JP5826514B2 - Effervescent composition - Google Patents
Effervescent composition Download PDFInfo
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- JP5826514B2 JP5826514B2 JP2011109197A JP2011109197A JP5826514B2 JP 5826514 B2 JP5826514 B2 JP 5826514B2 JP 2011109197 A JP2011109197 A JP 2011109197A JP 2011109197 A JP2011109197 A JP 2011109197A JP 5826514 B2 JP5826514 B2 JP 5826514B2
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- Prior art keywords
- foamable composition
- tablet
- component
- fragrance
- type
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- 239000000203 mixture Substances 0.000 title claims description 73
- 239000003205 fragrance Substances 0.000 claims description 57
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 16
- 229930195733 hydrocarbon Natural products 0.000 claims description 12
- 150000007524 organic acids Chemical class 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 11
- 239000005022 packaging material Substances 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 150000002430 hydrocarbons Chemical class 0.000 claims description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 8
- 229920003169 water-soluble polymer Polymers 0.000 claims description 7
- 239000004215 Carbon black (E152) Substances 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 239000002304 perfume Substances 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 238000005187 foaming Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 235000011837 pasties Nutrition 0.000 claims 1
- 125000004084 sesquiterpene group Chemical group 0.000 claims 1
- 125000002298 terpene group Chemical group 0.000 claims 1
- 238000003860 storage Methods 0.000 description 32
- -1 terpene hydrocarbons Chemical class 0.000 description 30
- 238000002156 mixing Methods 0.000 description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- 230000002265 prevention Effects 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 229910052782 aluminium Inorganic materials 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 239000004375 Dextrin Substances 0.000 description 7
- 229920001353 Dextrin Polymers 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 235000019425 dextrin Nutrition 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 241000283014 Dama Species 0.000 description 5
- 229920002907 Guar gum Polymers 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- JNSGIVNNHKGGRU-JYRVWZFOSA-N diethoxyphosphinothioyl (2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetate Chemical compound CCOP(=S)(OCC)OC(=O)C(=N/OC)\C1=CSC(N)=N1 JNSGIVNNHKGGRU-JYRVWZFOSA-N 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000000665 guar gum Substances 0.000 description 5
- 235000010417 guar gum Nutrition 0.000 description 5
- 229960002154 guar gum Drugs 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical group OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 239000001530 fumaric acid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 3
- 150000004354 sesquiterpene derivatives Chemical group 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 150000003505 terpenes Chemical group 0.000 description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000001341 hydroxy propyl starch Substances 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229940050526 hydroxyethylstarch Drugs 0.000 description 2
- 229920013818 hydroxypropyl guar gum Polymers 0.000 description 2
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229930004725 sesquiterpene Natural products 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000007586 terpenes Nutrition 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- ONAIRGOTKJCYEY-UHFFFAOYSA-N Sucrose monostearate Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(CO)O1 ONAIRGOTKJCYEY-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- AECIIQVDGKYLNI-VUAWYJOHSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O AECIIQVDGKYLNI-VUAWYJOHSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 229920001577 copolymer Chemical class 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、発泡性組成物に関する。 The present invention relates to a foamable composition.
従来より、水を加えて有機酸と炭酸塩とを反応させ、炭酸ガスを発生させることで香気を漂わせることのできる発泡性組成物が知られている。例えば、特許文献１には、（ａ）炭酸塩、（ｂ）有機酸及び（ｃ）多孔性軽質無水ケイ酸を含有する混合物を圧縮成形して得られる発泡性浴用錠剤が開示されており、香料を０．３０質量％配合した処方例が記載されている。ここには、（ｄ）無水硫酸塩や無水塩化ナトリウムを配合することで、保存安定性の向上を図ることも示されている。 2. Description of the Related Art Conventionally, foamable compositions are known in which aroma can be drifted by adding water to react an organic acid and a carbonate to generate carbon dioxide. For example, Patent Document 1 discloses an effervescent bath tablet obtained by compression molding a mixture containing (a) carbonate, (b) organic acid, and (c) porous light silicic acid anhydride. The formulation example which mix | blended the fragrance | flavor 0.30 mass% is described. Here, it is also shown that storage stability is improved by blending (d) anhydrous sulfate or anhydrous sodium chloride.
しかしながら、より香り立ちを高めるべく、発泡性組成物中の香料の含有量を増大させると、製造時に香料のダマが生じる可能性や、保存時や運搬時に炭酸ガスが発生するおそれがあり、保存安定性の点で問題が生じる可能性がある。 However, if the content of the fragrance in the foamable composition is increased in order to further enhance the fragrance, there is a possibility that fragrance lumps may be produced during production, and carbon dioxide gas may be generated during storage or transportation, which is preserved. Problems can arise in terms of stability.
