JP6851646B2 - Kit for external preparations for skin - Google Patents

Description

The present invention is a kit for obtaining an effervescent skin external preparation, in which the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. The present invention relates to a kit characterized by being a composition containing a carbon dioxide gas generating substance and a thickener.

Since carbon dioxide has an effect of promoting blood circulation in the skin when it acts on the skin, external preparations for the skin using various carbon dioxide have been proposed. Most of these generate carbon dioxide gas by the reaction of an acidic substance and a carbon dioxide gas generating substance. For example, in order to maintain the effect of the generated carbon dioxide gas, a method of mixing and using a hydrous viscous composition containing an acidic substance, water and a thickener and a solid carbon dioxide gas generating substance immediately before use has been proposed. (Patent Document 1). In addition, a granular substance containing a substance that hydrolyzes to produce an acid, a carbonate, a thickener, a gelling agent that gels with calcium ions, and a water-insoluble or sparingly water-soluble calcium salt is mixed with water immediately before use. A method to be used has been proposed (Patent Document 2).

WO99 / 24043 WO2006 / 80398

However, when carbon dioxide gas is generated by the method described in Patent Document 1, it is difficult to uniformly mix the hydrous viscous composition and the solid carbon dioxide gas generating substance, and foaming due to carbon dioxide gas tends to be uneven, resulting in foaming. It takes time to start. Further, the method described in Patent Document 2 is troublesome for the user because it takes time to measure water, and the viscosity and the amount of carbon dioxide gas generated at the time of use are not constant depending on the quality of the water used. , The effect will be different depending on the use.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a kit for obtaining an effervescent skin external preparation of constant quality, which is easily mixed uniformly at the time of mixing, carbon dioxide gas is generated evenly.

The present invention provides a kit for obtaining the following effervescent external preparation for skin (hereinafter, also referred to as the kit of the present invention).
<1> A kit for obtaining an effervescent skin external preparation, in which the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. A kit characterized by containing a gas generating substance and a thickener.
<2> The kit according to <1>, wherein the first agent further contains at least one of a thickener or a moisturizer.
<3> The kit according to any one of <1> and <2>, wherein the first agent is a composition having a viscosity of 10,000 mPa · s or less.
<4> The kit according to any one of <1> to <3>, wherein the second agent is a solid composition.
<5> The agent according to any one of <1> to <4>, wherein the first agent and the second agent are mixed in a weight ratio in the range of 0.1: 1 to 30: 1 and used. kit.

According to the present invention, it is possible to provide a kit for a user to easily mix uniformly at the time of mixing, carbon dioxide gas is generated evenly and immediately, and a constant quality effervescent skin external preparation is obtained. Further, by blending an acidic substance in the first agent and a carbon dioxide gas generating substance in the second agent, the quality can be kept stable. In particular, it is not necessary to add a storage stabilizer or an antioxidant in order to prevent deterioration of quality, or to limit the storage container to a specific one, which enables low-cost production. Furthermore, by using the effervescent skin external preparation obtained by using the kit of the present invention as a pack agent, it is possible to obtain a skin condition improving effect, particularly a whitening effect in a short time.

The water content of the stratum corneum after using the effervescent skin external preparation obtained by using the kits of Examples 1 and 2 and Comparative Example 1 is shown. The rate of increase in volume of the effervescent skin external preparation obtained by using the kit of Example 3 due to carbon dioxide gas is shown.

The present invention is a kit for obtaining an effervescent skin external preparation, in which the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. It is a kit characterized by containing a carbon dioxide generating substance and a thickener.

Then, in the kit of the present invention, the user can appropriately mix the first agent and the second agent at the time of use to cause foaming due to the generation of carbon dioxide gas, and apply the mixture to the skin for use. The kit of the present invention is characterized in that it has good storage stability by being divided into a first agent and a second agent, and is easy for the user to handle at the time of use. Hereinafter, each component contained in the kit of the present invention and the effervescent skin external preparation obtained by using the kit of the present invention and a method for producing the same will be described.

<First agent>
The first agent (hereinafter, also referred to as the first agent) in the kit of the present invention contains an acidic substance and water. Preferably, it contains an acidic substance, water, and at least one of a thickener or moisturizer.

≪Acid substances≫
The acidic substance used in the first agent of the present invention may be either an organic acid or an inorganic acid, and one or more of these may be used.

Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimeric acid, fumaric acid, maleic acid, and phthalic acid. Dicarboxylic acids such as acids, isophthalic acids and terephthalic acids or salts thereof, acidic amino acids such as glutamate and aspartic acid or salts thereof, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Examples of oxyacids such as acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid and gluconic acid or salts thereof, and inorganic acids include inorganic acids such as phosphoric acid and sulfite or salts thereof. One or more of these can be used. Among them, citric acid or its salts, ascorbic acid or its salts, malic acid or its salts, succinic acid or its salts are preferable, and citric acid or its salts and ascorbic acid are preferable from the viewpoint of safety and solubility in a second agent. Acids or salts thereof are more preferred. In the present invention, the acidic substance may be 0.01% by mass or more in the first agent, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and particularly preferably 0.5% by mass or more. .. Further, 30% by mass or less is preferable, 20% by mass or less is more preferable, and 10% by mass or less is particularly preferable. If the acidic substance is less than 0.01% by mass, not only the reaction with the carbon dioxide generating substance becomes difficult to occur, but also the effervescent skin external preparation after mixing with the second agent becomes basic. This can cause skin problems such as the skin becoming stiff after use and the protective power of the skin weakening. On the other hand, if it is more than 30% by mass, the skin is strongly irritated when only the first agent is mistakenly used, which is not preferable from the viewpoint of safety.

