JP2016008181A - Kit for skin external preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a kit that facilitates uniform mixture at the time of mixing and produces carbon dioxide without unevenness, for obtaining foamable skin external preparations of constant quality by saving a user the trouble of weighing and regardless of the quality of water to be used.SOLUTION: A kit for obtaining a foamable skin external preparation is characterized in that a first agent is a composition comprising acidic substance and water, and a second agent is a composition comprising carbon dioxide producing substance that reacts with the acidic substance to produce carbon dioxide and thickener.

Description

  The present invention is a kit for obtaining a foamable skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide. The present invention relates to a kit comprising a composition containing a carbon dioxide generating substance and a thickener.

  When carbon dioxide acts on the skin, there is an effect of promoting blood circulation in the skin. Therefore, various skin external preparations using carbon dioxide have been proposed. Many of these generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. For example, in order to maintain the effect of the generated carbon dioxide gas, a method of using a hydrous viscous composition containing an acidic substance, water and a thickening agent and a solid carbon dioxide gas generating substance immediately before use has been proposed. (Patent Document 1). In addition, it is mixed with water immediately before use in a granular material containing a substance that is hydrolyzed to produce an acid, carbonate, thickener, gelling agent that gels with calcium ions, and water-insoluble or poorly water-soluble calcium salt. A method of use has been proposed (Patent Document 2).

WO99 / 24043 WO 2006/80398

  However, when carbon dioxide is generated by the method described in Patent Document 1, it is difficult to uniformly mix the water-containing viscous composition and the solid carbon dioxide-generating substance. Takes time to start. In addition, the method described in Patent Document 2 is troublesome for the user because it takes time to measure water, and the viscosity and carbon dioxide generation amount during use are not constant depending on the quality of the water used. The effect will be different for each use.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a kit for obtaining a foamable skin external preparation of constant quality, which is easily mixed uniformly during mixing, generates carbon dioxide gas uniformly, and is of a uniform quality.

The present invention provides a kit for obtaining the following foamable skin external preparation (hereinafter also referred to as a kit of the present invention).
<1> A kit for obtaining an external preparation for foaming skin, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide. A kit comprising a gas generating substance and a thickener.
<2> The kit according to <1>, wherein the first agent further contains at least one of a thickener or a humectant.
<3> The kit according to any one of <1> and <2>, wherein the first agent is a composition having a viscosity of 10,000 mPa · s or less.
<4> The kit according to any one of <1> to <3>, wherein the second agent is a solid composition.
<5> The first agent and the second agent are mixed and used at a weight ratio in the range of 0.1: 1 to 30: 1, and any one of <1> to <4> kit.

  ADVANTAGE OF THE INVENTION According to this invention, a user can provide the kit for obtaining a foaming skin external preparation of a fixed quality which it is easy to mix uniformly at the time of mixing, a carbon dioxide gas generate | occur | produces immediately, and is uniform. Moreover, quality can be kept stable by mix | blending an acidic substance with a 1st agent and mix | blending a carbon dioxide generating substance with a 2nd agent. In particular, it is not necessary to add a storage stabilizer or an antioxidant in order to prevent quality deterioration, or to limit the storage container to a specific one, and it is possible to manufacture at a low cost. Furthermore, by using the foamable skin external preparation obtained using the kit of the present invention as a pack agent, an effect of improving the skin condition, particularly a whitening effect in a short time can be obtained.

The horny layer moisture content after using the foamable skin external preparation obtained using the kits of Examples 1 and 2 and Comparative Example 1 is shown. The increase rate of the volume by the carbon dioxide gas of the foamable skin external preparation obtained using the kit of Example 3 is shown.

  The present invention is a kit for obtaining a foamable skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide. A kit comprising a carbon dioxide generating substance and a thickener.

  In the kit of the present invention, the user can use the first agent and the second agent by mixing the first agent and the second agent as appropriate to cause foaming due to the generation of carbon dioxide gas and apply it to the skin. The kit of the present invention is characterized by good storage stability by being divided into the first agent and the second agent, and is easy for the user to handle during use. Hereafter, each component contained in the foamable skin external preparation obtained using the kit of this invention and the kit of this invention, and its manufacturing method are demonstrated.

<First Agent>
The first agent (hereinafter also referred to as the first agent) in the kit of the present invention contains an acidic substance and water. Preferably, it contains at least one of an acidic substance, water, and a thickener or humectant.

≪Acid substances≫
The acidic substance used in the first agent of the present invention may be either an organic acid or an inorganic acid, and one or more of these are used.