従って、本発明の課題は、斯かる実情に鑑み、香料の含有量を増大させても良好な製造性と充分な保存安定性とを確保することのできる、良好に発泡可能な発泡性組成物を提供することにある。 Therefore, in view of such circumstances, the object of the present invention is to provide a foamable composition that can be foamed satisfactorily and can ensure good manufacturability and sufficient storage stability even when the content of the fragrance is increased. Is to provide.
本発明者らは上記課題を解決すべく種々検討した結果、特定量の香料、固めカサ密度１．０ｇ／ｍＬ未満の特定量の炭酸ナトリウム、及び有機酸を含有する発泡性組成物が、香料を多く含みながらも良好な製造性と充分な保存安定性とを示すことを見出し、本発明を完成させるに至った。 As a result of various studies to solve the above-mentioned problems, the present inventors have found that a foaming composition containing a specific amount of a fragrance, a specific amount of sodium carbonate having a hardened bulk density of less than 1.0 g / mL, and an organic acid is a fragrance. It has been found that it exhibits good manufacturability and sufficient storage stability while containing a large amount of.
すなわち、本発明は、次の成分（Ａ）〜（Ｃ）:
（Ａ）香料 １．２〜５．０質量％、
（Ｂ）固めカサ密度１．０ｇ／ｍＬ未満の炭酸ナトリウム １５〜７０質量％、
（Ｃ）有機酸
を含有する発泡性組成物である。
That is, the present invention includes the following components (A) to (C):
(A) Fragrance 1.2-5.0% by mass,
(B) 15 to 70% by mass of sodium carbonate having a hard bulk density of less than 1.0 g / mL,
(C) A foamable composition containing an organic acid.
本発明の発泡性組成物によれば、充分な量の香料を含有し、高い香り立ちでありながら優れた保存安定性を発揮することができる。さらに、発泡性組成物製造時での混合によって香料のダマが生じることを有効に防止することができる。 According to the foamable composition of the present invention, it contains a sufficient amount of a fragrance and can exhibit excellent storage stability while having a high fragrance. Furthermore, it is possible to effectively prevent the fragrance from becoming lumpy due to mixing during the production of the foamable composition.
以下、本発明について詳細に説明する。
本発明の発泡性組成物に用いられる成分（Ａ）の香料は、発泡性組成物全量中に１．２〜５．０質量％、好ましくは１．５〜４．５質量％、より好ましくは２．２〜４．０質量％含有される。通常、炭酸塩及び有機酸を含有する発泡性組成物において、香料を上記数値範囲のように高含有量とすると、高い香り立ちは得られるものの、製造時に香料のダマが生じる可能性や、保存安定性が低下するおそれが高くなる。しかしながら、本発明では、後述する成分（Ｂ）及び成分（Ｃ）を含有することによって、充分な量の香料を含有し、高い香り立ちが得られつつも発泡性組成物の保存安定性の向上を図ることができる。さらに、発泡性組成物製造時での混合によって香料のダマが生じることを防止することができる。
Hereinafter, the present invention will be described in detail.
The fragrance | flavor of the component (A) used for the foamable composition of this invention is 1.2-5.0 mass% in a foamable composition whole quantity, Preferably it is 1.5-4.5 mass%, More preferably It is contained in an amount of 2.2 to 4.0% by mass. Usually, in a foamable composition containing a carbonate and an organic acid, if the fragrance has a high content as in the above numerical range, a high fragrance can be obtained, but there is a possibility that the fragrance will be lumped during production and storage. There is a high risk that the stability will decrease. However, in the present invention, by containing the component (B) and the component (C) described later, a sufficient amount of the fragrance is contained, and the storage stability of the foamable composition is improved while a high fragrance is obtained. Can be achieved. Furthermore, it is possible to prevent the fragrance from becoming lumpy due to mixing during the production of the foamable composition.
香料としては、所望の香気を漂わせるべく適宜選択することができる。具体的には、例えば、テルペン系炭化水素類、セスキテルペン系炭化水素類、アルコール類、エーテル類、アルデヒド類、ケトン類、オキサイド類、エステル類、ラクトン類、合成ムスク、含窒素・硫黄化合物が挙げられる。上記香料は１種単独で用いてもよく、２種以上組み合わせて用いてもよい。 As a fragrance | flavor, it can select suitably in order to make a desired fragrance drift. Specifically, for example, terpene hydrocarbons, sesquiterpene hydrocarbons, alcohols, ethers, aldehydes, ketones, oxides, esters, lactones, synthetic musks, nitrogen-containing / sulfur compounds Can be mentioned. The said fragrance | flavor may be used individually by 1 type, and may be used in combination of 2 or more type.
