JP2023138656A - Foamable skin external preparation - Google Patents

Abstract

To provide a foamable skin external preparation which has good use feeling and is effective for improving skin conditions.SOLUTION: There is provided a foamable skin external preparation having at least a solid acid substance and a solid carbon dioxide generating substance which generates carbon dioxide by reacting with the acid substance, which further contains at least one selected from a cellulose derivative and a starch derivative as a polysaccharide or a derivative thereof and at least one selected from a hydrophilic natural polymer which is alginic acid or a salt thereof, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum (provided that alginic acid or a salt thereof is excluded when sodium carboxymethyl cellulose is contained as a cellulose derivative), in which the skin external preparation is mixed with a water-containing substance when used.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a skin external preparation.

BACKGROUND ART Conventionally, external skin preparations containing synthetic or natural extracts that have a blood circulation promoting effect on the skin have been used.

These extracts are not sufficiently effective when combined in small amounts, and are too irritating to the skin when combined in large amounts, so we proposed an external skin preparation that contains carbon dioxide gas to enhance blood circulation promotion effects. is being done. Most of these generate carbon dioxide gas through a reaction between an acidic substance and a carbon dioxide generating substance. In order to maintain the carbonic acid generating ability of the external skin preparation for a long period of time, the dosage forms of these external skin preparations include those in which the acidic substance and the carbon dioxide gas-generating substance are made into separate formulations, and these are mixed and foamed at the time of use. known (Patent Documents 1 and 2).
On the other hand, there is also known an external skin preparation that contains an acidic substance and a carbon dioxide gas generating substance and is mixed with a viscous composition containing water and a thickener when used (Patent Document 3).

Japanese Unexamined Patent Publication No. 63-310807 Japanese Patent Application Publication No. 05-229933 WO99/24043 publication

Foaming skin preparations for external use that contain an acidic substance and a carbon dioxide gas generating substance and are mixed with a water-containing substance at the time of use have the advantage of being easy to handle when made into a single dosage form.
However, conventionally, this type of topical skin preparation has been used to improve the usability such as ease of mixing and application when mixed with water-containing substances, and the skin's ability to improve skin moisturization, elasticity, brightness, etc. This was insufficient from the viewpoint of achieving both the effect of improving the condition and the effect of improving the condition.

The present invention provides a foaming skin preparation for external use, which comprises at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
As the polysaccharide or its derivative, at least one selected from cellulose derivatives and starch derivatives;
At least one selected from hydrophilic natural polymers such as alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum (however, when containing sodium carboxymethylcellulose as a cellulose derivative, alginic acid or its salts) (excluding)
The present invention provides a foaming external skin preparation that is mixed with a water-containing substance when the skin external preparation is used.

The present invention also provides a foaming skin preparation for external use, which comprises at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
As a polysaccharide or a derivative thereof, it contains two or more types selected from hydrophilic natural polymers which are alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum or tamarind gum,
The present invention provides a foaming external skin preparation that is mixed with a water-containing substance when the skin external preparation is used.

The present invention also provides a foaming skin preparation for external use, which comprises at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
Containing two or more types selected from cellulose derivatives and starch derivatives as polysaccharides or derivatives thereof,
The present invention provides a foaming external skin preparation that is mixed with a water-containing substance when the skin external preparation is used.

The present invention also provides a foaming skin preparation for external use, which comprises at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
At least one polysaccharide or derivative thereof;
and at least one kind of hydrophilic synthetic polymer that is an inorganic hydrophilic thickening compound or an organic thickening agent,
The present invention provides a foaming external skin preparation that is mixed with a water-containing substance when the skin external preparation is used.

According to the present invention, it is possible to provide an external skin preparation that is comfortable to use and effective for improving skin conditions.

FIG. 1 is a graph showing the rate of change in L* value (whiteness) in Examples and Comparative Examples. FIG. 2 is a graph showing the rate of change in stratum corneum water content in Examples and Comparative Examples. FIG. 3 is a graph showing the rate of change in elasticity in Examples and Comparative Examples. FIG. 4 is a graph showing the foaming amount (volume increase rate of the mixture of the skin external preparation and the water-containing substance) in Examples and Comparative Examples. FIG. 5 is a graph showing the amount of carbon dioxide gas generated in Examples and Comparative Examples. FIG. 6 is a graph showing the rate of change in the amount of water transpiration in Examples. FIG. 7 is a graph showing the rate of change in stratum corneum water content in another example. FIG. 8 is a graph showing the rate of change in L* value in another example. FIG. 9 is a graph showing the rate of change in stratum corneum water content in another example. FIG. 10 is a graph showing the rate of change in elasticity in another example. FIG. 11 is a graph showing the rate of change in the amount of water transpiration in another example.

The skin external preparation of the present invention contains at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas.

When using the skin external preparation of the present invention, the user mixes the skin external preparation with a water-containing substance to generate foam due to carbon dioxide gas generation, and applies the mixture to the skin. Each component contained in the external skin preparation and its manufacturing method will be explained below.

<Solid acidic substance>
The solid acidic substance used in the present invention may be either an inorganic acid or an organic acid, and one or more of these may be used. Further, any solid dosage form may be used, but powder forms such as granules and powder are preferred, and powder forms are particularly preferred.

Inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, acid Examples include potassium pyrophosphate and sulfamic acid.

Examples of organic acids include straight chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, and isophthalic acid. acids, dicarboxylic acids such as terephthalic acid, acidic amino acids such as glutamic acid, aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid , oxyacids such as tropic acid, ascorbic acid, and gluconic acid.

Among these, citric acid, ascorbic acid, malic acid and succinic acid are preferred from the viewpoint of safety and solubility in water.

The content of the solid acidic substance in the skin external preparation of the present invention is preferably 1% by mass or more and 20% by mass or less, and more preferably 2% by mass or more and 18% by mass or less. preferable.

<Solid carbon dioxide gas generating substance>
As the solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide used in the present invention, various substances can be used without particular limitation. Further, any solid dosage form may be used, but powder forms such as granules and powder are preferred, and powder forms are particularly preferred.

The carbon dioxide gas generating substance includes carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, ammonium bicarbonate, potassium bicarbonate, sodium bicarbonate, lithium bicarbonate, cesium bicarbonate, and magnesium bicarbonate. , hydrogen carbonate such as calcium hydrogen carbonate, etc., and one or more of these may be used. Among these, hydrogen carbonate can be preferably used, and sodium hydrogen carbonate is more preferred since it can achieve a moderate foaming power.

The content of the carbon dioxide gas generating substance in the skin external preparation of the present invention is preferably 1% by mass or more and 30% by mass or less, and more preferably 2% by mass or more and 25% by mass or less. preferable.

<Polysaccharide or its derivative>
Examples of polysaccharides or derivatives thereof used in the present invention include various types that can be used in the cosmetic and pharmaceutical fields. Specific examples of polysaccharides include xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, gum tragacanth, tamarind gum, agar, agarose, mannan, hyaluronic acid and its salts, chondroitin sulfate and its Hydrophilic natural polymers such as salts, curdlan, pectin, alginic acid and its salts, starch, dextrin, cellulose; starch derivatives such as carboxymethyl starch and its salts, acrylic acid grafted starch and its salts, hydroxypropyl cellulose and Derivatives thereof, hydroxyethylcellulose and its derivatives, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose derivatives such as hydroxypropylmethylcellulose having hydrocarbon groups such as phthalate and stearyl groups, sulfonated cellulose derivatives, carboxymethylcellulose and its derivatives, and the like. salts, carboxymethylethylcellulose and its salts, cellulose acetate phthalate, cationized cellulose such as O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride (also referred to as "polyquaternium-10"), ethylcellulose , hydrophilic synthetic polymers such as cellulose derivatives such as chlorocarmellose and its salts. These can be used alone or in combination of two or more. As exemplified above, starch derivatives herein do not include dextrin. Further, examples of the above-mentioned salts include sodium salts, potassium salts, calcium salts, and the like. Examples of derivatives of hydroxypropylcellulose include hydroxypropylcellulose acetate, hydroxypropylcellulose propionate, etc.; examples of derivatives of hydroxyethylcellulose include hydroxyethylcellulose acetate, hydroxyethylcellulose propionate, polyquaternium-67, etc. Examples of methylcellulose derivatives include carboxymethylcellulose acetate, carboxymethylcellulose propionate, methylamide cellulose gum, and the like.

In addition, it is preferable to use polysaccharides or derivatives thereof that have high solubility and/or dispersibility in water, so that when the external preparation for skin of the present invention is mixed with a water-containing substance, it does not form lumps and is uniform. This is preferable because it can be dissolved and/or dispersed in the water, and the roughness of the skin caused by undissolved components can be alleviated. Here, the quality of solubility and dispersibility in water is determined by whether the topical skin preparation dissolves or disperses uniformly in a short time when water at room temperature is added and stirred, and whether lumps do not form during dissolution. It can be determined from

From the viewpoint of solubility and dispersibility in water, preferred polysaccharides or derivatives thereof include, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, gum tragacanth, Examples include tamarind gum, agar, agarose, mannan, hyaluronic acid and its salts, curdlan, alginic acid and its salts, starch and its derivatives, dextrin, cellulose and cellulose derivatives.

Among the polysaccharides or derivatives thereof used in the present invention, only one type may be used, but it is preferable to use two or more types in combination. This is due to the following reasons.
Most polysaccharides or derivatives thereof are dissolved or dispersed in water and exhibit a thickening effect. In addition, adding polysaccharides or their derivatives to skin preparations increases the stability of the skin preparations before use and during storage, and prevents the reaction between acids and carbon dioxide-generating substances to release carbon dioxide gas. It also has the advantage of preventing occurrence. Among polysaccharides and their derivatives, those that contribute more to the thickening effect than to the stability during storage (hereinafter referred to as type A polysaccharides or derivatives thereof) also contribute more to the stability during storage than to the thickening effect. Since there are also polysaccharides of type B (hereinafter referred to as type B polysaccharides or their derivatives) that contribute significantly to the viscosity, by combining both types of polysaccharides or their derivatives, it is possible to increase the viscosity and improve the stability during storage. It is possible to improve both. Type A polysaccharides or derivatives thereof include xanthan gum, carrageenan, hyaluronic acid, and cellulose and salts or derivatives thereof; preferred polysaccharides or derivatives thereof are starch or derivatives thereof, and dextrins. Listed as sugars. By using the B type polysaccharide or its derivative, it is possible to suppress the generation of carbon dioxide gas during storage of the skin external preparation. In particular, it is preferable to use starch or a derivative thereof because it effectively suppresses the generation of carbon dioxide gas and further improves long-term storage stability. When starch or its derivatives are used in the present invention, the preferred amount used is 3% by mass or more, particularly 5% by mass or more, especially 10% by mass or more in the skin external preparation.
In the present invention, it is also preferable that there are many types of polysaccharides or derivatives thereof, for example, a combination of three or more types.

Furthermore, as is clear from the Examples described below, for example, a comparison of Examples 1 and 2, the present inventors found that when two or more types of polysaccharides or derivatives thereof are used in combination, and when only one type is used, When mixed with water-containing substances, external skin preparations (mixtures) have a higher ability to retain carbon dioxide, prevent the mixture from dripping, and improve skin conditions such as reducing redness and improving elasticity. They found that it is easy to use, and that the usability, including ease of application and removal, is improved. Furthermore, as is clear from Examples 6 to 10, it was found that these effects were higher in the presence of an extract containing water-soluble proteins and/or natural surfactants, particularly saponin.

In the present invention, the content of the polysaccharide or its derivative in the skin external preparation is preferably 8% by mass or more and 50% by mass or less, more preferably 11% by mass or more and 45% by mass or less. It is preferable that the content of the polysaccharide or its derivative is 8% by mass or more and 50% by mass or less from the viewpoint of handling during use, particularly from the viewpoint of easy mixing with a water-containing substance and from being difficult to drip during use. If it is less than 8% by mass, it will easily drip during use, and if it is more than 50% by mass, it will be difficult to mix, and it will thicken immediately after mixing with a water-containing substance, making it difficult to apply to the area of use. Therefore, it is not desirable.

