JP7157488B2 - Kits for topical skin preparations - Google Patents

Description

The present invention is a kit for obtaining an effervescent external skin preparation, wherein the first agent is a composition containing a carbon dioxide generating substance, a gelling agent and water, and the second agent is an acid, water and a polyhydric It relates to a kit characterized by being a composition containing alcohol.

Since carbon dioxide gas acts on the skin to promote blood circulation in the skin, various external preparations for skin using carbon dioxide gas have been proposed. Many of these generate carbon dioxide through the reaction between an acid and a carbon dioxide-generating substance. For example, in order to maintain the effect of generated carbon dioxide, a method has been proposed in which a water-containing viscous composition containing acid, water and a thickening agent is mixed with a solid carbon dioxide generating substance just before use. (Patent Document 1). In addition, granules containing a substance that produces an acid when hydrolyzed, a carbonate, a thickener, a gelling agent that gels with calcium ions, and a water-insoluble or sparingly water-soluble calcium salt are mixed with water just before use. A method of using is proposed (Patent Document 2). A method using a composition that gels with xyloglucan and a polyhydric alcohol has also been proposed.

WO99/24043 WO2006/80398 JP 2014-181192 A

However, when carbon dioxide gas is generated by the method described in Patent Document 1, it is difficult to uniformly mix the water-containing viscous composition and the solid carbon dioxide-generating substance, and the carbon dioxide gas tends to cause uneven foaming. takes time to start. In addition, the method described in Patent Document 2 is troublesome for the user because it takes time and effort to measure water, and the viscosity and the amount of carbon dioxide generated during use are not constant depending on the quality of the water used. , the effect will be different for each use. In addition, in the method described in Patent Document 3, although it is easy to remove after use, it is difficult to obtain the effect of carbon dioxide gas because the composition has a high viscosity and is designed to easily gel.

The present invention has been devised in view of the above circumstances, and an object thereof is to provide a kit for obtaining an effervescent topical preparation for skin of constant quality, which is easily and uniformly mixed during mixing, generates carbon dioxide gas evenly, and has a constant quality.

The present invention provides a kit for obtaining the following foaming external preparation for skin (hereinafter also referred to as the kit of the present invention).
<1> A kit for obtaining an effervescent external preparation for skin, containing a carbon dioxide-generating substance, an acid, a gelling agent, a polyhydric alcohol and water, and any of the following (A) or (B) A kit in the form of:
(A) A composition in which the first agent contains a carbon dioxide generating substance, a gelling agent and water, and the second agent contains an acid, water and a polyhydric alcohol.
(B) A composition in which the first agent contains an acid, a gelling agent and water, and the second agent contains a carbon dioxide generating substance, water and a polyhydric alcohol.
<2> The kit according to <1>, wherein the gelling agent of the first agent is tamarind gum.
<3> The kit according to any one of <1> or <2>, wherein the second agent is a liquid composition.
<4> The kit according to any one of <1> to <3>, wherein the first agent has a viscosity of 100 mPa·s or more.
<5> The kit according to any one of <1> to <4>, wherein the second agent has a viscosity of 20,000 mPa·s or less.

According to the present invention, it is possible to provide a kit that is easy for the user to mix uniformly during mixing, that readily generates carbon dioxide without unevenness, that is easy to obtain the effect of carbon dioxide, and that is easy to remove after use. In addition, by using the foaming external preparation for skin obtained by using the kit of the present invention as a pack, it is possible to obtain a skin condition improving effect, particularly a whitening effect in a short period of time.

The present invention is a kit for obtaining an effervescent external preparation for skin, comprising a carbon dioxide-generating substance, an acid, a gelling agent, a polyhydric alcohol and water, and any one of the following (A) or (B) It relates to a kit characterized in that it is in the form of
(A) A composition in which the first agent contains a carbon dioxide generating substance, a gelling agent and water, and the second agent contains an acid, water and a polyhydric alcohol.
(B) A composition in which the first agent contains an acid, a gelling agent and water, and the second agent contains a carbon dioxide generating substance, water and a polyhydric alcohol.