なかでも、テルペン系炭化水素類やセスキテルペン系炭化水素類、すなわち、テルペン骨格を有する炭化水素及びセスキテルペン骨格を有する炭化水素は、発泡性組成物の保存安定性を高める役割を有する。香料中にテルペン骨格を有する炭化水素及び／又はセスキテルペン骨格を有する炭化水素を含有させることによって、充分な量の香料を含有しつつも、保存安定性を担保することができる。従って、香料中のテルペン骨格を有する炭化水素及びセスキテルペン骨格を有する炭化水素の合計含有量は、充分な量の香料を含有しながら、優れた保存安定性を発揮する点や、香りの質と強さを保持する観点から、１〜５０質量％が好ましく、３〜４０質量％がより好ましく、３〜３５質量％がさらに好ましい。 Among these, terpene hydrocarbons and sesquiterpene hydrocarbons, that is, hydrocarbons having a terpene skeleton and hydrocarbons having a sesquiterpene skeleton have a role of enhancing the storage stability of the foamable composition. By containing a hydrocarbon having a terpene skeleton and / or a hydrocarbon having a sesquiterpene skeleton in the fragrance, storage stability can be ensured while containing a sufficient amount of the fragrance. Therefore, the total content of the hydrocarbon having a terpene skeleton and the hydrocarbon having a sesquiterpene skeleton in the fragrance is a point that exhibits excellent storage stability while containing a sufficient amount of fragrance, From the viewpoint of maintaining strength, 1 to 50% by mass is preferable, 3 to 40% by mass is more preferable, and 3 to 35% by mass is more preferable.
本発明の発泡性組成物に用いられる成分（Ｂ）の炭酸ナトリウムは、固めカサ密度が１．０ｇ／ｍＬ未満のものであり、後述する成分（Ｃ）と反応して炭酸ガスを発生して、成分（Ａ）の香料の揮散を促進する一方で、成分（Ａ）の香料を良好に保持する作用をも有し、発泡性組成物の保存安定性を高めたり、発泡性組成物製造時での混合による香料のダマ発生を防止したりするのに大きく寄与する。上記固めカサ密度は、より効果的に保存安定性を高める観点から、好ましくは０．４〜０．９ｇ／ｍＬであり、より好ましくは０．５〜０．８ｇ／ｍＬである。なお、固めカサ密度とは、タッピングを加えて密充填にした場合の嵩密度であり、その測定法としてはCarrの流動性指数測定の固めカサ密度の測定方法を用いるのが好ましい。具体的には、容積１００ｍＬの容器に目開き２ｍｍの篩を通して試料を充填した後、容器上部の試料をすり切り、更に該容積１００ｍＬの容器に専用のキャップ（上部容器）を装着して余分に試料を追加充填し、落下高さ１８ｍｍで１８０回タッピングを行った後、該キャップ（上部容器）を外して、該容積１００ｍＬの容器上部の試料をすり切り、重量を測定して固めカサ密度を求める。 The component (B) sodium carbonate used in the foamable composition of the present invention has a solid bulk density of less than 1.0 g / mL and reacts with the component (C) described below to generate carbon dioxide. While promoting the volatilization of the fragrance of component (A), it also has the effect of favorably holding the fragrance of component (A), increasing the storage stability of the foamable composition, or at the time of producing the foamable composition This greatly contributes to preventing the generation of fragrances caused by mixing in the scent. From the viewpoint of enhancing storage stability more effectively, the above-mentioned solid density is preferably 0.4 to 0.9 g / mL, more preferably 0.5 to 0.8 g / mL. The solid bulk density is a bulk density in the case of close packing by adding tapping, and as the measurement method, it is preferable to use the measurement method of the solid bulk density of Carr's fluidity index measurement. Specifically, after a sample is filled into a 100 mL volume container through a sieve having an opening of 2 mm, the sample at the top of the container is ground, and a special cap (upper container) is further attached to the 100 mL volume container. Then, after tapping 180 times at a drop height of 18 mm, the cap (upper container) is removed, the sample in the upper part of the container with a volume of 100 mL is ground, the weight is measured, and the bulk density is obtained.
本発明の発泡性組成物は、成分（Ｂ）の炭酸ナトリウムを発泡性組成物全量中に、１５〜７０質量％含有する。適度な炭酸ガス発生量を確保する観点のみならず、発泡性組成物の保存安定性、混合時の香料のダマ発生防止及び高い香り立ちの観点から、好ましくは１７〜４０質量％、より好ましくは２０〜３０質量％含有する。 The foamable composition of this invention contains 15-70 mass% of sodium carbonate of a component (B) in the foamable composition whole quantity. From the viewpoint of ensuring an appropriate amount of carbon dioxide gas generation, as well as from the viewpoint of storage stability of the foamable composition, prevention of fragrance generation during mixing, and high aroma formation, it is preferably 17 to 40% by mass, more preferably 20-30 mass% is contained.