≪Water≫
As the water that can be used in the present invention, water that can be used in cosmetics, external medicines, non-pharmaceutical products, etc. can be used, but purified water, distilled water, membrane-filtered water, ion-exchanged water, etc. are preferable. The blending amount may be 5% by mass or more, preferably 10% by mass or more, and more preferably 15% by mass or more in the first agent. If the content is less than 5% by mass, problems such as difficulty in generating carbon dioxide gas when the first agent and the second agent are mixed and a decrease in the amount of carbon dioxide gas generated occur, and as a result. , It becomes impossible to obtain a sufficient blood circulation promoting effect.

≪Thickener≫
The first agent of the present invention preferably contains a thickener. Since the first agent contains a thickener, the first agent can have an appropriate viscosity in advance. As a result, an excellent amount of foaming can be obtained, and as is clear from Example 2 described later, the effect of improving the skin condition such as an increase in the water content of the stratum corneum, a moist feeling of the skin, brightness, redness, and warmth after use. Not only that, the feeling of use such as ease of mixing, resistance to dripping, and ease of removal during use is improved. The content of the thickener contained in the first agent may be 0.001% by mass or more, preferably 0.005% by mass or more, more preferably 0.01% by mass, and 0. 0.05% by mass or more is particularly preferable. Further, it may be 3% by mass or less, preferably 1% by mass or less, and more preferably 0.8% by mass or less. When the content of the thickener in the first agent is 0.001% by mass or less, the viscosity of the first agent is too low, and it becomes difficult to obtain the blood circulation promoting effect by carbon dioxide gas. Further, if it exceeds 3% by mass, the viscosity of the first agent becomes high, which makes it difficult to mix and remove after use, which not only reduces the usability, but also causes uneven generation of carbon dioxide gas. Problems such as a decrease in the amount of foaming due to carbon dioxide occur, and as a result, a sufficient blood circulation promoting effect due to carbon dioxide cannot be obtained.

The first agent of the present invention preferably has a low viscosity from the viewpoint of mixing with the second agent. Specifically, the viscosity at 25 ° C. is preferably 50,000 mPa · s or less, more preferably 30,000 mPa · s or less, particularly preferably 10,000 mPa · s or less, still more preferably 5,000 mPa · s or less.・ It is less than or equal to s. In the present invention, when the viscosity of the first agent exceeds 50,000 mPa · s, it becomes difficult for the first agent to be uniformly dispersed in the second agent, which is a viscous composition, when mixed with the second agent, and foaming due to carbon dioxide gas. Is prone to unevenness. Further, since it takes time to start foaming, it takes time to obtain the blood circulation promoting effect by carbon dioxide gas, for example, when it is used as a packing agent. The use of a low-viscosity liquid composition as the first agent has the effect of brightening the skin and improving the moist feeling, redness, and warmth after use, as is clear from Example 2 described later. At the same time, it is preferable because it improves the usability such as ease of mixing and application during use.

As the thickener used in the first agent, for example, a synthetic polymer, a semi-synthetic polymer, a natural polymer, a viscous mineral or the like can be used, and specifically, the synthetic polymer is a carboxyvinyl polymer or polyvinyl. Hydrophilic synthesis including alcohol, acrylic acid / alkyl methacrylate copolymer, Acrylate / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethyl cellulose, cationized cellulose, pluronic Examples of the polymer and semi-synthetic polymer include carboxymethyl cellulose or salts thereof, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sulfonated cellulose derivative and the like. Examples of the semi-synthetic polymer include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, and gelatin fatty acid amide. Natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragant gum, tamarind gum, agar, agarose, mannan, curdlan, etc. Arginic acid or its salts, gum arabic, pectin, quinceed, starch, algae colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acids or their salts, ribonucleic acid or its salts, casein, collagen, gelatin, albumin, fibroin, Examples thereof include water-soluble proteins such as elastin, keratin and sericin, hyaluronic acid or a salt thereof, and mucopolysaccharides such as chondroitin sulfate. Examples of clay minerals include laponite, bentonite, smectite kaolinite, and montmorillonite.

In the present invention, one or more of the above thickeners can be used, but it is preferable to use one of the above thickeners having high solubility or dispersibility in water at the time of use. It is preferable because it can alleviate the feeling of roughness of the skin caused by undissolved components and undispersed components. Here, the quality of solubility in water is that when water at about room temperature is added and stirred, the external preparation for skin is instantly dissolved in water or dispersed and uniformly dissolved to have sufficient viscosity. It can be judged from the fact that lumps do not occur at the time of dissolution or dispersion.

Examples of such thickeners include carboxyvinyl polymers, carboxymethyl celluloses or salts thereof, polyvinyl alcohols, sodium polyacrylate, acrylate / alkyl methacrylate copolymers, xanthan gum, succinoglycans, carrageenan, guar gum, and locusts. Bean gum, celluloses, galactan, arabic gum, tragant gum, tamarind gum, agar, mannan, curdran, alginic acid or its salts, collagen, gelatin, albumin, etc. can be mentioned, carboxymethyl cellulose or its salts, xanthan gum, carrageenan, etc. It is preferable to use tamarind gum and albumin.