  Examples of organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid and valeric acid or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid Acids, dicarboxylic acids such as isophthalic acid and terephthalic acid or salts thereof, acidic amino acids such as glutamic acid and aspartic acid or salts thereof, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Examples include acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and other oxyacids or salts thereof, and inorganic acids include phosphoric acid, sulfurous acid and other inorganic acids or salts thereof, These 1 type (s) or 2 or more types can be used. Of these, citric acid or a salt thereof, ascorbic acid or a salt thereof, malic acid or a salt thereof, succinic acid or a salt thereof is preferable, and citric acid or a salt thereof, ascorbine, from the viewpoint of safety and solubility in the second agent. An acid or a salt thereof is more preferable. In the present invention, the acidic substance may be 0.01% by mass or more in the first agent, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and particularly preferably 0.5% by mass or more. . Moreover, 30 mass% or less is preferable, 20 mass% or less is more preferable, and 10 mass% or less is especially preferable. When the acidic substance is less than 0.01% by mass, not only the reaction with the carbon dioxide generating substance is difficult to occur, but also the foamable skin external preparation after mixing with the second agent becomes basic. This can cause skin problems such as irritating skin after use and weakened skin protection. Moreover, when more than 30 mass%, the irritation | stimulation to the skin at the time of using only a 1st agent accidentally is strong, and it is unpreferable from a viewpoint of safety | security.

≪Water≫
As water that can be used in the present invention, water that can be used in cosmetics, topical medicines, quasi drugs, and the like can be used, but purified water, distilled water, membrane filtered water, and ion-exchanged water are preferable. The blending amount may be 5% by mass or more in the first agent, preferably 10% by mass or more, and more preferably 15% by mass or more. If the content is less than 5% by mass, problems such as difficulty in generating carbon dioxide when the first agent and the second agent are mixed, and a decrease in the amount of generated carbon dioxide occur. It becomes impossible to obtain a sufficient blood circulation promoting action.

≪Thickener≫
The first agent of the present invention preferably contains a thickener. When the first agent contains a thickener, the first agent can have an appropriate viscosity in advance. As a result, an excellent foaming amount is obtained, and as is clear from Example 2 described later, the effect of improving the skin condition such as an increase in stratum corneum moisture, moist skin, brightness, redness, and warmth after use. In addition, it improves the feeling of use, such as ease of mixing, ease of dripping, and ease of removal. The content of the thickener contained in the first agent may be 0.001% by mass or more in the first agent, preferably 0.005% by mass or more, more preferably 0.01% by mass, 0.05 mass% or more is particularly preferable. Moreover, what is necessary is just 3 mass% or less, 1 mass% or less is preferable and 0.8 mass% or less is more preferable. When the content of the thickener in the first agent is 0.001% by mass or less, the viscosity of the first agent is too low, so that it is difficult to obtain the blood circulation promoting effect by carbon dioxide gas. Also, if it exceeds 3% by mass, the viscosity of the first agent will be high and difficult to mix, and it will be difficult to remove after use, as well as unevenness in the generation of carbon dioxide gas, Problems such as a decrease in the amount of foaming due to carbon dioxide gas occur, and as a result, sufficient blood circulation promoting action due to carbon dioxide gas cannot be obtained.

  The first agent of the present invention preferably has a low viscosity from the viewpoint of miscibility with the second agent. Specifically, the viscosity at 25 ° C. is preferably 50,000 mPa · s or less, more preferably 30,000 mPa · s or less, particularly preferably 10,000 mPa · s or less, and further preferably 5,000 mPa · s. -S or less. In the present invention, when the viscosity of the first agent exceeds 50,000 mPa · s, it becomes difficult to uniformly disperse the first agent in the second agent which is a viscous composition when mixed with the second agent, and foaming by carbon dioxide gas. Unevenness is likely to occur. In addition, since it takes time until foaming starts, it takes time to obtain a blood circulation promoting effect by using carbon dioxide gas, for example, as a pack agent. Using a low-viscosity liquid composition as the first agent has the effect of brightening the skin and improving the moist feeling, redness, and warmth after use, as will be apparent from Example 2 described later. In addition, it is preferable because the feeling of use such as ease of mixing and ease of application during use is improved.

  As the thickener used in the first agent, for example, synthetic polymers, semi-synthetic polymers, natural polymers, viscosity minerals and the like can be used. Specifically, as synthetic polymers, carboxyvinyl polymer, polyvinyl Hydrophilic synthesis including alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic As the polymer and semi-synthetic polymer, examples of the cellulose derivative include carboxymethyl cellulose or salts thereof, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, Mud hydroxypropyl cellulose, sulfonated cellulose derivatives. Semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide, and the like. Natural polymers include polysaccharides and derivatives thereof such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or its salts, gum arabic, pectin, quinseed, starch, alge colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acid or its salts, ribonucleic acid or its salts, casein, collagen, gelatin, albumin, fibroin, Examples include water-soluble proteins such as elastin, keratin, and sericin, hyaluronic acid or salts thereof, mucopolysaccharides such as chondroitin sulfate, and the like. Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.