特に、高い香り立ちを維持しつつ発泡性組成物の保存安定性を高める点や、発泡性組成物製造時での混合による香料のダマ発生を防止する点から、本発明の発泡性組成物中における成分（Ａ）に対する成分（Ｂ）の質量比（Ｂ／Ａ）は、４．５〜４０であるのが好ましく、５．５〜３０であるのがより好ましく、６．５〜２０であるのがさらに好ましい。 In particular, in the foamable composition of the present invention from the viewpoint of enhancing the storage stability of the foamable composition while maintaining a high fragrance, and the prevention of perfume generation due to mixing during the production of the foamable composition. The mass ratio (B / A) of the component (B) to the component (A) is preferably 4.5-40, more preferably 5.5-30, and 6.5-20. Is more preferable.
本発明の発泡性組成物は、成分（Ｃ）の有機酸を含有する。成分（Ｃ）は上記成分（Ｂ）と反応して、炭酸ガスを発生する作用をもたらす。有機酸としては、フマル酸、リンゴ酸、酒石酸、クエン酸、マレイン酸、コハク酸、フタル酸、グルタル酸、アジピン酸、安息香酸、サリチル酸、シュウ酸等の室温（２５℃）で固体のものが挙げられる。これらを１種単独で用いてもよく、２種以上組み合せて用いてもよい。なかでも、高い香り立ち、発泡性組成物の保存安定性及び混合時の香料のダマ発生防止の点から、溶解度が１ｇ／１００ｇ（６０℃・水）以上、すなわち６０℃における１００ｇの水溶液中に有機酸を１ｇ以上含有し、且つ１０ｇ／１００ｇ以下（２０℃・水）、すなわち２０℃における１００ｇの水溶液中に１０ｇ以下の有機酸を含有すると好ましい。具体的には、フマル酸、コハク酸、アジピン酸、シュウ酸が好ましく、なかでもフマル酸が好ましい。 The foamable composition of this invention contains the organic acid of a component (C). The component (C) reacts with the component (B) to generate carbon dioxide gas. Organic acids such as fumaric acid, malic acid, tartaric acid, citric acid, maleic acid, succinic acid, phthalic acid, glutaric acid, adipic acid, benzoic acid, salicylic acid, oxalic acid and the like that are solid at room temperature (25 ° C.) Can be mentioned. These may be used alone or in combination of two or more. Among them, from the viewpoint of high fragrance, storage stability of the foamable composition and prevention of fragrance generation during mixing, the solubility is 1 g / 100 g (60 ° C./water) or more, that is, in a 100 g aqueous solution at 60 ° C. It is preferable to contain 1 g or more of organic acid and 10 g / 100 g or less (20 ° C./water), that is, 10 g or less of organic acid in 100 g of aqueous solution at 20 ° C. Specifically, fumaric acid, succinic acid, adipic acid and oxalic acid are preferable, and fumaric acid is particularly preferable.
成分（Ｃ）の有機酸の含有量は、適度な炭酸ガス発生量を確保する点のみならず、発泡性組成物の保存安定性、混合時の香料のダマ発生防止及び高い香り立ちの点から、発泡性組成物全量中、２０〜６０質量％が好ましく、３０〜５５質量％がより好ましい。 The content of the organic acid of the component (C) is not only from the point of securing an appropriate amount of carbon dioxide gas generation, but also from the viewpoint of storage stability of the foamable composition, prevention of fragrance generation during mixing, and high aroma. In the total amount of the foamable composition, 20 to 60% by mass is preferable, and 30 to 55% by mass is more preferable.
本発明の発泡性組成物は、上記成分（Ｂ）のほか、その他の炭酸塩、すなわち固めカサ密度が１．０ｇ／ｍＬ以上の炭酸ナトリウム、炭酸カリウム等の炭酸ナトリウム以外の炭酸ジアルカリ金属塩；炭酸水素塩である炭酸水素ナトリウム；二価以上の金属の炭酸塩である炭酸カルシウム等を含有してもよい。これらは１種単独で用いてもよく、２種以上組み合わせて用いてもよい。この場合、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止や、高い香り立ちの点から、本発明の発泡性組成物中の炭酸塩全量に対する成分（Ｂ）の質量比（Ｂ／炭酸塩全量）が、０．３５〜１．０であるのが好ましく、０．４０〜０．７５であるのがより好ましく、０．４５〜０．６５であるのがさらに好ましい。なお、本明細書において「炭酸塩」とは、上述のように、成分（Ｂ）を含む炭酸ジアルカリ金属塩、炭酸水素塩等をも含む意味である。 In addition to the above component (B), the foamable composition of the present invention includes other carbonates, that is, dialkali metal carbonates other than sodium carbonate such as sodium carbonate and potassium carbonate having a solid bulk density of 1.0 g / mL or more; Sodium hydrogen carbonate that is a hydrogen carbonate; calcium carbonate that is a carbonate of a metal having a valence of 2 or more may be contained. These may be used alone or in combination of two or more. In this case, the mass ratio of the component (B) to the total amount of carbonate in the foamable composition of the present invention from the viewpoint of storage stability of the foamable composition, prevention of fragrance generation during mixing, and high fragrance standing (B / carbonate total amount) is preferably 0.35 to 1.0, more preferably 0.40 to 0.75, and still more preferably 0.45 to 0.65. In the present specification, the term “carbonate” means, as described above, also including a dialkali metal carbonate, a hydrogen carbonate and the like containing the component (B).
