JP2018012683A - Foamable external preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a carbon dioxide gas foamable external preparation for skin capable of efficiently exerting skin condition improvement effect by a specific active ingredient.SOLUTION: A carbon dioxide gas foamable external preparation for skin of the present invention is a carbon dioxide gas foamable external preparation for skin containing an acid substance, a carbon dioxide gas generating substance which reacts with the acid substance to generate carbon dioxide gas, and thickener, in the same agent or 2 or more agents, and furthermore contains ascorbic acid glucoside or the like (note that in the case where the carbon dioxide gas foamable external preparation for skin consists of 1 agent, it should be mixed with a water-containing substance when in use, and in the case where the carbon dioxide gas foamable external preparation for skin consists of 2 or more agents, any agent should contain water). It is preferable that the carbon dioxide gas foamable external preparation for skin furthermore contain polyhydric alcohol.SELECTED DRAWING: None

Description

  The present invention relates to a foamable skin external preparation.

  Conventionally, an external preparation for skin containing a synthetic or natural extract having a blood circulation promoting action on the skin has been used.

These extracts are not effective with a small amount of formulation, and because of the reason that the skin irritation is too great with a large amount of formulation, a proposal of a topical skin preparation containing carbon dioxide gas to promote blood circulation promotion Has been made. Many of these generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide-generating substance. In a carbon dioxide foaming external preparation for skin, ingredients that are effective for plant extracts such as pine bark extract are conventionally blended (see Patent Document 1).
On the other hand, carbon dioxide gas has been known for a long time to have a blood circulation promoting effect. For example, a warm pack cosmetic containing a pyrogen is known (see Patent Document 2).

JP 2014-88345 A Japanese Patent Laid-Open No. 08-268828

However, there are cases where the effect exhibited by plant extracts such as pine bark extract is low, and further, whitening the skin, increasing the amount of moisture in the skin, reducing the amount of moisture transpiration, improving the skin elasticity, etc. In view of improving the skin condition, it has been desired to develop a carbon dioxide foaming topical skin preparation that is more effective.
Moreover, in the pack agent containing carbon dioxide gas known conventionally, although examination about the foaming property of carbon dioxide gas, the persistence of foam, physical irritation, etc. has been made, the effect of improving the skin condition by carbon dioxide gas has been studied. The examination has not been sufficient yet, and the usability and stability of the product and the feeling after use have not been sufficiently examined.

Therefore, in the present invention, by adding a new component to the carbon dioxide foaming topical skin preparation, the skin condition is improved and the usability, safety and stability are excellent, and the feeling after use is good after washing. Thus, various studies were conducted on active ingredients that can further enhance the effects of carbon dioxide gas.
As a result, it has been found that by adding a specific active ingredient to various carbon dioxide foaming topical skin preparations, the effect of carbon dioxide is improved and the above-mentioned problems are solved, and the present invention has been completed.

  The present invention is a carbon dioxide foaming skin external preparation containing an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener in the same agent or two or more agents, Furthermore, ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, pyridoxine hydrochloride, pyridoki Carbon dioxide foaming topical skin preparation containing at least one selected from zinc, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol and retinol palmitate (however, carbon dioxide foaming topical skin) When the agent is composed of one agent, it is mixed with a water-containing substance at the time of use, and when it is composed of two or more agents, any agent shall contain water) (hereinafter simply referred to as “external preparation for skin”) (Also called).

The present invention also provides a carbon dioxide-foaming skin external preparation (hereinafter also simply referred to as “skin external preparation kit” or “kit”), which is a two-part kit according to any one of the following (1) to (3). To do. In each of the following kits, the first agent and the second agent are mixed at the time of use.
(1) a first agent that is an acid-containing composition containing an acidic substance and water;
A second agent that is a base-containing composition containing a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and the first agent and / or the second agent contains a thickener. Furthermore, the first agent and / or the second agent are ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α acetate -Tocopherol, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, Pyridoxine hydrochloride Pyridoxine, zinc oxide, arbutin,-L-ascorbyl magnesium phosphate, ascorbyl dipalmitate, placenta, containing at least one selected from retinol and retinol palmitate.
(2) a first agent that is an acid-containing composition containing an acidic substance;
A carbon dioxide generating material that reacts with the acidic substance to generate carbon dioxide and a second agent that is a base-containing composition containing water, and the first agent and / or the second agent is a thickener. In addition, the first agent and / or the second agent is ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl acetate -Α-tocopherol, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, Phenol, pyrido hydrochloride Singh, pyridoxine, zinc oxide, arbutin,-L-ascorbyl magnesium phosphate, ascorbyl dipalmitate, placenta, containing at least one selected from retinol and retinol palmitate.
(3) a first agent that is an acid and base-containing composition containing an acidic substance and a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide;
A second agent which is a composition containing water, the first agent and / or the second agent contains a thickener, and the first agent and / or the second agent is glucoside ascorbic acid, Allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, Pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, L-ascorbyl phosphate Magnesium, ascorbyl dipalmitate, containing at least one placenta, selected from retinol and retinol palmitate.

The present invention also provides a carbon dioxide-foaming skin external preparation (hereinafter also simply referred to as “skin external preparation composition” or “composition”), which is a one-part composition of the following composition mixed with a water-containing substance at the time of use. It is to provide.
Composition: Contains acidic substance, carbonate and thickener, and further contains ascorbyl glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, Dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201 No., phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol Containing at least one member selected from fine retinol palmitate.

  According to the present invention, by adding a specific active ingredient, the effect of carbon dioxide gas is enhanced, so that the skin color is whitened, the moisture content of the skin is increased, the amount of moisture transpiration is reduced, and the skin elasticity is increased. In addition to improving the skin condition, it has excellent usability, safety and stability such as ease of mixing and ease of application, and a good feeling after use, with the effects of carbon dioxide, etc. Can be further enhanced. In addition to promoting the improvement of stratum corneum cells and / or skin turnover, carbon dioxide foaming skin with new effects such as excellent skin cell activation, small skin pores, and smooth texture An external preparation and a kit and a composition for obtaining the external preparation for skin can be provided.

