transpiration (g / m ² / hr) at the planned application position on the inner side of the forearm before application of the mixture was measured with the following measuring device. Thereafter, even after the mixture was removed and washed with water, the amount of water transpiration (g / m ² / hr) at the location where the mixture was applied on the inner side of the forearm was measured in the same manner.

-Moisture transpiration (g / m ² / hr): Measured with Tewameter TM300 (Courage + Khazaka). This measurement was performed by the standard method described in the instructions attached to the instrument.
From the measured values obtained, the average value of three subjects was determined. The average value before use was divided from the average value after use of the external preparation for skin to determine the rate of change. The rate of change in the amount of moisture transpiration obtained is shown in FIG. The lower the change rate, the higher the evaluation.

  From the results of FIG. 6 described above, when the skin external preparations of Example 14 in which hydrolyzed collagen was added, Example 15 in which placenta was added, and Example 16 in which arbutin was added to the composition of Example 17 were used, It can be seen that the amount of water transpiration in the sample is further suppressed. In particular, it can be seen that the suppression effect of Example 15 to which placenta is added is high.

<Examples 18 to 20>
Each component shown in Table 6 was blended and mixed in the composition shown in the same table to produce powdery skin external preparations of Examples 18-20. The numerical value of Table 6 is a mass ratio (mass%) in the external preparation for skin.

[Evaluation of Examples 18 to 20]
<Sensory evaluation>
Five healthy women in their 20s and 30s were randomly selected as subjects. Other than that, the same sensory evaluation as (1) sensory evaluation of [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] was performed. However, the evaluation items were 4 items of “smoothness of skin”, “moistness of skin”, “moisture feeling of skin”, and “softness of skin” as the state of skin after use. In addition, the subjects were given the seven grades shown in Table 2 based on Example 20 (4.0 points). After the aggregation, the average value of the five evaluation points was obtained. The results are shown in Table 7.

[Evaluation of Examples 18 and 19]
<Measurement of skin condition>
In <Sensory Evaluation> in [Evaluation of Examples 18 to 20] above, the stratum corneum moisture content at the mixture application planned location on the inner side of the forearm before application of the mixture was measured with the above-described measuring apparatus. And after removing a mixture and wash | cleaning with water, the stratum corneum moisture content of the location which apply | coated the mixture inside a forearm was measured similarly. The average value of five subjects was obtained from the obtained measured values. The average value after using the external preparation for skin was divided by the average value before use, and the obtained value was defined as the rate of change. The result is shown in FIG.

<Evaluation of external preparation for skin>
<3) <Amount of foaming> in [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] except that the amount of water used was 30 mL and the amount of powdery external preparation for skin use was 10 g. Similarly, the increase rate (%) of the volume of the mixture after stirring was determined. The results are shown in Table 8 below.

<Example 21>
Each component shown in Table 9 was blended and mixed in the composition shown in the same table to produce a powdery skin external preparation of Example 21. The numerical value of Table 9 is a mass ratio (mass%) in the external preparation for skin.

<Comparative example 4>
Each component shown in Table 10 was blended and mixed in the composition shown in the same table to produce a powder containing carbonate and a liquid containing acid. The numerical values in Table 10 are parts by mass. It was 16.9 mPa * s as a result of measuring the viscosity in 25 degreeC about the obtained liquid containing an acid using the viscometer (Brookfield RVT type | mold).

<Comparative Example 5>
Each component shown in Table 11 was blended and mixed in the composition shown in the same table to produce an acid-containing powder and a carbonate-containing viscous composition. The numerical values in Table 11 are parts by mass. It was 549,600 mPa * s as a result of measuring the viscosity in 25 degreeC about the obtained viscous composition using said viscometer.