なかでも、発泡性組成物を錠剤とする場合には、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止及び高い香り立ちの効果を維持しつつ、打錠性を向上させる観点から、炭酸水素塩、具体的には炭酸水素ナトリウムを含有するのが好ましい。従って、炭酸水素ナトリウムの含有量は、発泡性組成物全量中に、好ましくは５〜３５質量％であり、より好ましくは１０〜３０質量％であり、さらに好ましくは１５〜２５質量％である。 In particular, when the foamable composition is used as a tablet, the tableting property is improved while maintaining the storage stability of the foamable composition, the prevention of fragrance generation during mixing, and the effect of high fragrance. From the viewpoint, it is preferable to contain a bicarbonate, specifically, sodium bicarbonate. Therefore, the content of sodium hydrogen carbonate is preferably 5 to 35% by mass, more preferably 10 to 30% by mass, and further preferably 15 to 25% by mass in the total amount of the foamable composition.
なお、固めカサ密度が１．０ｇ／ｍＬ以上の炭酸ナトリウムは、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止及び高い香り立ちの観点から、本発明の発泡性組成物全量中に、好ましくは７質量％以下、より好ましくは３質量％以下含有するのがよく、含有しないのが最も好ましい。 In addition, the solid carbonate density of 1.0 g / mL or more of sodium carbonate is the foamable composition of the present invention from the viewpoints of storage stability of the foamable composition, prevention of fragrance generation during mixing, and high fragrance. The total amount is preferably 7% by mass or less, more preferably 3% by mass or less, and most preferably not contained.
本発明の発泡性組成物は、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止及び高い香り立ちの効果を維持しつつ、打錠性や溶解性を向上させる点から、さらに成分（Ｄ）の水溶性高分子を含有するのが好ましい。成分（Ｄ）の水溶性高分子としては、充分な量の香料を含有しながら、優れた保存安定性を発揮し、さらに発泡性組成物製造時での混合によって香料のダマが生じることを防止する点で、数平均分子量１０００以上の水溶性高分子が好ましい。なかでも、本発明で用いる水溶性高分子としては、常温（２５℃）で固体又はペースト状のものが好ましい。ここでペースト状とは、半固形状の物質である。具体的には、数平均分子量１０００〜２００００のポリエチレングリコール、デキストリン、炭素数１０〜４０の直鎖又は分岐のアルキル基を有するアルキルグリセリルエーテル及び／又はヒドロキシル基が置換していてもよい炭素数１〜５のスルホアルキルで修飾された多糖類、アクリル酸メタクリル酸アルキル共重合体、及びメチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、エチルヒドロキシエチルセルロース等の水溶性非イオン性セルロースエーテル、カチオン化セルロース、カルボキシメチルセルロース、カチオン化ヒドロキシエチルセルロース等のイオン性セルロース、グアーガム、ヒドロキシエチルグアーガム、メチルグアーガム、エチルグアーガム、ヒドロキシプロピルグアーガム、ヒドロキシエチルメチルグアーガム、ヒドロキシプロピルメチルグアーガム、スターチ、ヒドロキシエチルスターチ、メチルスターチ、エチルスターチ、ヒドロキシプロピルスターチ、ヒドロキシエチルメチルスターチ及びヒドロキシプロピルメチルスターチが挙げられる。これらは、単独で用いてもよく、２種以上組み合せて用いてもよい。このうち、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止及び高い香り立ちの点で、デキストリン又はポリエチレングリコールが好ましい。ポリエチレングリコールのなかでも、数平均分子量１０００〜２００００のポリエチレングリコールが好ましく、２０００〜１３０００のポリエチレングリコールがより好ましく、４０００〜９０００のポリエチレングリコールがさらに好ましい。また、デキストリンのなかでも、数平均分子量１５００〜１００００のデキストリンが好ましく、２０００〜８０００のデキストリンがより好ましく、２５００〜６０００のデキストリンがさらに好ましい。なお、ポリエチレングリコールやデキストリンの数平均分子量を測定する場合には、溶媒として水／エタノールを用い、ポリスチレンを標準としたＧＰＣ法を用いる。 The foamable composition of the present invention, while maintaining the storage stability of the foamable composition, the effect of preventing the occurrence of fragrance perfume during mixing and the effect of high fragrance, while improving tabletability and solubility, Furthermore, it is preferable to contain the water-soluble polymer of component (D). As the water-soluble polymer of component (D), it exhibits excellent storage stability while containing a sufficient amount of fragrance, and prevents the fragrance from becoming lumpy due to mixing during the production of the foamable composition. Therefore, a water-soluble polymer having a number average molecular weight of 1000 or more is preferable. Especially, as water-soluble polymer used by this invention, a solid or paste-like thing is preferable at normal temperature (25 degreeC). Here, the paste form is a semi-solid substance. Specifically, polyethylene glycol having a number average molecular weight of 1,000 to 20,000, dextrin, alkyl glyceryl ether having a linear or branched alkyl group having 10 to 40 carbon atoms, and / or a hydroxyl group which may be substituted with 1 carbon atom. 5 to 5 sulfoalkyl-modified polysaccharides, alkyl methacrylate copolymers, and water-soluble nonionic cellulose ethers