FIG. 1A shows the skin condition measurement results of Comparative Examples 1 to 3 and Examples 1-1 to 1-10, where (a) shows the result of color difference and (b) shows the result of moisture transpiration. FIG. 1B shows the skin condition measurement results of Comparative Examples 1 to 3 and Examples 1-1 to 1-10, (c) is the result of the stratum corneum moisture content, and (d) is the result of elasticity. FIG. 2A is a skin condition measurement result of Examples 1-11 to 1-20, (a) is a color difference result, and (b) is a moisture transpiration result. FIG. 2B shows the skin condition measurement results of Examples 1-11 to 1-20, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 3A is a skin condition measurement result of Examples 1-21 to 1-30, (a) is a color difference result, and (b) is a moisture transpiration result. FIG. 3B shows the skin condition measurement results of Examples 1-21 to 1-30, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 4A is a skin condition measurement result of Examples 1-31 to 1-35, (a) is a color difference result, and (b) is a moisture transpiration result. FIG. 4B shows the skin condition measurement results of Examples 1-31 to 1-35, (c) is the result of stratum corneum moisture content, and (d) is the result of elasticity. FIG. 5A shows the skin condition measurement results of Examples 2-1 to 2-5, where (a) shows the result of color difference and (b) shows the result of moisture transpiration. FIG. 5B shows the skin condition measurement results of Examples 2-1 to 2-5, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 6A is a result of skin condition measurement of Examples 3-1 to 3-5, (a) is a result of color difference, and (b) is a result of moisture transpiration. FIG. 6B shows skin state measurement results of Examples 3-1 to 3-5, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 7A shows the skin condition measurement results of Examples 4-1 to 4-5, where (a) shows the color difference results and (b) shows the moisture transpiration results. FIG. 7B shows the skin condition measurement results of Examples 4-1 to 4-5, (c) shows the results of the stratum corneum moisture content, and (d) shows the results of the elasticity. FIG. 8A shows the skin condition measurement results of Examples 5-1 to 5-5, where (a) shows the color difference results and (b) shows the moisture transpiration results. FIG. 8B shows the skin condition measurement results of Examples 5-1 to 5-5, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 10A shows the skin condition measurement results of Examples 6-1 to 6-5, where (a) shows the result of color difference and (b) shows the result of moisture transpiration. FIG. 10B shows the skin condition measurement results of Examples 6-1 to 6-5, (c) shows the result of stratum corneum moisture content, and (d) shows the result of elasticity. FIG. 10A is a skin condition measurement result of Comparative Example 4 and Examples 7-1 to 7-5, (a) is a result of color difference, and (b) is a result of moisture transpiration. FIG. 10B shows the skin condition measurement results of Comparative Example 4 and Examples 7-1 to 7-5, (c) is the result of stratum corneum moisture content, and (d) is the result of elasticity. FIG. 11A shows skin state measurement results of Comparative Example 5 and Examples 8-1 to 8-5, where (a) shows the result of color difference and (b) shows the result of moisture transpiration. FIG. 11B shows skin condition measurement results of Comparative Example 5 and Examples 8-1 to 8-5, (c) shows the results of stratum corneum moisture content, and (d) shows the results of elasticity. FIG. 12A is a skin condition measurement result of Comparative Example 6 and Examples 9-1 to 9-5, (a) is a result of color difference, and (b) is a result of moisture transpiration. FIG. 12B is a skin condition measurement result of Comparative Example 6 and Examples 9-1 to 9-5, (c) is a result of stratum corneum moisture content, and (d) is a result of elasticity. FIG. 13A shows the skin condition measurement results of Comparative Example 7 and Examples 10-1 to 10-5, where (a) shows the result of color difference and (b) shows the result of moisture transpiration. FIG. 13B shows the skin condition measurement results of Comparative Example 7 and Examples 10-1 to 10-5, (c) is the result of stratum corneum moisture content, and (d) is the result of elasticity. FIG. 14 shows the results of turnover tests of Comparative Examples 1 to 3 and Examples 1-1 to 1-10. FIG. 15 shows the result of the turnover test of Examples 1-11 to 1-20. FIG. 16 shows the results of turnover tests of Examples 1-21 to 1-30. FIG. 17 shows the results of the turnover test of Examples 1-31 to 1-35. FIG. 18 shows the results of turnover tests of Examples 2-1 to 2-5. FIG. 19 shows the results of the turnover test of Examples 3-1 to 3-5. FIG. 20 shows the results of turnover tests of Examples 4-1 to 4-5. FIG. 21 shows the results of turnover tests of Examples 5-1 to 5-5. FIG. 22 shows the results of turnover tests of Examples 6-1 to 6-5. FIG. 23 shows the results of the turnover test of Comparative Example 4 and Examples 7-1 to 7-5. FIG. 24 shows the results of the turnover test of Comparative Example 5 and Examples 8-1 to 8-5. FIG. 25 shows the results of the turnover test of Comparative Example 6 and Examples 9-1 to 9-5. FIG. 26 shows the results of the turnover test of Comparative Example 7 and Examples 10-1 to 10-5. FIG. 27 is a stratum corneum cell observation image before and after using the foamable skin external preparations of Comparative Example 1, Example 1-19, Example 2-3, and Example 4-3. FIG. 28 shows the evaluation results of the cell activation activity of Comparative Examples 8 to 10 and Examples 11 to 13.

  Hereinafter, the skin external preparation, the skin external preparation kit, and the skin external preparation composition of the present invention will be described based on preferred embodiments thereof. The kit for external preparation for skin and the composition for external preparation for skin of the present invention are each one form of the foamable external preparation for skin of the present invention. The foamable skin external preparation of the present invention may contain an acidic substance, a carbon dioxide generating substance, a thickener and the following specific components in the same agent, or may be divided into a plurality of agents, When dividing into a plurality of agents, the four components may be divided in any way. However, it is assumed that the amount of water necessary for generating an acidic substance, a carbon dioxide generating substance, and carbon dioxide is not included in the same agent. The water content of the same agent containing the acidic substance and the carbon dioxide generating substance is preferably 15% by mass or less, more preferably 10% by mass or less, and particularly preferably 8% by mass or less.

  The carbon dioxide foaming external preparation for skin according to the present invention can be used in any form of cosmetics, quasi-drugs, and pharmaceuticals. From the viewpoint of effectiveness and usability, cosmetics or quasi-drugs ( It is preferably used as a medicinal cosmetic product, and particularly preferably used as a quasi-drug (medicinal cosmetic product).

  Further, the carbon dioxide foaming skin external preparation according to the present invention can be externally applied to the skin including the scalp and the hair, and includes packs, hair restorers, facial cleansers, cleansing agents, lotions, emulsions, beauty gels, shampoos, It can be used in various forms such as a conditioner. In the case of washing away, it is preferable to use it for packs, facial cleansers and cleansing agents.

  First, main components used in the skin external preparation, skin external preparation kit, and skin external preparation composition of the present invention will be described. Hereinafter, when referred to as “skin external preparation”, a skin external preparation (for example, a skin external preparation kit, a composition for external skin preparation) before carbon dioxide generating substance, acidic substance and water come into contact with each other and these three are mixed. ) Or a carbon dioxide-containing external preparation for skin (for example, one obtained by mixing two agents of the kit or a composition for external preparation for skin) mixed with a water-containing substance. Sometimes obtained). Which is pointed to depends on the context. Below, the component etc. which are contained in the skin external preparation, kit, and composition of this invention are demonstrated collectively.

<Acid substance>
The acidic substance used in the present invention may be either an inorganic acid or an organic acid, and one or more of these are used.

  Inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, acidic sodium hexametaphosphate, acidic potassium hexametaphosphate, acidic sodium pyrophosphate, acidic Examples include potassium pyrophosphate and sulfamic acid.

  Examples of organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid and valeric acid or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid Acids, dicarboxylic acids such as isophthalic acid and terephthalic acid or salts thereof, acidic amino acids such as glutamic acid and aspartic acid or salts thereof, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Examples include acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and other oxyacids or salts thereof, and inorganic acids include phosphoric acid, sulfurous acid and other inorganic acids or salts thereof, These 1 type (s) or 2 or more types can be used.

  Of these, citric acid, ascorbic acid, malic acid and succinic acid are preferred from the viewpoints of safety and solubility in water.

  The content of the acidic substance in the external preparation for skin of the present invention is preferably 0.01 parts by mass or more and 30 parts by mass or less with respect to 100 parts by mass of the external preparation for skin from the viewpoint of efficiently expressing a cosmetic effect. And more preferably 0.05 parts by mass or more and 20 parts by mass or less. Similarly, the content of the acidic substance in the acid-containing composition of the kits (1) and (2) and the content of the acidic substance in the acid- and base-containing composition of the kit (3) The amount is preferably 0.01 parts by mass or more and 30 parts by mass or less, and more preferably 0.05 parts by mass or more and 20 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents. The amount of the external preparation for skin referred to in this specification may be the total amount of each agent in the kit at the start of mixing when the external preparation for skin of the present invention is a kit of two or more agents. When the external preparation for skin is obtained by mixing the composition for external preparation for skin of 1 type and the hydrated substance, the total amount of the composition and the hydrated substance at the start of mixing may be used.

Furthermore, the content of the acidic substance in the acid-containing composition (acid-containing water-containing composition) in the kit of (1) of the present invention is 0.01% by mass in the acid-containing composition (acid-containing water-containing composition). The content is preferably 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less.
The content of the acidic substance in the acid-containing composition in the kit of (2) of the present invention is preferably 0.1% by mass or more and 90% by mass or less in the solid content of the acid-containing composition. More preferably, it is 5 mass% or more and 80 mass% or less.
The content of the acidic substance in the acid and base-containing composition in the kit of (3) of the present invention is 0.01% by mass or more and 50% by mass or less in the solid content of the acid and base-containing composition. Preferably, it is 0.05 mass% or more and 40 mass% or less.
The content of the acidic substance in the composition for external skin preparation of the present invention is preferably 0.01% by mass or more and 40% by mass or less in the solid content of the composition for external skin preparation, and 0.05% by mass. % To 30% by mass is more preferable.

<Carbon dioxide generating substance>
The carbon dioxide generating substance that generates carbon dioxide by reacting with the acidic substance used in the present invention may be any substance that generates carbon dioxide by reacting with the acidic substance.