  In the present invention, one or more of the above thickeners can be used. Among the above thickeners, it is possible to use one having high solubility or dispersibility in water. This is preferable because it can reduce the feeling of rough skin caused by undissolved components and undispersed components. Here, the solubility in water is such that, when water at room temperature is added and stirred, the external preparation for skin has a sufficient viscosity because it is instantly dissolved in water or dispersed and uniformly dissolved. It can also be determined from the fact that no lumps occur during dissolution or dispersion.

  Examples of such a thickener include carboxyvinyl polymer, carboxymethyl cellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, mannan, curdlan, alginic acid or salts thereof, collagen, gelatin, albumin, etc. can be mentioned, carboxymethylcellulose or salts thereof, xanthan gum, carrageenan, Tamarind gum and albumin are preferably used.

≪Humectant≫
The first agent of the present invention preferably contains a humectant. As the humectant used in the present invention, polyhydric alcohols, saccharides, amino acids, organic acids, sterols, urea, proteins, plant extracts, etc., usually cosmetics, external medicines, quasi drugs, etc. Usable moisturizers can be used. Specific examples include, for example, polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, Polyhydric alcohols such as 3-propanediol, 1,2-pentanediol, sorbitol, polyglycerin derivatives, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidonecarboxylate, almond, avocado, altea, aloe, usvenia oyster, onionis, oats , Licorice, quince seed, clara (kujin), gardenia, grapefruit, watercress, gentiana, gentian pepper, burdock, wheat, saicin, cactus, cactus Saw, Hawthorn, Giant, Shimotsuke, Ginger, Zenihoi, Mulberry, Tychossow, Cordyceps, Dokudami, Hakka, Barley, Hamelis, Rose, Cypress, Buddhist Poppo, Grape, Prunes, Loofah, Bodhi, Hops, Pine, Quince, Melonier, Melonier Plant extracts such as cornflower, lily, lime, lavender, apple, rice and rice bran, black currant, Ibukitorano, Neubara, Ezoukogi, seaweed, etc., and one or more of these can be used . In the present invention, it is preferable to use one or more polyhydric alcohols. By using a moisturizing agent as the first agent, as will be apparent from Example 3 to be described later, there is an effect of keeping the freshness of the skin after use longer while keeping the amount of carbon dioxide generated during use high. . Moreover, it becomes possible to use it as a peeling agent only by the 1st agent by using together with an acidic substance and water.

<Second agent>
The second agent in the kit of the present invention contains a carbon dioxide generating material that reacts with an acidic substance to generate carbon dioxide and a thickener. The second agent may be in any form such as solid, liquid, gel, etc., but is preferably solid from the viewpoint of ease of mixing with the first agent and cost during production. Of these, granular, fine granular and powdery forms are particularly preferred.

≪Carbon dioxide generating substance≫
Various substances can be used as the carbon dioxide generating substance used in the second agent of the present invention without any particular limitation. The carbon dioxide generating substance used is preferably in the form of a solid, from the viewpoint of ease of mixing with other components contained in the second agent and ease of mixing when mixing with the first agent. , Fine particles, and powder are more preferable.

  Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Of these, sodium hydrogen carbonate is more preferable, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The carbon dioxide generating substance is preferably 1% or more, more preferably 3% or more, and particularly preferably 5% or more in the second agent. Moreover, 90 mass% or less is preferable, 80 mass% or less is more preferable, and 70 mass% or less is especially preferable. If the above range is exceeded, the stability of the second agent will deteriorate, the foamability during use will worsen, or the pH when used as a foaming skin external preparation will become strong carbon dioxide generation or strong basicity The irritation to the skin becomes stronger.

  The carbon dioxide generating substance can be used in the second agent as a mixture with other components. Here, when the granules of the carbon dioxide generating material are obtained by granulating the carbon dioxide generating material and other components, the content of the other components is not particularly limited, but is 95% by mass in the granules. It is preferable to make it less than. When other components are present in a content exceeding 95% by mass, foaming properties are lowered, which is not preferable.

  The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc. It can be produced according to a conventional method.

  For example, in the production of granules, a matrix substrate having functions such as granule molding may be used. When a low melting point compound is used as the matrix base, the carbon dioxide generating substance is added to the low melting point compound melted by heating in a container such as a beaker and sufficiently stirred and mixed. You may add an appropriate additive to this as needed. This is further stirred while gradually cooling at room temperature, and is allowed to stand until it hardens. If it hardens to some extent, it may be cooled rapidly in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide generating substance is dissolved or dispersed in this. After thoroughly mixing, heat in an oven to remove the solvent and dry. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.

  As the shape of the carbon dioxide generating substance, for example, an irregular shape, a planar shape, a polyhedron shape, a spherical shape, a drop shape, a fiber shape, a columnar shape, a fine powder shape and the like can be employed without particular limitation. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm or less are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

  The carbon dioxide generating substance may be blended as it is together with the components contained in the second agent, but may be blended so as not to come into physical contact with other components in the same agent and coexist. In this case, for example, either or both of the carbon dioxide generating substance and other components may be provided with a coat layer that wraps them, or either one or both of the carbon dioxide generating substance and other components may be provided. It may be encapsulated. In addition, a layer not containing the carbon dioxide generating substance and other components may be sandwiched between the carbon dioxide generating substance and the component so that they do not come into direct contact with each other, and compression molding may be performed.