In addition, when using a combination of A type polysaccharide or its derivative and B type polysaccharide or its derivative as the polysaccharide or its derivative, the mass ratio of both is 100% mass of A type polysaccharide or its derivative. It is preferable that the polysaccharide or its derivative B is 10 parts by mass or more and 1000 parts by mass or less, more preferably 20 parts by mass or more and 800 parts by mass or less.

The present inventors further found that when the skin external preparation of the present invention contains two or more types of polysaccharides or derivatives thereof in any of the following (1) to (3), "it has a good feeling of use, It has also been found that the present invention has a remarkable effect of "improving the condition of the skin."
(1) At least one selected from cellulose derivatives and starch derivatives, and at least one selected from hydrophilic natural polymers such as alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum (however, as a cellulose derivative, , when containing sodium carboxymethylcellulose, excluding alginic acid and its salts).
(2) When the polysaccharide or its derivative contains two or more types selected from hydrophilic natural polymers such as alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum (3) The polysaccharide or When the derivative contains two or more selected from cellulose derivatives and starch derivatives.

Hereinafter, hydrophilic natural polymers such as alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum may be simply referred to as "specific hydrophilic natural polymers."

First, case (1) will be explained.
In the case of (1), the embodiments containing two or more types of polysaccharides or derivatives thereof include the following embodiments (a) or (b), which are said to have a "good feeling of use and improve the skin condition." This is preferable from the viewpoint of more reliably enhancing the effects of the invention.
(a) As cellulose derivatives, hydroxyethylcellulose and its derivatives, carboxymethylcellulose and its derivatives and their salts, hydroxypropylmethylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose acetate phthalate, cationized cellulose , ethylcellulose, croscarmellose and its salts, or/and
Contains starch derivatives.

(b) Contains at least one selected from hydroxypropylcellulose and its derivatives as a cellulose derivative, and at least one selected from alginic acid and its salts, carrageenan, guar gum, xanthan gum, and tamarind gum as a hydrophilic natural polymer.

In the case of (1), particularly preferred embodiments containing two or more types of polysaccharides or derivatives thereof include any of the following cases (a) to (c).
(a) As a cellulose derivative, it contains at least one selected from hydroxypropylmethylcellulose and its derivatives and cationized cellulose, and/or as a starch derivative, carboxymethyl starch and its salts and acrylic acid grafted starch and its salts Contains at least one selected from.
(a) Contains at least one selected from hydroxyethyl cellulose and its derivatives as a cellulose derivative, and at least one selected from alginic acid and its salts, carrageenan, guar gum, locust bean gum, and tamarind gum as a hydrophilic natural polymer. .
(c) Contains at least one selected from carboxymethylcellulose, its derivatives, and salts thereof as a cellulose derivative, and at least one selected from carrageenan, guar gum, locust bean gum, and tamarind gum as a hydrophilic natural polymer.

In the case of (1), particularly preferred embodiments containing two or more types of polysaccharides or derivatives thereof include cases in which the polysaccharides or derivatives thereof contain any of the following combinations.
A combination of at least one selected from hydroxypropyl methylcellulose and its derivatives and at least one selected from alginic acid and its salts and xanthan gum;
Combination of cationized cellulose and tamarind gum;
Combination of starch derivative and tamarind gum;
A combination of at least one selected from hydroxyethylcellulose and its derivatives and at least one selected from alginic acid and its salts, and carrageenan;
A combination of at least one selected from carboxymethylcellulose, derivatives thereof, and salts thereof, and at least one selected from carrageenan and guar gum.

When a cellulose derivative or a starch derivative is combined with a specific hydrophilic natural polymer as in the case of (1) above, the amount of the specific hydrophilic natural polymer per 100 parts by mass of the cellulose derivative or starch derivative is preferably 1 part by mass or more and 10,000 parts by mass or less from the viewpoint of more reliably obtaining the effects of the present invention. From this point of view, the amount of the specific hydrophilic natural polymer relative to 100 parts by mass of the cellulose derivative or starch derivative is preferably 1 part by mass or more and 10,000 parts by mass or less, and preferably 5 parts by mass or more and 5,000 parts by mass or less. More preferably, the amount is 10 parts by mass or more and 1000 parts by mass or less. In addition, the amount of cellulose derivative or starch derivative here is the total amount when the skin external preparation contains a cellulose derivative and a starch derivative. The amounts of cellulose derivatives, starch derivatives, and hydrophilic natural polymers mentioned here refer to the amounts of cellulose derivatives, starch derivatives, and hydrophilic natural polymers when the skin external preparation of the present invention contains specific types of cellulose derivatives, starch derivatives, and hydrophilic natural polymers. The amount of seeds can be cellulose derivatives, starch derivatives, hydrophilic natural polymers. Furthermore, regarding the respective amounts of cellulose derivatives, starch derivatives, and hydrophilic natural polymers mentioned below, the skin external preparation of the present invention contains specific types of cellulose derivatives, starch derivatives, and hydrophilic natural polymers. If so, the amount of the specific type of cellulose derivative, starch derivative, or hydrophilic natural polymer can be determined.

In both cases (1) and (2) to (4) below, the total proportion of cellulose derivatives, starch derivatives, and specific hydrophilic natural polymers in the external skin preparation is 5% by mass or more. It is preferable that the amount is 50% by mass or less in order to enhance the effect of the present invention, and it is preferable that the amount is 50% by mass or less to ensure the amount of acidic substances and carbon dioxide gas-generating substances and reduce the foaming property of the external skin preparation of the present invention. It is preferable from the viewpoint of preventing this and ensuring functionality such as the feeling of use and the effect of improving skin condition. From this point of view, it is more preferable that the total amount of cellulose derivatives, starch derivatives, and specific hydrophilic natural polymers in the skin external preparation be 10% by mass or more and 45% by mass or less, and 12% by mass or more and 45% by mass. % or less is particularly preferable.

Next, case (2) will be explained. In the case of (2) above, the skin external preparation contains two or more hydrophilic natural polymers selected from alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum as the polysaccharide or its derivative. contains. In this case, from the viewpoint of making the effect of the present invention, which is "comfortable to use and improves the skin condition", the combination of two or more specific hydrophilic natural polymers is as follows: Particularly preferred is any one of (A) to (C).

(A) A combination of alginic acid or its salts and at least one selected from carrageenan, guar gum, locust bean gum, and tamarind gum.
(B) A combination of carrageenan and at least one selected from alginic acid and its salts, guar gum, xanthan gum, and tamarind gum.
(C) A combination with two or more selected from guar gum, locust bean gum, xanthan gum, and tamarind gum.

Particularly preferred combinations when two or more specific hydrophilic natural polymers are contained include any of the following (A)' to (C)'.
(A) 'A combination of alginic acid or its salts and at least one selected from carrageenan and tamarind gum;
(B) 'A combination of carrageenan and at least one selected from xanthan gum and tamarind gum;
(C) 'A combination of tamarind gum and at least one selected from guar gum and xanthan gum.

As in (2), when the polysaccharide or its derivative contains two or more hydrophilic natural polymers selected from alginic acid or its salts, carrageenan, guar gum, locust bean gum, xanthan gum, or tamarind gum, The content of any one of the other types relative to 100 parts by weight of one of them is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and 10 parts by mass. It is particularly preferable that the amount is 1000 parts by mass or less.

In the case of (A), the content of at least one selected from carrageenan, guar gum, locust bean gum, and tamarind gum is 1 part by mass or more and 10,000 parts by mass or less per 100 parts by mass of alginic acid or its salt. is more preferable, more preferably 5 parts by weight or more and 5000 parts by weight or less, particularly preferably 10 parts by weight or more and 1000 parts by weight or less.
In the case of (B), the content of at least one selected from alginic acid and its salts, guar gum, xanthan gum, and tamarind gum is preferably 1 part by mass or more and 10,000 parts by mass or less, based on 100 parts by mass of carrageenan. It is more preferably 5 parts by mass or more and 5000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.
In addition, the "content of at least one type" here means the total amount of two or more types.
In the case of (C), the total amount of the other three types relative to 100 parts by weight of one type selected from guar gum, locust bean gum, xanthan gum, and tamarind gum is preferably 1 part by weight or more and 10,000 parts by weight or less. , more preferably 5 parts by mass or more and 5000 parts by mass or less, particularly preferably 10 parts by mass or more and 1000 parts by mass or less.

In the case of (2), it is preferable that the total amount of the specific hydrophilic natural polymer in the skin external preparation be 5% by mass or more in order to enhance the effect of the present invention. % by mass or less, to ensure the amount of acidic substances and carbon dioxide gas-generating substances, to prevent a decrease in foaming properties of the external skin preparation of the present invention, and to improve the feeling of use and skin condition of the external skin preparation of the present invention. This is preferable from the viewpoint of ensuring functionality such as a condition improving effect. From this point of view, the proportion of the total amount of specific hydrophilic natural polymers in the skin external preparation is more preferably 10% by mass or more and 45% by mass or less, and more preferably 12% by mass or more and 45% by mass or less. Particularly preferred.

Next, (3) the case where two or more types selected from cellulose derivatives and starch derivatives are contained as polysaccharides or derivatives thereof will be explained.

In the case of (3), from the viewpoint of making the effects of the present invention even more reliably noticeable, (a) containing a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives; or (b) it is preferable to contain a combination of two or more specific cellulose derivatives.

In the case of (a), for example, as a cellulose derivative, hydroxyethylcellulose and its derivatives, hydroxypropylmethylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylcellulose and its derivatives and their salts, carboxymethylethylcellulose and its salts, acetic acid At least one selected from cellulose phthalate, cationized cellulose, ethyl cellulose, and croscarmellose and its salts, and at least one starch derivative selected from carboxymethyl starch and its salts, and acrylic acid grafted starch and its salts. It is particularly preferable to contain these in combination.
In the case of (a), it is particularly preferable to use at least one type selected from carboxymethyl cellulose, derivatives thereof, and salts thereof as the cellulose derivative.

In the case of (b), for example, the following cases (X) or (Y) are mentioned as preferable examples.
(X) The cellulose derivative contains at least one selected from hydroxypropyl methyl cellulose and its derivatives, and at least one selected from hydroxyethyl cellulose, its derivatives, and cationized cellulose.
(Y) as a cellulose derivative, at least one selected from carboxymethylcellulose and its derivatives and salts thereof, hydroxyethylcellulose and its derivatives, hydroxypropylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, It contains at least one selected from cellulose acetate phthalate, cationized cellulose, ethyl cellulose, and croscarmellose and its salts.

When the skin external preparation contains two or more selected from cellulose derivatives and starch derivatives as polysaccharides or derivatives thereof, as in (3), the content of any other one per 100 parts by mass of one of these The amount is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less.
Furthermore, when the skin external preparation contains a combination of at least one selected from cellulose derivatives and at least one selected from starch derivatives as in (a), the effects of the present invention will be even more pronounced. From the viewpoint of Particularly preferably, the amount is not more than parts by mass.

Further, as in (X) in (B), the skin external preparation contains at least one selected from hydroxypropylmethylcellulose and its derivatives (the former), and at least one selected from hydroxyethylcellulose and its derivatives, and cationized cellulose. When containing seeds (latter), the latter is preferably contained in a total amount of 1 part by mass or more and 10,000 parts by mass or less, and preferably 5 parts by mass or more and 5,000 parts by mass or less, per 100 parts by mass of the former. is more preferable, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less.

In addition, as in (Y) in (B), the skin external preparation contains at least one cellulose derivative selected from carboxymethylcellulose, derivatives thereof, and salts thereof (the former), hydroxyethylcellulose and its derivatives, and hydroxyethylcellulose and its derivatives. When containing at least one member selected from propylcellulose and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose acetate phthalate, cationized cellulose, ethylcellulose, and croscarmellose and its salts (the latter) The total amount of the latter is preferably 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and 10 parts by mass or more, per 100 parts by mass of the former. It is particularly preferable that the amount is 1000 parts by mass or less.