  Carbon dioxide generators include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonate is preferably used, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The content of the carbon dioxide generating substance in the external preparation for skin of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and 0.05% by mass or more and 20% by mass with respect to 100 parts by mass of the external preparation for skin. % Or less is more preferable. Similarly, the content of the carbon dioxide generating substance in the base-containing composition of the kits (1) and (2) and the content of the carbon dioxide generating substance in the acid and base-containing composition in the kit of (3) are: The amount is preferably 0.01 parts by mass or more and 30 parts by mass or less, and more preferably 0.05 parts by mass or more and 20 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents in the corresponding kit.

The content of the carbon dioxide generating substance in the base-containing composition in the kit of (1) of the present invention is preferably 0.1% by mass or more and 90% by mass or less in the solid content of the base-containing composition. More preferably, it is 0.5 mass% or more and 80 mass% or less.
The content of the carbon dioxide generating substance in the base-containing composition (aqueous composition) in the kit of (2) of the present invention is preferably 0.01% by mass or more and 30% by mass or less in the base-containing composition. The content is more preferably 0.05% by mass or more and 20% by mass or less.
The content of the carbon dioxide generating substance in the acid and base-containing composition in the kit of (3) of the present invention is 0.01% by mass or more and 50% by mass or less in the solid content of the acid and base-containing composition. It is preferably 0.05% by mass or more and 40% by mass or less.
The content of the carbon dioxide generating substance in the composition for external skin preparation of the present invention is preferably 0.01% by mass or more and 40% by mass or less in the solid content of the composition for external skin preparation. More preferably, the content is from 05% by mass to 30% by mass.

<Thickener>
Examples of the thickener used in the present invention include various types that can be used in the cosmetics and pharmaceutical fields. As the thickener, for example, synthetic polymers, semi-synthetic polymers, natural polymers, viscosity minerals and the like can be used. Specifically, synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / methacrylic acid. Acid alkyl copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic, (PEG-240 / decyltetradeceth-20 / HDI) hydrophilic synthetic polymers including copolymers and semi-synthetic polymers include, for example, carboxymethylcellulose or its salts, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, Mud carboxymethyl cellulose, and cellulose derivatives such as sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide and the like. Natural polymers include polysaccharides and derivatives thereof such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, Alginic acid or salts thereof, gum arabic, pectin, quinseed, starch, alge colloid, alkathylan, chondroitin sulfate or salts thereof, chitosan and derivatives thereof, nucleic acid or salts thereof, ribonucleic acid or salts thereof, casein, collagen, gelatin, albumin And water-soluble proteins such as fibroin, elastin, keratin, and sericin, hyaluronic acid or salts thereof, and mucopolysaccharides such as chondroitin sulfate. Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.
As said salts, an alkali metal salt is mentioned preferably, for example, sodium salt and potassium salt.

  In the present invention, one or more of the above thickeners can be used, but among the above thickeners, it is not possible to use one having high solubility or dispersibility in water. This is preferable because it can relieve the roughness of the skin caused by dissolved components and undispersed components. Here, whether water solubility is good or bad is that when water is added at about room temperature and stirred, it dissolves instantly in water or has a sufficient viscosity by being dispersed and evenly dissolved. Alternatively, it can be determined from the fact that no lumps occur during dispersion.

  Preferred examples of the thickener from the viewpoint of solubility and dispersibility in water described above include, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, PEG-240 / decyltetradeceth-20 / HDI) copolymer, Alkathylan, polyacrylic acid soda, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, cellulose derivatives (celluloses), galactan, gum arabic, tragacanth gum, Tamarind gum, agar, mannan, curdlan, alginic acid or salts thereof, collagen, gelatin, albumin and the like can be mentioned. Particularly preferred are alginic acid or salt thereof, hydroxyethyl ether, carboxymethyl ether. Examples include roulose or salts thereof, xanthan gum, carrageenan, tamarind gum, and albumin.

  The amount of the thickener contained in the external preparation for skin of the present invention is preferably 0.01 parts by mass or more and 40 parts by mass or less, and 0.1 to 30 parts by mass with respect to 100 parts by mass of the external preparation for skin. More preferably, it is at most parts. Similarly, the content of the thickener in the acid-containing composition and / or base-containing composition in the kits of (1) and (2) and the acid- and base-containing composition and / or water-containing composition in the kit of (3) The content of the thickener in the product is preferably 0.01 parts by weight or more and 40 parts by weight or less, and 0.1 parts by weight or more and 30 parts by weight or less with respect to 100 parts by weight of the total amount of the two agents in the corresponding kit. It is still more preferable that it is below mass parts. The amount of the thickener in the acid-containing composition and / or the base-containing composition here is the amount when one of these contains a thickener, and both contain the thickener. If so, the total amount is the same, and the amount of the thickener in the base-containing composition and / or the water-containing composition is the same.

  The content of the thickener in the composition for external skin preparation of the present invention is preferably 0.1% by mass or more and 40% by mass or less in the solid content of the composition for external skin use. More preferably, it is 5 mass% or more and 30 mass% or less.

<Water>
As water that can be used in the present invention, water that can be used in cosmetics, topical medicines, quasi drugs, and the like can be used, but purified water, distilled water, membrane filtered water, and ion-exchanged water are preferable.

  The amount of water in the external skin preparation of the present invention (or the amount of water used in the external skin preparation) is 20 parts by mass with respect to 100 parts by mass of the external skin preparation from the viewpoint of sufficiently achieving the cosmetic effect of the present invention. The amount is preferably 95 parts by mass or less, and more preferably 30 parts by mass or more and 90 parts by mass or less. In the case of a composition for external preparation for skin, the amount of water here is the ratio of water to the total of the amount of water and the amount of composition. Similarly, the water content in the kits (1) to (3) is preferably 20 parts by mass or more and 95 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents in the corresponding kit, 30 More preferably, it is at least 90 parts by mass. The amount of water in the kit here is the total amount of water in the two agents, and is the amount of water in the agent when only one of the two agents contains water.

<Polyhydric alcohol>
In the present invention, it is preferable that the skin external preparation contains a polyhydric alcohol from the viewpoint that a high moisturizing effect can be exhibited by a combination with a specific component described later. Examples of the polyhydric alcohol include polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, 3-propanediol, 1,2-pentanediol, sorbitol, polyglycerin derivatives, glucose, fructose, glyceraldehyde, lactose, arabinose, maltose and other reducing sugars, erythritol, maltitol, sorbitol, xylitol and other sugar alcohols, etc. These may be used alone or in combination of two or more. Among them, the number of carbon atoms is preferably 2 or more, and more preferably 2 or more from the viewpoint of high moisturizing effect.

  The amount of the polyhydric alcohol contained in the external preparation for skin of the present invention is 1 part by mass or more and 80 parts by mass with respect to 100 parts by mass of the external preparation for skin, from the viewpoint of sufficiently achieving the cosmetic effect by the combination with the specific component described above. Part or less, preferably 5 parts by weight or more and 70 parts by weight or less. Similarly, the content of polyhydric alcohol in the acid-containing composition and / or base-containing composition in the kits of (1) and (2) and the acid- and base-containing composition and / or water-containing composition in the kit of (3) The content of the polyhydric alcohol in the product is preferably 1 part by mass or more and 80 parts by mass or less, and preferably 5 parts by mass or more and 70 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents in the corresponding kit. More preferably it is. The amount of the polyhydric alcohol in the acid-containing composition and / or the base-containing composition here is the amount when one of them contains the polyhydric alcohol, and both of them contain the polyhydric alcohol. If so, the total amount is the same, and the amount of the polyhydric alcohol in the base-containing composition and / or the water-containing composition is the same.

  One feature of the skin external preparation of the present invention is that it contains a specific active ingredient (hereinafter also referred to as a specific ingredient). Such components are described in detail below.