  Hereinafter, the coexistence means for coexisting the carbon dioxide generating substance and other components in the same agent will be specifically described, but the invention is not limited thereto.

[Coat layer formation]
As a coating layer forming method, for example, a method of forming a coating layer with at least one of a carbon dioxide generating substance and other components may be used. Providing a coat layer is preferable from the viewpoint of stability and durability of the carbon dioxide generating substance, the other components, and other components in the same agent.

  A preferable coating agent for constituting the coating layer can be used without particular limitation as long as it has low reactivity with the carbon dioxide generating material or the other components. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Examples thereof include copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropylcellulose, wheat starch, polysaccharides (for example, sucrose and lactose), and organic acid salts such as citrate. The coat layer may be formed using solid hydrocarbon wax, solid fat or the like that dissolves at a certain temperature or higher by heating. When the coating layer is formed on the carbon dioxide generating substance, it is preferable that the coating material constituting the coating layer does not hinder the reaction between the acidic substance in the first agent and the carbon dioxide generating substance in the second agent. For example, in a pack agent using polyethylene glycol as a coating layer, it takes time to react with the acidic substance in the first agent, so it takes time to generate carbon dioxide gas, which is excellent in an extremely short time of 10 seconds. A pack agent with foaming power cannot be obtained.

  The amount of the coating agent used for the carbon dioxide generating substance and / or other components is preferably 1 to 20% (w / w), more preferably 1 to 10% (w / w) based on the carbon dioxide generating substance or other components. w) About.

  The coating layer may be coated by any method as long as it is usually used for coating particles. For example, it may be coated at the same time as granulation by spray granulation or tumbling granulation, etc., and the powder or granulated product is coated with oil and fat, granulation coating, transport layer method, pan coating, rolling coating, fluid coating or You may coat | cover using methods, such as dry coating. When excessive heat or physical force is applied during coating, the carbon dioxide generating substance or the other component is destroyed and the generated film is broken, and the surface of the carbon dioxide generating substance or the other component is destroyed. Not only is it difficult to uniformly coat the above-mentioned lipid powder on the whole, but the carbon dioxide gas generating substance or the other component leaks out on the surface and solidifies due to moisture absorption, or it may cause adverse effects on other components at the time of blending. The coating conditions must be such that the coating layer and the coating object are not destroyed.

[Encapsulation]
When encapsulating the carbon dioxide generating substance and / or other components, a known method may be employed without any particular limitation.

  As the encapsulation method, a known method can be applied without any particular limitation. Examples of the encapsulation material include gelatin, starch, gum arabic, methylcellulose, acrylic acid ester, methacrylic acid ester, vinyl acetate, Polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acid, higher alcohol, and the like, and those formed with a multilayer of surfactants such as liposomes are included, but can be widely used without being limited thereto. For example, the basic structure of the capsule is composed of a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, and styrene, or the monomer and acrylic acid, methacrylic acid, divinyl A resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate is also preferable. In such a microcapsule, the contents and the polymer constituent monomer constituting the capsule shell are emulsified in a reaction solvent such as water, and polymerization of azobisisobutyronitrile, benzoyl peroxide, etc. is started. What is necessary is just to add an agent and to perform emulsion polymerization. As a surface active component used for such emulsification, for example, hexlite sold under the name of “Laponite XLG” can be suitably exemplified. The produced microcapsules are separated by means such as centrifugation, and washed if desired, whereby the microcapsules of the present invention can be produced.

[Compression molding]
As a compression molding method, a substance other than the carbon dioxide generating substance and the other components (so that they do not directly contact between the first layer containing the carbon dioxide generating substance and the second layer containing the other ingredients ( For example, a method in which a third layer made of an excipient, a thickener, etc.) is sandwiched and compression molded may be employed. The compression-molded dosage form may be any dosage form as long as it is solid, such as a tablet, sphere, or plate. Here, the carbon dioxide generating substance and the other components to be used may be used as they are, or the carbon dioxide generating substance in which a coating layer is provided on one or more of the first layer and the second layer by the above method. Alternatively, the other component, the encapsulated carbon dioxide generating material, or the other component may be used. The compression molding method is not particularly limited, and a known method can be applied.

  The carbon dioxide generating substance and the other components contained in the first layer and the second layer may be used as they are, or in addition, excipients, thickeners and the like may be mixed and used. . As the excipient, thickener and the like used for the first layer, the second layer and the third layer, those described in the description of the granule can be used without any particular limitation.

≪Thickener≫
The thickener used in the second agent of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi drugs, and the like. Molecules, natural polymers, viscous minerals, etc. can be used.

  Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cation And hydrophilic synthetic polymers such as fluorinated cellulose and pluronic.