In the kit of the present invention, the user can appropriately mix the first agent and the second agent at the time of use to cause foaming due to the generation of carbon dioxide gas, and can be applied to the skin. The kit of the present invention is characterized by good storage stability and ease of handling by the user at the time of use by separating the first agent and the second agent. In addition, by containing a gelling agent and a polyhydric alcohol, the gelling agent aggregates due to the dehydration action, and a high-order network is formed by hydrogen bonding between the polyhydric alcohol and the gelling agent. can be easily removed after use. Hereinafter, each component contained in the kit of the present invention and the effervescent external preparation for skin obtained using the kit of the present invention, and a method for producing the same will be described.

The kit of the present invention contains a carbon dioxide generating substance, an acid, a gelling agent, a polyhydric alcohol and water. Details of the present invention are described below.

≪Carbon dioxide generating substances≫
Various materials can be used as the carbon dioxide generating substance used in the present invention without any particular limitation. In addition, the carbon dioxide generating substance to be used is preferably solid, and more preferably granular, fine granular, or powdery from the viewpoint of solubility in water or a moisturizing agent.

Carbon dioxide-generating substances include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, and magnesium hydrogen carbonate. , bicarbonate such as calcium bicarbonate, and the like, and one or more of these are used. Among these, hydrogencarbonate can be preferably used, and sodium hydrogencarbonate is more preferable in that moderate foaming power can be achieved.

The amount of the carbon dioxide-generating substance is preferably 0.05 to 40% by mass, more preferably 0.1 to 35% by mass, and particularly preferably 0.5 to 30% by mass in the first agent or the second agent. . In addition, it is preferably 0.01 to 30% by mass, more preferably 0.05 to 25% by mass, and particularly preferably 0.1 to 20% by mass in the foaming external preparation for skin.

≪Acid≫
The acid used in the present invention may be either an organic acid or an inorganic acid, and one or more of these may be used.

Examples of organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid, or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, and phthalic acid. Acids, dicarboxylic acids such as isophthalic acid and terephthalic acid or their salts, acidic amino acids such as glutamic acid and aspartic acid or their salts, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and the like, and salts thereof; These 1 type(s) or 2 or more types can be used. Among them, citric acid or salts thereof, ascorbic acid or salts thereof, malic acid or salts thereof, succinic acid or salts thereof are preferable from the viewpoint of safety and solubility in the second agent, and citric acid or salts thereof, ascorbic acid Acids or salts thereof are more preferred.

The content of the acid is preferably 0.01 to 40% by mass, more preferably 0.05 to 35% by mass, and particularly preferably 0.1 to 30% by mass in the first or second agent. Also, it is preferably 0.001 to 30% by mass, more preferably 0.005 to 25% by mass, and particularly preferably 0.01 to 20% by mass in the foaming external preparation for skin.

≪Gelling agent≫
The gelling agent used in the present invention has the property of reacting with a polyhydric alcohol to form a gel. Specific examples of gelling agents that can be used include tamarind gum.

The content of the gelling agent in the first agent is preferably 0.01 to 40% by mass, more preferably 0.05 to 35% by mass, and particularly preferably 0.1 to 30% by mass. Also, it is preferably 0.001 to 30% by mass, more preferably 0.005 to 25% by mass, and particularly preferably 0.01 to 20% by mass in the foaming external preparation for skin.

≪Polyhydric alcohol≫
The polyhydric alcohol used in the present invention is not particularly limited as long as it has two or more hydroxy groups in one molecule and can be used in ordinary cosmetics, topical drugs, quasi-drugs, etc. For example, Polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, erythritol , maltitol, mannitol, sorbitol, xylitol and other sugar alcohols, polyglycerin derivatives, sucrose, trehalose and other sugars. Among the above-mentioned polyhydric alcohols, it is preferable to use at least one type of polyhydric alcohol from the viewpoint of the storage stability and production cost of the second agent, and to alleviate irritation to the skin during use, and two or more types are used. is preferred. It is particularly preferred to use at least one of glycerin, diglycerin, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol and polyethylene glycol.