[Evaluation of Example 21 and Comparative Examples 4 and 5]
(1) Sensory evaluation Four healthy women in their 20s and 30s were randomly selected as subjects. Other than that, the same sensory evaluation as (1) sensory evaluation of [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] was performed. However, in Example 21, the powdered external preparation for skin and water were mixed at a mass ratio of 1: 2.7. In Comparative Example 4, a powder containing carbonate and a liquid containing acid were mixed at a mass ratio of 1: 3 to obtain a mixture. In Comparative Example 5, an acid-containing powder and a carbonate-containing viscous composition were mixed at a mass ratio of 1: 3.68 to obtain a mixture. In addition, the evaluation items are two items of “skin elasticity” and “skin redness” as the skin condition after the use of the external preparation for skin, and the 7-point score shown in Table 2 is based on Comparative Example 4 (4. A score of 0 was assigned. After aggregation, the average value of the four evaluation points was determined. The results are shown in Table 12. In addition, when the viscosity of 25 degreeC of the water used in Example 21 was measured with the said viscometer, the numerical value below the lower limit (10 mPa * s) of a viscometer was shown.

(2) Measurement of skin condition In the sensory evaluation of (1) above, before applying the mixture, the L * value at the planned application location of the mixture on the inner side of the forearm was measured with the above measuring device. Then, the coating and the mixture were removed and washed with water. At each time point 15 minutes, 60 minutes, and 120 minutes after the end of removal, the L * value of the portion where the mixture on the inner side of the forearm was applied was measured with the above measuring device. From the measured values obtained, the average value of four subjects was determined. The value obtained by subtracting the average value before use from the average value after using the external preparation for skin was used as the change value. Table 13 shows the obtained change value of the L * value (whiteness). In the same table, the higher the change value, the higher the evaluation.

  As is apparent from the descriptions in Tables 12 and 13, Example 21 in which an external preparation containing an acidic substance, a carbon dioxide generating substance and a polysaccharide or a derivative thereof was mixed with a hydrous substance, It can be seen that the effect of improving the condition of the skin after use is high as compared with Comparative Example 4 mixed with the liquid containing and Comparative Example 5 mixed with the powder containing acid and the viscous composition containing carbonate.

<Examples 22 to 23>
Each component was blended and mixed at the blending ratio shown in Table 14 below to produce a powdery external skin preparation. The numerical value in Table 14 is a mass ratio (mass%) in the external preparation for skin.

[Evaluation of Examples 22 to 23]
<Evaluation of storage stability>
Nine grams of each of the powdery skin external preparations obtained in Examples 22 to 23 was sealed in an aluminum film bag having an inner surface laminated with polyethylene terephthalate. It was stored at 50 ° C. or 60 ° C. for 2 months, and during the storage period, the presence or absence of carbon dioxide gas was observed using the presence or absence of bag expansion as an index. The results are shown in Table 15. In the table, “None” indicates that carbon dioxide gas was not generated during the storage period (2 months).

As is apparent from Table 15, Example 22 was formulated with potato starch at 10% by mass or more.
In Nos. And 23, even when stored at 60 ° C. for 2 months, generation of carbon dioxide gas was not observed, and good storage stability could be confirmed.

<Example 24>
Each component was blended and mixed at the blending ratio shown in Table 16 below to produce a powdery external skin preparation. The numerical value in Table 16 is a mass ratio (mass%) in the external preparation for skin.

  According to the following [Example 24], the properties of the external preparations for skin of the above Examples and Comparative Examples were evaluated.

[Evaluation of Example 24]
<Anti-wrinkle function evaluation>
As subjects, 16 adult women with wrinkles in the corners of their eyes were selected. The powdered skin preparation for external use and water are mixed at a ratio of 1: 3 (mass ratio) in a container, and the mixture, which is a foam pack cosmetic, is applied to the specified half-face centered on either the right or left eye corner. Applied. Ten minutes after application, the mixture was removed and rinsed with water or lukewarm water. The subjects performed this once a day for 4 weeks. For the evaluation of wrinkles, replicas of wrinkles on the left and right corners of the subject (with and without application of the mixture) were collected, and image analysis was performed using the replicas. The replica was collected using a replica agent (SILFLO) in the range of 4 cm × 4 cm outward from the outer eye corner of the subject. The obtained replica was analyzed for a range of 10 mm × 10 mm with a point about 5 mm away from the outer eye corner to the outside of the face. The analysis was carried out using a replica analysis system for reflection (ASA-03RXD) and 3D skin analysis software. Table 17 shows the results of the maximum wrinkle maximum depth, which is the evaluation result of wrinkles. When the amount of change is positive, it indicates that the wrinkles are deeper than before use, and when the amount is negative, it indicates that the wrinkles are shallower than before use.