In the case of (3), the total proportion of cellulose derivatives and starch derivatives in the skin external preparation is preferably 5% by mass or more, and 50% by mass or less, in order to enhance the effect of the present invention. This is preferable from the viewpoint of ensuring the functionality of the skin external preparation of the present invention, such as the feeling of use and the effect of improving skin condition. From this point of view, the proportion of the total amount of cellulose derivatives and starch derivatives in the external skin preparation is more preferably 10% by mass or more and 45% by mass or less, particularly preferably 12% by mass or more and 45% by mass or less. .

The skin external preparation of the present invention, which adopts any of the following configurations (1) to (3), is easier to use after using the skin external preparation than when a conventional combination of polysaccharides or derivatives thereof is used. Compared to before, the amount of water evaporation from the skin is suppressed. Or/and, after using the skin external preparation, whiteness, skin moisture content and/or elasticity increase compared to before use. As a result, skin conditions such as skin moistness, elasticity, brightness, redness, smoothness, and/or smoothness are improved.
Moreover, when the skin external preparation of the present invention adopts any of the following configurations (1) to (3), the characteristics of the effect are that, in addition to the above-mentioned effect of improving the skin condition, it also improves the feeling of use. There is a significant improvement in this. When the skin external preparation of the present invention adopts the following configurations (1) to (3), it is easier to mix, dissolve, and apply, compared to when a combination of conventional polysaccharides or derivatives thereof is used. It has the characteristics required of an external skin preparation that foams when mixed with a water-containing substance, such as ease of use, resistance to dripping, and/or ease of removal.
Furthermore, in addition to this, when the skin external preparation of the present invention adopts the following configurations (1) to (3), foam smoothness, foam fineness, lack of roughness, foam elasticity, foam retention, etc. , a high level of carbonic acidity, and/or a high degree of persistence of carbonic acidity. Therefore, the skin external preparation of the present invention has a significantly improved feel when used compared to the case where a conventional combination of polysaccharides or derivatives thereof is employed.
In addition, the skin external preparation of the present invention, which provides a long-lasting carbonated feeling, also provides a high skin tightening feeling.
By obtaining these effects, the skin external preparation of the present invention, by adopting any of the following configurations (1) to (3), "feels good in use and improves the skin condition." This effect becomes noticeable.
The effects of the present invention can be obtained by the agent of the present invention containing a specific combination of the polysaccharides or derivatives thereof described in (1) to (3) together with a solid acidic substance and a solid carbon dioxide gas generating substance. This is the effect of Therefore, for example, one or both of the combinations (1) to (3) may be contained together with water to form a viscous composition, and this viscous composition may be used as a solid acidic substance and/or as a solid carbon dioxide gas generating substance. It cannot be obtained depending on the agent mixed with.

It is further preferable that the skin external preparation of the present invention contains a water-soluble protein. Here, water-soluble protein refers to concentrated, separated, and purified animal or vegetable protein, and refers to a protein that has the property of easily dispersing or dissolving in water and various liquids. Specifically, It refers to something that can be uniformly dispersed or dissolved without forming lumps when added in an amount of 5% by mass or more to water at 25°C under 1 atm. Water-soluble proteins include protein hydrolysates. The hydrolyzate is preferably one obtained by hydrolyzing proteins derived from various organisms such as animals and fish by alkali treatment or enzyme treatment. As specific water-soluble proteins, casein, collagen, hydrolyzed collagen such as gelatin, albumin, elastin, keratin, sericin, etc. can be used. These can be used alone or in combination of two or more. Among these, the skin external preparation of the present invention preferably contains albumin, collagen, and hydrolyzed collagen as water-soluble proteins. Water-soluble protein also plays a role as a foaming aid, and in particular has the function of increasing the strength of bubbles and keeping the foam stable for a long period of time. Therefore, the addition of water-soluble protein contributes to the ease of adjusting the viscosity of the skin preparation for external use, to the improvement in water solubility, and to the increase in the amount of carbon dioxide generation, thereby easily improving the effect of improving skin condition. The present inventors have found that the effects of this water-soluble protein are improved by containing a polysaccharide or a derivative thereof, particularly two or more types of polysaccharides or derivatives thereof.

Moreover, although the skin external preparation of the present invention may contain only one type of water-soluble protein, it is also preferable to contain two or more types of water-soluble proteins. This is shown, for example, in a comparison between Examples 13 and 14 and Example 17, which will be described later. As is clear from these examples, when collagen or hydrolyzed collagen is contained together with albumin, compared to the case where only albumin is contained as a water-soluble protein, the effect of improving skin quality such as moisturizing and smoothing of the skin after use, The feeling of use of a mixture obtained by mixing an external skin preparation with a water-containing substance is likely to be improved.
In particular, when the foaming skin external preparation of the present invention contains hydrolyzed collagen, ease of application, comfort when applied, and good appearance are likely to be improved, as is clear from Example 14 described below. As is clear from the comparison of Examples 18 and 19, which will be described later, even when hydrolyzed collagen is used alone, it does not affect the retention of carbon dioxide in the mixture of the external skin preparation and the water-containing substance, and the skin condition after using the external skin preparation. It is as effective as or more effective than albumin in improving

When the skin external preparation of the present invention contains a water-soluble protein, the water-soluble protein is preferably 0.01% by mass or more and 10% by mass or less, and 0.05% by mass or more and 8% by mass or less in the skin external preparation. It is more preferable that A content of 0.01% by mass or more and 10% by mass or less is preferable because it is easy to obtain effects such as increasing the strength of bubbles containing water-soluble protein and keeping the foam stable for a long period of time.

In addition, when the external skin preparation contains a water-soluble protein, the content of the water-soluble protein is determined from the viewpoint of further increasing the carbon dioxide retention capacity when the external skin preparation of the present invention is dissolved in water. It is preferably 0.1 part by mass or more, and more preferably 1 part by mass or more and 50 parts by mass or less, per 100 parts by mass.

The external skin preparation of the present invention may contain various components other than the solid acidic substance, the solid carbon dioxide generating substance, polysaccharide or its derivative, and water-soluble protein, depending on the use and purpose. . Such components are further described below.

In the skin external preparation of the present invention, the use of surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants is preferable from the viewpoint of foam retention. At this time, from the viewpoint of storage stability, it is best to use a surfactant in the form of a water-free solution, solid, flake, granule, fine granule, or powder. It is preferable to use granular, fine granular, or powdered materials. As the surfactant, natural surfactants are preferred. Natural surfactants refer to surfactants derived from animals and plants, such as phospholipids such as lecithin, lanolin, cholesterol, saponins, sphingolipids, pectin, dipotassium glycyrrhizinate, and plant-extracted amino acid surfactants. Can be mentioned. The skin external preparation of the present invention preferably contains a natural surfactant of 0.001% by mass or more and 10% by mass or less, more preferably 0.005% by mass or more and 8% by mass or less.

Among those listed above, the natural surfactant used in the present invention is preferably phospholipid, saponin, pectin, glycyrrhizic acid or a salt thereof, and contains an extract containing saponin and/or glycyrrhizic acid or a salt thereof. It is particularly preferable that Saponin is a glycoside that is widely distributed in plants, and is a general term for a group of compounds that have steroids and triterpenoids as non-sugar parts. Depending on the type of aglycone (non-sugar part of glycoside), there are triterpenoid saponins, It can be broadly classified into steroidal saponins. A common property of saponins is that their aqueous solutions have high foaming properties.

As mentioned above, saponin is known to have foaming properties, and the present inventors have added an extract containing this saponin instead of water-soluble protein to create a water-soluble protein. It has been found that the foam has a long-term stability that is equivalent to, or even better than, the long-term stability of the foam, which improves the feel of the mixture, such as less dripping and ease of mixing, and improves the skin condition, such as moisturizing and elasticity. External skin preparations containing water-soluble proteins may be difficult to use, for example, for users with allergies, but extracts containing saponin can be effectively used as a substitute for water-soluble proteins. It is. Furthermore, since the addition of an extract containing saponin has the effect of increasing the amount of carbon dioxide gas generated, it can contribute to effectively promoting blood circulation in the skin. The present inventors have demonstrated the effect of adding a saponin-containing extract by containing polysaccharides or derivatives thereof, especially two or more types of polysaccharides or derivatives thereof, particularly improving the feeling of use and improving the skin condition. It has been found that the effects of these methods are excellent.

As the saponin-containing extract used in the external skin preparation of the present invention, it is preferable to use a plant-derived extract. Examples of plants that contain triterpenoid saponins include soybean, loofah, adzuki bean, green bean, spinach, sugar beet, grape, bellflower, licorice, senega, quillaya, sapinosa, soapwort, panax ginseng, tea seed, Examples of plants containing steroidal saponins include plants of the Liliaceae family, plants of the Dioscoreaceae family, chimo (chimo), and bakumondo (barley).
In the agent of the present invention, it is preferable to use an extract of any one or more of the above-mentioned plants containing triterpenoid saponins among these plants as the extract containing saponin, such as Sapindrum, Soybean, Licorice, and Loofah. It is preferable to contain an extract of one or more plants selected from the following, and it is particularly preferable to contain an extract of Sapindica sapinata. Here, Sapindus is a plant belonging to Sapindaceae, Sapindus genus, and S. mukurossi and S. Delavayi etc. fall under this category.

Plant parts that serve as raw materials for extracts include whole plants, leaves (leaf blades, petioles, etc.), fruits (ripe, immature, etc.), seeds, flowers (petals, ovaries, etc.), stems, rhizomes, and roots. , tuberous roots, etc. In the present invention, when an extract of Sapindium saponin is used as an extract containing saponin, it is preferably an extract of the fruit and/or pericarp of Sapindica, and particularly preferably an extract of the pericarp.

The extract can be used by using the whole plant or the above-mentioned parts as it is, or by cutting, crushing, crushing, or squeezing the plant, or by drying or powdering the processed product. These treatments can be carried out singly or in combination.

Examples of solvents used for extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, Organic solvents such as isopropyl acetate, ethyl ether, and acetone can be mentioned. These can be used alone or in combination of two or more. From the viewpoint of safety, it is preferable to use water, ethanol, or a mixed solvent thereof, which is harmless to the human body, as the extraction solvent. Extraction may be performed at a temperature below the boiling point of the extraction solvent, and the extraction time can be changed as appropriate depending on the extraction temperature. The extract may contain water as an extraction solvent, but in the case of the one-dose external skin preparation of the present invention, the acidic substance and the carbon dioxide generating substance react with each other during storage, and carbon dioxide gas is generated. Since the extraction solvent does not substantially contain water unless it contains the amount of water necessary for the extraction, an extraction solvent containing water can also be used.

After removing impurities from the extract by filtration, it is incorporated into the skin external preparation of the present invention in a solid form such as a powder. Examples of the method for making it into a solid form include a method in which the extract obtained by extraction with the above-mentioned solvent is made into a powder form by freeze-drying, spray-drying, or the like. Before converting the extract into a solid form, a purification operation may be performed to the extent that the saponin's physiological effects are not impaired.

From the viewpoint of further enhancing the above effects, when the external skin preparation of the present invention contains an extract containing saponin, the content thereof should be 0.001% by mass or more and 10% by mass or less in the external skin preparation. The content is preferably 0.005% by mass or more and 8% by mass or less. It is preferable that the content of the extract is 0.001% by mass or more and 10% by mass or less from the viewpoint of achieving both long-term foam stability and skin condition improvement effect.