The content of the polyhydric alcohol in the second agent may be 10% by mass or more, preferably 30% by mass or more, and more preferably 30 to 99% by mass. In addition, the polyhydric alcohol is preferably blended in the first agent as well, and when blended, it may be 1% by mass or more, preferably 3 to 50% by mass, more preferably 5 to 30% by mass. Furthermore, the content of the polyhydric alcohol in the foaming external preparation for skin may be 5% by mass or more, preferably 10 to 90% by mass, more preferably 20 to 80% by mass or more, and 30 to 70% by mass. Especially preferred. If the content of the polyhydric alcohol in the foaming external preparation for skin is less than 5% by mass, not only does it become difficult to gel upon use, but also the effect on the skin such as the amount of diffused moisture and elasticity decreases, resulting in poor handling during use. Ease of use, for example, ease of mixing, ease of application, resistance to dripping, ease of removal is impaired.

≪Water≫
As the water used in the present invention, water that can be used in cosmetics, external medicines, quasi-drugs, etc. can be used, but purified water, distilled water, membrane-filtered water, and ion-exchanged water are preferred. In the present invention, each of the first agent and the second agent should be blended in an amount of 0.1% by mass or more, preferably 0.5% by mass or more. Moreover, water may be blended in the foaming external preparation for skin in an amount of 5% by mass or more, preferably 10 to 85% by mass, more preferably 20 to 80% by mass. If the water content is less than 5% by mass, problems such as difficulty in generating carbon dioxide gas and a decrease in the amount of carbon dioxide gas generated when mixed occur, and as a result, it is impossible to obtain a sufficient effect of promoting blood circulation. become unable.

In the present invention, the mixing ratio (mass ratio) of polyhydric alcohol to water in the foaming external preparation for skin is not particularly limited, but is preferably 1:0.05 to 20, more preferably 1:0.1 to 1:0.1. 10, particularly preferably 1:0.5-5. When the blending ratio of water to polyhydric alcohol is less than 0.05, it takes time to dissolve the carbon dioxide generating substance, acid, and thickener in the first and second agents, resulting in poor production efficiency. Not only does it become worse, but the rate of carbon dioxide gas generation due to the reaction between the first agent and the second agent is remarkably lowered. Moreover, since the gelation speed after mixing the first agent and the second agent is fast, the gelation occurs before carbon dioxide gas is generated, making it difficult to obtain the effect of carbon dioxide gas such as blood circulation promoting action. Also, if the water content is more than 20% with respect to the polyhydric alcohol, the gelation after mixing the first agent and the second agent is remarkably retarded, making it difficult to peel off after use, making it difficult for the user to use. .

The first agent of the present invention preferably has a high viscosity. Specifically, the viscosity at 25° C. is preferably 100 mPa·s or more, more preferably 500 mPa·s or more, and particularly preferably 1,000 mPa·s or more. In the present invention, if the viscosity of the first agent is less than 100 mPa·s, the composition after being mixed with the second agent tends to sag and is not only difficult to use. It becomes difficult to obtain the effects of external skin preparations.

It is more preferable that the second agent of the present invention has a low viscosity. Specifically, the viscosity at 25° C. is preferably 20,000 mPa·s or less, more preferably 10,000 mPa·s or less, and particularly preferably 5,000 mPa·s or less. In addition, the second agent of the present invention is preferably liquid, and when it contains a thickener, it is preferably less than 0.2% by mass, and more preferably contains substantially no thickener. . Here, "substantially free of a thickening agent" means that the second agent does not contain a thickening agent, which will be described later. In the present invention, when the viscosity of the second agent exceeds 20,000 mPa s, as is clear from Reference Examples 1 and 2, it is difficult to mix with the first agent, and uneven mixing occurs. Foaming tends to be uneven.

In the present invention, it is preferable that the viscosity of the first agent is 100 mPa·s or more and the viscosity of the second agent is 20,000 mPa·s or less. More preferably, the viscosity of the first agent is 500 mPa s or more, and the viscosity of the second agent is 10,000 mPa s or less, and more preferably the viscosity of the first agent is 1,000 mPa s or more, and The viscosity of the second agent is 5,000 mPa·s or less. By setting the viscosities of the first agent and the second agent within the above range, it is possible to achieve a good balance between the gelling ability of the foaming external preparation for skin and the effect of carbon dioxide gas on the skin. In particular, as is clear from the examples described later, skin conditions such as moistness, elasticity, brightness, redness, smoothness, smoothness, and tightness are improved, and it is easy to mix, easy to apply, and drips when used. It is easy to handle for the user because it is difficult to remove and can be easily peeled off after use.