<Ascorbic acid glucoside>
Examples of the ascorbic acid glucoside include 2-O-α-D-glucopyranosyl-L-ascorbic acid (sometimes referred to as AA-2G, ascorbic acid-2-glucoside, L-ascorbic acid 2-glucoside, etc.). Ascorbic acid glucoside may be isolated from nature or biochemically synthesized. Ascorbic acid glucoside is said to have an inhibitory action on melanin production, and is used in whitening cosmetics and quasi drugs. The present inventor has found that the effect of this ascorbic acid glucoside is efficiently exerted in a carbon dioxide foaming skin external preparation obtained when mixed with an acidic substance, a carbon dioxide generating substance, a thickener and water. . Ascorbic acid glucoside may be contained in any kit of (1) to (3), or may be contained in a one-component composition for external preparation for skin. When ascorbic acid glucoside is included in a two-component kit, one of the two agents is a gel and the other is a solid agent, and one of the two agents is a gel and the other is a liquid agent, 2 The agent may be a gel-like agent, one of two agents is liquid and the other is a solid agent, or both agents are liquid. The agent containing the following various specific components including ascorbic acid glucoside may be solid, liquid, or gel.

  In the present invention, ascorbic acid glucoside is preferably used in an amount of 0.01% by mass or more and 20% by mass or less in the external skin preparation from the viewpoint of efficiently exhibiting the advantageous effects of ascorbic acid glucoside. From this viewpoint, the amount of ascorbic acid glucoside in the external preparation for skin is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less. The amount is particularly preferably 1 part by mass or more and 5 parts by mass or less. Similarly, the content of ascorbic acid glucoside in the acid-containing composition and / or base-containing composition in the kits of (1) and (2) and the acid- and base-containing composition and / or water-containing composition in the kit of (3) The content of ascorbic acid glucoside in the product is preferably 0.01 parts by mass or more and 20 parts by mass or less, and 0.05 parts by mass or more and 10 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents of the corresponding kit. The content is more preferably no greater than part by mass, and particularly preferably no less than 0.1% by mass and no greater than 5% by mass. The amount of ascorbic acid glucoside in the acid-containing composition and / or base-containing composition here is the amount when one of these contains ascorbic acid glucoside, and both contain ascorbic acid glucoside. If so, that is the total amount. The same applies to the amount of ascorbic acid glucoside in the acid and base-containing composition and / or the water-containing composition.

  Ascorbic acid glucoside may be contained in any of the acid-containing composition (water-containing composition) and the base-containing composition when included in the kit of (1). When ascorbic acid glucoside is contained in the acid-containing composition of the kit of (1), the content thereof is 0.01% in the acid-containing composition from the viewpoint of efficiently exhibiting the advantageous effects of ascorbic acid glucoside. It is preferable that it is mass% or more and 20 mass% or less, and it is more preferable that it is 0.05 mass% or more and 10 mass% or less. When ascorbic acid glucoside is contained in the base-containing composition of the kit of (1), the content is preferably 0.1% by mass or more and 90% by mass or less in the solid content of the base-containing composition. More preferably, the content is 0.5% by mass or more and 80% by mass or less.

  When the ascorbic acid glucoside is contained in the kit of (2), it is preferable that the ascorbic acid glucoside is contained in the acid-containing composition from the viewpoint that the effect of ascorbic acid glucoside can be efficiently exhibited in the external preparation for skin. On the other hand, when it is contained in the base-containing composition, it is difficult to stably exist in the kit. When ascorbic acid glucoside is contained in the acid-containing composition of the kit of (2), the content thereof is preferably 90% by mass or less, and 0.1% by mass or more in the solid content of the acid-containing composition. More preferably, it is 80 mass% or less.

  Ascorbic acid glucoside may be contained in any of the acid- and carbonate-containing composition and the water-containing composition when included in the kit of (3). When ascorbic acid glucoside is contained in the acid and carbonate-containing composition of the kit of (3), the content thereof is 0.1% by mass or more and 50% by mass or less in the solid content of the acid and carbonate-containing composition. It is preferable that it is 0.5 mass% or more and 40 mass% or less. When ascorbic acid glucoside is contained in the water-containing composition of the kit of (3), the content is preferably 0.01% by mass or more and 20% by mass or less in the water-containing composition, and 0.05% by mass. It is more preferable that it is 10% by mass or more.

  The content of glucoside ascorbic acid in the composition for external preparation for skin of the present invention is preferably 0.1% by mass or more and 30% by mass or less in the solid content of the composition for external preparation for skin, 0.5 More preferably, it is at least 20% by mass.

<Another specific component>
Even when the skin external preparation, skin external preparation kit, and skin external preparation composition of the present invention contain specific active ingredients other than ascorbic acid glucoside, they exhibit effects such as beauty by containing the ingredients. can do. Such components are listed below. In addition, the preferable ratio with respect to the total amount of 2 agents of the specific component contained in the kit for external preparations of this invention is the same as the preferable amount of the specific component in the external preparation for skin shown below. Moreover, preferable content of the specific component in the composition for skin external preparations is the same as the preferable amount in solid content of the skin external preparation of the specific component shown below.

Allantoin is a compound having a composition of C ₄ H ₆ N ₄ O ₃ and is a diureido of glyoxylic acid. Also known as 5-ureidohydantoin or glyoxydiureido, known as an anti-inflammatory agent. When the skin external preparation contains allantoin, the amount is preferably 0.001% by mass to 20% by mass, and more preferably 0.01% by mass to 10% by mass in the skin external preparation. The amount of allantoin is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less in the solid content of the external preparation for skin.

  When allantoin is contained in the acid-containing composition of the kit of (1), the content is preferably 0.01% by mass or more and 20% by mass or less in the acid-containing composition. More preferably, the content is from 10% by mass to 10% by mass. Moreover, when allantoin is contained in the base-containing composition of the kit of (1), the content thereof is preferably 0.01% by mass or more and 30% by mass or less in the solid content of the base-containing composition. More preferably, the content is 0.05% by mass or more and 20% by mass or less.

  When allantoin is contained in the acid-containing composition of the kit of (2), the content is preferably 0.01% by mass or more and 30% by mass or less in the solid content of the acid-containing composition. More preferably, the content is from 05% by mass to 20% by mass. When allantoin is contained in the base-containing composition of the kit of (2), the content is preferably 0.01% by mass or more and 20% by mass or less in the base-containing composition, and 0.05% by mass. It is more preferable that it is 10% by mass or more.

  When allantoin is contained in the acid and carbonate-containing composition of the kit of (3), the content thereof is 0.01% by mass or more and 30% by mass or less in the solid content of the acid and carbonate-containing composition. It is preferably 0.05% by mass or more and 20% by mass or less. Moreover, when allantoin is contained in the water-containing composition of the kit of (3), the content thereof is preferably 0.01% by mass or more and 20% by mass or less, and 0.05% by mass or more in the water-containing composition. More preferably, it is 10 mass% or less.

  Tranexamic acid is also called trans-4- (aminomethyl) cyclohexanecarboxylic acid, and is known as an anti-inflammatory agent and a whitening agent. When the external preparation for skin contains tranexamic acid, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less, and more preferably 0.1% by mass or more and 10% by mass or less in the external preparation for skin. The amount of tranexamic acid is preferably 0.1% by mass or more and 80% by mass or less, and more preferably 1% by mass or more and 70% by mass or less in the solid content of the external preparation for skin.

  When tranexamic acid is contained in the acid-containing composition of the kit of (1), the content is preferably 0.1% by mass or more and 60% by mass or less in the acid-containing composition. It is more preferable that the content is not less than 50% and not more than 50% by mass. When tranexamic acid is contained in the base-containing composition of the kit of (1), the content is preferably 1% by mass or more and 90% by mass or less in the solid content of the base-containing composition, and 5% by mass. It is more preferable that the content is not less than 80% and not more than 80% by mass.

  When tranexamic acid is contained in the acid-containing composition of the kit of (2), the content is preferably 1% by mass or more and 90% by mass or less in the solid content of the acid-containing composition, and 5% by mass. More preferably, it is 80 mass% or less. Moreover, when tranexamic acid is contained in the base-containing composition of the kit of (2), the content is preferably 0.1% by mass or more and 60% by mass or less in the base-containing composition, and is preferably 1% by mass. More preferably, it is 50 mass% or less.

