JP5894790B2 - Solid bath agent - Google Patents
Solid bath agent Download PDFInfo
- Publication number
- JP5894790B2 JP5894790B2 JP2011288496A JP2011288496A JP5894790B2 JP 5894790 B2 JP5894790 B2 JP 5894790B2 JP 2011288496 A JP2011288496 A JP 2011288496A JP 2011288496 A JP2011288496 A JP 2011288496A JP 5894790 B2 JP5894790 B2 JP 5894790B2
- Authority
- JP
- Japan
- Prior art keywords
- component
- bath
- solid
- oil
- cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013041 solid bath agent Substances 0.000 title claims description 30
- 239000001913 cellulose Substances 0.000 claims description 28
- 229920002678 cellulose Polymers 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 24
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 22
- 238000006266 etherification reaction Methods 0.000 claims description 21
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 20
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 19
- 239000007787 solid Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000002202 Polyethylene glycol Substances 0.000 claims description 15
- 229920001223 polyethylene glycol Polymers 0.000 claims description 15
- 239000003788 bath preparation Substances 0.000 claims description 12
- 235000010980 cellulose Nutrition 0.000 description 24
- -1 isostearic acid Fatty acid esters Chemical class 0.000 description 24
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 239000003205 fragrance Substances 0.000 description 12
- 239000008187 granular material Substances 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 229920003169 water-soluble polymer Polymers 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000013040 bath agent Substances 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N iso-octadecanoic acid Natural products CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 3
- 229920003124 powdered cellulose Polymers 0.000 description 3
- 235000019814 powdered cellulose Nutrition 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 239000003245 coal Substances 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 description 2
- MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- ZAZKJZBWRNNLDS-UHFFFAOYSA-N methyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC ZAZKJZBWRNNLDS-UHFFFAOYSA-N 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000010666 rose oil Substances 0.000 description 2
- 235000019719 rose oil Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BODMYPYTCKYRSP-UHFFFAOYSA-N 1,1-dioctylcyclohexane Chemical compound CCCCCCCCC1(CCCCCCCC)CCCCC1 BODMYPYTCKYRSP-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 description 1
- LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
- YICVJSOYNBZJAK-UHFFFAOYSA-N 14-methylpentadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C YICVJSOYNBZJAK-UHFFFAOYSA-N 0.000 description 1
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- SAMYFBLRCRWESN-UHFFFAOYSA-N 16-methylheptadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C SAMYFBLRCRWESN-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- FVKRIDSRWFEQME-UHFFFAOYSA-N 3-methylbutyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCC(C)C FVKRIDSRWFEQME-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- NDKYEUQMPZIGFN-UHFFFAOYSA-N Butyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCC NDKYEUQMPZIGFN-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 239000001293 FEMA 3089 Substances 0.000 description 1
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- 235000019501 Lemon oil Nutrition 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
本発明は、固形浴用剤に関する。 The present invention relates to a solid bath agent.
従来より、香料や界面活性剤等の液状浴用成分を含有させた固形浴用剤が知られており、浴水中で浴用剤が溶解する際に液状浴用成分も浴水中へ拡散して、種々の作用をもたらす。こうした固形浴用剤のなかには、ポリエチレングリコールを用いているものがある。例えば、特許文献1には、多量のポリエチレングリコール中に、溶解分散助剤と共に薬用植物抽出物が溶解又は分散していることを特徴とする入浴剤組成物が開示されている。 Conventionally, a solid bath agent containing a liquid bath component such as a fragrance or a surfactant has been known, and when the bath agent dissolves in the bath water, the liquid bath component diffuses into the bath water and has various functions. Bring. Some of these solid bath agents use polyethylene glycol. For example, Patent Document 1 discloses a bath composition containing a medicinal plant extract dissolved or dispersed in a large amount of polyethylene glycol together with a dissolution and dispersion aid.
一方、セルロースを軽度にカルボキシメチル化したカルボキシメチルセルロース又はその塩は、人体に無害である上、吸水性や保湿性等にも優れる成分であり、食品や医薬等、種々の分野での利用が期待されるものである(特許文献2参照)。例えば、特許文献3には、グルコース単位当たりのカルボキシメチル基の置換度が、0.1〜1.0のカルボキシメチルセルロース又はその塩をシートの基材として用い、かかるシートで包装された入浴剤が開示されている。 On the other hand, carboxymethylcellulose or a salt thereof obtained by lightly carboxymethylating cellulose is a component that is harmless to the human body and excellent in water absorption and moisture retention, and is expected to be used in various fields such as food and medicine. (See Patent Document 2). For example, Patent Document 3 discloses a bath agent packaged in such a sheet using carboxymethyl cellulose or a salt thereof having a substitution degree of carboxymethyl group per glucose unit of 0.1 to 1.0 as a base material of the sheet. It is disclosed.
しかしながら、一般的に、充分な量の液状浴用成分を固形物のなかに封じ込めた上で更に良好な硬度を保持するには、多量のポリエチレングリコールが必要となってしまう。ところが、このようにポリエチレングリコールを多量に含有すると、固形浴用剤の溶解性が悪化する傾向にあるため、良好な硬度を保持しながら溶解性の向上をも図るには、更なる検討を要する。 However, in general, a large amount of polyethylene glycol is required in order to maintain a better hardness after enclosing a sufficient amount of liquid bath components in a solid. However, when a large amount of polyethylene glycol is contained in this manner, the solubility of the solid bath preparation tends to deteriorate, and further studies are required to improve the solubility while maintaining good hardness.