Furthermore, examples of glycyrrhizic acid and its salts as natural surfactants in the present invention include dipotassium glycyrrhizinate (GK2). As described below, glycyrrhizic acid and its salts also function as anti-inflammatory agents and whitening agents. In the present invention, when glycyrrhizic acid and its salts are used as natural surfactants (or anti-inflammatory agents, whitening agents), as is clear from the comparison of Examples 4 and 5 described later, the skin external preparation and water-containing substances are Carbon dioxide gas is easily retained in the mixture for a long period of time, and the amount of carbon dioxide gas generated can be increased.In addition, the moisture content of the stratum corneum increases, and the effect of improving skin conditions such as increasing redness increases, which improves the skin. It is possible to improve the usability of external preparations. The preferable content of glycyrrhizic acid and its salt in the skin external preparation of the present invention is the same as the preferable content of the anti-inflammatory agent described below.

Further, the skin external preparation of the present invention preferably contains at least one selected from a bactericidal agent, an anti-inflammatory agent, and a whitening agent.

Bactericidal agents are substances that have bactericidal, bacteriostatic or antibacterial effects and do not cause problems on the skin when incorporated into external skin preparations; examples include salicylic acid and its salts or salicylic acid derivatives; erythromycin, clinda Antibiotics such as mycin, gentamicin, penicillin, chloramphenicol, and tetracycline; benzoyl peroxide; nadifloxacin; ethanol; benzalkonium chloride; sulfur; parahydroxybenzoate esters; hinokitiol; triclosan; homosulfamine; chloramine T; catechin; Derivatives thereof include chitin and chitosan derivatives. Furthermore, extracts having antibacterial activity can be used as antibacterial agents, and examples of such extracts include fennel, sagebrush, tea, rosehip, chamomile, orange, yarrow, turmeric, gardenia, clove, sage, and saxifrage. , clove, eucalyptus, cypress, cedar, and other extracts. These can be used alone or in combination of two or more.

Among these disinfectants, salicylic acid and its salts or salicylic acid derivatives are particularly preferably used, and salicylic acid is particularly preferably used. As is clear from the Examples described below, when a disinfectant such as salicylic acid is used in the skin external preparation of the present invention, it is possible to improve the stratum corneum water content and elasticity of the skin after use.
From the viewpoint of further enhancing this effect, when the external skin preparation of the present invention contains a bactericide, the content thereof in the external skin preparation is preferably 0.001% by mass or more and 20% by mass or less, and 0. More preferably, it is .005% by mass or more and 10% by mass or less.

An anti-inflammatory agent is a substance that has the effect of suppressing inflammation, and examples thereof include glycyrrhizic acid and its salts, and derivatives thereof, which are mentioned above as natural surfactants. Examples of other anti-inflammatory agents include glycyrrhetinic acid and its salts, mefenamic acid and its salts, phenylbutazone, indomethacin, ibuprofenic acid and its salts, ketoprofen, allantoin, guaiazulene and their derivatives, ε-aminocaproic acid, Examples include zinc oxide, diclofenac sodium, and proanthocyanidins. Furthermore, extracts having anti-inflammatory effects can also be used as anti-inflammatory agents, such as saxifrage extract, licorice extract, aloe extract, rhubarb extract, salvia extract, arnica extract, etc. , chamomile extract, birch extract, Hypericum perforatum extract, eucalyptus extract, peach leaf extract, pine bark extract, grape seed extract, lingonberry extract, and other animal and plant extracts. These can be used alone or in combination of two or more.

Among these anti-inflammatory agents, it is particularly preferable to use glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, and derivatives thereof.For the above-mentioned reasons, it is particularly preferable to use glycyrrhizic acid and its salts, and especially glycyrrhizic acid and its salts. Preferably, dipotassium (GK2) is used. When an anti-inflammatory agent is used in the external skin preparation of the present invention, it is possible to suppress skin inflammation and obtain the effect of preventing acne and rough skin.
From the viewpoint of further enhancing such effects, when the external skin preparation of the present invention contains an anti-inflammatory agent, the content thereof is preferably 0.001% by mass or more and 20% by mass or less in the external skin preparation, More preferably, it is 0.005% by mass or more and 10% by mass or less.
When GK2 is used in the external skin preparation of the present invention, as is clear from Example 7 described below, not only a high effect of improving the whiteness of the skin can be obtained, but also a high degree of improvement in skin condition such as an improvement in the moisture content and elasticity of the stratum corneum. Effects can be obtained. Furthermore, the external skin preparation using GK2 has excellent usability, such as ease of mixing and resistance to dripping, as is clear from the descriptions in sections 16 and 7 below.

As the whitening agent, those having tyrosinase activity or those having the activity of decolorizing melanin pigment are mainly used. Examples include L-cysteine and its derivatives, ascorbic acid and its derivatives, tranexamic acid derivatives, glabridin, liquiritin, isoliquiritin, hydroquinone, arbutin, kojic acid, placenta, and the like. Moreover, the above-mentioned glycyrrhizic acid or salt, glycyrrhetinic acid and its salt, and derivatives thereof can also be used as a whitening agent. Furthermore, extracts having a whitening effect can also be used as whitening agents, and examples of such extracts include succulentia extract, acanthica extract, a trumpet extract, a quince extract, a clara extract, a hawthorn extract, Examples include white lily extract, hops extract, and wildflower extract. These can be used alone or in combination of two or more.

Among these whitening agents, it is preferable to use one or more selected from arbutin, placenta, glycyrrhizic acid or its salt, ascorbic acid and its derivatives.

Arbutin used in the present invention is a compound whose systematic name is also 4-(β-D-glucopyranosyloxy)phenol.
As is clear from Example 10 described below, when arbutin is used in the external skin preparation of the present invention, it not only has a high effect of improving skin whiteness, but also has a high effect of improving skin conditions such as moisturizing and elasticity of the skin. can get. Furthermore, as is clear from the descriptions of Examples 10 and 16 below, the external skin preparation using arbutin has excellent usability, such as ease of application, comfort during application, spreadability, and ease of removal. ing.

Placenta refers to placenta from animals, particularly pigs, horses, cows, sheep, and humans, from which growth factors and other nutrients that promote cell division are extracted, from fish ovarian membranes from which nutrients are extracted, and from plant embryos. It is a general term for the nutritional components extracted from. As is clear from the description of Example 15 below, the external skin preparation of the present invention containing placenta has the effect that the amount of water evaporation tends to decrease after application, and smoothness and smoothness tend to increase. In the present invention, any placenta can be used, but animal-derived placenta and fish-derived placenta can be preferably used.

From the viewpoint of further enhancing the above effects, when the external skin preparation of the present invention contains a whitening agent, the content thereof is preferably 0.001% by mass or more and 30% by mass or less in the external skin preparation, More preferably, it is 0.005% by mass or more and 20% by mass or less.

In the skin external preparation of the present invention, other active ingredients can be used in place of or in addition to the above saponin-containing extract, bactericide, anti-inflammatory agent, and whitening agent. Such active ingredients include gold leaf, pearl powder, mud, charcoal, gypsum, enzymes, herbs, seaweed, yogurt, whey, sake, fermented products such as koji, honey, propylene glycol, polyethylene glycol, and sorbitol. , moisturizing ingredients such as sodium lactate and sodium pyrolipyrrolidone carboxylate, plant ingredients such as licorice, and vitamins. Among these, gold leaf and pearl powder are particularly preferred. As is clear from the description of Example 11, which will be described later, the use of gold foil improves the feeling of use, such as the pleasant feeling during application and the good appearance, and also provides an effect of improving skin condition. Further, as is clear from the description of Example 12, which will be described later, when pearl powder is used, the effect of improving skin conditions such as skin brightness can be obtained, and the feeling of use is also improved.

Pearl powder refers to cultured or natural pearls that are spherical or amorphous metabolic products formed in the bodies of marine shellfish such as pearl oysters, black oysters, white oysters, mabe, abalone, and freshwater mollusks such as oyster oysters. It is a powder that is pulverized by a known method such as a ball mill, jet mill, or turbo mill, and then sieved. When pearl powder is contained, its content is preferably 0.0001% by mass or more and 10% by mass or less in the skin external preparation. When gold foil is contained, its content is preferably 0.0001% by mass or more and 10% by mass or less in the skin external preparation.

In addition, the foaming skin external preparation of the present invention includes thickeners other than polysaccharides and their derivatives and water-soluble proteins; excipients, granulating agents; pH adjusters; oils and fats; fragrances; colorants; antioxidants. It can contain one or more of the ingredients normally used in external preparations for the skin, such as; antibacterial and fungicidal agents; alcohols, polyhydric alcohols; inorganic salts; lubricants; solvents; and extracts of plants and animals.

Examples of organic thickeners other than polysaccharides and their derivatives and water-soluble proteins include polyvinyl alcohol, acrylates/alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide/polyacrylamide copolymer, Examples include hydrophilic synthetic polymers such as poloxamer (Pluronic (registered trademark)), polyvinylpyrrolidone, and acrylic acid/alkyl methacrylate copolymers; examples of inorganic polymers include hydrophilic polymers such as laponite, bentonite, and smectite. Examples include clay minerals and hydrophilic thickening compounds such as silica and talc. The acrylic acid/alkyl methacrylate copolymer is a compounding component that functions as a polymer emulsifier, and for example, (acrylates/alkyl acrylate (C10-30)) crosspolymer can be used.

As the excipient or granulating agent, for example, powders such as lactose, powdered sugar, xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, sucrose, urea, etc. can be used alone without particular limitation. or a combination of two or more types can be used. When such excipients and/or granulating agents are contained, their content is preferably 10% by mass or more, and 20% by mass or more and 88% by mass or less in the skin external preparation of the present invention. It is more preferable.

In the skin external preparation of the present invention, the acidic substance, the carbon dioxide gas generating substance, the polysaccharide or its derivative, the water-soluble protein, the natural surfactant, the bactericide, the anti-inflammatory agent, the whitening agent, the The total content of other components other than excipients or granulating agents is preferably 40% by mass or less, more preferably 30% by mass or less.

The skin external preparation of the present invention includes (4) in addition to the polysaccharide or its derivative, the above-mentioned inorganic hydrophilic thickening compound and organic thickening agent as a thickening agent other than the above-mentioned polysaccharide and its derivative and water-soluble protein. Similarly to cases (1) to (3) in which two or more types of polysaccharides or their derivatives are combined, the use of at least one type selected from the above-mentioned hydrophilic synthetic polymers as an agent will also improve the feeling of use. The effect of ``improving skin condition'' is noticeable.
The effect of the present invention is that the agent of the present invention contains a polysaccharide or a derivative thereof, the hydrophilic thickening compound or the hydrophilic synthetic polymer together with a solid acidic substance and a solid carbon dioxide gas generating substance. This is the effect obtained by doing so. Therefore, the effect of the present invention is, for example, when a viscosity containing either or both of the above polysaccharide or its derivative (4) and the hydrophilic viscosity-thickening compound or the above-mentioned hydrophilic synthetic polymer together with water. This viscous composition cannot be obtained by using an agent that is mixed with a solid acidic substance and/or a solid carbon dioxide gas generating substance when the viscous composition is used.

In the present invention, when containing (4) a hydrophilic synthetic polymer that is an inorganic hydrophilic thickening compound or an organic thickening agent, as a preferable example of the polysaccharide or its derivative contained in the skin external preparation, hydrophilic Natural polymers, cellulose derivatives or starch derivatives may be mentioned. Examples of the hydrophilic natural polymer include alginic acid and its salts, carrageenan, locust bean gum, tamarind gum, and guar gum.

In particular, polysaccharides or derivatives thereof in (4) include alginic acid and its salts, carrageenan, locust bean gum, tamarind gum, guar gum, ethyl cellulose, carboxymethyl cellulose and its derivatives and their salts, hydroxyethyl cellulose and its derivatives, hydroxypropyl methyl cellulose. and its derivatives, sulfonated cellulose derivatives, carboxymethylethylcellulose and its salts, cellulose acetate phthalate, cationized cellulose, and croscarmellose and its salts, preferably at least one selected from alginic acid and its salts, carrageenan, Particularly preferred is at least one selected from carboxymethyl cellulose and its derivatives and salts thereof, guar gum, hydroxyethyl cellulose and its derivatives, and cationized cellulose.