<External preparation for skin>
The effervescent external preparation for skin produced using the kit of the present invention contains ingredients contained in the first and second agents, as well as other active ingredients, thickeners, moisturizing agents, and preservatives, depending on the application and purpose. Surfactants such as agents, pH adjusters, oils and fats, fragrances, coloring agents, antioxidants, antibacterial and antifungal agents, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants , inorganic salts, lubricants, solvents, and the like, which are commonly used in external preparations for skin, can be used. In this case, the component to be added can be used in either the first agent or the second agent, or may be used in either agent.

Hereinafter, representative ingredients other than acids, carbon dioxide-generating substances, gelling agents, thickeners, and polyhydric alcohols contained in the effervescent external preparation for skin produced using the kit of the present invention are described below. I will explain further.

The active ingredient used in the present invention is not particularly limited, and drugs and plants used in cosmetics, topical drugs, quasi-drugs, etc. can be used depending on the purpose. Representative examples include, for example, glycyrrhizic acid and derivatives thereof and salts thereof, glycyrrhizic acid and derivatives thereof and salts thereof, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, panthenol, Anti-inflammatory agents such as allantoin, ascorbic acid and its derivatives and their salts, cysteine and its derivatives and their salts, glabridin, glabren, liquiritin, isoliquiritin, placenta, hydroquinone and its derivatives, resorcin and its derivatives, whitening agents such as glutathione , sulfur, antiseborrheic agents such as thiantol, fungicides such as salicylic acid and Phellodendron bark extract, tocopherol and its derivatives, plant components such as licorice, aloe vera and tea leaves, and hormones such as estradiol. When using plant ingredients, the whole plant, leaves (leaf blade, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovaries, etc.), stems, rhizomes, roots, tuberous roots, etc. can be used directly by cutting, crushing, pulverizing, squeezing, or extracting, or by drying or pulverizing these processed products. The active ingredient used in the present invention can be used as both the first agent and the second agent.

When extracts are used in the present invention, solvents used for extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol. , glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, and acetone. These can be used singly or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof, which are harmless to the human body, as the extraction solvent. Extraction can be performed at a temperature below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature.

The thickening agent used in the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi-drugs, etc., and synthetic polymers, semi-synthetic polymers, natural high Molecules, clay minerals, etc. can be used. The thickener can be used in both the first agent and the second agent, but is preferably used in the first agent.

Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, alkyl acrylate/methacrylate copolymer, acrylates/alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide/polyacrylamide copolymer, carboxymethyl cellulose, cationic Hydrophilic synthetic polymers such as modified cellulose and Pluronic are included.

Examples of semisynthetic polymers include cellulose derivatives such as carboxymethylcellulose or salts thereof, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide, and the like.

Examples of natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, agar, agarose, mannan, curdlan, alginic acid or its derivatives. salts, gum arabic, pectin, quinseed, starch, algecolloid, chondroitin sulfate or its salts, chitosan and its derivatives, and the like. Other natural polymers include nucleic acids or their salts, ribonucleic acids or their salts, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, water-soluble proteins such as sericin, hyaluronic acid or its salts, chondroitin sulfate and the like. Examples include mucopolysaccharides.

Clay minerals include laponite, bentonite, smectite kaolinite, montmorillonite, and the like.

Among the above thickeners, those with high solubility or dispersibility can be used to uniformly dissolve or disperse without causing clumps of the thickener, and the skin caused by undissolved components and undispersed components It is preferable because it can alleviate the rough feeling of the surface.

Such thickeners include, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, alkyl acrylate/methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, and locust. Examples include bean gum, celluloses, galactan, gum arabic, tragacanth gum, agar, mannan, curdlan, alginic acid or its salts, collagen, gelatin, albumin, etc. Carboxymethylcellulose or its salts, xanthan gum, carrageenan and albumin are used. is preferred. 1 type(s) or 2 or more types can be used for the said thickener.