≪Moisturizer≫
It is also preferable that the first agent of the present invention contains a moisturizer. Moisturizers used in the present invention include polyhydric alcohols, sugars, amino acids, organic acids, sterols, ureas, proteins, plant extracts, etc., and are usually used in cosmetics, external medicines, quasi-drugs, etc. A moisturizer that can be used can be used. Specific examples include polyglycerin such as glycerin, diglycerin, triglycerin, and tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, Polyhydric alcohols such as 3-propanediol, 1,2-pentanediol, sorbitol, polyglycerin derivative, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidone carboxylate, almond, avocado, artea, aloe, usvenia oi, ononis, crow wheat , Luminous, quince seed, clara (kujin), cutinashi, grapefruit, creson, gentiana, gennoshouko, gobo, wheat, saishin, cactus, sabonsou, sanzashi, jiou, shimotsuke, ginger, zeniaoi, mulberry, tachijakousou Hakka, Hatomugi, Hamamelis, Rose, Hinoki, Fukitanpopo, Grape, Prune, Hechima, Bodaiju, Hop, Pine, Marumello, Maronnier, Melissa, Yagurumasou, Yuri, Lime, Lavender, Apple, Rice and rice bran, Black currant, Ibukitranoo, Examples thereof include plant extracts such as Neubara, Glycerol, and seaweed, and one or more of these can be used. In the present invention, it is preferable to use one or more kinds of polyhydric alcohols. By using a moisturizer as the first agent, as is clear from Example 3 described later, it has the effect of keeping the amount of carbon dioxide generated during use high and keeping the skin fresh after use for a longer period of time. .. In addition, when used in combination with an acidic substance and water, it can be used as a peeling agent with only the first agent.

<Second agent>
The second agent in the kit of the present invention contains a carbon dioxide gas generating substance that reacts with an acidic substance to generate carbon dioxide gas and a thickener. The second agent may be in any of solid, liquid, gel and other dosage forms, but the solid form is preferable from the viewpoint of ease of mixing with the first agent and cost during production. Above all, it is more preferable that it is in the form of granules, fine granules, or powder.

≪Carbon dioxide generator≫
As the carbon dioxide gas generating substance used in the second agent of the present invention, various substances can be used without particular limitation. The carbon dioxide generating substance to be used is preferably in a solid state, and is granules from the viewpoint of ease of mixing with other components contained in the second agent and ease of mixing with the first agent. More preferably, it is in the form of fine granules or powder.

Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, ammonium hydrogencarbonate, potassium hydrogencarbonate, sodium hydrogencarbonate, lithium hydrogencarbonate, cesium hydrogencarbonate, and magnesium hydrogencarbonate. , Bicarbonates such as calcium hydrogen carbonate, and the like, and one or more of these are used. Of these, sodium hydrogen carbonate is more preferable in that hydrogen carbonate can be preferably used and moderate foaming power can be realized.

The carbon dioxide generating substance is preferably 1% or more, more preferably 3% or more, and particularly preferably 5% or more in the second agent. Further, 90% by mass or less is preferable, 80% by mass or less is more preferable, and 70% by mass or less is particularly preferable. If it exceeds the above range, the stability of the second agent deteriorates, the foaming property at the time of use deteriorates, and the pH when used as a foaming skin external preparation becomes strong carbon dioxide gas generation or strong basicity. As a result, the irritation to the skin becomes stronger.

The carbon dioxide gas generating substance can be used as a second agent as a mixture with other components. Here, when granules of the carbon dioxide generating substance are obtained by granulating the carbon dioxide generating substance and other components, the content of the other components is not particularly limited, but is 95% by mass in the granules. It is preferably less than. If the other components are present in a content of more than 95% by mass, the foamability is lowered, which is not preferable.

The method for producing the powder or granules is not limited to this embodiment, and includes a dry crushing granulation method, a wet crushing granulation method, a fluidized bed granulation method, a high-speed stirring granulation method, an extrusion granulation method, and the like. Can be manufactured according to conventional methods.

For example, in the production of granules, a matrix base material having a function such as forming granules may be used. When a low melting point compound is used as the matrix base, the carbon dioxide gas generating substance is added to the low melting point compound melted by heating in a container such as a beaker, and the mixture is sufficiently stirred and mixed. Appropriate additives may be added to this as needed. This is further stirred while gradually cooling at room temperature, and left to stand until it hardens. When it hardens to some extent, it may be cooled rapidly in a refrigerator or the like.

Further, for example, the above-mentioned material may be put into a fluidized bed granulator, mixed with an air flow for several minutes, and then granulated by spraying water on the material.

When a low melting point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide gas generating substance is dissolved or dispersed therein. After sufficiently mixing, heat in an oven or the like to remove the solvent and dry. When it is completely solidified, it is crushed, sieved to make the grain size uniform, and then made into granules.

As the shape of the carbon dioxide generating substance, for example, an irregular shape, a flat shape, a polyhedral shape, a spherical shape, a drop shape, a fibrous shape, a columnar shape, a fine powder shape, or the like can be adopted without particular limitation. Further, as the particle size, a wide range can be used without particular limitation. In particular, from the viewpoint of ease of handling and ease of mixing with the viscous composition, those having a particle size distribution of about 1,000 μm or less are more preferable. The particle size distribution in the present invention can be obtained by a normal laser diffraction / scattering method.