したがって、本発明の課題は、界面活性剤や油性成分等の非水液状浴用成分を良好に保持しつつも適度な硬度と、優れた溶解性とを兼ね備えた固形浴用剤を提供することにある。 Accordingly, an object of the present invention is to provide a solid bath agent that has appropriate hardness and excellent solubility while maintaining good non-aqueous liquid bath components such as surfactants and oily components. .
そこで本発明者は、種々検討したところ、特定のエーテル化度を有するカルボキシメチルセルロース若しくはその塩、及び/又は特定の表面処理がなされたセルロースと、特定のポリエチレングリコールとを併用すると、非水液状浴用成分を良好に保持しつつ高い硬度と優れた溶解性を併せ持つ固形浴用剤が得られることを見出した。 Therefore, the present inventor has made various studies and found that when carboxymethyl cellulose having a specific degree of etherification or a salt thereof and / or cellulose having a specific surface treatment and a specific polyethylene glycol are used in combination, a non-aqueous liquid bath is used. It has been found that a solid bath agent having both high hardness and excellent solubility can be obtained while maintaining the components well.
すなわち、本発明は、次の成分(A)、(B)並びに(C):
(A)非水液状浴用成分、
(B)エーテル化度が0.01〜0.5のカルボキシメチルセルロース若しくはその塩(b−1)、及び/又は水溶性高分子で表面処理されたセルロース(b−2)、並びに
(C)数平均分子量1500〜20000のポリエチレングリコール
を含有し、成分(C)に対する成分(B)の質量比(B/C)が0.1〜1.5である固形浴用剤を提供するものである。
That is, the present invention includes the following components (A), (B) and (C):
(A) Non-aqueous liquid bath component,
(B) Carboxymethyl cellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof (b-1) and / or cellulose (b-2) surface-treated with a water-soluble polymer, and (C) number A solid bath agent containing polyethylene glycol having an average molecular weight of 1500 to 20000 and having a mass ratio (B / C) of component (B) to component (C) of 0.1 to 1.5 is provided.
本発明によれば、高い硬度を有しつつ非水液状浴用成分を固形浴用剤中に良好に高含有させることができるとともに、浴水に投入した際には優れた溶解性を発揮して非水液状浴用成分を良好に拡散させることができる。したがって、錠剤の形態を呈する固形浴用剤に成型した際も、非水液状浴用成分が染み出すおそれがなく、良好な成型性を発揮する上、これを浴水に投入した際にも優れた溶解性を発揮することができる。 According to the present invention, the non-aqueous liquid bath component can be satisfactorily contained in the solid bath agent while having high hardness, and exhibits excellent solubility when introduced into bath water. The water-liquid bath component can be diffused well. Therefore, when molded into a solid bath agent that takes the form of a tablet, there is no risk of non-aqueous liquid bath components leaching out, exhibiting good moldability, and excellent dissolution when introduced into bath water Can demonstrate its sexuality.
以下、本発明について詳細に説明する。
本発明の固形浴用剤は、非水液状浴用成分(A)を含有する。非水液状浴用成分とは、室温(25℃)で液状であって、水以外の浴用成分を意味する。好ましい非水液状浴用成分(A)としては、ClogP値が4〜18の液状浴用成分であり、例えば、ClogP値が4〜18の油性成分及び界面活性剤等が挙げられる。これらは1種単独で用いてもよく、2種以上組み合わせて用いてもよい。これら非水液状浴用成分(A)は、それぞれの成分独自の作用、例えば、温浴効果や香り立ちの付与、保湿効果等の作用をもたらすことができる。
Hereinafter, the present invention will be described in detail.
The solid bath agent of the present invention contains a non-aqueous liquid bath component (A). The non-aqueous liquid bath component is liquid at room temperature (25 ° C.) and means a bath component other than water. The preferred non-aqueous liquid bath component (A) is a liquid bath component having a ClogP value of 4 to 18, and examples thereof include oily components and surfactants having a ClogP value of 4 to 18. These may be used alone or in combination of two or more. These components (A) for non-aqueous liquid bath can bring about actions unique to each component, for example, actions such as warm bathing effect, imparting aroma, moisturizing effect and the like.