  When tranexamic acid is contained in the acid and carbonate-containing composition of the kit of (3), the content thereof is 0.1% by mass or more and 80% by mass or less in the solid content of the acid and carbonate-containing composition. It is preferable that the content is 1% by mass or more and 75% by mass or less. When tranexamic acid is contained in the water-containing composition of the kit of (3), the content thereof is preferably 0.01% by mass or more and 30% by mass or less in the water-containing composition, and 0.1% by mass. More preferably, it is 20 mass% or less.

  d-Camphor has a chemical name of (1R, 4R) -1,7,7-Trimethylcyclo [2.2.1] heptan-2-one, and is one of bicyclic monoterpene ketones such as camphor tree. It is obtained by steam distillation of a piece of material contained in. When the skin external preparation contains d-camphor, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. The amount of d-camphor is preferably 0.01% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

Salicylic acid is a compound of the chemical formula C ₇ H ₆ O ₃ . When the skin external preparation contains salicylic acid, the amount is preferably 0.0001% by mass or more and 10% by mass or less in the skin external preparation. The amount of salicylic acid is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

  Biotin is called D-[(+)-cis-hexahydro-2-oxo-1H-thieno- (3,4) -imidazole-4-valeric acid] and is a kind of water-soluble vitamin classified into the vitamin B group It is. When the skin external preparation contains biotin, the amount is preferably 0.0001 mass% or more and 1 mass% or less in the skin external preparation. The amount of biotin is preferably 0.0001% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

Resorcin is a compound represented by the chemical formula C ₆ H ₄ (OH) ₂ and corresponds to 1,3-dihydroxybenzene. When the skin external preparation contains resorcin, the amount is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. The amount of resorcin is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the external preparation for skin.

  Trichlorocarbanilide is also referred to as triclocarban or 3,4,4'-trichlorocarbanilide. When the external preparation for skin contains trichlorocarbanilide, the amount is preferably 0.001% by mass or more and 10% by mass or less in the external preparation for skin. Moreover, 0.01 mass% or more and 20 mass% or less are preferable in the solid content of the skin external preparation of a trichlorocarbanilide.

  Triclosan is also referred to as 5-chloro-2- (2 ', 4'-dichlorophenoxy) phenol. When the skin external preparation contains triclosan, the amount thereof is preferably 0.0001 mass% or more and 10 mass% or less in the skin external preparation. The amount of triclosan is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

Benzethonium chloride is represented by the chemical formula C ₂₇ H ₄₂ ClNO ₂ and is a kind of cationic surfactant. When the skin external preparation contains benzethonium chloride, the amount thereof is preferably 0.0001 mass% or more and 10 mass% or less in the skin external preparation. The amount of benzethonium chloride is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

  Sulfur is a simple substance represented by the chemical formula S. When the skin external preparation contains sulfur, the amount thereof is preferably 0.001% by mass or more and 20% by mass or less in the skin external preparation. The amount of sulfur is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the external preparation for skin.

  Photosensitive element 201 is also called pionine. When the skin external preparation contains Photosensitive Element 201, the amount is preferably 0.0001% by mass or more and 5% by mass or less in the skin external preparation. The amount of pionine is preferably 0.0005% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

  Pyridoxine is a water-soluble compound called 4,5-bis (hydroxymethyl) -2-methylpyridin-3-ol or vitamin B6. When the skin external preparation contains pyridoxine, the amount thereof is preferably 0.0001% by mass or more and 5% by mass or less in the skin external preparation. The amount of pyridoxine is preferably 0.0005% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

  Pyridoxine hydrochloride is obtained by converting pyridoxine into hydrochloride, and is also called 5-hydroxy-6-methylpyridine-3,4-dimethyl monohydrochloride. When the skin external preparation contains pyridoxine hydrochloride, the amount is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. The amount of pyridoxine hydrochloride is preferably 0.01% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

  Zinc oxide is represented by the chemical formula ZnO. When the skin external preparation contains zinc oxide, the amount is preferably 0.01% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.05 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation.

  Arbutin includes β-arbutin and α-arbutin, and β-arbutin called 4- (β-D-glucopyranosyloxy) phenol is common. When the skin external preparation contains arbutin, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less, and more preferably 0.1% by mass or more and 10% by mass or less in the skin external preparation. Moreover, 0.1 mass% or more and 50 mass% or less are preferable in the solid content of a skin external preparation, and, as for the quantity of arbutin, 1 mass% or more and 40 mass% or less are more preferable.

  When arbutin is contained in the acid-containing composition of the kit of (1), the content is preferably 0.1% by mass or more and 30% by mass or less in the acid-containing composition. More preferably, it is 20 mass% or less. Moreover, when arbutin is contained in the base-containing composition of the kit of (1), the content thereof is preferably 1% by mass or more and 90% by mass or less in the solid content of the base-containing composition, and 5% by mass. More preferably, it is 85 mass% or less.

  When arbutin is contained in the acid-containing composition of the kit of (2), the content is preferably 1% by mass or more and 90% by mass or less in the solid content of the acid-containing composition, and 5% by mass or more. More preferably, it is 85 mass% or less. Moreover, when arbutin is contained in the base-containing composition of the kit of (2), the content thereof is preferably 0.1% by mass or more and 30% by mass or less in the base-containing composition, and preferably 1% by mass or more. More preferably, it is 20 mass% or less.

  When arbutin is contained in the acid and carbonate-containing composition of the kit of (3), the content thereof may be 1% by mass or more and 80% by mass or less in the solid content of the acid and carbonate-containing composition. Preferably, it is 5 mass% or more and 70 mass% or less. Moreover, when arbutin is contained in the water-containing composition of the kit of (3), the content thereof is preferably 0.1% by mass or more and 30% by mass or less in the water-containing composition, and 1% by mass or more and 20% by mass. % Or less is more preferable.

  Phosphoric acid-L-ascorbyl magnesium is also referred to as L-ascorbic acid-2-magnesium phosphate. When the skin external preparation contains L-ascorbic acid-2-magnesium phosphate, the amount is preferably 0.01% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.05 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation.

  Ascorbyl dipalmitate is also called L-ascorbic acid 2,6-dipalmitate. When the skin external preparation contains ascorbyl palmitate, the amount is preferably 0.01% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.05 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation.

  Examples of glycyrrhizic acid include β-glycyrrhizic acid. Examples of the glycyrrhizic acid derivative include dipotassium glycyrrhizinate (sometimes referred to as “dipotassium glycyrrhizinate”), monoammonium glycyrrhizinate, and stearyl glycyrrhetinate. Monoammonium glycyrrhizinate may be an anhydride or a hydrate. When the skin external preparation contains these glycyrrhizic acids and derivatives thereof, the amount and the total amount of these are preferably 0.0001% by mass or more and 10% by mass or less, and 0.001% by mass or more in the skin external preparation. 1 mass% or less is more preferable. Moreover, 0.001 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation, and, as for content of glycyrrhizic acid and its derivative (s), 0.005 mass% or more and 10 mass% or less are more preferable.

  When glycyrrhizic acid and its derivative are contained in the acid-containing composition of the kit of (1), the content is preferably 0.001% by mass or more and 10% by mass or less in the acid-containing composition. 0.005 mass% or more and 5 mass% or less is more preferable. Moreover, when glycyrrhizic acid and its derivative are contained in the base-containing composition of the kit of (1), the content thereof is 0.01% by mass or more and 20% by mass or less in the solid content of the base-containing composition. Is preferable, and it is more preferable that it is 0.05 mass% or more and 10 mass% or less.

  When glycyrrhizic acid and its derivative are contained in the acid-containing composition of the kit of (2), the content thereof may be 0.01% by mass or more and 20% by mass or less in the solid content of the acid-containing composition. Preferably, it is 0.05 mass% or more and 10 mass% or less. Further, when glycyrrhizic acid and its derivative are contained in the base-containing composition of the kit of (2), the content is preferably 0.001% by mass or more and 10% by mass or less in the base-containing composition, More preferably, it is 0.005 mass% or more and 5 mass% or less.