The carbon dioxide gas generating substance may be blended as it is with the component contained in the second agent, or may be blended so as not to physically contact other components in the same agent and may coexist. In this case, for example, a coat layer may be provided on either one or both of the carbon dioxide generating substance and the other component, or one or both of the carbon dioxide generating substance and the other component may be provided. It may be encapsulated. Further, a layer containing no carbon dioxide generating substance and other components may be sandwiched between the carbon dioxide generating substance and the components so that they do not come into direct contact with each other, and compression molding may be performed.

Hereinafter, the means for coexisting the carbon dioxide gas generating substance and other components in the same agent will be specifically described, but the present invention is not limited thereto.

[Coat layer formation]
As a method for forming a coat layer, for example, a method of forming a coat layer with at least one of a carbon dioxide gas generating substance or other components may be used. By providing the coat layer, it is preferable from the viewpoint of stability and durability of the carbon dioxide generating substance, the other component and the other component in the same agent.

The coating agent preferable for forming the coat layer can be used without particular limitation as long as it has low reactivity with the carbon dioxide gas generating substance or the other components. For example, fats and oils, fatty acids, fatty acid salts, acetyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethyl cellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid. Examples thereof include copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropyl cellulose, wheat starch, polysaccharides (for example, sucrose, lactose, etc.), organic acid salts such as citrate, and the like. A coat layer may be formed by using a solid hydrocarbon wax, a solid fat or oil, which is melted at a certain temperature or higher by heating. When a coat layer is formed on a carbon dioxide generating substance, the coating agent constituting the coating layer preferably does not interfere with the reaction between the acidic substance in the first agent and the carbon dioxide generating substance in the second agent. For example, in a pack agent using polyethylene glycol as a coating layer, it takes time to react with an acidic substance in the first agent, so it takes time to generate carbon dioxide gas, which is excellent in an extremely short time of 10 seconds. It is not possible to obtain a packing agent having foaming power.

The amount of the coating agent used for the carbon dioxide generating substance and / or other components is preferably 1 to 20% (w / w), more preferably 1 to 10% (w / w) with respect to the carbon dioxide generating substances or other components. w) It is said to be about.

The coating method of the coat layer may be any method as long as it is usually used for coating particles. For example, it may be coated at the same time as granulation by spray granulation, rolling granulation, etc., and the powder or granulated product may be coated with oil or fat coating, granulation coating, transport layer method, pan coating, rolling coating, fluid coating or It may be coated by a method such as dry coating. When excessive heat or physical force is applied during coating, the carbon dioxide generating substance or the other component is destroyed, and the formed film is broken, so that the surface of the carbon dioxide generating substance or the other component is destroyed. Not only is it difficult to uniformly coat the lipid powder on the whole, but also the carbon dioxide gas generating substance or the other components leak out to the surface and solidify due to moisture absorption, or cause an adverse effect on other components at the time of compounding. The coating conditions need to be such that the coat layer and the coating target are not destroyed.

[Encapsulation]
When encapsulating the carbon dioxide generating substance and / or other components, a known method may be adopted without particular limitation.

As the encapsulation method, a known method can be applied without particular limitation, and as the encapsulation material, gelatin, starch, arabic rubber, methyl cellulose, acrylic acid ester, methacrylic acid ester, vinyl acetate, etc. Polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acid, higher alcohol, etc., and those in which a multilayer of surfactants such as liposomes are formed are included, but the present invention is not limited to these and can be widely used. For example, the basic structure of the capsule consists of a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, styrene, or the monomer and acrylic acid, methacrylate, divinyl. It is also preferable to use a resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate. In such microcapsules, the contents and the constituent monomers of the polymer constituting the outer shell of the capsule are emulsified in a reaction solvent such as water, and polymerization of azobisisobutyronitrile, benzoyl peroxide, etc. is started. An agent may be added to carry out emulsion polymerization. As the surfactant component used for such emulsification, for example, hexlite sold under the name of "raponite XLG" and the like can be preferably exemplified. The microcapsules of the present invention can be produced by separating the generated microcapsules by means such as centrifugation and, if desired, washing.

[Compression molding]
As a method of compression molding, the carbon dioxide generating substance and substances other than the other components (so that they do not come into direct contact with each other between the first layer containing the carbon dioxide generating substance and the second layer containing the other components ( For example, a method of compression molding by sandwiching a third layer made of an excipient, a thickener, etc. may be adopted. The compression-molded dosage form may be any solid form such as a tablet shape, a spherical shape, and a plate shape. Here, the carbon dioxide gas generating substance and the other components used may be used as they are, or the carbon dioxide gas generating substance in which a coat layer is provided on one or more of the first layer or the second layer by the above method. Alternatively, the other component, the encapsulated carbon dioxide generating substance, or the other component may be used. The method of compression molding is not particularly limited, and a known method can be applied.

The carbon dioxide generating substance and the other components contained in the first layer and the second layer may be used as they are, or may be used by mixing excipients, thickeners and the like. .. As the excipients, thickeners and the like used for the first layer, the second layer and the third layer, those described in the above description of the granules can be used without particular limitation.

≪Thickener≫
The thickener used in the second agent of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi-drugs, etc., and is a synthetic polymer or semi-synthetic high molecular weight agent. Molecules, natural polymers, viscous minerals, etc. can be used.

Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylic acid / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethyl cellulose, cation. Examples thereof include hydrophilic synthetic polymers such as celluloseized cellulose and Pluronic.

Examples of the semi-synthetic polymer include carboxymethyl cellulose or salts thereof, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide and the like.

Natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragant gum, tamarind gum, agar, agarose, mannan, curdlan, etc. Arginic acid or its salts, gum arabic, pectin, quinceed, starch, algae colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acids or their salts, ribonucleic acid or its salts, casein, collagen, gelatin, albumin, fibroin, Examples thereof include water-soluble proteins such as elastin, keratin and sericin, hyaluronic acid or a salt thereof, and mucopolysaccharides such as chondroitin sulfate.

Examples of clay minerals include laponite, bentonite, smectite kaolinite, and montmorillonite.

In the present invention, one or more of the above thickeners can be used, but among the above thickeners, those having high solubility or dispersibility in the first agent can be used. It is preferable because the second agent can be uniformly dissolved or dispersed without causing lumps, and the rough feeling of the skin caused by the undissolved component or the undispersed component can be alleviated. Here, the quality of the solubility in the first agent is determined by the fact that when the first agent at about room temperature is added and stirred, the external preparation for skin is instantly dissolved in the first agent or dispersed and uniformly dissolved. It can be judged from the fact that it has a sufficient viscosity to retain carbon dioxide gas and that lumps do not occur at the time of dissolution or dispersion.

Examples of such thickeners include carboxyvinyl polymers, carboxymethyl celluloses or salts thereof, polyvinyl alcohols, sodium polyacrylate, acrylate / alkyl methacrylate copolymers, xanthan gum, succinoglycans, carrageenan, guar gum, and locusts. Bean gum, celluloses, galactan, arabic gum, tragant gum, tamarind gum, agar, mannan, curdran, alginic acid or its salts, collagen, gelatin, albumin, etc. can be mentioned, carboxymethyl cellulose or its salts, xanthan gum, carrageenan, etc. It is preferable to use tamarind gum and albumin. As the thickener, one kind or two or more kinds can be used. When two or more kinds are used, it is preferable to use a water-soluble protein from the viewpoint of retention of generated carbon dioxide gas and foam quality due to carbon dioxide gas, and it is possible to use the water-soluble protein in combination with other thickeners. More preferred. As the water-soluble protein, collagen, gelatin and albumin are preferable.

The amount of the thickener to be blended can be appropriately adjusted according to the blending ratio with the first agent, but 1% or more is preferable, 3% or more is more preferable, and 5% or more is particularly preferable in the second agent. preferable. Further, 90% by mass or less is preferable, 80% by mass or less is more preferable, and 70% by mass or less is particularly preferable. If the above content is low, when the first agent and the second agent are mixed, a feeling of roughness due to the undissolved component or the undispersed component is likely to occur, so that the feeling of use is impaired. In addition, it tends to drip during use and lacks adhesion to the skin, and the ability to retain the generated carbon dioxide gas is also inferior, so that a sufficient blood circulation promoting effect cannot be obtained. On the other hand, if the content of the thickener exceeds the above range, the solubility and dispersibility in the second agent are inferior, lumps are generated, and discomfort occurs when applied to the skin, or the content of the thickener is higher than that of the first agent. Since the viscosity after mixing is too high, it becomes difficult to apply it to the skin or wash it off. In addition, the generation of carbon dioxide gas becomes uneven, and the holding capacity of the generated carbon dioxide gas is not so high, so that a sufficient blood circulation promoting action cannot be obtained.

Excipients can be used as the second agent if necessary. Excipients that can be used can be excipients that can be used in cosmetics, external medicines, quasi-drugs, and the like. Specific examples include glucose, maltitol, lactose, dextrin, starch, talc, silica and the like, with glucose, dextrin and starch being preferred.

<Kit for external preparations for skin>
As described above, the kit for external preparations for skin of the present invention contains a first agent containing an acidic substance and water, and a second agent containing a carbon dioxide gas generating substance and a thickener. Preferably, it comprises a first agent containing at least one of an acidic substance, water, a thickener and a moisturizer, and a second agent containing a carbon dioxide gas generating substance and a thickener. The kit of the present invention can improve storage stability by using an acidic substance and a carbon dioxide gas generating substance as separate agents. In addition, by using a thickener or a moisturizer in combination with the first agent, the effect and usability when used as an external preparation for skin can be improved at the same time. In particular, by containing a thickener in both the first agent and the second agent, it is possible to increase the strength of the bubbles, so that a foaming aid having a function of keeping the foam stable for a long time is used. As is clear from Example 2 described later, not only the effect of improving the skin condition such as moisturizing feeling, brightness, and redness of the skin, but also the ease of mixing, the ease of application, and the difficulty of dripping during use. It has the effect of improving usability. In particular, when the thickener is contained only in the first agent, as is clear from Comparative Example 1, not only the foaming amount of carbon dioxide gas is reduced, but also the usability such as ease of mixing, ease of application, and ease of removal is achieved. Also gets worse. When a thickener is used for both the first agent and the second agent in the present invention, the thickeners used may be the same or different.

<External skin preparation>
The effervescent skin external preparation obtained by using the kit of the present invention includes other active ingredients, preservatives, pH adjusters, fats and oils, in addition to the ingredients contained in the first and second agents, depending on the application and purpose. Surfactants such as fragrances, colorants, antioxidants, antibacterial and antifungal agents, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, inorganic salts, lubricants, One or more of the components usually used for external preparations for skin such as a solvent can be used. In this case, the component to be added can be used for either the first agent or the second agent, or may be used for either agent.