Surfactants used in the present invention include nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants. Both synthetic surfactants and natural surfactants can be used as surfactants, but natural surfactants are preferred from the viewpoint of skin safety. The term "natural surfactant" as used herein refers to a substance having a surfactant effect, which is mainly derived from animals or plants. Specific examples include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, ceramide, sphingolipids, pectin, glycyrrhizinate, bile acid, plant-extracted amino acid-based surfactants, and the like. Among them, it is preferable to contain an extract containing phospholipids, saponins, sphingolipids, pectin and glycyrrhizinate, and it is particularly preferable to contain an extract containing saponin. A plant-derived extract is preferably used as the saponin-containing extract. Examples of saponin-containing plants include soybean, adzuki bean, kidney bean, spinach, sugar beet, grape, bellflower, licorice, senega, quillaya, soapberry, soapwort, panax ginseng, luffa, tea seed, pagoda, liliaceous plants, and Dioscoreaceae. Plants, Chimo (Chimo), Bakmundo (Barmundong), etc. can be mentioned. In the present invention, the saponin-containing extract preferably contains an extract of one or more plants selected from among these plants, soybean, adzuki bean, licorice, soapberry, and loofah, and especially an extract of soap. It is preferable to contain

When the natural surfactant is used in combination with a thickening agent, air bubbles can be maintained for a longer period of time.

<Usage Form of Effervescent External Skin Preparation>
When the kit of the present invention is used to obtain an effervescent external preparation for skin, the first agent and the second agent are mixed in appropriate amounts in a container to cause foaming by carbon dioxide gas. The first agent and the second agent are preferably mixed in a ratio of 1:0.1 to 1:30, more preferably in a ratio of 1:0.5 to 1:10.

As a method for preserving the kit of the present invention, a method for preserving cosmetics, topical drugs, quasi-drugs, etc. can be used, and there is no particular limitation. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup-like, tube-like, bag-like, bottle-like, stick-like, pump-like, jar-like, and canned-like shapes. Materials constituting the storage container may be selected from, for example, plastic, glass, aluminum, paper, various polymers, and the like, but not limited to these.

Specific examples of containers include storage containers such as aluminum sticks and aluminum bags laminated with polyethylene terephthalate on the inner surface, standing pouches with zippers, and polyethylene terephthalate on the inner surface in terms of airtightness, storage stability of contents, and manufacturing costs. A storage container or the like made of polyethylene terephthalate, the lid of which is heat-sealed with an aluminum film or the like laminated with , is preferred.

<Application of Effervescent External Skin Preparation>
The effervescent topical preparation for skin obtained by using the kit of the present invention promotes an increase in skin blood flow, whitening, improvement of skin quality, improvement of freckles, rejuvenation of skin, tightening of skin, partial thinning of skin, and tightening of skin. Purifies, conditions skin, conditions skin texture, keeps skin healthy, prevents rough skin, tightens skin, provides moisture to skin, supplements and maintains skin moisture and oil, maintains skin flexibility, Protects skin, prevents dry skin, softens skin, gives skin firmness, gives skin luster, smoothes skin, prevents spots and freckles caused by sunburn, makes fine wrinkles caused by dryness stand out In addition to cosmetics aimed at eliminating rough skin, prevention of rough skin, heat rash, frostbite, cracks, chapped skin, acne, oily skin, razor burn, spots and freckles caused by sunburn, sunburn・For the purpose of preventing hot flashes after snow burn, tightening the skin, purifying the skin, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing dryness of the skin, etc. , cosmetics, quasi-drugs, drugs, and other pharmaceuticals. The external preparation for skin of the present invention is preferably used as cosmetics and quasi-drugs, and more preferably used as cosmetics such as emulsions, creams, packs and peeling agents, and medicinal cosmetics. In particular, it is preferable to use it as a pack agent, because it gives a good feeling when used and it is easy to obtain a high skin condition improving effect in a short time.