such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, Ionic cellulose such as cationized cellulose, carboxymethylcellulose, cationized hydroxyethylcellulose, guar gum, hydroxyethyl guar gum, methyl guar gum, Chill guar gum, hydroxypropyl guar gum, hydroxyethyl guar gum, hydroxypropyl guar gum, starch, hydroxyethyl starch, methyl starch, ethyl starch, hydroxypropyl starch, and hydroxyethyl starch and hydroxypropyl starch. These may be used alone or in combination of two or more. Among these, dextrin or polyethylene glycol is preferable in terms of storage stability of the foamable composition, prevention of fragrance generation during mixing, and high smell. Among polyethylene glycols, polyethylene glycol having a number average molecular weight of 1000 to 20000 is preferable, polyethylene glycol having 2000 to 13000 is more preferable, and polyethylene glycol having 4000 to 9000 is more preferable. Among dextrins, dextrins having a number average molecular weight of 1500 to 10000 are preferable, dextrins having 2000 to 8000 are more preferable, and dextrins having 2500 to 6000 are more preferable. When measuring the number average molecular weight of polyethylene glycol or dextrin, GPC method using water / ethanol as a solvent and polystyrene as a standard is used.
成分（Ｄ）の水溶性高分子の含有量は、打錠性のみならず、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止及び高い香り立ちの点から、発泡性組成物全量中、１〜３０質量％が好ましく、２〜２０質量％がより好ましく、３〜１４質量％がさらに好ましい。 The content of the water-soluble polymer of component (D) is not only tabletable, but also has a foamable composition from the viewpoint of storage stability of foamable composition, prevention of fragrance generation during mixing, and high fragrance. 1-30 mass% is preferable in the whole thing, 2-20 mass% is more preferable, and 3-14 mass% is further more preferable.
本発明の発泡性組成物中における成分（Ｄ）に対する成分（Ａ）の質量比（Ａ／Ｄ）は、高い香り立ちのみならず、発泡性組成物の保存安定性や、混合時の香料のダマ発生防止の点から、好ましくは０．０５〜０．５であり、より好ましくは０．１〜０．４である。 The mass ratio (A / D) of the component (A) to the component (D) in the foamable composition of the present invention is not only high in fragrance, but also the storage stability of the foamable composition and the perfume during mixing. From the standpoint of preventing lumps, it is preferably 0.05 to 0.5, and more preferably 0.1 to 0.4.
本発明の発泡性組成物には、上記成分以外に、水中での香料成分の溶解性等の点から、非イオン界面活性剤を含有してもよい。非イオン界面活性剤としては、例えば、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビトール脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルケニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルケニルエーテル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシプロピレンアルキルエーテル等が挙げられる。これらは１種単独で用いてもよいが、２種以上組み合わせて用いることにより、上記効果をさらに向上させることができるため好ましい。なかでも、本発明の発泡性組成物が前述の効果を発揮する点で、ショ糖脂肪酸エステルが好ましく、ＨＬＢ１０〜１６のものがより好ましい。具体的には、ショ糖ベヘニン酸エステル、ショ糖ステアリン酸エステル、ショ糖パルミチン酸エステル、ショ糖ミリスチン酸エステル、ショ糖ラウリン酸エステル、ショ糖オレイン酸エステル等が挙げられる。 In addition to the above components, the foamable composition of the present invention may contain a nonionic surfactant from the viewpoint of the solubility of the fragrance component in water. Examples of the nonionic surfactant include sucrose fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, Polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkenyl ether, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, sorbitan Examples include fatty acid esters and polyoxypropylene alkyl ethers. These may be used singly or in combination of two or more, since the above effects can be further improved. Among these, sucrose fatty acid esters are preferable and those having HLB of 10 to 16 are more preferable in that the foamable composition of the present invention exhibits the above-described effects. Specific examples include sucrose behenic acid ester, sucrose stearic acid ester, sucrose palmitic acid ester, sucrose myristic acid ester, sucrose lauric acid ester, and sucrose oleic acid ester.