  From Table 17, it was confirmed that by using the external preparation for skin of the present invention, the maximum wrinkle maximum depth of the outer corner of the eye was shallower than when not using it. From the above results, it can be seen that the use of the foamable skin external preparation of the present invention has the effect of making wrinkles less noticeable.

[Prescription example of one-part skin external preparation]
The specific formulation example of the one-part skin external preparation of this invention is shown below further.

<Example 25>
Each component was mix | blended with the mixture ratio of Table 18, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 3 and stirred, a foamy pack cosmetic was obtained.

<Example 26>
Each component was blended at the blending ratio shown in Table 19 to obtain a powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 5 and stirred, a foamy pack cosmetic was obtained.

<Example 27>
Each component was mix | blended with the mixture ratio of Table 20, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 28>
Each component was mix | blended with the mixture ratio of Table 21, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 3 and stirred, a foamy pack cosmetic was obtained.

<Example 29>
Each component was mix | blended with the mixture ratio of Table 22, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 4 and stirred, a foamy pack cosmetic was obtained.

<Example 30>
Each component was mix | blended with the mixture ratio of Table 23, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 31>
Each component was mix | blended with the mixture ratio of Table 24, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 4 and stirred, a foamy pack cosmetic was obtained.

<Example 32>
Each component was mix | blended with the mixture ratio of Table 25, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was placed in a container and water was added to the powder 1 in a mass ratio of 4 and stirred, a foamy pack cosmetic was obtained.

<Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2>
Each component described in Table A below was blended and mixed in the composition shown in the same table, and the powdery skin external preparations of Examples 2-1 to 2-28 and Comparative Examples 2-1 and 2-2 were used. A powdery external preparation for skin was produced. The numerical value of the following Table A is a mass ratio (mass%) in a skin external preparation. In addition, as carboxymethylcellulose described in Table A below, sodium carboxymethylcellulose was used. In addition, as an acrylic acid / alkyl methacrylate copolymer described in Table A below, (acrylates / alkyl acrylate (C10-30)) crosspolymer was used. In addition, the “pattern” in Table A is a combination of the above-mentioned (1) to (3) relating to a combination of two or more polysaccharides or derivatives thereof, or a polysaccharide or derivative thereof and an inorganic or organic thickening compound. It indicates which of the above (4) is applicable. This classification is also listed in Table C below.

The characteristics of the external preparations for skin of <Examples 2-1 to 2-28 and Comparative Examples 2-1 and 2-2> having the composition shown in Table A above are described above [Examples 1 to 10 and Comparative Examples 1 to 3]. Evaluation] was evaluated by the same method as the sensory evaluation of (1). However, the questionnaire items were as shown in the following Table C (1) to (19). The results are shown in Table C below. The evaluation criteria were the 7-step absolute evaluation described in Table B below. In Table C, “(4) Fineness of foam” was rated higher as the foam was finer. "(10) Carbonic acid feeling (prickly feeling)" was rated higher as the prickly feeling was higher. "(11) Sustained carbonic acid feeling" was evaluated as high as the carbonic acid feeling was sustained. “(12) Skin feeling” was rated higher as the feeling of skin was higher.

  CMC in Table C is an abbreviation for sodium carboxymethylcellulose, tamarind is an abbreviation for tamarind gum, HPMC is an abbreviation for hydroxypropylmethylcellulose, HEC is an abbreviation for hydroxyethylcellulose, and graft starch is a sodium acrylate graft Abbreviation for starch, acrylic acid is an abbreviation for acrylic acid / alkyl methacrylate copolymer, and PVP is an abbreviation for polyvinylpyrrolidone.

  As is clear from the results in Table C, the skin external preparations of Examples 2-1 to 2-28 corresponding to any of (1) to (4) employ a combination of conventional polysaccharides or derivatives thereof. Compared to the topical skin preparations of Comparative Examples 2-1 and 2-2, the evaluations of ease of mixing, ease of dissolution, ease of removal, and skin brightness are equivalent or better, and the fineness of foam and uniformity , Ease of application, foam elasticity, foam retention, carbonic acid, persistence of carbonic acid, moist skin, skin elasticity, redness of skin, smoothness of skin, smoothness of skin, firmness of skin Was also excellent. Therefore, it is clear that the effect of “good use and improved skin condition” according to the external preparation for skin of the present invention corresponding to any one of (1) to (4) is remarkable.