When the foaming external preparation for skin obtained using the kit of the present invention is used as a pack, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover the desired site. By applying it to a thickness of 0.2 mm or more, it is possible to obtain the skin condition improving effect of carbon dioxide gas. Also, the usage time may be 1 minute or longer, preferably 3 minutes or longer, and more preferably 5 minutes or longer. After the application is completed, it may be wiped off, washed away with water or the like, or both may be performed.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the scope of the present invention is not limited to these Examples. In each of the following examples and reference examples, commercially available raw materials were used unless otherwise specified.

<Production of Effervescent External Skin Preparation>
A kit of the present invention was produced according to the composition shown in Table 1.

Examples 1-8, Reference Examples 1-3
[First agent]
Purified water was added to the beaker, then the raw materials described in the first agent were added and stirred to obtain the first agent.
[Second agent]
Purified water was added to the beaker, then the raw materials described in the second agent were added and stirred to obtain the second agent.

<Evaluation of characteristics of foaming external preparation for skin>
The properties of the foaming external preparations for skin obtained in Examples 1 to 3 and Reference Examples 1 to 3 were evaluated according to the following procedures.
[Evaluation example 1. Evaluation of second agent viscosity]
In the second agent shown in Table 1, the viscosities of Examples 1 to 8 and Reference Examples 1 to 3 at 25° C. were measured using a viscometer (RVT model manufactured by Brookfield). Table 2 shows the viscosity results of the first agent, and Table 3 shows the viscosity measurement results of the second agent.

[Evaluation example 2. Measurement of skin condition before and after use]
Using the kits of the present invention obtained in Examples 1 to 8 and Reference Examples 1 to 3, a foaming skin external preparation was prepared, and the stratum corneum water content (measurement Equipment: SKICON-200EX), water loss (measuring equipment: TewameterTM300), color difference (measuring equipment: color difference meter) and elasticity (measuring equipment: Cutometer MPA580) were measured.
The subjects (two females in their thirties) washed the insides of their forearms with facial cleanser and sat quietly in the measurement room for 15 minutes. Next, measurements were taken before using the foaming external preparation for skin. Next, the foaming external preparation for skin prepared by mixing the first agent and the second agent at a ratio of 2:1 was applied to the measurement site and allowed to stand for 10 minutes. The effervescent topical skin preparation was then removed and wiped off with a cloth lightly dampened with water. After 15 minutes from washing, the measurement after using the foaming external preparation for skin was performed. During the measurement, the subject sat quietly in the measurement room.
Table 4 shows the skin condition measurement results after use. Table 4 shows the measurement results of stratum corneum water content, water loss, color difference and elasticity. Table 4 shows comparative values with the value before use of the effervescent topical skin preparation set to 1. A higher value for the moisture content in the stratum corneum indicates that the skin is more moist, while a lower value for the moisture loss indicates that the barrier function is in place and a better result is obtained. The higher the elasticity value, the more firm the skin.

[Evaluation example 3. Evaluation of feeling of use of effervescent external preparation for skin]
Using the kits of the present invention obtained in Examples 1 to 8 and Reference Examples 1 to 3, foaming external skin preparations were prepared, and when and after use of the resulting foaming skin external preparations, Table 5 and the items shown in Table 6 were evaluated.
First, the insides of the forearms of the subjects (two women in their thirties) were washed with a facial cleanser and rested for 15 minutes. Next, the foaming external preparation for skin prepared by mixing the first agent and the second agent at a ratio of 2:1 was applied to the measurement site and allowed to stand for 10 minutes. The effervescent topical skin preparation was then removed and wiped off with a cloth lightly dampened with water. After that, a questionnaire was conducted on the 8 items in Table 5 and the 7 items in Table 6. In the evaluation of the questionnaire, the following items were evaluated on a 7-point scale from 1 (very bad) to 7 (very good), and the average score was calculated. During the measurement, the subject sat quietly in the measurement room.