これらの非イオン界面活性剤の含有量は、発泡性組成物の保存安定性や混合時の香料のダマ発生防止及び高い香り立ちの観点から、発泡性組成物全量中、好ましくは０．００１〜０．１質量％であり、より好ましくは０．００５〜０．０５質量％である。 The content of these nonionic surfactants is preferably 0.001 to the total amount of the foamable composition from the viewpoints of storage stability of the foamable composition and prevention of perfume generation and high fragrance during mixing. It is 0.1 mass%, More preferably, it is 0.005-0.05 mass%.
さらに、本発明で用いる発泡性組成物には、本発明の効果を阻害しない範囲内で、上記以外の成分を適宜配合することができる。このような成分としては、酸化マグネシウム、ケイ酸カルシウム、メタリン酸ナトリウム、塩化ナトリウム、塩化カルシウム、塩化マグネシウム等の無機塩類のほか、油性成分、賦形剤、消泡剤、酸化防止剤、防菌・防黴剤、色素、生薬類等が挙げられる。 Furthermore, in the foamable composition used in the present invention, components other than those described above can be appropriately blended within a range that does not impair the effects of the present invention. Such components include magnesium oxide, calcium silicate, sodium metaphosphate, sodium chloride, calcium chloride, magnesium chloride and other inorganic salts, as well as oil components, excipients, antifoaming agents, antioxidants, antibacterial agents -Antifungal agents, pigments, herbal medicines and the like.
本発明の発泡性組成物は、必要に応じて押出造粒機や転動造粒機による造粒手段を用いながら、各成分を適宜混合して粒状や顆粒状の形態としてもよく、また打錠等の圧縮成形法により錠剤等の形態としてもよい。なかでも、香料を安定に保持して保存安定性を確保した上で高い香り立ちが得られる観点から、錠剤等の形態とするのが好ましい。錠剤の形態とした場合、打錠性も向上するため、特に好ましい。 The foamable composition of the present invention may be formed into a granular or granular form by appropriately mixing each component while using a granulating means using an extrusion granulator or a rolling granulator as necessary. It is good also as forms, such as a tablet, by compression molding methods, such as a tablet. Especially, it is preferable to set it as the form of a tablet etc. from a viewpoint from which a fragrance | flavor is hold | maintained stably and a high fragrance is obtained after ensuring storage stability. In the case of a tablet form, tableting properties are also improved, which is particularly preferable.
本発明の発泡性組成物は、適宜、袋状包材に包装されて保存される。この場合、本発明に用いる袋状包材の材質の水蒸気透過度は、４０℃、９０％ＲＨの条件下で０．６ｇ／ｍ2・ｄａｙ以下、好ましくは０．３ｇ／ｍ2・ｄａｙ以下であり、さらに実質的に水蒸気を透過しないものが最も好ましい。このような水蒸気透過度を示す袋状包材の材質としては、アルミ積層フィルムなどが挙げられ、ガラス蒸着処理したＰＥＴ（ポリエチレンテレフタレート）フィルム等の透明性を有したものも好ましい袋状包材の材質として挙げられる。 The foamable composition of the present invention is appropriately packaged and stored in a bag-shaped packaging material. In this case, the water vapor permeability of the material of the bag-like packaging material used in the present invention is 0.6 g / m 2 · day or less, preferably 0.3 g / m 2 · day or less under the conditions of 40 ° C. and 90% RH. And most preferably those that do not substantially transmit water vapor. Examples of the material of the bag-like packaging material exhibiting such water vapor permeability include aluminum laminated films, and those having transparency such as a PET (polyethylene terephthalate) film subjected to glass deposition treatment are also preferred bag-like packaging materials. Listed as a material.
本発明の発泡性組成物の容積に対する発泡性組成物を包装する袋状包材の内容積の比（袋状包材の内容積／発泡性組成物の容積）は、好ましくは１．２〜５であり、より好ましくは１．５〜４である。この場合、より香り立ちを高めるべく、発泡性組成物中の香料の含有量を単純に増大させると、保存時や運搬時に包材が膨らんで破損する可能性が高まる。しかしながら、本発明の発泡性組成物であれば、上述のとおり優れた保存安定性を奏するため、袋状包材内に格納して保存した場合にも炭酸ガスの発生を充分に抑制して、包材の破損を有効に防止することができる。 The ratio of the internal volume of the bag-shaped packaging material for packaging the foamable composition to the volume of the foamable composition of the present invention (the internal volume of the bag-shaped packaging material / the volume of the foamable composition) is preferably 1.2 to 5, more preferably 1.5-4. In this case, if the content of the fragrance in the foamable composition is simply increased in order to further increase the fragrance, the possibility that the packaging material swells and is damaged during storage or transportation increases. However, if it is a foamable composition of the present invention, it exhibits excellent storage stability as described above, and even when stored and stored in a bag-like packaging material, the generation of carbon dioxide gas is sufficiently suppressed, Damage to the packaging material can be effectively prevented.