Hereinafter, typical components other than acidic substances, carbon dioxide gas generating substances, thickeners, and moisturizers contained in the effervescent skin external preparation obtained by using the kit of the present invention will be further described.

The active ingredient used in the present invention is not particularly limited, and drugs, plants and the like used in cosmetics, external medicines, quasi-drugs and the like can be used depending on the purpose. Representative examples include glycyrrhizic acid and its derivatives and their salts, glycyrrhetinic acid and its derivatives and their salts, mephenamic acid, phenylbutazone, indomethacin, ibprofen, ketoprofen, allantin, guaiazulene, pantenol, etc. Anti-inflammatory agents such as allantin, ascorbic acid and its derivatives and their salts, cysteine and its derivatives and their salts, glabridin, glabrene, liquiritin, isoliquilithin, placenta, hydroquinone and its derivatives, resorcin and its derivatives, whitening agents such as glutathione , Anti-fat leaking agents such as sulfur and thiantolol, bactericides such as salicylic acid and aubaku extract, tocopherols and their derivatives, plant components such as licorice, aloe and tea leaves, hormones such as estradiol and the like. When using plant components, the whole plant, leaves (leaf blades, petioles, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tubers, etc. Can be used as it is by cutting, crushing, crushing, exploiting, extracting and using, or these treated products can be dried or powdered and used. The active ingredient used in the present invention can be used for both the first agent and the second agent.

When the extract is used in the present invention, the solvent used for the extraction is, for example, water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol. , Glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, acetone and other organic solvents. These can be used alone or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof, which are harmless to the human body, as the extraction solvent. The extraction may be performed as long as it is below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. When the extract is used in the second agent of the present invention, the extract may contain water used as an extraction solvent, but when used as a component of the second agent, it may contain substantially no water. preferable. Here, substantially free of water means that the second agent does not contain the amount of water required to deteriorate the quality during storage.

Examples of the surfactant used in the present invention include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. As the surfactant, either a synthetic surfactant or a natural surfactant can be used, but from the viewpoint of skin safety, the natural surfactant is preferable. The term "natural surfactant" as used herein refers to a substance having a surface-active effect mainly derived from animals or plants, and specific examples thereof include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, and ceramide. Examples thereof include sphingolipids such as glycyrrhizinate, bile acids, and plant-extracted amino acid-based surfactants. Among them, it is preferable to contain an extract containing phospholipid, saponin, sphingolipid, pectin, and glycyrrhizate, and it is particularly preferable to contain an extract containing saponin. As the extract containing saponin, it is preferable to use a plant-derived extract. Examples of plants containing saponin include soybeans, azuki beans, green beans, spinach, sugar cane, grapes, kikyo, licorice, polygala senega, ginseng, mukuroji, saponin, ginseng, hechima, tea seeds, enju, liliaceae, and yams. Plants, chimo (common bean), ginseng (wheat gate winter), etc. can be mentioned. In the present invention, as an extract containing saponin, it is preferable to contain an extract of one or more plants selected from soybean, adzuki bean, licorice, mukuroji, and loofah among these plants, and in particular, an extract of mukuroji. Is preferably contained.

The above-mentioned surfactant can keep bubbles longer when used in combination with a thickener. The thickener that can be used in combination is the same as that used for the first agent or the second agent.

<Usage form of topical effervescent skin>
When used to obtain an effervescent skin external preparation, the kit of the present invention causes foaming due to carbon dioxide gas by mixing an appropriate amount of the first agent and the second agent in a container. The first agent and the second agent are preferably mixed at a ratio of 0.1: 1 to 30: 1, more preferably 0.5: 1 to 20: 1, and 1: 1 to 10 It is particularly preferable to mix at a ratio of 1.

As a method for storing the kit of the present invention, a method for storing cosmetics, external medicines, quasi-drugs, etc. can be used, and there is no particular limitation, but the first agent is stored in a state where it blocks water and does not come into contact with it. It is good to be done. The shape of the storage container to be used can be appropriately selected depending on the intended purpose, and examples thereof include a cup shape, a tube shape, a bag shape, a bottle shape, a stick shape, a pump shape, a jar shape, and a canned shape. Further, as the material constituting the storage container, for example, plastic, glass, aluminum, paper, various polymers and the like can be used alone or by selecting two or more kinds, but the material is not limited thereto.

Specific examples of containers include aluminum sticks whose inner surface is laminated with polyethylene terephthalate, storage containers such as aluminum bags, stand pouches with chucks, and polyethylene terephthalate on the inner surface in terms of airtightness, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate whose lid is heat-sealed with an aluminum film or the like laminated with the above is preferable.