成分(A)として用いることのできるClogP値が4〜18の油性成分としては、具体的には、例えば、オクタン酸セチル、イソオクタン酸セチル、乳酸ミリスチル、乳酸セチル、ミリスチン酸イソプロピル、ミリスチン酸ミリスチル、ミリスチン酸イソセチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、パルミチン酸イソステアリル、アジピン酸イソプロピル、ステアリン酸ブチル、ステアリン酸イソセチル、イソノナン酸イソトリデシル、オレイン酸デシル、イソステアリン酸コレステロール、ラウリン酸ブチル、ラウリン酸イソアミル、ミリスチン酸メチル、ミリスチン酸エチル、ステアリン酸エチル、イソノナン酸イソノニル、リノール酸イソプロピル、イソステアリン酸イソステアリル、イソステアリン酸イソプロピル、オレイン酸メチル、オレイン酸エチル、オレイン酸オレイル等の脂肪酸エステル類;分子内に脂肪酸エステル構造を有するトリ(カプリル酸・カプリン酸)グリセリン、トリカプリル酸グリセリル等の脂肪酸グリセリド類;大豆油、ヌカ油、ホホバ油、アボガド油、アーモンド油、オリーブ油、カカオ脂、ゴマ油、パーシック油、ヒマシ油、ヤシ油、ミンク油等の天然油脂、これらの天然油脂を水素添加して得られる油脂及びミリスチン酸グリセリド、2−エチルヘキサン酸グリセリド等のグリセリド類;流動パラフィン、スクワラン、スクアレン、ジオクチルシクロヘキサン、ブリスタン等の炭化水素油;オレイン酸、リノール酸、リノレン酸、ラノリン酸、イソステアリン酸等の高級脂肪酸類;エタノール、イソプロピルアルコール、グリセリン、オレイルアルコール、2−ヘキシルデカノール等のアルコール類;数平均分子量1500未満の液状のポリエチレングリコール等のポリエーテル類;シリコーン油類;ハッカ油、ジャスミン油、ショウ脳油、ヒノキ油、トウヒ油、リュウ油、テレピン油、ケイ皮油、ベルガモット油、ミカン油、ショウブ油、パイン油、ラベンダー油、ベイ油、クローブ油、ヒバ油、バラ油、ユーカリ油、レモン油、タイム油、ペパーミント油、ローズ油、セージ油等の精油;メントール、シネオール、オイゲノール、シトラール、シトロネラール、ボルネオール、リナロール、ゲラーオール、カンファー、チモール、スピラントール、ピネン、リモネン等のような、テルペン系炭化水素類香料、セスキテルペン系炭化水素類香料、アルコール類香料、エーテル類香料、アルデヒド類香料、ケトン類香料、エステル類香料、ラクトン類香料、合成ムスク、含窒素・硫黄化合物等の香料のうち、ClogP値が4〜18であり、かつ室温(25℃)で液状のものが挙げられる。 Specific examples of the oily component having a ClogP value of 4 to 18 that can be used as the component (A) include cetyl octanoate, cetyl isooctanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, Isocetyl myristate, octyldodecyl myristate, isopropyl palmitate, isostearyl palmitate, isopropyl adipate, butyl stearate, isocetyl stearate, isotridecyl isononanoate, decyl oleate, cholesterol isostearate, butyl laurate, isoamyl laurate, Methyl myristate, ethyl myristate, ethyl stearate, isononyl isononanoate, isopropyl linoleate, isostearyl isostearate, isostearic acid Fatty acid esters such as propyl, methyl oleate, ethyl oleate, oleyl oleate; fatty acid glycerides such as tri (caprylic acid / capric acid) glycerin and glyceryl tricaprylate having a fatty acid ester structure in the molecule; soybean oil, nuka Oil, jojoba oil, avocado oil, almond oil, olive oil, cocoa butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, and other natural fats and oils and myristic acid glycerides obtained by hydrogenating these natural fats and oils Glycerides such as 2-ethylhexanoic acid glycerides; hydrocarbon oils such as liquid paraffin, squalane, squalene, dioctylcyclohexane and bristan; higher fatty acids such as oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid; ethanol , Isopropyl Alcohols such as coal, glycerin, oleyl alcohol, 2-hexyldecanol; polyethers such as liquid polyethylene glycol having a number average molecular weight of less than 1500; silicone oils; mint oil, jasmine oil, pepper brain oil, cypress oil, spruce oil , Ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, ginger oil, pine oil, lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, Essential oils such as rose oil and sage oil; menthol, cineole, eugenol, citral, citronellal, borneol, linalool, gellarol, camphor, thymol, spirantol, pinene, limonene, terpene hydrocarbon fragrances, sesquiterpene Hydrocarbon fragrances, al Among fragrances such as coal fragrances, ether fragrances, aldehyde fragrances, ketone fragrances, ester fragrances, lactone fragrances, synthetic musks, nitrogen-containing / sulfur compounds, etc., the ClogP value is 4 to 18 and room temperature ( 25 ° C.).
成分(A)として用いることのできるClogP値が4〜18の界面活性剤としては、例えば、陰イオン界面活性剤、陽イオン界面活性剤、両性界面活性剤、及び、非イオン界面活性剤の何れであっても良く、具体的には、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビトール脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルケニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルケニルエーテル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシプロピレンアルキルエーテル等の非イオン界面活性剤等のうち、ClogP値が4〜18であり、かつ室温(25℃)で液状のものが挙げられる。 Examples of the surfactant having a ClogP value of 4 to 18 that can be used as the component (A) include any of an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant. Specifically, sucrose fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether , Polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkenyl ether, polyethylene glycol fatty acid ester, polyoxyethylene Among nonionic surfactants such as castor oil, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxypropylene alkyl ether, etc., ClogP value is 4-18, and room temperature (25 ° C.) And liquid form.
非水液状浴用成分(A)の含有量は、成分独自の作用を充分に発揮させる点、及び高い硬度と良好な溶解性とを両立させる点で、本発明の固形浴用剤中に、好ましくは0.01〜35質量%であり、より好ましくは0.1〜20質量%であり、さらに好ましくは0.5〜10質量%である。 The content of the non-aqueous liquid bath component (A) is preferably in the solid bath preparation of the present invention in terms of sufficiently exhibiting the unique action of the component and achieving both high hardness and good solubility. It is 0.01-35 mass%, More preferably, it is 0.1-20 mass%, More preferably, it is 0.5-10 mass%.
本発明の固形浴用剤は、エーテル化度が0.01〜0.5のカルボキシメチルセルロース若しくはその塩、及び/又は水溶性高分子で表面処理されたセルロース(B)を含有する。以下、エーテル化度が0.01〜0.5のカルボキシメチルセルロース又はその塩を成分(b−1)、水溶性高分子で表面処理されたセルロースを成分(b−2)と称する。 The solid bath agent of the present invention contains carboxymethylcellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof, and / or cellulose (B) surface-treated with a water-soluble polymer. Hereinafter, carboxymethylcellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof is referred to as component (b-1), and cellulose surface-treated with a water-soluble polymer is referred to as component (b-2).