Further, in the present invention, when (4) the above-mentioned inorganic hydrophilic thickening compound or hydrophilic synthetic polymer which is an organic thickening agent is contained, it is also preferable to use xanthan gum as the polysaccharide or its derivative. In this case, it is particularly preferred to combine xanthan gum and talc.

In case (4), when the skin external preparation of the present invention contains a specific hydrophilic natural polymer, cellulose derivative or starch derivative as the polysaccharide or its derivative, the hydrophilic natural polymer, cellulose The amount of the hydrophilic synthetic polymer which is an inorganic hydrophilic thickening compound or an organic thickener relative to 100 parts by weight of the derivative or starch derivative is preferably 1 part by weight or more and 10,000 parts by weight or less, and 5 parts by weight. It is more preferably 10 parts or more and 1000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1000 parts by mass or less. Here, the amount of the specific hydrophilic natural polymer, cellulose derivative, or starch derivative is the total amount if two or more of these are contained. Further, the amount of the hydrophilic thickening compound or the hydrophilic synthetic polymer is the total amount of these two or more, if the composition contains two or more of them. In addition, if specific types of hydrophilic natural polymers, cellulose derivatives, starch derivatives, hydrophilic thickening compounds, and hydrophilic synthetic polymers are contained, the above-mentioned hydrophilic natural polymers, cellulose derivatives, and starch The amount of the derivative, hydrophilic thickening compound, and hydrophilic synthetic polymer may be the amount of the specific type of hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound, and hydrophilic synthetic polymer. Can be done (the same applies hereafter).

In the skin external preparation of the present invention, the total content of the specific hydrophilic natural polymer, cellulose derivative, starch derivative, hydrophilic thickening compound, and hydrophilic synthetic polymer is 5% by mass or more and 50% by mass. It is preferably at least 10% by mass and at most 45% by mass, particularly preferably at least 12% by mass and at most 45% by mass.

The dosage form of the skin external preparation of the present invention is usually solid, and examples include powder, granules, fine granules, pellets, or a combination of two or more of these. A powder form is preferable from the viewpoint of cost reduction during production and ease of dissolution during use.

For example, when the skin external preparation of the present invention is made into granules, the entire preparation may be made into granules, or a portion may be made into granules. When a part of the substance is in the form of granules, the acidic substance and/or the carbon dioxide gas generating substance may be in the form of granules. In this case, the granules may contain other components (one or more of the various components described above, such as excipients, granulating agents, polysaccharides or derivatives thereof, and water-soluble proteins). Further, components other than the acidic substance and the carbon dioxide gas generating substance may be in the form of granules.

For example, when obtaining granules of the solid acidic substance and/or the solid carbon dioxide gas generating substance by granulating a mixture of the acidic substance and/or the carbon dioxide gas generating substance and other components, The content of other components is not particularly limited, but is preferably less than 80% by mass in the granules. If other components are present in a content exceeding 80% by mass, foaming properties will decrease, which is not preferable.

The method for producing the granules is not limited to the present example, and conventional methods such as dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc. It can be manufactured according to the following.

For example, when a low melting point compound is used as a matrix base in a granulating agent, the low melting point granulating agent is melted by heating in a container such as a beaker, and the acidic substance and/or the carbon dioxide gas generating substance and the necessary Add other ingredients as required and stir and mix thoroughly. Appropriate additives may be added to this as necessary. This is further stirred while gradually cooling to room temperature and left until solidified. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator, etc.

Alternatively, for example, the above-mentioned materials may be put into a fluidized bed granulator, mixed with air flow for several minutes, and then granulated by spraying water thereon.

When a low melting point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the acidic substance and/or the carbon dioxide gas generating agent are added to this. After the substance and other components as necessary are dissolved or dispersed and thoroughly mixed, the mixture is heated in an oven or the like to remove the solvent and dried. Once completely solidified, it is crushed, passed through a sieve to adjust the particle size, and then made into granules.

Examples of the shape of the solidified acidic substance or solid carbon dioxide gas generating substance as described above include irregular shape, planar shape, polyhedral shape, spherical shape, droplet shape, fibrous shape, columnar shape, fine powder shape, etc. can be adopted without any particular restrictions. Furthermore, a wide range of particle sizes can be used without any particular restrictions. In particular, from the viewpoint of ease of handling and ease of mixing with water-containing substances, particles with a particle size distribution of about 1,000 μm are more preferable. The above particle size distribution in the present invention can be determined by a conventional laser diffraction/scattering method.

In the present invention, the acidic substance and the carbon dioxide gas generating substance are contained in the same agent, and the acidic substance and the carbon dioxide gas generating substance are blended and coexist in the same agent so that they do not physically come into contact with each other. It is preferable. The coexistence means is not particularly limited and can be widely applied.

When the acidic substance and the carbon dioxide gas generating substance are blended so that they do not come into physical contact with each other, for example, either or both of the acidic substance and the carbon dioxide gas generating substance are provided with a coating layer that covers them. Alternatively, either one or both of the acidic substance and the carbon dioxide generating substance may be encapsulated. Further, compression molding may be performed by sandwiching a layer not containing the acidic substance and the carbon dioxide gas generating substance between the acidic substance and the carbon dioxide gas generating substance so that they do not come into direct contact with each other.

Hereinafter, means for coexisting the acidic substance and the carbon dioxide gas generating substance in the same agent will be specifically described, but the present invention is not limited thereto.

[Coat layer formation]
As a method for forming the coat layer, for example, a method may be used in which the coat layer is formed using at least one of an acidic substance or a carbon dioxide gas generating substance. By providing a coating layer, even if the acidic substance, the carbon dioxide gas-generating substance, and other components coexist in the same agent, there is no risk of unexpected carbon dioxide gas generation during production or storage, resulting in improved stability. Preferable from the viewpoint of durability.

Preferred coating materials for forming the coating layer are not particularly limited as long as they have low reactivity with the acidic substance or the carbon dioxide gas generating substance. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Examples include copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropyl cellulose, wheat starch, white sugar, lactose, and citrate. In particular, when coating an acidic substance such as citric acid, it is preferable to employ a citrate salt such as calcium citrate. Further, the coating layer may be formed using solid hydrocarbon wax, solid oil, or the like, which melts at a certain temperature or higher when heated.

The amount of coating agent used for acidic substances and/or carbon dioxide gas generating substances is preferably 1 to 20% (w/w), more preferably 1 to 10% (w/w), based on the acidic substances or carbon dioxide gas generating substances. w) degree.

The coating layer may be coated by any method commonly used for coating particles. For example, coating may be performed simultaneously with granulation by spray granulation, rolling granulation, etc., and powder or granules may be coated with oil or fat coating, granulation coating, transport layer method, pan coating, rolling coating, fluid coating, or It may be coated using a method such as dry coating. During coating, if excessive heat or physical force is applied, the acidic substance or carbon dioxide gas generating substance is destroyed, the formed film is broken, and the surface of the acidic substance or carbon dioxide gas generating substance is destroyed. Not only will it be difficult to uniformly coat the entire surface with the lipid powder, but the acidic substance or carbon dioxide gas-generating substance may leak onto the surface and solidify due to moisture absorption, or may have an adverse effect on other ingredients during blending. The coating conditions must be such that the coating layer and the object to be coated are not destroyed.

[Encapsulation]
When encapsulating an acidic substance and/or a carbon dioxide gas-generating substance, any known method may be used without particular limitation.

As the encapsulation method, any known method can be applied without particular limitation, and the encapsulation materials include gelatin, starch, gum arabic, methylcellulose, acrylic ester, methacrylic ester, vinyl acetate, Examples include polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acids, higher alcohols, etc., and those formed with multiple layers of surfactants such as liposomes, but are not limited to these and can be widely used. For example, the basic structure of the capsule is composed of a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, and styrene, or the capsule is composed of a homopolymer or a copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, and styrene, or the above monomer and acrylic acid, methacrylic acid, divinyl It is also preferable to use a resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate. Such microcapsules are produced by emulsifying the contents and the constituent monomers of the polymer that makes up the outer shell of the capsule in a reaction solvent such as water, and adding a polymerization initiator such as azobisisobutyronitrile or benzoyl peroxide to this. Emulsion polymerization may be carried out by adding the agent. As a surface active ingredient used for such emulsification, for example, Hexlite sold under the name "Laponite XLG" can be suitably exemplified.
The microcapsules of the present invention can be produced by separating the resulting microcapsules by means such as centrifugation and, if desired, washing them.

[Compression molding]
As for the compression molding method, the first layer containing the acidic substance and the second layer containing the carbon dioxide gas generating substance are mixed with substances other than the acidic substance and the carbon dioxide gas generating substance ( For example, a method may be adopted in which a third layer consisting of excipients, thickeners, etc.) is sandwiched and compression molded. The compression-molded dosage form may be any solid dosage form, such as tablet, spherical, or plate shape. Here, the acidic substance and the carbon dioxide gas generating substance used may be used as they are, or the acidic substance or the carbon dioxide gas generating substance may be used as is, or the acidic substance or the carbon dioxide gas generating substance may be used as is, or the acidic substance or the A carbon dioxide gas-generating substance, the encapsulated acidic substance, or the carbon dioxide gas-generating substance may be used. The compression molding method is not particularly limited, and any known method can be applied.

The external skin preparation of the present invention may be other than the following skin external preparations.
``A one-dose external skin preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, and a thickener, and does not contain water, The thickener is contained in an amount of 12 to 45% by mass in all the skin external preparations, and the thickener is used in combination with albumin and other thickeners, and mixed with a liquid containing water when the skin external preparation is used. A single-dose topical skin preparation. Here, examples of thickeners include polyvinyl alcohol, hydroxyethylcellulose, hydroxypropylmethylcellulose, sulfonated cellulose derivatives, acrylates/alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide/polyacrylamide copolymer, carboxylic In addition to hydrophilic synthetic polymers such as methylcellulose, cationized cellulose, and pluronics, and hydrophilic natural polymers such as starch, xanthan gum, sodium alginate, succinoglycan, carrageenan, guar gum, locust bean gum, and celluloses. , chondroitin sulfate, hydrophilic protein compounds such as casein, collagen, gelatin, and albumin, and hydrophilic thickening compounds such as hydrophilic clay minerals such as laponite, bentonite, and smectite.