  Examples of the semisynthetic polymer include cellulose derivatives such as carboxymethylcellulose or salts thereof, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and sulfonated cellulose derivatives. Examples of other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide, and the like.

  Natural polymers include polysaccharides and derivatives thereof such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or its salts, gum arabic, pectin, quinseed, starch, alge colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acid or its salts, ribonucleic acid or its salts, casein, collagen, gelatin, albumin, fibroin, Examples include water-soluble proteins such as elastin, keratin, and sericin, hyaluronic acid or salts thereof, mucopolysaccharides such as chondroitin sulfate, and the like.

Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.

  In the present invention, one or more of the above thickeners can be used. Among the above thickeners, it is preferable to use one having high solubility or dispersibility in the first agent. The second agent is preferable because the second agent can be uniformly dissolved or dispersed without causing lumps, and the feeling of rough skin caused by undissolved components and undispersed components can be reduced. Here, the quality of the solubility in the first agent is determined by the fact that when the first agent at room temperature is added and stirred, the external preparation for skin is instantly dissolved in the first agent or dispersed and uniformly dissolved. It can be judged from having sufficient viscosity to hold the carbon dioxide gas or not causing lumps during dissolution or dispersion.

  Examples of such a thickener include carboxyvinyl polymer, carboxymethyl cellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, mannan, curdlan, alginic acid or salts thereof, collagen, gelatin, albumin, etc. can be mentioned, carboxymethylcellulose or salts thereof, xanthan gum, carrageenan, Tamarind gum and albumin are preferably used. The said thickener can use 1 type (s) or 2 or more types. When using 2 or more types, it is preferable to use water-soluble protein from the viewpoint of retention of generated carbon dioxide gas and foam quality by carbon dioxide gas, and it is possible to use a combination of water-soluble protein and other thickeners. More preferred. As the water-soluble protein, collagen, gelatin and albumin are preferable.

  The amount of the thickener can be adjusted appropriately according to the blending ratio with the first agent, but is preferably 1% or more, more preferably 3% or more, and particularly preferably 5% or more in the second agent. preferable. Moreover, 90 mass% or less is preferable, 80 mass% or less is more preferable, and 70 mass% or less is especially preferable. If the content is small, a feeling of roughness is likely to occur due to an undissolved component or an undispersed component when the first agent and the second agent are mixed. In addition, it tends to sag during use and lacks adhesion to the skin, and also has a poor ability to retain the generated carbon dioxide gas, so that a sufficient blood circulation promoting effect cannot be obtained. On the other hand, if the content of the thickener exceeds the above range, it is inferior in solubility and dispersibility in the second agent, causing lumps and causing discomfort when applied to the skin, Since the viscosity after mixing is too high, it becomes difficult to apply to the skin or to wash off. In addition, unevenness occurs in the generation of carbon dioxide gas, and the ability to retain the generated carbon dioxide gas is not so high, so that a sufficient blood circulation promoting action cannot be obtained.

  As the second agent, an excipient can be used as necessary. As the excipient that can be used, an excipient that can be used in cosmetics, external medicines, quasi drugs, and the like can be used. Specific examples include glucose, maltitol, lactose, dextrin, starch, talc, silica and the like, with glucose, dextrin and starch being preferred.

<Skin kit for external preparation>
As described above, the kit for external skin preparation of the present invention comprises a first agent containing an acidic substance and water, and a second agent containing a carbon dioxide generating substance and a thickener. Preferably, it consists of a first agent containing at least one of an acidic substance, water, a thickener and a humectant, and a second agent containing a carbon dioxide generating substance and a thickener. In the kit of the present invention, the storage stability can be enhanced by using an acidic substance and a carbon dioxide generating substance as separate agents. Moreover, the effect and usability | use_condition at the time of using as a skin external preparation can be improved simultaneously by using a thickener or a moisturizer together with a 1st agent. In particular, it is possible to increase the strength of the bubbles by containing a thickener in both the first agent and the second agent. As is clear from Example 2 described later, not only the skin moisturizing effect, brightness, redness, and the like, but also the ease of mixing, ease of application, and difficulty of dripping There is an effect of improving the feeling of use. In particular, when the thickener is contained only in the first agent, as is apparent from Comparative Example 1, not only the foaming amount of carbon dioxide gas is reduced, but also the feeling of use such as ease of mixing, ease of application, and ease of removal. Also gets worse. In the present invention, when a thickener is used for both the first agent and the second agent, the thickener used may be the same or different.

<External preparation for skin>
In addition to the components contained in the first agent and the second agent, the foamable type skin external preparation obtained using the kit of the present invention has other active ingredients, preservatives, pH adjusters, fats and oils, Perfume, coloring agent, antioxidant, antibacterial and fungicidal agent, alcohol, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, surfactant, inorganic salt, lubricant, One or more kinds of components that are usually used in external preparations for skin, such as a solvent, can be used. In this case, the component to be added can be used for either the first agent or the second agent, or may be used for either agent.