本発明で用いるエーテル化度が0.01〜0.5のカルボキシメチルセルロース又はその塩(b−1)は、一般的に浴用剤に配合されるカルボキシメチルセルロース又はその塩のエーテル化度が1.0〜1.5であることから、エーテル化度が非常に低いカルボキシメチルセルロース又はその塩である。このような成分(b−1)は、保存中の固形浴用剤において、後述する数平均分子量1500〜20000のポリエチレングリコール(C)と相まって、予想外にも高い硬度を発現することができ、非水液状浴用成分(A)を固形浴用剤中に有効に封じ込めることができる。その一方で、かかる構成を有する本発明の固形浴用剤であれば、浴水に投入された際には速やかに溶解し、成分(A)を直ちに拡散することができる。 Carboxymethyl cellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof (b-1) used in the present invention generally has a degree of etherification of 1.0 or more of carboxymethyl cellulose or a salt thereof blended in a bath agent. Since it is -1.5, it is carboxymethylcellulose or its salt with a very low degree of etherification. Such a component (b-1) can exhibit unexpectedly high hardness in combination with polyethylene glycol (C) having a number average molecular weight of 1500 to 20000, which will be described later, in a solid bath agent during storage. The aqueous liquid bath component (A) can be effectively contained in the solid bath agent. On the other hand, if it is the solid bath agent of this invention which has this structure, it will melt | dissolve rapidly when thrown into bath water, and a component (A) can be spread | diffused immediately.
成分(b−1)のカルボキシメチルセルロース又はその塩のより好ましいエーテル化度は0.05〜0.3であり、更に好ましくは0.1〜0.2である。ここでエーテル化度とは、グルコース単位あたりのカルボキシメチル基の置換度をいう。エーテル化度は、例えばCMC工業会分析法(灰化法)に従い得ることができる。カルボキシメチルセルロースナトリウム1gを精秤し、磁性ルツボに入れて600℃で灰化し、灰化によって生成した酸化ナトリウムをN/10硫酸でフェノールフタレインを指示薬として滴定し、カルボキシメチルセルロースナトリウム1gあたりの滴定量YmLを次式に入れて計算し、求めたエーテル化度を示すことができる。
エーテル化度=(162×Y)/(10,000−80×Y)
The more preferable degree of etherification of the component (b-1) carboxymethylcellulose or a salt thereof is 0.05 to 0.3, and more preferably 0.1 to 0.2. Here, the degree of etherification refers to the degree of substitution of carboxymethyl groups per glucose unit. The degree of etherification can be obtained, for example, according to the CMC industry association analysis method (ashing method). Weigh precisely 1 g of sodium carboxymethylcellulose, put it in a magnetic crucible, incinerate at 600 ° C., titrate sodium oxide produced by incineration with N / 10 sulfuric acid using phenolphthalein as an indicator, and titrate per 1 g of sodium carboxymethylcellulose. YmL can be calculated by putting it in the following formula and the obtained degree of etherification can be shown.
Degree of etherification = (162 × Y) / (10,000-80 × Y)
カルボキシメチルセルロースの塩としては、ナトリウム、カリウムなどのアルカリ金属塩、アンモニウム塩などが挙げられ、安価な点、並びに入手容易性及び浴水への溶解性に優れる点から、カルボキシメチルセルロースナトリウムが好ましい。 Examples of the salt of carboxymethylcellulose include alkali metal salts such as sodium and potassium, ammonium salts, and the like, and sodium carboxymethylcellulose is preferable from the viewpoints of inexpensiveness, availability, and solubility in bath water.
また、成分(b−1)のカルボキシメチルセルロース又はその塩の平均粒子径は、高い硬度と良好な溶解性とを両立させる点から、好ましくは1〜100μmであり、より好ましくは10〜50μmである。 Moreover, the average particle diameter of the component (b-1) carboxymethylcellulose or a salt thereof is preferably 1 to 100 μm, more preferably 10 to 50 μm, from the viewpoint of achieving both high hardness and good solubility. .
本発明で用いる水溶性高分子で表面処理されたセルロース(b−2)は、セルロースの表面を水溶性高分子でコーティングする等の処理が施され、水との親和性が高められたセルロースである。このような成分(b−2)は、本発明の固形浴用剤において、成分(b−1)と同様の効果を発揮する成分である。 Cellulose (b-2) surface-treated with a water-soluble polymer used in the present invention is a cellulose that has been subjected to a treatment such as coating the surface of cellulose with a water-soluble polymer and has increased affinity with water. is there. Such a component (b-2) is a component which exhibits the same effect as a component (b-1) in the agent for solid baths of this invention.
成分(b−2)のセルロースを表面処理する水溶性高分子としては、カルボキシメチルセルロース塩、メチルセルロース、ヒドロキシセルロース、キサンタンガム、カラヤガム、デキストリン、カラギーナン、アルギン酸塩等が挙げられる。これらは1種単独で用いてもよく、2種以上組み合わせて用いてもよい。また、表面処理するセルロースとしては、通常のセルロース、すなわち、結晶セルロースや粉末セルロースを用いることができ、好ましくは結晶セルロースを用いることができる。 Examples of the water-soluble polymer for surface-treating the component (b-2) cellulose include carboxymethylcellulose salt, methylcellulose, hydroxycellulose, xanthan gum, karaya gum, dextrin, carrageenan, and alginates. These may be used alone or in combination of two or more. Further, as the cellulose to be surface-treated, normal cellulose, that is, crystalline cellulose or powdered cellulose can be used, and preferably crystalline cellulose can be used.