<Usage form of external skin preparation>
When the external skin preparation of the present invention is used, foaming is generated by mixing it with a water-containing substance on the palm of the hand or in a container.
The skin external preparation of the present invention may be used as a single-pack type skin preparation, or it may be used as a two-pack type containing a water-containing substance and a kit. When the external skin preparation of the present invention is in the form of a single dosage form, the external skin preparation is usually a solid composition as described above, and is preferably in the form of solid, granules, fine particles, or powder. A granular, fine granular, or powder form is particularly preferable because it is easy to mix with a water-containing substance and foaming occurs easily. Furthermore, when the skin external preparation of the present invention is in the form of a single dosage form, it usually does not substantially contain water. Here, "substantially free of water" means that it does not contain the amount of water necessary for the reaction between acidic substances and carbon dioxide gas-generating substances during storage of the skin preparation to generate carbon dioxide gas. . Specifically, the amount of water contained in the external skin preparation of the present invention is 15% by mass or less, preferably 10% by mass or less, and more preferably 8% by mass or less. When the skin external preparation of the present invention is a two-dose type comprising a water-containing substance and a kit, the agent containing an acidic substance, a carbon dioxide gas-generating substance, and at least one type of polysaccharide is usually a solid composition, A solid, granular, fine granule, or powder form is more preferable, and a granular, fine granule, or powder form is preferable because it is easy to mix with a water-containing substance and foaming occurs easily. Particularly preferred. Further, when the external skin preparation of the present invention is of a two-dose type, the solid composition usually does not substantially contain water. Here, "substantially free of water" means that it does not contain the amount of water necessary for the reaction between acidic substances and carbon dioxide gas-generating substances during storage of the skin preparation to generate carbon dioxide gas. . Specifically, the amount of water contained in the external skin preparation of the present invention is 15% by mass or less, preferably 10% by mass or less, and more preferably 8% by mass or less. When the external skin preparation of the present invention is a single-dose type, the user usually prepares a water-containing substance to be mixed with the skin external use formulation, and when it is a two-dose form, the skin external use formulation of the present invention is prepared as described above. and a water-containing substance constitute a kit. When an external skin preparation is a single-dose type, a liquid containing water is often used as the water-containing substance. In the case of a two-dose type, examples of the water-containing substance include liquids and gels containing water. The water-containing substance is preferably a liquid, more preferably a liquid with low viscosity, and particularly preferably a liquid with no viscosity. Preferably, the water-containing substance is substantially free of the above-mentioned thickener. Specifically, the content of the thickener in the water-containing substance is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, and 0.01% by mass or less. is particularly preferred. In particular, when the external skin preparation is a two-dose type, the effects of the present invention are more effective when the external skin preparation is mixed with a liquid, especially a liquid with relatively low viscosity, than when mixed with a gel. It is preferable because it is played. When the external skin preparation of the present invention is mixed with a gel or a liquid with relatively high viscosity, it is not preferable because it is difficult to mix the two agents and it tends to take a long time to foam. Specifically, the viscosity of the water-containing substance at 25° C. is preferably 50,000 mPa·s or less, more preferably 30,000 mPa·s or less, particularly preferably 10,000 mPa·s or less, and even more preferably 5,000 mPa·s or less. . This viscosity can be measured with the viscometer used in the Examples below. Further, the water content in the water-containing substance may be 10% by mass or more, and preferably 30% by mass or more. It is more preferably 40% by mass or more, still more preferably 50% by mass, particularly preferably 70% by mass or more, especially 80% by mass or more. When the water content is less than 10% by mass, carbon dioxide gas is less likely to be generated when the external skin preparation and the water-containing substance are mixed, making it impossible to obtain effects such as promoting blood flow during use.
Here, a high lower limit such as 70% by mass or more or 80% by mass or more can be adopted in both a one-dose type and a two-dose type, but is particularly preferred in the case of a one-dose type.

The single-dose form of the skin external preparation of the present invention is characterized by being lower in cost and easier for users to handle than two-dose forms. In the case of a one-dose type, the water-containing substance used in the present invention includes liquids containing water that are normally used in cosmetics, pharmaceuticals, etc., or used in general households. The liquid containing water may be water itself. Specifically, in addition to tap water, distilled water, membrane-filtered water, ion-exchanged water, and deep ocean water, alcoholic beverages such as sake and wine, soy milk, drinkable yogurt, acerola juice, sports drinks, carbonated water, and other beverages, and rice. Examples include Notogijiruya. These may be used alone or in combination of two or more.

In addition, when the skin external preparation of the present invention and a water-containing substance are combined to form a two-dose type, the water-containing substance includes a liquid or gel containing water, as mentioned above, and the above-mentioned water and water. In addition to liquids containing these, examples include liquids containing these with optional components added. As this component, known components included in the liquid formulation of the two-component skin preparation, such as humectants, surfactants, pH adjusters, volatile alcohols, oils and fats, fragrances, and extracts of plants and animals may be added. I can do it. For example, humectants include polyglycerin such as glycerin, diglycerin, triglycerin, and tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, , 3-propanediol, sorbitol, polyhydric alcohols such as polyglycerin derivatives, polyoxyalkylene alkyl glucosides, sodium lactate, sodium pyrrolidone carboxylate, almonds, avocados, althea, aloe, malva, ononis, oats, licorice, quince seeds, Clara, gardenia, grapefruit, watercress, gentian, burdock, wheat, rhinoceros, cactus, soapwort, hawthorn, rhododendron, meadowsweet, ginger, mallow, mulberry, thyme, cordyceps sinensis, dokudami, mentha, adlay, hamamelis, Roses, cypress, coltsfoot, grapes, prunes, loofah, bodega, hops, pine, quince, horse chestnut, melissa, cornflower, lily, lime, lavender, apple, rice and rice bran, black currant, Ibukitoran, wild rose, eleuthero, seaweed, etc. These include plant extracts, and one or more of these can be used.

The amount of the water-containing substance to be used is not particularly limited and can be used within a wide range, but for example, it is preferably added in an amount of 1 to 10 times the weight of the skin external preparation, and 2 to 5 times the amount by weight. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the skin external preparation can be rapidly dissolved and a sufficient amount of carbon dioxide gas can be generated. On the other hand, by adding a liquid within 10 times the amount, it is possible to prevent the external skin preparation from dripping due to a decrease in viscosity.

The temperature of the water-containing substance to be used is not particularly limited and can be used within a wide range, but it is particularly preferable to cool it before use because the effect of the active ingredient of the skin external preparation is enhanced. Regarding the usable temperature range, it is preferable to use water or tap water at about room temperature from the viewpoint of the feeling of use during application and convenience for the user.

There are no particular restrictions on the method of storing the skin preparation, as long as it is kept protected from moisture and does not come in contact with the skin. The shape of the storage container to be used can be appropriately selected depending on the purpose, and examples thereof include a cup shape, a tube shape, a bag shape, a bottle shape, a stick shape, a pump shape, a jar shape, and a can shape. Further, the material constituting the storage container may be, for example, plastic, glass, aluminum, paper, various polymers, etc., used alone or in combination of two or more, but is not limited to these.

Specific examples of containers include aluminum sticks with inner surfaces laminated with polyethylene terephthalate, storage containers such as aluminum bags, stand pouches with zippers, and inner surfaces made of polyethylene terephthalate in terms of airtightness, storage stability of contents, manufacturing costs, etc. Preferably, a storage container made of polyethylene terephthalate, the lid of which is heat-sealed with an aluminum film laminated with aluminum film or the like.

According to the skin external preparation of the present invention, as is clear from the description of the examples described later, it is easy to use and provides excellent skin condition improvement effects. Examples of usability include ease of mixing the mixture of the external skin preparation and water-containing substance onto the skin, ease of application, resistance to dripping, ease of removal, smoothness of the foam, fineness of the foam, Examples include the uniformity of the foam (no roughness of the powder), the elasticity of the foam, the longevity of the foam, the carbonated feeling (irritating feeling), and the persistence of the carbonated feeling. In addition, the skin condition improving effects include improvements in moisturizing, elasticity, brightness, redness, smoothness, tightness, whiteness, increase in stratum corneum water content, and suppression of water evaporation. As is clear from Example 24, which will be described later, the skin external preparation of the present invention can also have the effect of making wrinkles less noticeable.

<Applications of external skin preparations>
The external skin preparation of the present invention promotes an increase in skin blood flow, and makes use of the above-mentioned effects to whiten the skin, improve skin quality, improve freckles, rejuvenate the skin, tighten the skin, thin areas, and purify the skin. to condition the skin, adjust the texture of the skin, keep the skin healthy, prevent rough skin, tighten the skin, moisturize the skin, replenish and maintain skin moisture and oil, maintain skin flexibility, skin protects the skin from dryness, softens the skin, gives firmness to the skin, gives luster to the skin, smoothes the skin, prevents spots and freckles caused by sunburn, makes fine wrinkles caused by dryness less noticeable. In addition to cosmetics aimed at preventing skin irritation, it also prevents rough skin, irritation, prickly heat, chilblains, cracks, chapped skin, acne, oily skin, prevention of razor burn, prevention of spots and freckles caused by sunburn, and prevention of sunburn. The purpose is to prevent hot flashes after snowburn, tighten the skin, purify the skin, condition the skin, keep the skin healthy, moisturize the skin, protect the skin, prevent skin dryness, etc. It can be suitably used for both quasi-drugs and pharmaceuticals such as drugs. The skin external preparation of the present invention is preferably used as cosmetics or quasi-drugs, and preferably used as cosmetics such as emulsions, creams, packs, peeling agents, and medicinal cosmetics. Among them, it is particularly preferable to use it as a pack agent because it feels good when used and is easy to obtain a high effect on improving skin condition.

EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the scope of the present invention is not limited to these Examples. In each of the following Examples and Comparative Examples, commercially available raw materials were used unless otherwise specified.

<Examples 1 to 10, Comparative Examples 1 to 3>
Each component listed in Table 1 was blended and mixed according to the composition shown in the same table to produce powdered external skin preparations of Examples 1 to 10 and powdered external skin preparations of Comparative Examples 1 to 3. . The numerical values in Table 1 below are the mass proportions (mass %) in the skin external preparation.

The characteristics of the external skin preparations of the above Examples and Comparative Examples were evaluated in accordance with the procedure described below [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3].

[Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3]
(1) Sensory evaluation Three healthy women in their 20s to 30s were randomly selected as subjects. The subject's inner forearm was washed with facial cleanser, and the subject was allowed to rest for 15 minutes in the measurement room. Subsequently, a powdered external skin preparation sample and water were mixed in a container at a ratio of 1:3 (mass ratio) to obtain a mixture as a foam pack cosmetic. This mixture was applied to a 4 cm x 4 cm area on the inside of the forearm. Ten minutes after application, the mixture was removed from the forearm and the forearm was washed with water. Afterwards, we evaluated the feeling of use using four items: ``Easy to mix,'' ``Easy to apply,'' ``Difficulty dripping,'' and ``Easy to remove.'' We also evaluated the condition of the skin after use, including ``Moist feeling.'''', ``skin elasticity'', ``skin brightness'', and ``skin redness''. For each item, scores were assigned to the 7 levels shown in Table 2, and after tabulation, the average value of the three participants was determined. The results are shown in Table 3. Regarding "difficulty in dripping", the more difficult it was for the mixture to drip from the skin after application, the higher the rating. In addition, for "moisture content", the higher the moisture content of the skin, the higher the score was given, and for "skin redness", the more red the skin, the higher the score was given.

From the results in Table 3 above, the skin external preparations of each Example containing polysaccharides or their derivatives had poor usability such as ease of mixing, ease of application, resistance to dripping, ease of removal, and moist feeling. It can be seen that these products are superior to Comparative Examples 1 to 3 in terms of both skin condition improvement effects such as elasticity, brightness, and redness. Furthermore, it can be seen that Examples 2 and 6 to 10 containing two or more types of polysaccharides or derivatives thereof are even more effective in both improving the feeling of use and improving the skin condition. In addition, as in Examples 3, 6, 8, and 10, when water-soluble protein is contained, the effect of improving the feeling of use and skin condition is even higher; It can be seen that when an extract containing saponin, which is a natural surfactant, is contained instead of water-soluble protein, these effects are as high as or higher than that of water-soluble protein. It can also be seen that high effects were obtained in Examples 3 and 5 to 10 containing GK2, salicylic acid, or arbutin. For example, as is clear from the comparison of Examples 4 and 5, by containing GK2, which is a natural surfactant (and anti-inflammatory agent and whitening agent), it not only enhances the effect of improving skin conditions such as redness, but also improves skin condition. It also improves the usability of external preparations. From the above results, compared to Example 1 in which one type of polysaccharide or its derivative was used, cases in which two types of polysaccharide or its derivatives were used as in Examples 2 to 5, water-soluble protein, and natural surfactant were used. It can be seen that when used together, a higher usability and skin condition improving effect can be obtained. Furthermore, it can be seen that by using two or more types of polysaccharides or their derivatives together with water-soluble proteins or natural surfactants as shown in Examples 6 to 10, both the feeling of use and the effect of improving skin condition are further improved. .

(2) Measurement of skin condition Regarding the sensory evaluation in (1) above, the L* value, stratum corneum moisture content, and elasticity at the area where the mixture was to be applied on the inner side of the forearm before applying the mixture were measured using the following measuring devices. After removing the mixture and washing with water, the L* value, stratum corneum water content, and elasticity of the area on the inner side of the forearm where the mixture was applied were measured in the same manner. From the obtained measured values, the average value of the three subjects was determined. The average value after use of the skin external preparation was divided by the average value before use, and the obtained value was taken as the rate of change. Figure 1 shows the rate of change in L* value (whiteness), Figure 2 shows the rate of change in stratum corneum water content, and Figure 3 shows the rate of change in elasticity. In these figures, the higher the rate of change, the higher the evaluation.