L * values before and after use of the skin external preparations of <Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2> in the formulation of Table A above, the stratum corneum moisture content (μS), The elasticity was measured by the same method as described in “(2) Measurement of skin condition” in [Evaluation of Examples 1 to 10, Comparative Examples 1 to 3] described above. For the obtained L * value, stratum corneum moisture content, and elasticity, the ratio of the measured value after use to the measured value before use of the external preparation for skin was determined and used as the rate of change. The results are shown in FIGS. Moreover, the amount of moisture transpiration (g / m ² / hr) before and after use of the external preparation for skin of <Examples 2-1 to 2-28 and Comparative Examples 2-1 and 2-2> in the formulation of Table A above ) Was measured by a method similar to the method described in “<Measurement of skin condition>” in [Evaluation of Examples 14 to 17] described above. About the obtained moisture transpiration | evaporation amount, ratio of the measured value after use with respect to the measured value before use of a skin external preparation was calculated | required, and it was set as the rate of change. The result is shown in FIG.

  As is clear from the results of FIGS. 8 to 10, the rate of change in the elasticity of the external preparation for skin of Examples 2-1 to 2-28 corresponding to any of (1) to (4) is Comparative Example 2-2. It was equal to or greater than that of the external preparation for skin and exceeded that of Comparative Example 2-1. Further, the L * value and the rate of change in the amount of keratin moisture of the external preparation for skin of Examples 2-1 to 2-28 were superior to those of Comparative Examples 2-1 and 2-2. Therefore, it is clear that the effect of “the skin condition is improved” according to the external preparation for skin of the present invention corresponding to any one of (1) to (4) is remarkable.

Claims (4)

A foamable skin external preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
As a polysaccharide or a derivative thereof , it contains a combination of any one of the following (1) to (3) of a cellulose derivative or starch derivative and a hydrophilic natural polymer, and is mixed with a water-containing substance at the time of using the skin external preparation Effervescent skin external preparation.
(1) A combination of at least one selected from alginic acid and its salts and hydroxyethyl cellulose
(2) A combination of at least one selected from hydroxyethyl cellulose, acrylic acid grafted starch and salts thereof, and cationized cellulose and tamarind gum
(3) A combination of at least one selected from carboxymethylcellulose and salts thereof and guar gum A foamable skin external preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
A foamable skin external preparation containing a combination of the following (4) or (5) selected from hydrophilic natural polymers as a polysaccharide or a derivative thereof , and mixed with a water-containing substance when the skin external preparation is used.
(4) A combination of at least two selected from xanthan gum, carrageenan and tamarind gum
(5) Combination of guar gum and tamarind gum A foamable skin external preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
As a polysaccharide or a derivative thereof , containing a combination of the following (6) or (7) selected from cellulose derivatives and starch derivatives,
A foamable skin external preparation to be mixed with a water-containing substance when the skin external preparation is used.
(6) A combination of at least one selected from acrylic acid grafted starch and salts thereof and at least one selected from carboxymethyl cellulose and salts thereof
(7) Combination of cationized cellulose and hydroxypropyl methylcellulose A foamable skin external preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
Any of the following (8) to (13): at least one polysaccharide or derivative thereof and at least one selected from an inorganic hydrophilic thickening compound and a hydrophilic synthetic polymer that is an organic thickener Containing combinations that are
A foamable skin external preparation to be mixed with a water-containing substance when the skin external preparation is used.
(8) A combination of at least one selected from alginic acid and salts thereof and at least one selected from talc and silica
(9) A combination of carrageenan and at least one selected from talc and silica
(10) A combination of at least one selected from xanthan gum, carboxymethylcellulose and salts thereof, and talc
(11) A combination of polyvinylpyrrolidone and at least one selected from guar gum and cationized cellulose
(12) A combination of hydroxyethyl cellulose and at least one selected from silica and an acrylic acid / alkyl methacrylate copolymer
(13) A combination of at least one selected from alginic acid and its salts and an acrylic acid / alkyl methacrylate copolymer