成分(b−2)のセルロースは、高い硬度と良好な溶解性とを両立させる点から、含有するセルロース及び水溶性高分子の質量比(セルロース:水溶性高分子)が、1:1〜50:1であるのが好ましく、3:1〜30:1であるのがより好ましく、4:1〜20:1であるのがさらに好ましい。 The component (b-2) cellulose has a mass ratio of cellulose to water-soluble polymer (cellulose: water-soluble polymer) of 1: 1 to 50 in order to achieve both high hardness and good solubility. : 1 is preferred, 3: 1 to 30: 1 is more preferred, and 4: 1 to 20: 1 is even more preferred.
本発明の固形浴用剤において、成分(B)として、上記成分(b−1)及び成分(b−2)の一方の成分を単独で用いてもよく、双方の成分を組み合わせて用いてもよい。なかでも、高い硬度と良好な溶解性とを両立させる点から、少なくとも成分(b−1)を用いるのが好ましい。 In the solid bath agent of the present invention, as the component (B), one of the components (b-1) and (b-2) may be used alone, or both components may be used in combination. . Especially, it is preferable to use a component (b-1) at least from the point which makes high hardness and favorable solubility compatible.
成分(B)の含有量は、後述する数平均分子量1500〜20000のポリエチレングリコール(C)と相まって高い硬度を発現する点から、本発明の固形浴用剤中に、成分(b−1)及び成分(b−2)の合計含有量は、好ましくは0.01〜35質量%、より好ましくは0.1〜20質量%、さらに好ましくは0.7〜10質量%である。 The content of the component (B), in combination with the polyethylene glycol (C) having a number average molecular weight of 1500 to 20000, which will be described later, expresses high hardness in the solid bath preparation of the present invention, the component (b-1) and the component The total content of (b-2) is preferably 0.01 to 35% by mass, more preferably 0.1 to 20% by mass, and still more preferably 0.7 to 10% by mass.
本発明の固形浴用剤は、数平均分子量1500〜20000のポリエチレングリコール(C)を含有する。成分(C)は成分(B)と相まって、成分(A)を予想外に良好に保持することができる。かかる数平均分子量は、より高い硬度を発現しつつ良好な溶解性を付与する点で、2000〜13000であるのが好ましく、3000〜9000であるのがより好ましい。なお、ポリエチレングリコールの数平均分子量を測定する場合には、溶媒として水/エタノールを用い、ポリスチレンを標準としたGPC法を用いる。 The solid bath agent of the present invention contains polyethylene glycol (C) having a number average molecular weight of 1500 to 20000. Component (C), in combination with component (B), can keep component (A) better than expected. The number average molecular weight is preferably 2000 to 13000, and more preferably 3000 to 9000, from the viewpoint of imparting good solubility while expressing higher hardness. When measuring the number average molecular weight of polyethylene glycol, GPC method using water / ethanol as a solvent and polystyrene as a standard is used.
成分(C)のポリエチレングリコールの含有量は、高い硬度と良好な溶解性の両立を図る点から、本発明の固形浴用剤中に、好ましくは0.01〜35質量%、より好ましくは0.1〜20質量%、さらに好ましくは0.5〜10質量%である。 The content of the polyethylene glycol as the component (C) is preferably 0.01 to 35% by mass, more preferably 0.00% in the solid bath preparation of the present invention from the viewpoint of achieving both high hardness and good solubility. It is 1-20 mass%, More preferably, it is 0.5-10 mass%.
本発明の固形浴用剤は、成分(C)に対する成分(A)の質量比(A/C)は、高い硬度と良好な溶解性の両立をより有効に図る点から、好ましくは0.5〜5であり、より好ましくは0.8〜2.0である。本発明の固形浴用剤であれば、このように(C)成分に対して(A)成分を高含有させても、(B)成分を特定量配合することで良好な硬度と良好な溶解性の両立を図ることが可能である。 In the solid bath preparation of the present invention, the mass ratio (A / C) of the component (A) to the component (C) is preferably from 0.5 to more effectively achieving both high hardness and good solubility. 5, more preferably 0.8 to 2.0. In the case of the solid bath preparation of the present invention, even if the component (A) is highly contained in the component (C), good hardness and good solubility can be obtained by blending a specific amount of the component (B). It is possible to achieve both.
本発明の固形浴用剤は、成分(B)に対する成分(A)の質量比(A/B)は、高い硬度と良好な溶解性の両立をより有効に図る点から、好ましくは0.1〜10であり、より好ましくは0.5〜5.0であり、さらに好ましくは0.8〜2.0である。 In the solid bath preparation of the present invention, the mass ratio (A / B) of the component (A) to the component (B) is preferably from 0.1 to more effectively achieving both high hardness and good solubility. It is 10, More preferably, it is 0.5-5.0, More preferably, it is 0.8-2.0.
本発明の固形浴用剤は、成分(C)に対する成分(B)の質量比(B/C)は、0.1〜1.5である。高い硬度と良好な溶解性の両立をより有効に図る点から、かかる質量比(B/C)は、好ましくは0.3〜1.4であり、より好ましくは0.4〜1.3である。 In the solid bath preparation of the present invention, the mass ratio (B / C) of the component (B) to the component (C) is 0.1 to 1.5. The mass ratio (B / C) is preferably 0.3 to 1.4, more preferably 0.4 to 1.3 from the viewpoint of more effectively achieving both high hardness and good solubility. is there.