  When glycyrrhizic acid and its derivative are contained in the acid and carbonate-containing composition of the kit of (3), the content thereof is 0.01% by mass or more and 20% by mass in the solid content of the acid and carbonate-containing composition. % Or less, more preferably 0.05% by mass or more and 10% by mass or less. When glycyrrhizic acid and its derivative are contained in the water-containing composition of the kit of (3), the content is preferably 0.001% by mass to 10% by mass in the water-containing composition. More preferably, it is 050 mass% or more and 5 mass% or less.

  Each of the above preferred amounts for the amount of glycyrrhizic acid and its derivative may be one amount of glycyrrhizic acid and its derivative, or the total amount of glycyrrhizic acid and its derivative.

  Retinol is also called vitamin A. When the skin external preparation contains retinol, the amount is preferably 0.00001% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.00005 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

  Retinol palmitate is also called vitamin A palmitate. When the skin external preparation contains retinol palmitate, the amount is preferably 0.00001% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.00005 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

  Estradiol is the generic name estra-1.3.5 (10) triene-3.17β-diol. Ethinylestradiol is the generic name 17-ethynylestradi-1,3,5 (10) -triene-3β, 17β-diol. When the skin external preparation contains these estradiols, the amount and the total amount thereof are preferably 0.00001 mass% to 5 mass% in the skin external preparation. Moreover, 0.00005 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

  Both dl-α tocopherol acetate and dl-α tocopherol nicotinate are known as vitamin E derivatives. When the skin external preparation contains dl-α tocopherol acetate and / or dl-α tocopherol nicotinate, the amount and the total amount thereof are preferably 0.0001 mass% or more and 10 mass% or less in the skin external preparation. . Moreover, 0.001 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

  D-pantothenyl alcohol is also called (R) -2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethylbutanamide. When the skin external preparation contains D-pantothenyl alcohol, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.05 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation.

  Pantotenyl ethyl ether is also called (2R) -N- (3-ethoxypropyl) -2,4-dihydroxy-3,3-dimethylbutanamide. When the skin external preparation contains pantotenyl ethyl ether, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. Moreover, 0.005 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

Phenol has a structure in which the formula is C ₆ H ₅ OH, and one of the hydrogen atoms of benzene is substituted with a hydroxyl group. When the skin external preparation contains phenol, the amount is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. Moreover, 0.005 mass% or more and 10 mass% or less are preferable in solid content of a skin external preparation.

  Placenta is a collective term for growth factors and other nutrients that promote cell division in animals, preferably pigs, horses, cattle, sheep, human placenta, nutrients in fish ovarian membranes, and nutrients in plant embryos. The placenta used in the present invention is not particularly limited as long as it can be used as a normal cosmetic or quasi drug. In the present invention, commercially available water-soluble extracts and powders can be used. When the skin external preparation contains placenta, the amount is preferably 0.01% by mass or more and 20% by mass or less in the skin external preparation. Moreover, 0.05 mass% or more and 20 mass% or less are preferable in solid content of a skin external preparation.

  Among these specific components, allantoin, dipotassium glycyrrhizinate, stearyl glycyrrhizinate, d-camphor, salicylic acid, arbutin and placenta are preferably contained in a two-part skin external preparation kit, particularly in the present invention. It is preferable to be contained in the kit of (1) or (2). It goes without saying that the specific components including these may be contained in a one-part composition for external skin preparation or may be contained in a two-part composition for external skin preparation. In particular, the specific component is preferably used in a two-component kit from the viewpoint of increasing the amount of keratin moisture after use or exhibiting an excellent turnover effect. Further, the skin condition improving effect and usability improving effect of the present invention are not limited by the type of the thickener, but the desired effect of these may be further improved depending on the type of the thickener combined with the specific component. It can be further increased.

  For each specific component, one of the two agents is gel-like and the other is a solid agent, two of the agents are one gel-like and the other is a liquid agent, two agents are both gel-like agents, One of the two agents may be used as either a liquid agent and the other as a solid agent, or both agents may be liquid agents. Regarding dl-α tocopherol acetate, one of the two agents is gel-like and the other is liquid. Two agents are gel-like. One of the two agents is liquid and the other is solid. It is preferable to use it for the agent which is a liquid agent or two agents. Furthermore, for placenta, one of the two agents is a gel and the other is a solid agent, and one of the two agents is a gel and the other is a liquid agent, or both of them are gel agents, or It is preferable that both of the two agents are used as liquid agents.

  In the kits of (1) to (3), estradiol, ethinyl estradiol, dl-α-tocopherol nicotinate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantotenyl ethyl ether, phenol, and placenta are water-containing. It is preferable to be included in the composition (the acid-containing composition of the kit of (1), the base-containing composition of the kit of (2), the water-containing composition of the kit of (3)). These specific components (estradiol, ethinylestradiol, dl-α-tocopherol nicotinate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl alcohol, pantothel) contained in these water-containing compositions in the kits of (1) to (3) As for the amount of tenyl ethyl ether, phenol, and placenta, a preferable ratio in the total amount of the two agents is preferably the same ratio as the preferable ratio of these specific components in the above-mentioned external preparation for skin.

  Allantoin, glycyrrhizic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzonium chloride, sulfur, photosensitizer 201, pyridoxines, zinc oxide, arbutin, retinol, palmitic acid Regarding retinol, the effect of being contained in the base-containing composition or acid-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid and base-containing composition of the kit of (3) It is preferable in demonstrating. These specific components (allantoin, glycyrrhizic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, which are contained in these compositions in the kits of (1) to (3), The amount of benzonium chloride, sulfur, photosensitizer 201, pyridoxine, zinc oxide, arbutin, retinol, retinol palmitate) is preferably a ratio of the total amount of the two agents to 100 parts by mass of the above-mentioned external preparation for skin. It is preferable that it is the ratio similar to the preferable ratio of these specific components.

<Other ingredients>
The external preparation for skin of the present invention includes other active ingredients, preservatives, pH adjusters, fats and oils, fragrances, colorants, antioxidants, antibacterial and antifungal agents, alcohol, nonionic surfactants, anionic surfactants, and cationic interfaces. One or more components that are usually used in external preparations for skin, such as surfactants such as surfactants and amphoteric surfactants, inorganic salts, lubricants, and solvents can be used. These are contained in the composition for external preparation for skin of the present invention. Moreover, in the kit of this invention, the component to add can be used for any one agent of a 1st agent and a 2nd agent, and may be used for any agent.

  Inclusion of other components (water, acidic substances, carbon dioxide generating substances, thickeners, polyhydric alcohols, and components other than the specific components) in the external preparation for skin, kit and external preparation for skin of the present invention The total amount is preferably 30% by mass or less, and more preferably 25% by mass or less.

<Kit dosage form and amount of ingredients>
The kits (1) to (3) will be further described in detail. In the kits of (1) to (3), the water-containing composition of each kit (the acid-containing composition of the kit of (1), the base-containing composition of the kit of (2), the water-containing composition of the kit of (3)) Examples of the dosage form include gel or liquid. In addition, as the dosage form of the other agent of each kit (base-containing composition of kit of (1), acid-containing composition of kit of (2), acid and base-containing composition of kit of (3))) Any dosage form such as solid, liquid or gel may be used. In the case of a solid form, it is preferably in the form of granules, fine granules, and powders from the viewpoint of ease of mixing with the other agent and cost during production.

<Water-containing composition of kit of (1) to (3)>
The preferred amounts of the carbon dioxide generating substance, the acidic substance and the specific component in the water-containing composition of the kits (1) to (3) are as described above. Moreover, it is preferable from a viewpoint of the mixability with the other agent of each kit that the ratio of the water | moisture content in the said water-containing composition of the kit of (1)-(3) is 20 mass% or more, especially 30 mass% or more, It is preferable that it is 95 mass% or less, especially 90 mass% or less from the point which contains the other component and improves the cosmetic effect etc. as a skin external preparation.

  (1) to (3) when the polyhydric alcohol is contained in the water-containing composition of the kit, and the proportion of the polyhydric alcohol in the water-containing composition is 1% by mass or more, particularly 10% by mass or more. It is preferable from the viewpoint of enhancing the moisturizing effect by combining with a specific component, etc., and it is 90% by mass or less, particularly 80% by mass or less, and particularly 70% by mass or less, and contains other components as a cosmetic external preparation for skin. This is preferable from the viewpoint of enhancing the effect.