<Use of topical effervescent skin>
The effervescent skin external preparation obtained by using the kit of the present invention promotes an increase in skin blood flow, and whitens, improves skin quality, improves freckles, rejuvenates the skin, tightens the skin, partially thins the skin, and relieves the skin. Cleanse, condition the skin, condition the skin, keep the skin healthy, prevent rough skin, tighten the skin, moisturize the skin, keep the skin moisturized and oiled, keep the skin soft, Protects the skin, prevents dryness on the skin, softens the skin, gives the skin firmness, gives the skin gloss, smoothes the skin, prevents stains and buckwheat due to sunburn, and notices fine wrinkles due to dryness Not only cosmetics aimed at eliminating, but also rough skin, rough skin, prevention of rash, rash, cracks, cracks, acne, oily skin, prevention of shavings, prevention of stains and freckles due to sunburn, sunburn・ The purpose is to prevent burning after snow burning, tighten the skin, cleanse the skin, condition the skin, keep the skin healthy, moisturize the skin, protect the skin, prevent the skin from drying out, etc. , Cosmetics, non-pharmaceutical products, pharmaceuticals and other pharmaceutical products. The external preparation for skin of the present invention is preferably used as a cosmetic or quasi-drug, and more preferably used as a cosmetic such as a milky lotion, a cream, a pack, a peeling agent, or a medicated cosmetic. Among them, it is preferable to use it as a pack agent because it has a good usability and it is easy to obtain a high skin condition improving effect in a short time as compared with a type using a composition having a high viscosity.

When the effervescent skin external preparation obtained by using the kit of the present invention is used as a packing agent, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover a desired portion. By applying to a thickness of 0.2 mm or more, the effect of improving the skin condition by carbon dioxide can be obtained. The usage time may be 1 minute or longer, preferably 3 minutes or longer, and more preferably 5 minutes or longer. After the application is completed, it may be wiped off, rinsed with water or the like, or both.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the scope of the present invention is not limited to these Examples. In each of the following Examples and Comparative Examples, commercially available raw materials were used unless otherwise specified.

<Manufacturing of effervescent skin external preparation>
The kit of the present invention was produced according to the composition shown in Table 1.

Examples 1-2, Comparative Example 1
[First agent]
Purified water was added to the beaker, then the raw materials described in the first agent were added and stirred to obtain the first agent of a liquid or viscous composition.
[Second agent]
The raw materials described in the second agent were mixed to obtain a powdered first agent.

<Characteristic evaluation of effervescent skin external preparation>
The characteristics of the effervescent skin external preparations obtained in Examples 1 and 2 and Comparative Example 1 were evaluated according to the following procedure.
[Evaluation example 1. Evaluation of second agent viscosity]
In the second agent shown in Table 1, the viscosities of Examples 1 and 2 and Comparative Example 1 were measured using a viscometer (RVT type manufactured by Brookfield). The results are shown in Table 2.

[Evaluation example 2. Evaluation of foaming amount]
The first agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, the second agent was added thereto, and the mixture was stirred 20 times in 10 seconds. The amount of each used was the mass shown in Table 1. The volume immediately after stirring was measured, and the rate of increase in volume with respect to the volume before stirring was measured. The results are shown in Table 2.

[Evaluation example 3. Skin condition measurement before and after use]
An effervescent skin external preparation was prepared using the kit of the present invention obtained in Examples 1 and 2 and Comparative Example 1, and the amount of water in the stratum corneum before and after the use of the obtained effervescent skin external preparation (measurement device: SKICON-200EX) was measured.
The inside of the forearms of the subjects (three women in their twenties to thirties) was washed with a cleanser and spent 15 minutes at rest in the measurement room. Next, the measurement before using the effervescent skin external preparation was performed. Next, the above effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent external preparation for skin was removed and washed with water. After 15 minutes had passed after washing, the measurement was performed after using the effervescent skin external preparation. The subject spent a rest in the measurement room during the measurement.
The results of skin condition measurement after use are shown in FIG. The value is a relative value when 1 is set before use.

[Evaluation example 4. Evaluation of usability of topical effervescent skin]
An effervescent skin external preparation was prepared using the kit of the present invention obtained in Examples 1 and 2 and Comparative Example 1, and Table 4 shows the use and post-use of the obtained effervescent skin external preparation. The items shown were evaluated.
First, the inside of the forearms of the subjects (three women in their twenties to thirties) was washed with a cleanser and spent 15 minutes at rest. Next, the above effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent external preparation for skin was removed and washed with water. After that, a questionnaire was conducted on eight items (1) to (8) in Table 4. The evaluation of the questionnaire is based on Example 1 for the following items (1) to (8), and the case equivalent to Example 1 is 4 (neither), and 1 (bad) to 7 (good). The evaluation was made on a 7-point scale, and the average score of 3 people was calculated. The subject spent a rest in the measurement room during the measurement.

From Table 2, it can be seen that Examples 1 and 2 are liquid compositions in which the second agent is not viscous and exhibits excellent fluidity. In addition, the amount of carbon dioxide generated was more than double in Examples 1 and 2 as compared with Comparative Example 1. From this, it can be seen that the amount of foaming in Examples 1 and 2 is larger than that in Comparative Example 1 in an extremely short time of 10 seconds.
As for the condition of the skin after use in FIG. 1, good results were obtained in the order of Example 2> Example 1> Comparative Example 1 in terms of the water content of the stratum corneum. That is, it was found that Examples 1 and 2 are more effective in improving the condition after use than in Comparative Example 1, and in particular, the effect is higher in Example 2 in which the first agent is used in combination with the thickener. You can see that it keeps the skin fresh.
Further, from Table 3, it can be seen that the effervescent skin external preparation obtained by using the kit of the present invention is highly evaluated at the time of use as compared with Comparative Example 1. In particular, it is easy to mix when mixing the first and second agents, it is hard to drip, it is easy to remove after use, you can feel an appropriate irritation at the time of foaming, and the skin becomes moist and bright after use. Since the effect of confirming the redness and warmth of the skin has been obtained, it can be seen that the user can easily use the skin and the effect on the skin is high.
From the above results, it was found that the effervescent external preparation for skin obtained by using the kit of the present invention is easy for the user to use and has a high effect on the skin. It can be seen that when a thickener is used in combination, the effect is remarkable.