- L* value: Measured with a color difference meter (CR-400 manufactured by Konica Minolta).
- Horny moisture content: Measured using a skin surface horny moisture content measuring device SKICON-200EX (manufactured by IBS). This skin surface stratum corneum water content measuring device evaluates skin conductance (electrical conductivity, unit: μS) as the stratum corneum water content.
- Elasticity: Measured with a skin viscoelasticity measuring device Cutometer MPA580 (manufactured by Courage+Khazaka).
These measurements were performed using standard methods as described in the instructions provided with the equipment.

From the results shown in Figures 1 to 3, it can be seen that each Example achieved a change rate equal to or higher than each Comparative Example in the L* value, stratum corneum moisture content, and elasticity of the skin after using the topical skin preparation. I understand. In particular, it contains two or more types of polysaccharides or their derivatives, contains water-soluble proteins, contains extracts containing saponin, which is a natural surfactant, and glycyrrhizinate, which is a natural surfactant (inflammatory agent and whitening agent). It can be seen that the L* value, the moisture content of the stratum corneum, and the rate of change in elasticity increase due to one or more factors selected from the content of , other whitening agents, or bactericidal agents. For example, a comparison of Examples 1 and 2 shows that when two or more types of polysaccharides or derivatives thereof are contained, the L* value, stratum corneum moisture content, and elasticity are improved. Furthermore, from a comparison of Examples 1 and 3, it can be seen that containing water-soluble protein and glycyrrhizinate improves the L* value, stratum corneum moisture content, and elasticity. Furthermore, from a comparison of Examples 1 and 4, it can be seen that when an extract containing saponin is contained, the L* value, stratum corneum moisture content, and elasticity are improved. Furthermore, a comparison of Examples 4 and 5 shows that containing glycyrrhizinate improves the stratum corneum moisture content. Further, from the comparison of Examples 6 and 8 and the comparison of Examples 7 and 9, it is found that the inclusion of a bactericide improves the moisture content and elasticity of the stratum corneum. Furthermore, from Example 10, it can be seen that the L* value is improved when arbutin is contained as a whitening agent.

(3) Evaluation of external skin preparations Pour 27 mL of water into a bottle (225 mL) with a diameter of approximately 4.8 cm and a height of approximately 10.5 cm, add 9 g of powdered external skin preparation sample, and add 20 times in 10 seconds. Stirred. The resulting mixture was evaluated for the following <amount of foaming> and <amount of carbon dioxide gas generated>.

<Foaming amount>
The volume of the mixture was measured 1 minute, 10 minutes, and 20 minutes after stirring, and the rate of increase (%) in volume with respect to the volume before stirring was determined. The results are shown in FIG.

<Amount of carbon dioxide gas generated>
Carbon dioxide gas generated from the stirred mixture was collected by displacement on water. The cumulative amount (mL) of carbon dioxide gas collected at each time point 3, 5, 7, 10, 15, 20, and 30 minutes after stirring was measured. The results are shown in FIG.

From the results in FIG. 4, it can be seen that in the skin external preparations of each Example, the volume of the mixture does not easily decrease even after time passes after stirring, and a certain amount of carbon dioxide gas is retained in the mixture. This effect is selected from the following: containing two or more types of polysaccharides or derivatives thereof, containing water-soluble proteins, containing extracts containing saponin, containing glycyrrhizinate, and containing other whitening agents or bactericidal agents. It is increased by one or more factors, especially the inclusion of extracts containing water-soluble proteins or saponins, and the inclusion of glycyrrhizinate. For example, a comparison of Examples 1 and 2 shows that when two or more types of polysaccharides or derivatives thereof are contained, the carbon dioxide retention capacity in the resulting mixture is improved. Further, from a comparison of Examples 1 and 3, it can be seen that the inclusion of water-soluble protein and glycyrrhizinate improves the carbon dioxide retention capacity of the resulting mixture. Further, from a comparison of Examples 1 and 4, it can be seen that when an extract containing saponin is contained, the carbon dioxide retention capacity in the resulting mixture is improved. Further, from a comparison of Examples 4 and 5, it can be seen that the inclusion of glycyrrhizinate improves the carbon dioxide retention capacity in the resulting mixture.
On the other hand, it can be seen that in each of the comparative examples, the air bubbles in the mixture are difficult to retain, and the volume of the mixture after stirring tends to decrease, that is, the amount of carbon dioxide gas that can be retained in the mixture is small.

From the results in Figure 5, it can be seen that in each Example, carbon dioxide gas was generated relatively slowly during the period from stirring to 5 minutes, and even after that, although the gradient was gentle in some cases, carbon dioxide gas generation from the mixture did not stop. It is clear that it continues without any problems. In particular, in Examples 2 to 10 containing extracts containing two or more types of polysaccharides or their derivatives, water-soluble proteins or saponins, glycyrrhizinates, or other whitening agents and bactericides, carbon dioxide gas is generated. It can be seen that there is a tendency for this to continue for a long time. For example, a comparison of Examples 1 and 3 shows that containing water-soluble protein and glycyrrhizinate improves the amount of carbon dioxide gas generated. Furthermore, from a comparison of Examples 1 and 4, it can be seen that when an extract containing saponin is contained, the amount of carbon dioxide gas generated is improved. Furthermore, from a comparison of Examples 4 and 5, it can be seen that containing glycyrrhizinate improves the amount of carbon dioxide gas generated.
On the other hand, in each of Comparative Examples 1 to 3, although the rate of carbon dioxide gas generation is high until 3 minutes after stirring, it can be seen that the generation stops after that or the amount of carbon dioxide gas itself generated is low. .

<Examples 11 to 17>
Each component was blended and mixed in the proportions shown in Table 4 below to produce a powdered skin preparation. The numerical values in Table 4 are the mass proportions (mass %) in the skin external preparation.

[Evaluation of Examples 11 to 17]
<Sensory evaluation>
Three healthy women in their 20s to 30s were randomly selected as subjects different from the subjects who evaluated Examples 1 to 10 and Comparative Examples 1 to 3 above. Other than that, after using the powdered skin external preparation sample in the same manner as "(1) Sensory evaluation" in [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] above, each subject was given the following: We conducted a questionnaire regarding the following evaluation items. For each item, scores were assigned in seven stages shown in Table 2 above using Example 17 as the standard (4.0 points), and after tabulation, the average value of the three participants was determined. The results are shown in Table 5 below. Regarding the "stimulating sensation" described below, the more tingly the sensation, the higher the evaluation. In addition, the less sticky the skin was, the higher the rating.
Evaluation items: During use: "Ease of application", "Comfort when applying", "Good appearance of the applied mixture", "Difficulty dripping", "Irritation (presence or absence of tingling sensation)", " 8 items: ``Easy to spread the mixture'', ``Difficulty in stickiness of the mixture'', ``Easy to remove the mixture'', ``Moist feeling of the skin'', ``Smoothness of the skin'', ``Skin condition'' after use. A total of 15 items, 7 items: "Skin smoothness", "Skin stickiness", "Skin firmness", "Skin tightness", and "Skin brightness".

From the results in Table 5 above, it can be seen that each active ingredient (including a second type of water-soluble protein) is added to the composition of Example 17, which contains an acidic substance, a carbon dioxide gas-generating substance, a polysaccharide or its derivative, and one type of water-soluble protein. It can be seen that in Examples 11 to 16, in which the ingredients were added, both the feeling of use and the effect of improving the skin condition were improved. In particular, when the external skin preparation of Example 11 in which gold foil was added was used, it was found that the usability, such as the pleasant feeling during application and the good appearance, was improved. It was also found that when the external skin preparation of Example 12 containing pearl powder was used, the brightness of the skin was improved. It is also found that when the external skin preparation of Example 13 containing collagen is used, the moist feeling and smoothness are particularly improved. In addition, when the skin external preparation of Example 14 containing hydrolyzed collagen is used, the ease of application, comfort, appearance, etc. during use are improved, and the skin feels moist and smooth after use. It is clear that it will improve. It is also found that when the external skin preparation of Example 15 containing placenta is used, the smoothness, smooth feeling, etc. after use are improved. It can be seen that when Example 16 containing arbutin is used, the ease of application, comfort, and spreadability during use are improved, and the smoothness, brightness, etc. of the skin after use are improved.

[Evaluation of Examples 14 to 17]
<Measurement of skin condition>
In the <sensory evaluation> of the above [Evaluation of Examples 11 to 17], the amount of water evaporation (g/m ² /hr) at the planned application site on the inner side of the forearm before applying the mixture was measured using the following measuring device. Thereafter, after removing the mixture and washing with water, the amount of water evaporation (g/m ² /hr) at the area on the inner side of the forearm where the mixture was applied was measured in the same manner.

- Moisture transpiration (g/m ² /hr): Measured with Tewameter TM300 (manufactured by Courage+Khazaka). This measurement was performed using the standard method described in the instructions provided with the equipment.
From the obtained measured values, the average value of the three subjects was determined. The rate of change was calculated by dividing the average value before use from the average value after use of the skin external preparation. The obtained rate of change in the amount of water transpiration is shown in FIG. The lower the value of this rate of change, the higher the evaluation.

From the results shown in FIG. 6 above, when using the external skin preparations of Example 14, in which hydrolyzed collagen was added to the composition of Example 17, Example 15, in which placenta was added, and Example 16, in which arbutin was added, the skin It can be seen that the amount of water transpiration is further suppressed. In particular, it can be seen that the suppressing effect of Example 15 in which placenta was added was high.

<Examples 18-20>
Each component listed in Table 6 was blended and mixed according to the composition shown in the same table to produce powdered external skin preparations of Examples 18 to 20. The numerical values in Table 6 are the mass proportions (mass %) in the skin external preparation.

[Evaluation of Examples 18 to 20]
<Sensory evaluation>
Five healthy women in their 20s to 30s were randomly selected as subjects. Other than that, the same sensory evaluation as (1) sensory evaluation of [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] was performed. However, the four evaluation items were ``smoothness of the skin'', ``moisture of the skin'', ``moisture of the skin'', and ``softness of the skin'' as the condition of the skin after use. In addition, the test subjects were asked to give evaluation scores on a 7-level scale shown in Table 2, with Example 20 as the standard (4.0 points). After tabulation, the average value of the five evaluation scores was calculated. The results are shown in Table 7.

[Evaluation of Examples 18 and 19]
<Measurement of skin condition>
In the <sensory evaluation> of the above [Evaluation of Examples 18 to 20], the moisture content of the stratum corneum at the area where the mixture was to be applied on the inner side of the forearm before applying the mixture was measured using the above-mentioned measuring device. After removing the mixture and washing with water, the moisture content of the stratum corneum at the area on the inner side of the forearm where the mixture was applied was measured in the same manner. From the obtained measured values, the average value of the five subjects was determined. The average value after use of the skin external preparation was divided by the average value before use, and the obtained value was taken as the rate of change. The results are shown in FIG.

<Evaluation of external skin preparations>
Except that the amount of water used was 30 mL and the amount of powdered external skin preparation sample was 10 g, the same conditions as <foaming amount> in (3) of [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] Similarly, the volume increase rate (%) of the mixture after stirring was determined. The results are shown in Table 8 below.

<Example 21>
Each component listed in Table 9 was blended and mixed in the composition shown in Table 9 to produce a powdered skin preparation for external use of Example 21. The numerical values in Table 9 are the mass proportions (mass %) in the skin external preparation.

<Comparative example 4>
Each component listed in Table 10 was blended and mixed in the composition shown in Table 10 to produce a carbonate-containing powder and an acid-containing liquid, respectively. The values in Table 10 are parts by mass. The viscosity of the obtained acid-containing liquid at 25° C. was measured using a viscometer (model RVT manufactured by Brookfield), and the result was 16.9 mPa·s.