以下、本発明について、実施例に基づき具体的に説明するが、本発明はこれら実施例に限定されるものではない。 EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.
[実施例１〜６、比較例１〜２]
表１に示す処方に従って錠剤（重量２０ｇ）を作製し、下記基準に従って香りの強さ、保存安定性及び打錠性の評価を行った。結果を表１に示す。
[Examples 1-6, Comparative Examples 1-2]
Tablets (20 g in weight) were prepared according to the formulation shown in Table 1, and the fragrance strength, storage stability, and tabletability were evaluated according to the following criteria. The results are shown in Table 1.
《保存安定性》
得られた錠剤１０錠を各々袋状のアルミピロー（４０℃、９０％ＲＨの条件下で０ｇ／ｍ2・ｄａｙ）内に密封し（アルミピローの内容積／発泡性組成物の容積＝２）、４０℃で１カ月間保存した後、アルミピローの膨れの有無を目視により確認し、以下の評価基準に従って評価した。
４：アルミピローの外観にまったく変化を認めない
３：アルミピローの外観にごくわずかに膨れを認める
２：アルミピローにやや膨れを認める
１：アルミピローに膨れを認める
<Storage stability>
Each of the obtained 10 tablets was sealed in a bag-shaped aluminum pillow (0 g / m 2 · day under the conditions of 40 ° C. and 90% RH) (inner volume of aluminum pillow / volume of foamable composition = 2). ) After storage at 40 ° C. for one month, the presence or absence of swelling of the aluminum pillow was visually confirmed and evaluated according to the following evaluation criteria.
4: No change in the appearance of the aluminum pillow. 3: A slight bulge in the appearance of the aluminum pillow. 2: A slight bulge in the aluminum pillow. 1: A bulge in the aluminum pillow.
《香りの強さ》
得られた錠剤（重量２０ｇ）を４０℃、２００ミリリットルの湯に溶かし、全量が溶解した直後の香り立ちについて、３名の専門パネラーが以下の評価基準に従って評価した。評価は協議により決定した。
１：無臭
２：ほとんど香らない
３：弱く香る
４：ちょうど良く香る
５：はっきり香る
<Strength of fragrance>
The obtained tablet (20 g in weight) was dissolved in 200 ml of hot water at 40 ° C., and three specialized panelists evaluated the fragrance immediately after the entire amount was dissolved according to the following evaluation criteria. Evaluation was determined by consultation.
1: Odorless 2: Almost unscented 3: Scented weakly 4: Scented well 5: Scented clearly
《打錠性》
ロータリー式打錠機を用い、重量２０ｇの錠剤を１００錠打錠した後のスティッキング及び混合時のダマを以下の評価基準に従って評価した。評価は協議により決定した。
５：スティッキング・ダマ全く問題なし
４：スティッキング・ダマ問題なし
３：スティッキング・ダマ許容範囲
２：スティッキング・ダマ有り
１：スティッキング・ダマ著しい
<Tabletability>
Using a rotary tableting machine, stickiness after tableting of 100 tablets having a weight of 20 g was evaluated according to the following evaluation criteria. Evaluation was determined by consultation.
5: No problem with sticking / dama 4: No problem with sticking / dama 3: Tolerable range for sticking / dama 2: With sticking / dama 1: Remarkable sticking / dama
表１によれば、実施例１〜６は、比較例１〜２に比べ、保存安定性に優れるとともに良好な打錠性をも有することがわかる。 According to Table 1, it turns out that Examples 1-6 are excellent in storage stability compared with Comparative Examples 1-2, and also have favorable tableting property.
Claims (10)
（Ａ）香料 １．５〜５．０質量％、
（Ｂ）固めカサ密度１．０ｇ／ｍＬ未満の炭酸ナトリウム １５〜７０質量％、
（Ｃ）有機酸
（Ｄ）水溶性高分子 ２〜２０質量％
を含有する錠剤型発泡性組成物。 Next components (A) to (D) :
(A) perfume 1.5-5.0% by weight,
(B) 15 to 70% by mass of sodium carbonate having a hard bulk density of less than 1.0 g / mL,
(C) Organic acid
(D) Water-soluble polymer 2 to 20% by mass
A tablet-type effervescent composition.
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