  In addition, each of the water-containing compositions (1) to (2) preferably contains the above-described acidic substance, carbon dioxide generating substance, and specific component in the amounts described above. Moreover, to each water-containing composition of (1) to (3), a moisturizer other than polyhydric alcohol, a surfactant, a pH adjuster, a volatile alcohol, fats and oils, a fragrance, an extract of animals and plants, and the like should be added. Can do. For example, as a moisturizer other than polyhydric alcohol, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidonecarboxylate, almond, avocado, altea, aloe, usvenia oyster, onionis, oats, licorice, quince seed, clara (kujin), Gardenia, grapefruit, watercress, gentiana, genus shochu, burdock, wheat, saishin, cactus, savannah, hawthorn, gibbon, shimotsuke, ginger, mallow, mulberry, ladybug, cordyceps, dodder, mint, pearl beetle, poultry, poultry , Grapes, prunes, loofahs, bodaiges, hops, pine, quince, maronier, melissa, cornflower, lily, lime, lavender, apple, rice and rice bran Kkukaranto, bistorta officinalis, R. multiflora, Siberian ginseng, include plant extracts such as seaweed, it is possible to use one or more of these.

  The liquid agent has a viscosity at 25 ° C. of preferably less than 5000 mPa · s, more preferably less than 4000 mPa · s. The gel-like agent preferably has a viscosity at 25 ° C. of 5000 Pa · s or more. This viscosity is measured by, for example, a viscometer (Brookfield RVT type). Further, the amount of the thickener in the liquid agent is preferably less than 0.05% by mass, more preferably less than 0.01% by mass, and particularly preferably less than 0.005% by mass. On the other hand, the amount of the thickener in the gel-like agent is preferably 0.01% by mass or more, more preferably 0.05% by mass or more.

<Base-containing composition of kit of (1), acid-containing composition of kit of (2), acid- and base-containing composition of kit of (3)>
Preferred amounts of the acid, carbon dioxide generating substance and specific component in these compositions are as described above. When these compositions are solid, the preferred amount of the thickener and the content thereof are 0.01 mass% or more and 20 mass% or less, particularly 0 when the other agent is gel. 0.05 mass% or more and 15 mass% or less is preferable from the viewpoint of good foaming properties, carbon dioxide retention, and the effect of a specific component. When the other agent is liquid, 0% is contained in these compositions. 0.01 mass% or more and 30 mass% or less, particularly 0.05 mass% or more and 25 mass% or less from the viewpoint of easy mixing with the liquid agent, foamability, carbon dioxide retention, and the effect of specific components. preferable.

  In addition, as described above, the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid- and base-containing composition of the kit of (3) may be gel-like or liquid. Good. In this case, the preferable amount of the thickener in these compositions is the same as the preferable amount of the thickener that is liquid or gel-like in the water-containing composition of the kits (1) to (3) described above. When the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid and base-containing composition of the kit of (3) are gel-like or liquid, in these compositions, The water content is preferably 7% by mass or more, more preferably 10% by mass or more, and particularly preferably 20% by mass or more from the viewpoints of foamability, bubble persistence, etc., and is 95% by mass or less, particularly 90% by mass or less. Is preferable because it contains other ingredients and enhances the cosmetic effect as a skin external preparation.

  (1) Kit-containing composition of kit, (2) Kit-containing acid-containing composition, (3) Kit-containing acid and base-containing composition containing polyhydric alcohol, and these compositions Is gel-like or liquid, the content of polyhydric alcohol in these compositions is preferably 1% by mass or more, particularly 10% by mass or more from the viewpoint of ease of use at the time of use, and 90% by mass. % Or less, particularly 80% by mass or less, and particularly preferably 70% by mass or less from the viewpoint of enhancing the cosmetic effect as a skin external preparation by containing other components. The base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), the acid and base-containing composition of the kit of (3) are included in these compositions when they are gel or liquid Examples of the components include surfactants, preservatives, preservatives, pH adjusters, fragrances, colorants, antioxidants, fungicides and fungicides.

  When the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid- and base-containing composition of the kit of (3) are solid, The method is mentioned.

When granules are obtained by granulating an acidic substance and / or carbon dioxide generating substance as a mixture with other components, the content of other components is not particularly limited, but is less than 95% by mass in the granules. It is preferable. When other components are present in a content exceeding 95% by mass, foaming properties are lowered, which is not preferable.
The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc. It can be produced according to a conventional method.

  For example, in the production of granules, a matrix substrate having functions such as granule molding may be used. When a low melting point compound is used as the matrix base, the carbon dioxide generating substance is added to the low melting point compound melted by heating in a container such as a beaker and sufficiently stirred and mixed. You may add an appropriate additive to this as needed. This is further stirred while gradually cooling at room temperature, and is allowed to stand until it hardens. If it hardens to some extent, it may be cooled rapidly in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide generating substance is dissolved or dispersed in this. After thoroughly mixing, heat in an oven to remove the solvent and dry. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.

  As the shape of the acidic substance and / or carbon dioxide generating substance, for example, an irregular shape, a planar shape, a polyhedral shape, a spherical shape, a drop shape, a fiber shape, a columnar shape, a fine powder shape and the like can be employed without any particular limitation. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm or less are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

  Acidic substances and / or carbon dioxide generating substances may be blended as they are, together with the components contained in the same agent, but they are blended so that they do not come into physical contact with other components in the same agent. Also good. In this case, for example, the acidic substance and / or the carbon dioxide generating substance may be provided with a coating layer that wraps the acidic substance and / or the carbon dioxide generating substance, or the other component, Either one or both may be encapsulated. In addition, the acidic substance and / or carbon dioxide generating substance is compressed by sandwiching a layer not containing the carbon dioxide generating substance, acidic substance and other components so that they do not directly contact each other or other components. You may shape | mold. As the means for coexisting the acidic substance and / or carbon dioxide generating substance and other components in the same agent, a known method may be mentioned.

  When the kits of (1) to (3) are water-containing compositions, the mixing ratio (mass ratio) of both is preferably 1: 0.1 or more and 20 or less, and 1: 0.2 or more and 10 The following is more preferable. When the kit of (1) to (3) is composed of a water-containing composition and a composition that does not substantially contain water (for example, a composition in which the proportion of water is 5% by mass or less), the mixing ratio (mass ratio) of the two ) Is preferably 1: 0.01 or more and 30 or less, more preferably 1: 0.05 or more and 20 or less.

  The amount of each of the acidic substance, carbon dioxide generating substance, thickener, water and specific component used in the skin external preparation of the present invention (or used for mixing to obtain a carbon dioxide-containing skin external preparation) is based on the total amount. The acidic substance is 0.1 to 15% by mass, the carbon dioxide generating substance is 0.1 to 20% by mass, the thickener is 0.1 to 20% by mass, the water is 40 to 99.6% by mass, and the specific component is 0.01-30 mass% is preferable. When the skin external preparation contains a polyhydric alcohol, the acidic substance in the skin external preparation (or used for mixing to obtain a carbon dioxide-containing skin external preparation), the carbon dioxide generating substance, the thickener, water, the specific component, and The amount of each polyhydric alcohol used is 0.1 to 10% by mass for the acidic substance, 0.1 to 10% by mass for the carbon dioxide generating substance, and 0.1 to 15% by mass for the thickener relative to the total amount. Water is preferably 30 to 97 mass%, the specific component is preferably 0.01 to 20 mass%, and the polyhydric alcohol is preferably 0.05 to 50 mass%. The amount of these components can be obtained as an amount in a kit or a composition for external skin preparation for obtaining an external preparation for skin, or an amount of water mixed with the composition.

<Usage form of composition for external preparation for skin>
The composition for external skin preparation of the present invention may be in any form such as solid, liquid, gel, etc., but it is solid from the viewpoint of ease of mixing when mixing with the other agent and cost during production. The shape is preferable, and it is more preferable that it is in the form of granules, fine particles, and powders among solid forms. When the composition for external preparation for skin is used, foaming is caused by mixing with a water-containing substance on the palm or in a container. Examples of the water-containing substance used include liquids containing water that are usually used in cosmetics, pharmaceuticals, etc., and used in general households. The liquid containing water may be water itself. Specifically, in addition to tap water, distilled water, membrane filtered water, ion exchange water, deep ocean water, sake, wine and other alcoholic beverages, soy milk, drinking yogurt, acerola juice, sports beverages, carbonated water beverages, rice Notogi soup and so on. These may be used alone or in combination of two or more.