本発明の固形浴用剤は、硬度をより有効に高める点から、さらにエーテル化度が0のセルロース(D)を含有するのが好ましい。成分(D)のセルロースを含有することにより、成分(B)と成分(C)とが相まって成分(A)を良好に保持しつつ硬度を高めると共に溶解性を向上させる作用をより高めることができる。このような成分(D)として、例えば、結晶セルロースや粉末セルロースを用いることができ、好ましくは結晶セルロースを用いることができる。本発明の固形浴用剤が成分(D)を含有する場合、成分(D)に対する成分(B)の質量比(B/D)は、好ましくは0.2〜5であり、より好ましくは0.3〜3である。 The solid bath agent of the present invention preferably further contains cellulose (D) having a degree of etherification of 0 from the viewpoint of more effectively increasing the hardness. By containing the cellulose of the component (D), the component (B) and the component (C) can be combined to increase the hardness and improve the solubility while maintaining the component (A) in a good condition. . As such a component (D), for example, crystalline cellulose or powdered cellulose can be used, and preferably crystalline cellulose can be used. When the solid bath preparation of the present invention contains the component (D), the mass ratio (B / D) of the component (B) to the component (D) is preferably 0.2 to 5, more preferably 0.8. 3 to 3.
成分(D)のエーテル化度が0のセルロースの含有量は、高い硬度と良好な溶解性の両立を図る点から、本発明の固形浴用剤中に、好ましくは0.01〜20質量%、より好ましくは0.1〜18質量%、さらに好ましくは0.3〜10質量%である。 The content of the cellulose having a degree of etherification of component (D) of 0 is preferably 0.01 to 20% by mass in the solid bath preparation of the present invention, from the viewpoint of achieving both high hardness and good solubility. More preferably, it is 0.1-18 mass%, More preferably, it is 0.3-10 mass%.
本発明の固形浴用剤が有する硬度は、例えば、FUDOH RHEOMETER NRM−2010J−CWを用いることにより測定される針入硬度を指標とすることができる。具体的には、測定する固形浴用剤のサンプルをガラス瓶に入れて80℃の湯浴に浸すことによって溶解した後、撹拌し、直径3cm、深さ1cmの円柱形の容器に試験試料を注入し、スライドグラスで蓋をして容器ごと室温(25℃)の水に半分の高さまで浸して冷却し、固める。次いで、スライドグラスを取り去り、容器に入れたまま測定プローブとして直径1mmの針(先端は平坦)を2.0cm/分で垂直に降ろし、1.0mm進入するまでの最大応力を測定し、成分(B)、成分(C)、および成分(D)を1.0:2.0:1.0の割合で混合したコントロール試料で同様に測定した場合の最大応力との相対値(試験試料の最大応力/コントロール試料の最大応力)を針入硬度とする。この場合、針入硬度は、0.5以上であるのが好ましく、0.7以上であるのがより好ましい。 The hardness which the agent for solid baths of this invention has can use the penetration hardness measured by using FUDOH RHEOMETER NRM-2010J-CW as a parameter | index, for example. Specifically, a solid bath agent sample to be measured is dissolved in a glass bottle and immersed in an 80 ° C. hot water bath, and then stirred, and the test sample is injected into a cylindrical container having a diameter of 3 cm and a depth of 1 cm. Then, cover with a slide glass, soak the entire container in water at room temperature (25 ° C) to half height, cool and harden. Next, the slide glass is removed, and a 1 mm diameter needle (tip is flat) is lowered vertically at 2.0 cm / min as a measurement probe while being placed in a container, and the maximum stress until it enters 1.0 mm is measured. B), relative value to the maximum stress when the component (C) and the component (D) were similarly measured with a control sample mixed at a ratio of 1.0: 2.0: 1.0 (maximum of the test sample) Stress / maximum stress of control sample) is defined as penetration hardness. In this case, the penetration hardness is preferably 0.5 or more, and more preferably 0.7 or more.
本発明の固形浴用剤は、押出造粒機や転動造粒機、或いは滴下等による造粒手段を用いながら、各成分を適宜混合して粒状又は顆粒状の形態として用いる。このようにして作製された粒状又は顆粒状の固形浴用剤に、さらに所望の浴用成分を添加及び混合して粒状又は顆粒状の形態を呈する固形浴用剤を作製してもよく、打錠等の圧縮成形法により錠剤の形態を呈する固形浴用剤を作製してもよい。 The solid bath agent of the present invention is used in the form of a granular or granular form by appropriately mixing each component while using a granulating means such as an extruding granulator, a rolling granulator, or dropping. To the granular or granular solid bath agent thus prepared, a desired bath component may be added and mixed to prepare a solid bath agent exhibiting a granular or granular form, such as tableting. You may produce the agent for solid baths which show the form of a tablet with a compression molding method.