  Hereinafter, typical components other than the acidic substance, carbon dioxide generating substance, thickener and moisturizer contained in the foamable external skin preparation obtained using the kit of the present invention will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs, plants and the like used in cosmetics, external medicines, quasi drugs and the like can be used according to the purpose. Representative examples include, for example, glycyrrhizic acid and derivatives thereof and salts thereof, glycyrrhetinic acid and derivatives thereof and salts thereof, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, panthenol, Anti-inflammatory agents such as allantoin, ascorbic acid and derivatives thereof and salts thereof, cysteine and derivatives thereof and salts thereof, whitening agents such as grabrizine, glabrene, liquiritin, isoliquiritin, placenta, hydroquinone and derivatives thereof, resorcin and derivatives thereof, and glutathione , Antiseborrheic agents such as sulfur and thiantrol, bactericides such as salicylic acid and agar extract, tocopherols and derivatives thereof, plant components such as licorice, aloe, tea leaves, estradio Hormones, etc. and the like. When using plant components, the whole plant, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc. Can be used by cutting, crushing, crushing, exploiting, extracting, or drying or pulverizing those treated. The active ingredient used in the present invention can be used for either the first agent or the second agent.

  When the extract is used in the present invention, examples of the solvent used for extraction include water; methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and hexylene glycol. And organic solvents such as glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, and acetone. These can be used alone or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof, which is harmless to the human body, as an extraction solvent. The extraction may be performed at or below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature. When the extract is used in the second agent of the present invention, the extract may contain water used as an extraction solvent, but when used as a component of the second agent, the extract is substantially free of water. preferable. Here, “substantially free of water” means that it does not contain a sufficient amount of water to deteriorate the quality during storage of the second agent.

  Examples of the surfactant used in the present invention include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. As the surfactant, either a synthetic surfactant or a natural surfactant can be used, but a natural surfactant is preferable from the viewpoint of safety to the skin. The term “natural surfactant” as used herein refers to a substance having a surfactant effect derived mainly from animals or plants. Specific examples include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, and ceramide. Sphingolipids such as glycyrrhizinate, bile acids, plant-extracted amino acid surfactants and the like. Among these, it is preferable to contain an extract containing phospholipid, saponin, sphingolipid, pectin and glycyrrhizinate, and it is particularly preferred to contain an extract containing saponin. As the extract containing saponin, it is preferable to use a plant-derived extract. Examples of plants containing saponins include soybeans, azuki bean, green beans, spinach, sugar beet, grapes, yellow pepper, licorice, senega, kiraya, mukuroji, bonito, ginseng, loofah, tea seeds, enju, lily family, and genus yam Plants, chimo (my mother), bakumondou (barley winter) and the like. In the present invention, the extract containing saponin preferably contains an extract of at least one plant selected from soybean, azuki bean, licorice, mukuroji and loofah among these plants, and in particular, an extract of mukuroji It is preferable to contain.

  When the surfactant is used in combination with a thickener, the bubbles can be kept longer. The thickener that can be used in combination is the same as that used for the first or second agent.

<Usage form of effervescent skin external preparation>
When using the kit of the present invention to obtain a foamable skin external preparation, foaming by carbon dioxide gas is caused by mixing an appropriate amount of a first agent and a second agent in a container. The first agent and the second agent are preferably mixed at a ratio of 0.1: 1 to 30: 1, more preferably mixed at a ratio of 0.5: 1 to 20: 1. It is particularly preferred to mix at a ratio of: 1.

  As a method for preserving the kit of the present invention, a method for preserving cosmetics, external medicines, quasi drugs, etc. can be used, and there is no particular limitation. Good to have been. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, for example, It is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

<Use of foaming skin external preparation>
The effervescent skin external preparation obtained using the kit of the present invention promotes an increase in skin blood flow, whitening, skin quality improvement, freckles improvement, skin rejuvenation, skin tightening, partial thinning, Cleanse, condition skin, condition skin, keep skin healthy, prevent rough skin, squeeze skin, moisturize skin, supplement skin moisture and oil, maintain skin flexibility, Protects the skin, prevents dryness, softens the skin, gives skin elasticity, glosses the skin, smoothes the skin, prevents spots and freckles due to sunburn, and notices fine wrinkles due to dryness Not only cosmetics intended to eliminate, but also skin, tingling, prevention of ash, moyake, cracks, redheads, acne, oily skin, prevention of razor baldness, sunburn spots and freckles, sunburn・ Snow burn Cosmetics and medicines for the purpose of preventing hot flashes, irritating the skin, purifying the skin, preparing the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing the skin from drying out, etc. It can be suitably used for pharmaceuticals such as quasi-drugs and drugs. The external preparation for skin of the present invention is preferably used as a cosmetic or quasi-drug, and more preferably used as a cosmetic such as an emulsion, cream, pack, or peeling agent, or as a medicated cosmetic. In particular, the use as a pack agent is preferable because the feeling of use is good, and a high skin condition improving effect is easily obtained in a short time as compared with the type using a composition having a high viscosity.