<Manufacturing of effervescent skin external preparation>
The kit of the present invention was produced according to the composition shown in Table 4.

Example 3

<Characteristic evaluation of effervescent skin external preparation>
The characteristics of the effervescent skin external preparation obtained in Example 3 above were evaluated according to the following procedure.
[Evaluation example 1. Evaluation of first agent viscosity]
In the second agent shown in Table 1, the viscosity of Example 3 was measured using a viscometer (RVT type manufactured by Brookfield). The results are shown in Table 5.

[Evaluation example 2. Evaluation of foaming amount]
27 g of the second agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, 9 g of the first agent was added thereto, and the mixture was stirred 20 times for 10 seconds. The volume after 1 minute, 10 minutes, and 20 minutes was measured, and the rate of increase in volume with respect to the volume before stirring was measured. The result is shown in FIG.

[Evaluation example 3. Skin condition measurement before and after use]
An effervescent skin external preparation was prepared using the kit of the present invention obtained in Example 3 above, and the amount of water in the stratum corneum (measuring device: SKICON-200EX) before and after the use of the obtained effervescent skin external preparation was measured. did.
The inside of the forearms of the subjects (three women in their twenties to thirties) was washed with a cleanser and spent 15 minutes at rest in the measurement room. Next, the measurement before using the effervescent skin external preparation was performed. Next, the above effervescent skin external preparation was applied to the measurement site and allowed to stand for 10 minutes. Next, the effervescent external preparation for skin was removed and washed with water. After 15 minutes had passed after washing, the measurement was performed after using the effervescent skin external preparation. The subject spent a rest in the measurement room during the measurement.
Table 5 shows the results of skin condition measurement after use. In Table 5, the water content of the stratum corneum represents a comparative value of 1 before the use of the effervescent skin external preparation. The larger the value, the better the water content of the stratum corneum.

From Table 5, it can be seen that Example 3 is a liquid composition in which the second agent is not viscous and exhibits excellent fluidity. Further, from FIG. 2, the volume increase rate of the effervescent skin external preparation obtained by using the kit of Example 3 is maintained at 400% or more even after 10 minutes after mixing, and the generated carbon dioxide gas is efficiently used. You can see that it can be held.
As for the skin condition after the use of the effervescent skin external preparation obtained by using the kit of Example 3, the result that the water content of the stratum corneum was good was obtained from Table 5. That is, it can be seen that Example 3 is effective in improving the condition after use, and that the combined use of water and a moisturizer keeps the skin fresh.
From the above, it can be seen that the kit of the present invention containing an acidic substance, water, and a moisturizer as the first agent achieves both retention of carbon dioxide gas and improvement of skin condition.

Specific examples of the formulation of the kit of the present invention are shown below. Both the first agent and the second agent can be produced by the same production method as that of Example 1 or a general cosmetic production method.

With the formulations shown in Table 6, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit in a ratio of 3: 1, an effervescent skin external preparation can be obtained.

Example 4

With the formulations shown in Table 7, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit at a ratio of 5: 1, an effervescent skin external preparation can be obtained.

Example 5

With the formulations shown in Table 8, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. A foaming skin external preparation can be obtained by mixing the first agent and the second agent of the obtained kit at a ratio of 2: 1.

Example 6

With the formulations shown in Table 9, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. A foaming skin external preparation can be obtained by mixing the first agent and the second agent of the obtained kit at a ratio of 2: 1.

Example 7

With the formulations shown in Table 10, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. A foaming skin external preparation can be obtained by mixing the first agent and the second agent of the obtained kit at a ratio of 2: 1.

Example 8

With the formulations shown in Table 11, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit in a ratio of 5: 2, an effervescent skin external preparation can be obtained.

Example 9

With the formulations shown in Table 12, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit in a ratio of 3: 1, an effervescent skin external preparation can be obtained.

Example 10

With the formulations shown in Table 13, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit in a ratio of 3: 1, an effervescent skin external preparation can be obtained.

Example 11

With the formulations shown in Table 14, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit at a ratio of 4: 1, an effervescent external preparation for skin can be obtained.

Example 12

With the formulations shown in Table 15, a kit for external preparation for effervescent skin was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit at a ratio of 9: 1, an effervescent skin external preparation can be obtained.

Example 13

As is clear from the above studies, the kit of the present invention is easy to mix uniformly, and has the effect of evenly generating carbon dioxide gas during use. Furthermore, it can be seen that the use of the effervescent skin external preparation obtained by using the kit of the present invention has the effect of keeping the skin white and fresh.

Claims (1)

A kit for obtaining an effervescent skin external preparation for use as a packing agent, in which the first agent is an acidic substance, water and a thickener (excluding hydrophobic modified alkyl cellulose and sclerothium gum ). A composition containing 30,000 mPa · s or less and having a second agent reacting with the acidic substance to generate carbon dioxide gas and a thickener (however, hydrophobized modified alkyl cellulose and thickener). A kit characterized by being a composition containing (excluding sclerothium gum).

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