所望の浴用成分を添加及び混合して作製された固形浴用剤の場合、かかる固形浴用剤全量中における非水液状浴用成分(A)の含有量は、成分独自の作用を充分に発揮させる点、及び高い硬度と良好な溶解性とを両立させる点で、好ましくは0.01〜10質量%であり、より好ましくは0.1〜5質量%であり、さらに好ましくは0.5〜3質量%である。また、所望の浴用成分を添加及び混合して作製された固形浴用剤全量中における成分(B)のセルロースの含有量は、成分(C)と相まって高い硬度を発現する点から、好ましくは0.01〜10質量%、より好ましくは0.1〜6質量%、さらに好ましくは0.7〜4質量%である。さらに、所望の浴用成分を添加及び混合して作製された固形浴用剤全量中における成分(C)のポリエチレングリコールの含有量は、高い硬度と良好な溶解性の両立を図る点から、好ましくは0.01〜10質量%、より好ましくは0.1〜5質量%、さらに好ましくは0.5〜3質量%である。 In the case of a solid bath agent prepared by adding and mixing a desired bath component, the content of the non-aqueous liquid bath component (A) in the total amount of the solid bath agent sufficiently exerts the unique action of the component, In terms of achieving both high hardness and good solubility, it is preferably 0.01 to 10% by mass, more preferably 0.1 to 5% by mass, and further preferably 0.5 to 3% by mass. It is. In addition, the cellulose content of the component (B) in the total amount of the solid bath agent prepared by adding and mixing desired bath components is preferably from the point of expressing high hardness in combination with the component (C). It is 01-10 mass%, More preferably, it is 0.1-6 mass%, More preferably, it is 0.7-4 mass%. Further, the content of the polyethylene glycol of the component (C) in the total amount of the solid bath agent prepared by adding and mixing desired bath components is preferably 0 from the viewpoint of achieving both high hardness and good solubility. 0.01 to 10% by mass, more preferably 0.1 to 5% by mass, and still more preferably 0.5 to 3% by mass.
錠剤の形態を呈する固形浴用剤とした場合にも、一旦作製した粒状又は顆粒状の固形浴用剤が高い硬度を保持して成分(A)を安定に保持しながらも良好な溶解性を有するため、打錠等の際には、成分(A)が染み出すのを有効に防止して優れた成型性を発揮するとともに、浴水に投入した際には、錠剤が速やかに溶解して直ちに成分(A)を浴水中に拡散させることができる。 Even in the case of a solid bath agent that takes the form of a tablet, the once-prepared granular or granular solid bath agent retains high hardness and has good solubility while maintaining stable component (A). In tableting, etc., it effectively prevents the component (A) from oozing out and exhibits excellent moldability, and when it is poured into bath water, the tablet dissolves quickly and the component immediately (A) can be diffused in the bath water.
上記浴用成分として、さらに、炭酸ガスの発生によって温浴効果等が付与された浴用剤を得る点から、炭酸ガス発生物を配合するのが好ましい。炭酸ガス発生物は、酸と炭酸塩とを組み合わせたものが好ましい。酸としては、有機酸及び無機酸のいずれでも使用できるが、室温(25℃)で固体のものが好ましく、例えば、フマル酸、リンゴ酸、酒石酸、クエン酸、マレイン酸、コハク酸、フタル酸、グルタル酸、アジピン酸、安息香酸、サリチル酸、シュウ酸等の有機酸がより好ましい。無機酸としては、ホウ酸、メタケイ酸、無水ケイ酸等が挙げられる。また炭酸塩としては、炭酸ナトリウム、炭酸水素ナトリウム、炭酸マグネシウム、炭酸カリウム、炭酸カルシウム等が好ましい。これらの酸及び炭酸塩は、1種単独で用いてもよく、2種以上組み合わせて用いてもよい。 As the bath component, it is preferable to add a carbon dioxide gas generator from the viewpoint of obtaining a bath agent to which a warm bath effect or the like is imparted by the generation of carbon dioxide gas. The carbon dioxide generator is preferably a combination of acid and carbonate. As the acid, either an organic acid or an inorganic acid can be used, and those that are solid at room temperature (25 ° C.) are preferable. For example, fumaric acid, malic acid, tartaric acid, citric acid, maleic acid, succinic acid, phthalic acid, Organic acids such as glutaric acid, adipic acid, benzoic acid, salicylic acid and oxalic acid are more preferred. Examples of the inorganic acid include boric acid, metasilicic acid, and silicic anhydride. Moreover, as carbonate, sodium carbonate, sodium hydrogencarbonate, magnesium carbonate, potassium carbonate, calcium carbonate, etc. are preferable. These acids and carbonates may be used alone or in combination of two or more.
炭酸ガス発生物の含有量は、本発明の固形浴用剤中に、好ましくは10〜95質量%、より好ましくは30〜93質量%、さらに好ましくは50〜90質量%である。 The content of the carbon dioxide generator is preferably 10 to 95% by mass, more preferably 30 to 93% by mass, and still more preferably 50 to 90% by mass in the solid bath preparation of the present invention.
またさらに、その他の浴用成分を適宜配合することができる。このような成分としては、酸化マグネシウム、ケイ酸カルシウム、メタリン酸ナトリウム、塩化ナトリウム、塩化カルシウム、塩化マグネシウム等の無機塩類のほか、ブドウ糖等の糖類、消泡剤、酸化防止剤、防菌・防黴剤、色素、生薬等が挙げられる。 Furthermore, other bath components can be appropriately blended. In addition to inorganic salts such as magnesium oxide, calcium silicate, sodium metaphosphate, sodium chloride, calcium chloride, and magnesium chloride, such ingredients include sugars such as glucose, antifoaming agents, antioxidants, antibacterial and antibacterial properties. Examples include glazes, pigments, and crude drugs.
以下、本発明について、実施例に基づき具体的に説明するが、本発明はこれら実施例に限定されるものではない。 EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.