From Table 2, in Examples 1 to 8, the viscosity of the first agent is 500 mPa·s or more and the viscosity of the second agent is 20,000 mPa·s or less. On the other hand, in Reference Examples 1 and 2, the viscosity of the first agent is 500 mPa s or more, but the viscosity of the second agent is 20,000 mPa s or more, and in Reference Example 3, the viscosity of the first agent is 500 mPa s. In addition, it can be seen that the viscosity of the second agent is 20,000 mPa·s or less.
From Table 4, the condition of the skin after use, the water content of the stratum corneum is Example 7>Example 5>Example 8>Example 6>Example 3>Example 4>Example 2>Example 1>Reference Good results were obtained in the order of Example 1>Reference Example 2>Reference Example 3, and the amount of water loss was Example 7>Example 3>Example 5>Example 4>Example 2>Example 6>Example 8. > Example 1 > Reference Example 3 > Reference Example 2 > Reference Example 1 gave good results, and the color difference was obtained in Example 6 > Example 8 > Example 7 > Example 5 > Example 4 > Example 3 > Example 2 > Example 1 > Reference Example 2 > Reference Example 1 > Reference Example 3 gave good results, and the elasticity of Example 6 > Example 8 > Example 4 > Example 5 > Example 7 >Example 3>Example 1>Example 2>Reference Example 1>Reference Example 3>Reference Example 2, in this order, good results were obtained. That is, it was found that Examples 1 to 8 are more effective in improving the condition after use than Reference Examples 1 to 3. It can be seen that the effect is enhanced, that is, the skin is kept fresh, the barrier function is improved, and the skin becomes white and firm.
Moreover, from Table 5, it can be seen that the effervescent external preparation for skin obtained using the kit of the present invention is highly evaluated during use as compared with Reference Examples 1-3. In particular, it can be seen that the first part and the second part are easy to mix, easy to apply after mixing, not easy to drip, and easy to peel off after use.
In addition, from Table 6, the effects of confirming the moist feeling, elasticity, brightening of the skin, redness of the skin, smoothness of the skin, smoothness, and tightening after use are obtained, so it is easy for users. It can be seen that it is easy to use for skin and has a high effect on the skin.
From the above results, it can be seen that the foaming external preparation for skin obtained by using the kit of the present invention is easy for the user to use and is highly effective on the skin.

Specific formulation examples of the kit of the present invention are shown below. Both the first agent and the second agent can be produced by the same production method as in Example 1 or by a general cosmetic production method.

Example 9

An effervescent skin preparation kit was prepared in the same manner as in Example 1 using the formulation shown in Table 7. By mixing the first agent and the second agent of the obtained kit at a ratio of 1:1, a foaming external preparation for skin can be obtained.

Example 10

Using the formulation shown in Table 8, an effervescent skin preparation kit was prepared in the same manner as in Example 1. By mixing the first agent and the second agent of the obtained kit at a ratio of 3:1, a foaming external preparation for skin can be obtained.

Example 11

An effervescent kit for external skin preparation was prepared in the same manner as in Example 1 using the formulation shown in Table 9. By mixing the first agent and the second agent of the obtained kit at a ratio of 1:1, a foaming external preparation for skin can be obtained.

Example 12

An effervescent skin external preparation kit was prepared in the same manner as in Example 1 using the formulations shown in Table 10. By mixing the first agent and the second agent of the obtained kit at a ratio of 2:1, a foaming external preparation for skin can be obtained.

As is clear from the above studies, the kit of the present invention is easy to mix uniformly, and has the effect of generating carbon dioxide gas evenly during use. Furthermore, it can be seen that the use of the effervescent external preparation for skin obtained by using the kit of the present invention has the effect of keeping the skin fresh, improving the barrier function, and providing white and firm skin.

Claims (1)

A kit for obtaining an effervescent external preparation for skin, comprising a carbon dioxide-generating substance, an acid, a gelling agent, a polyhydric alcohol and water, the first agent having a viscosity of 5200 to 430300 mPa s, and the second agent A kit characterized in that the agent has a viscosity of 2740 mPa·s or less and is in the form of either (A) or (B) below.
(A) A composition in which the first agent contains a carbon dioxide generating substance, a gelling agent and water, and the second agent contains an acid, water and a polyhydric alcohol.
(B) A composition in which the first agent contains an acid, a gelling agent and water, and the second agent contains a carbon dioxide generating substance, water and a polyhydric alcohol.