  When the foamable skin external preparation obtained using the kit of the present invention is used as a pack agent, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover a desired site. By applying to a thickness of 0.2 mm or more, the skin condition improvement effect by carbon dioxide gas can be obtained. Moreover, the usage time should just be 1 minute or more, Preferably it is 3 minutes or more, More preferably, it is 5 minutes or more. After the application is completed, it may be wiped off, washed away with water, or both.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples. In the following examples and comparative examples, commercially available products were used unless otherwise specified.

<Manufacture of effervescent skin external preparation>
According to the composition shown in Table 1, the kit of the present invention was produced.

Example 1, Comparative Examples 1-2
[First agent]
Purified water was added to the beaker, then the ingredients described in the first agent were added and stirred to obtain the first agent in a liquid or viscous composition.
[Second agent]
The raw materials described in the second agent were mixed to obtain a powdery first agent.

<Characteristic evaluation of effervescent skin external preparation>
The characteristics of the foamable skin external preparations obtained in Example 1 and Comparative Examples 1 and 2 were evaluated according to the following procedures.
[Evaluation Example 1. Evaluation of second agent viscosity]
In the second agent described in Table 1, the viscosities of Example 1 and Comparative Examples 1 and 2 were measured using a viscometer (Brookfield RVT type). The results are shown in Table 2.

[Evaluation Example 2. Evaluation of foaming amount]
The first agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm. The second agent was added to the bottle and stirred 20 times for 10 seconds. The amount of each used was the mass described in Table 1. The volume immediately after stirring was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The results are shown in Table 2.

[Evaluation Example 3. Skin condition measurement before and after use]
A foamable skin external preparation was prepared using the kits of the present invention obtained in Examples 1 and 2 and Comparative Example 1, and the stratum corneum moisture content before and after use of the obtained foamable skin external preparation (measuring instrument: SKICON-200EX) was measured.
The inside of the forearm of the subjects (three women in their 20s to 30s) was washed with face wash and rested for 15 minutes in the measurement room. Next, measurement was performed before using the foamable skin external preparation. Next, the said foamable skin external preparation was apply | coated to the measurement site | part, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. After 15 minutes from washing, the measurement after using the foamable skin external preparation was performed. The subject was resting in the measurement room during the measurement.
The skin condition measurement results after use are shown in FIG. The value is a relative value when the value before use is 1.

[Evaluation Example 4. Evaluation of Usability of Effervescent Skin Topic Agent]
Table 4 shows the foaming skin external preparations prepared using the kits of the present invention obtained in Examples 1 and 2 and Comparative Example 1 above, and the use and after use of the foaming skin external preparations obtained. The items shown were evaluated.
First, the inside of the forearm of the test subjects (three women in their 20s to 30s) was washed with a face wash and rested for 15 minutes. Next, the said foamable skin external preparation was apply | coated to the measurement site | part, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. Then, the questionnaire was implemented about 8 items of (1)-(8) of Table 4. The evaluation of the questionnaire is based on Example 1 for the following items (1) to (8), and the case equivalent to Example 1 is 4 (neither), and 1 (bad) to 7 (good) Evaluation was made on a 7-point scale, and the average score of 3 people was calculated. The subject was resting in the measurement room during the measurement.

From Table 2, it can be seen that Examples 1 and 2 are liquid compositions in which the second agent has no viscosity and exhibits excellent fluidity. In addition, the amount of carbon dioxide generated in Examples 1 and 2 was twice or more that in Comparative Example 1. From this, it can be seen that Examples 1 and 2 have a larger amount of foaming in a very short time of 10 seconds than Comparative Example 1.
As for the state of the skin after use in FIG. 1, good results were obtained in the order of Example 2> Example 1> Comparative Example 1 for the stratum corneum moisture content. That is, it can be seen that Examples 1 and 2 are more effective in improving the state after use than Comparative Example 1, and the effect is particularly high in Example 2 in which a thickener is used in combination with the first agent, that is, It can be seen that the skin is kept fresh.
Moreover, it can be seen from Table 3 that the foamable skin external preparation obtained using the kit of the present invention has a higher evaluation in use than Comparative Example 1. In particular, it is easy to mix when mixing the first agent and the second agent, difficult to sag, easy to remove after use, can feel moderate irritation when foaming, and moisturizes the skin after use, lightens the skin Since the effect of confirming the redness and warmth of the skin is obtained, it is easy to use for the user and the effect on the skin is high.
From the above results, it can be seen that the external preparation for foaming skin obtained using the kit of the present invention is easy for the user to use and has a high effect on the skin. It turns out that the effect appears notably when a sticky agent is used together.

<Manufacture of effervescent skin external preparation>
According to the composition shown in Table 4, the kit of the present invention was produced.