[実施例1〜6、比較例1〜5]
表1に示す処方に従って、非水液状浴用成分として香料を含む顆粒を予め作製した後、かかる顆粒と各成分を混合し、約10MPaの圧力で直径5cmの円柱状に圧縮成型して錠剤(重量40g)を製造した。得られた顆粒又は錠剤を用い、下記方法にしたがって、各評価を行った。結果を表1に示す。
[Examples 1-6, Comparative Examples 1-5]
In accordance with the formulation shown in Table 1, granules containing a fragrance as a non-aqueous liquid bath component are prepared in advance, and then the granules and each component are mixed and compressed into a cylindrical shape having a diameter of 5 cm at a pressure of about 10 MPa. 40 g) was produced. Each evaluation was performed according to the following method using the obtained granule or tablet. The results are shown in Table 1.
《針入硬度》
上述の方法にしたがって、予め作製した非水液状浴用成分として香料を含む顆粒の針入硬度を測定した。
《Penetration hardness》
According to the above-mentioned method, the penetration hardness of granules containing a fragrance as a non-aqueous liquid bath component prepared in advance was measured.
《成型性》
圧縮成型時における成分(A)の染み出しの有無、及び錠剤の破損や崩れの有無を目視により確認し、下記評価基準に従って成型性としての評価を行った。
◎:成分(A)の染み出しが全くなく、錠剤の破損や崩れも全く認められなかった
○:成分(A)の染み出しがほとんどなく、錠剤の破損や崩れもほとんど認められなかった
×:成分(A)の染み出し、或いは錠剤の破損や崩れのうち、少なくとも一方が認められた
<Moldability>
The presence or absence of the component (A) at the time of compression molding and the presence or absence of breakage or collapse of the tablet were visually confirmed, and evaluation as moldability was performed according to the following evaluation criteria.
◎: Component (A) did not exude at all, and no breakage or collapse of the tablet was observed. ○: Component (A) did not exude, and damage or collapse of the tablet was hardly observed. At least one of the exudation of component (A) or breakage or collapse of the tablet was observed.
《溶解性》
得られた錠剤を40℃、150Lの浴水に投入し、投入時から錠剤が全量溶解するまでの時間(分)を測定した。
<< Solubility >>
The obtained tablets were put into a bath water of 40 ° C. and 150 L, and the time (minutes) from the time of charging until the whole amount of the tablets was dissolved was measured.
表1によれば、エーテル化度が0.01〜0.5のカルボキシメチルセルロース又はその塩(b−1)及び/又は水溶性高分子で表面処理されたセルロース(b−2)を含有する顆粒を用いた実施例1〜6は、顆粒の硬度が高く、得られる錠剤の成型性及び溶解性に優れることがわかる。なかでも、成分(D)のエーテル化度が0のカルボキシメチルセルロース又はその塩を併用した顆粒を用いた実施例3〜4は、さらに優れた効果を発揮する。 According to Table 1, granules containing carboxymethyl cellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof (b-1) and / or cellulose (b-2) surface-treated with a water-soluble polymer. It can be seen that in Examples 1 to 6 using the above, the hardness of the granules is high and the moldability and solubility of the resulting tablets are excellent. Especially, Examples 3-4 using the granule which used together the carboxymethylcellulose whose etherification degree of a component (D) is 0, or its salt show the further outstanding effect.
一方、エーテル化度の高いカルボキシメチルセルロース又はその塩を実施例1の成分(b−1)と同量で含有する顆粒を用いた比較例1、並びに結晶セルロースや粉末セルロースを含有する顆粒を用いた比較例3及び5は、実施例1に比べ、顆粒の硬度が低く、得られる錠剤の成型性及び溶解性も低下してしまうことがわかる。また、成分(D)のエーテル化度が0のカルボキシメチルセルロース又はその塩をエーテル化度が0.5より高いカルボキシメチルセルロース又はその塩と併用した顆粒を用いた比較例2及び4では、実施例3〜4のように効果を高めることができず、得られる錠剤は溶け残りが生じてしまうほど溶解性が悪化することがわかる。 On the other hand, Comparative Example 1 using granules containing carboxymethyl cellulose having a high degree of etherification or a salt thereof in the same amount as the component (b-1) of Example 1, and granules containing crystalline cellulose or powdered cellulose were used. In Comparative Examples 3 and 5, it can be seen that the hardness of the granules is lower than that in Example 1, and the moldability and solubility of the resulting tablets are also lowered. In Comparative Examples 2 and 4, in which the carboxymethyl cellulose having a degree of etherification of component (D) or a salt thereof in combination with carboxymethyl cellulose having a degree of etherification higher than 0.5 or a salt thereof was used in Comparative Example 2 and 4, Example 3 It can be seen that the effect cannot be increased as in ˜4, and the solubility of the resulting tablet deteriorates as undissolved residue occurs.
Claims (4)
(A)非水液状浴用成分、
(B)エーテル化度が0.01〜0.5のカルボキシメチルセルロース若しくはその塩(b−1)、並びに
(C)数平均分子量1500〜20000のポリエチレングリコール
を含有し、成分(C)に対する成分(B)の質量比(B/C)が0.3〜1.5である固形浴用剤。 The following components (A), (B) and (C):
(A) Non-aqueous liquid bath component,
(B) Carboxymethyl cellulose having a degree of etherification of 0.01 to 0.5 or a salt thereof (b-1) , and (C) polyethylene glycol having a number average molecular weight of 1500 to 20000, A solid bath agent having a mass ratio (B / C) of B) of 0.3 to 1.5.
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