<Comparative example 5>
Each component listed in Table 11 was blended and mixed according to the composition shown in the same table to produce a powder containing an acid and a viscous composition containing a carbonate, respectively. The values in Table 11 are parts by mass. The viscosity of the obtained viscous composition at 25° C. was measured using the viscometer described above, and the result was 549,600 mPa·s.

[Evaluation of Example 21 and Comparative Examples 4 and 5]
(1) Sensory evaluation Four healthy women in their 20s to 30s were randomly selected to serve as subjects. Other than that, the same sensory evaluation as (1) sensory evaluation of [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] was performed. However, in Example 21, a powdered skin preparation for external use and water were mixed at a mass ratio of 1:2.7. In Comparative Example 4, a powder containing a carbonate and a liquid containing an acid were mixed at a mass ratio of 1:3 to obtain a mixture. In Comparative Example 5, a mixture was obtained by mixing a powder containing an acid and a viscous composition containing a carbonate at a mass ratio of 1:3.68. In addition, the two evaluation items were "skin elasticity" and "skin redness" as the condition of the skin after using the topical skin preparation, and the 7-level scores shown in Table 2 are based on Comparative Example 4 (4. An evaluation score was given as 0 points). After tabulation, the average value of the evaluation scores of the four participants was determined. The results are shown in Table 12. In addition, when the viscosity of the water used in Example 21 at 25° C. was measured using the viscometer described above, it showed a value below the lower limit of the viscometer (10 mPa·s).

(2) Measurement of skin condition In the sensory evaluation in (1) above, before applying the mixture, the L* value at the area where the mixture was to be applied on the inner side of the forearm was measured using the measuring device described above. The applied mixture was then removed and washed with water.
At each time point 15 minutes, 60 minutes, and 120 minutes after the completion of removal, the L* value of the area on the inner side of the forearm to which the mixture was applied was measured using the above measuring device. From the obtained measured values, the average value of the four subjects was determined. The change value was obtained by subtracting the average value before use from the average value after use of the skin external preparation. Table 13 shows the change in L* value (whiteness) obtained. In the same table, the higher the change value, the higher the evaluation.

As is clear from the descriptions in Tables 12 and 13, in Example 21, in which a skin external preparation containing an acidic substance, a carbon dioxide gas-generating substance, and a polysaccharide or its derivative was mixed with a water-containing substance, powder containing carbonate was mixed with an acid. It can be seen that the effect of improving the skin condition after use is higher than in Comparative Example 4, in which the powder containing an acid was mixed with a viscous composition containing a carbonate, and in Comparative Example 5, in which a powder containing an acid was mixed with a viscous composition containing a carbonate.

<Examples 22-23>
Each component was blended and mixed in the proportions listed in Table 14 below to produce a powdered skin preparation for external use.
The numerical values in Table 14 are the mass proportions (mass %) in the skin external preparation.

[Evaluation of Examples 22-23]
<Evaluation of storage stability>
Each 9 g of the powdered skin external preparations obtained in Examples 22 to 23 above was sealed in an aluminum film bag whose inner surface was laminated with polyethylene terephthalate. The bag was stored at 50° C. or 60° C. for 2 months, and during the storage period, the presence or absence of carbon dioxide gas generation was observed using the presence or absence of swelling of the bag as an indicator. The results are shown in Table 15. In the table, "none" indicates that no carbon dioxide gas was generated during the storage period (2 months).

As is clear from Table 15, in Examples 22 and 23, which contained 10% by mass or more of potato starch, no carbon dioxide gas was generated even after storage at 60°C for 2 months, confirming good storage stability. did it.

<Example 24>
Each component was blended and mixed in the proportions shown in Table 16 below to produce a powdered skin preparation for external use.
The numerical values in Table 16 are the mass proportions (mass %) in the skin external preparation.

The characteristics of the external skin preparations of the above Examples and Comparative Examples were evaluated according to the procedure of [Example 24] below.

[Evaluation of Example 24]
<Anti-wrinkle function evaluation>
Sixteen adult women with wrinkles around the corners of their eyes were selected as subjects. Mix a powdered external skin preparation sample and water at a ratio of 1:3 (mass ratio) in a container and apply the mixture, which is a foamy pack cosmetic, to the specified half of the face, centered on the outer corner of either the left or right eye. Coated. The mixture was removed 10 minutes after application and rinsed with water or lukewarm water. The subjects performed this once a day for 4 weeks. For evaluation of wrinkles, replicas of the wrinkles at the left and right corners of the eyes of the subjects (with and without application of the mixture) were taken, and image analysis was performed using the replicas. A replica was collected using a replica agent (SILFLO) in an area of 4 cm x 4 cm outward from the lateral canthus of the subject. Regarding the obtained replica, analysis was performed on an area of 10 mm x 10 mm, with a point approximately 5 mm away from the outer canthus of the face as a base point. The analysis was performed using a reflection replica analysis system (ASA-03RXD) and three-dimensional skin analysis software. Table 17 shows the results of the maximum wrinkle depth, which is the wrinkle evaluation result. If the amount of change is positive, it means that the wrinkles are deeper than before use, and if it is negative, it means that the wrinkles are shallower than before use.

From Table 17, it was confirmed that by using the skin external preparation of the present invention, the maximum depth of the crow's feet wrinkles was shallower than when it was not used. The above results show that the use of the foaming skin external preparation of the present invention is effective in making wrinkles less noticeable.

[Example of prescription for single-dose external skin preparation]
Below, further specific formulation examples of the one-dose external skin preparation of the present invention are shown.

<Example 25>
Each component was blended in the proportions listed in Table 18 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and when water was added in a mass ratio of 3 to 1 powder and stirred, a foamy pack cosmetic was obtained.

<Example 26>
Each component was blended in the proportions listed in Table 19 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, water was added in a mass ratio of 5 to 1 of the powder, and the mixture was stirred to obtain a foamy pack cosmetic.

<Example 27>
Each component was blended in the proportions listed in Table 20 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and water was added in a mass ratio of 10 parts to 1 part of the powder, and the mixture was stirred to obtain a foamy pack cosmetic.

<Example 28>
Each component was blended in the proportions listed in Table 21 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and when water was added in a mass ratio of 3 to 1 powder and stirred, a foamy pack cosmetic was obtained.

<Example 29>
Each component was blended in the proportions listed in Table 22 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and water was added in a mass ratio of 4 to 1 of the powder and stirred to obtain a foamy pack cosmetic.

<Example 30>
Each component was blended in the proportions listed in Table 23 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and when water was added in a mass ratio of 1 to 10 parts of the powder and stirred, a foamy pack cosmetic was obtained.

<Example 31>
Each component was blended in the proportions listed in Table 24 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and when water was added in a mass ratio of 4 to 1 powder and stirred, a foamy pack cosmetic was obtained.

<Example 32>
Each component was blended in the proportions listed in Table 25 to form a powdered one-dose external skin preparation. This one-dose external skin preparation powder was placed in a container, and water was added in a mass ratio of 4 to 1 of the powder and stirred to obtain a foamy pack cosmetic.

<Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2>
Each component listed in Table A below was blended and mixed according to the composition shown in the same table, and powdered external skin preparations of Examples 2-1 to 2-28 and Comparative Examples 2-1 and 2-2 were prepared. A powdered skin preparation for external use was produced. The numerical values in Table A below are the mass proportions (mass %) in the skin external preparation. Note that sodium carboxymethyl cellulose was used as the carboxymethyl cellulose listed in Table A below. Furthermore, as the acrylic acid/alkyl methacrylate copolymer listed in Table A below, (acrylates/alkyl acrylate (C10-30)) crosspolymer was used. In addition, "pattern" in Table A refers to the above (1) to (3) relating to the combination of two or more types of polysaccharides or their derivatives, or the combination of polysaccharides or their derivatives and inorganic or organic thickening compounds. Indicate which of the above (4) regarding the combination falls under. This classification is also listed in Table C below.

The characteristics of the external skin preparations of <Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2> with the formulations in Table A above are as follows. The evaluation was carried out in the same manner as the sensory evaluation in (1) of [Evaluation]. However, the questionnaire items were as shown in (1) to (19) in Table C below. The results are shown in Table C below. The evaluation criteria were the 7-level absolute evaluation shown in Table B below. In Table C, for "(4) Fineness of bubbles", the finer the bubbles, the higher the evaluation. Regarding "(10) Carbonated feeling (crackling feeling)", the higher the crackling feeling, the higher the evaluation. Regarding "(11) Sustainability of carbonated feeling (crackling feeling)", the longer the carbonated feeling lasted, the higher the rating. Regarding "(12) Skin tightening feeling", the higher the tightening feeling, the higher the evaluation.

In Table C, CMC stands for sodium carboxymethyl cellulose, tamarind stands for tamarind gum, HPMC stands for hydroxypropyl methyl cellulose, HEC stands for hydroxyethyl cellulose, and grafted starch stands for sodium acrylate grafted starch. It is an abbreviation for starch, acrylic acid is an abbreviation for acrylic acid/alkyl methacrylate copolymer, and PVP is an abbreviation for polyvinylpyrrolidone.

As is clear from the results in Table C, the skin external preparations of Examples 2-1 to 2-28, which fall under any of (1) to (4), employed a combination of conventional polysaccharides or derivatives thereof. Compared to the skin external preparations of Comparative Examples 2-1 and 2-2, the evaluation of ease of mixing, ease of dissolving, ease of removal, and brightness of the skin was the same or better, and the fineness of the bubbles and the uniformity of the skin were better. , ease of application, foam elasticity, foam retention, carbonated feel, sustainability of carbonated feeling, moist skin, skin elasticity, skin redness, skin smoothness, smooth skin, and skin tightening. It was also excellent. Therefore, it is clear that the skin external preparations of the present invention that fall under any of (1) to (4) have remarkable effects of "feeling good on use and improving the skin condition."

L* value, stratum corneum moisture content (μS), elasticity before and after use of the skin external preparations of <Examples 2-1 to 2-28, Comparative Examples 2-1 and 2-2> with the formulations in Table A above was measured in the same manner as described in "(2) Measurement of skin condition" in [Evaluation of Examples 1 to 10 and Comparative Examples 1 to 3] above. Regarding the obtained L* value, stratum corneum water content, and elasticity, the ratio of the measured value before and after use of the skin external preparation was determined and used as the rate of change. The results are shown in Figures 8-10. In addition, the amount of water evaporation (g/m ² /hr ) was measured in the same manner as described in "<Measurement of skin condition>" in [Evaluation of Examples 14 to 17] above. Regarding the obtained amount of water evaporation, the ratio of the measured value before use of the skin external preparation to the measured value after use was determined, and this was taken as the rate of change. The results are shown in FIG.

As is clear from the results in FIGS. 8 to 10, the rate of change in elasticity of the external skin preparations of Examples 2-1 to 2-28, which correspond to any of (1) to (4), was higher than that of Comparative Example 2-2. It was equivalent to or better than the skin external preparation, and was superior to Comparative Example 2-1. Furthermore, the L* value and the rate of change in the moisture content of the skin of Examples 2-1 to 2-28 were superior to those of Comparative Examples 2-1 and 2-2. Therefore, it is clear that the skin external preparation of the present invention that falls under any of (1) to (4) has a remarkable effect of "improving the skin condition."

Claims (2)

A one-dose foaming external skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
At least one polysaccharide or derivative thereof;
Contains at least one selected from dipotassium glycyrrhizinate, salicylic acid, arbutin and placenta,
A foaming skin external preparation that is mixed with water when the skin external preparation is used. A one-dose foaming external skin preparation comprising at least a solid acidic substance and a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, further comprising:
At least one polysaccharide or derivative thereof;
Contains at least one selected from salicylic acid and placenta,
A foaming skin external preparation that is mixed with a water-containing substance having a viscosity of 50,000 mPa·s or less when the skin external preparation is used.