Example 3

<Characteristic evaluation of effervescent skin external preparation>
The characteristics of the foamable skin external preparation obtained in Example 3 were evaluated according to the following procedures.
[Evaluation Example 1. Evaluation of first agent viscosity]
In the second agent shown in Table 1, the viscosity of Example 3 was measured using a viscometer (RVT type manufactured by Brookfield). The results are shown in Table 5.

[Evaluation Example 2. Evaluation of foaming amount]
27 g of the second agent was put in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, 9 g of the first agent was added thereto, and the mixture was stirred 20 times for 10 seconds. The volume after 1 minute, 10 minutes, and 20 minutes was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The result is shown in FIG.

[Evaluation Example 3. Skin condition measurement before and after use]
A foamable skin external preparation was prepared using the kit of the present invention obtained in Example 3 above, and the stratum corneum moisture content (measuring instrument: SKICON-200EX) before and after use of the obtained foamable skin external preparation was measured. did.
The inside of the forearm of the subjects (three women in their 20s to 30s) was washed with face wash and rested for 15 minutes in the measurement room. Next, measurement was performed before using the foamable skin external preparation. Next, the said foamable skin external preparation was apply | coated to the measurement site | part, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. After 15 minutes from washing, the measurement after using the foamable skin external preparation was performed. The subject was resting in the measurement room during the measurement.
Table 5 shows the skin condition measurement results after use. In Table 5, the stratum corneum moisture content represents a comparative value with 1 before using the foamable skin external preparation. The larger the numerical value, the better the stratum corneum moisture content.

From Table 5, it can be seen that Example 3 is a liquid composition having no viscosity in the second agent and exhibiting excellent fluidity. Further, from FIG. 2, the volume increase rate of the foamable skin external preparation obtained using the kit of Example 3 is maintained at 400% or more after 10 minutes after mixing, and the generated carbon dioxide gas is efficiently removed. It can be seen that it is retained.
As for the skin condition after using the foamable skin external preparation obtained by using the kit of Example 3, the results that the stratum corneum moisture content is good from Table 5 were obtained. That is, Example 3 is found to be effective in improving the condition after use, and it can be seen that the skin is kept fresh by using water and a humectant in combination.
From the above, it can be seen that the kit of the present invention containing an acidic substance, water, and a moisturizer in the first agent achieves both retention of carbon dioxide gas and improvement of skin condition.

Below, the specific prescription example of the kit of this invention is shown. Both the first agent and the second agent can be produced by the same production method as in Example 1 or a general cosmetic production method.

  With the formulation shown in Table 6, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 3: 1, an effervescent skin external preparation can be obtained.

Example 4

  With the formulation shown in Table 7, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 5: 1, an effervescent skin external preparation can be obtained.

  Example 5

  With the formulation shown in Table 8, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 2: 1, an effervescent skin external preparation can be obtained.

  Example 6

  A foamable skin external preparation kit was prepared in the same manner as in Example 1 with the formulation shown in Table 9. When the 1st agent and 2nd agent of the obtained kit are mixed by 2: 1, an effervescent skin external preparation can be obtained.

  Example 7

  With the formulation shown in Table 10, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 2: 1, an effervescent skin external preparation can be obtained.

  Example 8

  A foamable skin external preparation kit was prepared in the same manner as in Example 1 using the formulation shown in Table 11. When the first agent and the second agent of the obtained kit are mixed at 5: 2, a foamable skin external preparation can be obtained.

  Example 9

  A foamable skin external preparation kit was prepared in the same manner as in Example 1 with the formulation shown in Table 12. When the 1st agent and 2nd agent of the obtained kit are mixed by 3: 1, an effervescent skin external preparation can be obtained.

  Example 10

  With the formulation shown in Table 13, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 3: 1, an effervescent skin external preparation can be obtained.

  Example 11

  With the formulation shown in Table 14, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 4: 1, an effervescent skin external preparation can be obtained.

  Example 12

  With the formulation shown in Table 15, a foamable skin external preparation kit was prepared in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 9: 1, an effervescent skin external preparation can be obtained.

  Example 13

  As is clear from the above study, the kit of the present invention is easy to mix uniformly, and produces the effect that carbon dioxide gas is generated evenly during use. Furthermore, it turns out that there exists an effect of keeping skin white and fresh by using the foamable skin external preparation obtained using the kit of the present invention.

Claims (5)

  A kit for obtaining an effervescent skin external preparation, wherein the first agent is a composition containing an acidic substance and water, and the second agent reacts with the acidic substance to generate carbon dioxide gas. And a thickener.   The kit according to claim 1, wherein the first agent further contains at least one of a thickener or a humectant.   The kit according to claim 1, wherein the first agent is a composition having a viscosity of 10,000 mPa · s or less.   The kit according to any one of claims 1 to 3, wherein the second agent is a solid composition.   The kit according to any one of claims 1 to 4, wherein the first agent and the second agent are mixed and used at a weight ratio in the range of 0.1: 1 to 30: 1.

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