  The amount of the water-containing substance to be used is not particularly limited and can be used in a wide range. For example, it is preferably added in an amount of 1 to 10 times by mass with respect to the external preparation for skin, and 2 to 5 times. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, dripping due to a decrease in viscosity of the external preparation for skin can be prevented by adding the liquid within 10 times the amount.

  The temperature of the water-containing substance to be used is not particularly limited, and a wide range can be used. However, it is possible to enhance the effect of carbon dioxide gas by using a specific component of the external preparation for skin when cooled in advance. Is particularly preferable. The usable temperature range is preferably water at about room temperature or tap water from the viewpoint of usability during application and user convenience.

  When the composition for external preparation for skin or the component of the kit is a solid, the method for storing the kit is not particularly limited as long as it is stored in a state where moisture is blocked and is not in contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, for example, It is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

<Uses of external preparations for skin>
The skin external preparation of the present invention promotes an increase in skin blood flow due to the action of carbon dioxide. The skin external preparation of this invention is excellent in the skin improvement effect of making the skin color white, increasing the amount of moisture in the skin, reducing the amount of moisture transpiration, and improving the skin elasticity. In addition, the external preparation for skin of the present invention has a feeling of use (ease of mixing, smoothness of foam, fineness of foam, uniform feeling of foam, ease of application, difficulty of dripping, elasticity of foam, carbonic acid feeling and In addition to being excellent in the degree of sustainability, etc., it is also excellent in feeling after use (moist skin, elasticity, brightness, redness, smoothness, smoothness, feeling of tightening, etc.). Moreover, the skin external preparation of this invention accelerates | stimulates the metabolism (turnover) of skin. Furthermore, the skin external preparation of this invention has a skin cell activation effect | action by containing a specific active ingredient in a carbon dioxide-foaming skin external preparation, and can be used as an activator of skin cells. Moreover, the skin external preparation of this invention has the activation of the metabolism of the skin resulting from a cell activation effect, an ATP production promotion effect, etc. Taking advantage of these effects, the topical skin preparation of the present invention is whitening, improving skin quality, improving freckles, rejuvenating the skin, tightening the skin, partially thinning, purifying the skin, preparing the skin, and adjusting the texture of the skin. , Keep skin healthy, prevent skin irritating, moisturize skin, moisturize skin, keep skin moisture and oil supplement, keep skin flexible, protect skin, prevent skin dryness, skin Not only cosmetics intended to soften, soften skin, gloss, smooth skin, prevent spots and freckles caused by sunburn, and make wrinkles due to drying inconspicuous. Prevents skin irritation, tingling, skin rashes, skin blemishes, cracks, redheads, acne, oily skin, razor ablation, sunburn spots, freckles, sunburn, sunburn and hot flashes Cleanse the skin Suitable for both quasi-drugs and pharmaceuticals, such as to make skin, condition skin, keep skin healthy, moisturize skin, protect skin, prevent skin dryness, etc. Can be used. The external preparation for skin of the present invention is preferably used as cosmetics and quasi drugs, and is preferably used as cosmetics such as emulsions, creams, packs, and peeling agents, and medicinal cosmetics. Of these, use as a pack agent is particularly preferable because it provides a good feeling of use and a high skin condition improving effect.

  The present invention also relates to an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, a thickener, and a carbon dioxide foaming external preparation for skin obtained by mixing water, The present invention provides a carbon dioxide-foaming skin external preparation (carbon dioxide-containing composition) containing the specific component.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples. In the following examples and comparative examples, commercially available products were used unless otherwise specified. The arbutin used below is β-arbutin.

<Manufacture of effervescent skin external preparation>
Each component described in Tables 1 to 6 was mixed so as to have the composition shown in the same table, and kits for external preparations for skin of Examples and Comparative Examples were produced. In each of the examples and comparative examples described in Tables 1 to 6, the agent not containing water is in powder form, the agent having water and a thickener is gel-like, has water and has no thickener. The agent was liquid.
Moreover, each component of the composition shown in following Table 7 was mixed, and the powdery composition for external preparations for skin was manufactured.
The external preparation for skin obtained by mixing the A agent and B agent of each Example described in Tables 1 to 6 with the masses described in Tables 1 to 6 is easy to apply to the skin during use. It was easy. Moreover, it had a cosmetic effect on the skin after use. Moreover, the skin external preparation which mixed 9 g of compositions and 27 g of water was the same as the composition for external skin preparation of Table 7 as described in Table 7. In Tables 1 to 7, the acidic substance is also simply referred to as “acid”, and the carbon dioxide generating substance is also simply referred to as “carbonate”. In addition, glucose described in “Others” includes use as a polyhydric alcohol.

The following [Evaluation 1] was performed for each of the above Examples and Comparative Examples.
[Evaluation 1]
As subjects, two healthy women in their 20s and 30s were randomly selected. The inner surface of each subject's forearm was washed with face wash and allowed to rest in the measurement room for 15 minutes. Next, the color difference, moisture transpiration amount, stratum corneum moisture content, and elasticity were measured by the following method for the measurement part of the 4 cm × 4 cm planned area for application of the foamable skin external preparation on the inner side of the forearm. Next, the said foamable skin external preparation was apply | coated to the said measurement site | part, and it left still for 10 minutes. Thereafter, the foamable skin external preparation was removed and washed with water. After 15 minutes from the washing, the same measurement was performed after using the foamable skin external preparation. The subject was resting in the measurement room during the measurement.
The skin condition measurement results after use are shown in FIGS. 1A to 13B. In addition, the value in FIG. 1A-FIG. 13B is a relative value (change rate) when the measured value before using foaming skin external preparation is set to 1. The color difference indicates that the larger the value, the whiter the color is; the smaller the value, the better the barrier function, and the higher the value, the better the stratum corneum moisture value. The elasticity indicates that the larger the value, the better.

The skin condition before and after application of the effervescent skin external preparation was measured using the following apparatuses. These measurements were carried out by standard methods described in the instructions attached to the instrument.
Color difference: Measured with a color difference meter (CR-400 manufactured by Konica Minolta).
-Moisture transpiration: measured using Tevameter (registered trademark) TM300 (CK Corporation).
-Stratum corneum moisture content: Measured with skin surface stratum corneum moisture measuring device SKICON-200EX (manufactured by IBI S Co., Ltd.). This skin surface stratum corneum moisture content measuring apparatus evaluates the skin conductance (electrical conductivity, unit: μS) as the moisture content of the stratum corneum.
Elasticity: Measured with a skin viscoelasticity measuring device Cutometer MPA580 (Courage + Khazaka).

  As shown in FIG. 1A to FIG. 13B, the foamable skin external preparation of each Example containing a specific component is different from the foamable skin external preparation of each Comparative Example that does not contain this, color difference and corners before use. The increase in layer moisture and elasticity was large, and the decrease in moisture transpiration was small. Therefore, it is clear that the foaming skin external preparation of the present invention having a specific component has a high skin condition improving effect.

The following [Evaluation 2] was performed for each of the above Examples and Comparative Examples.
[Evaluation 2]
As subjects, three healthy women in their 20s to 30s were randomly selected. The inner surface of each subject's forearm was washed with face wash and allowed to rest in the measurement room for 15 minutes. Next, the said foamable skin external preparation was apply | coated to the measurement site | part inside a forearm, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. The evaluation items (16 items) at the time of use and after use were evaluated based on the seven-step evaluation criteria. The evaluation criteria are shown in Table A below, and the results are shown in Table B to Table G below. In addition, the following result is an average value of three evaluation points.

  As shown in Tables B to G, the effervescent skin external preparation of each Example containing a specific component is more comfortable to use (easy to mix) than the effervescent skin external preparation of each Comparative Example not containing this. It is excellent in smoothness of foam, fineness of foam, uniform feeling of foam, ease of application, resistance to dripping, elasticity of foam, feeling of carbonic acid and its persistence), and feeling after use (moist feeling of skin, It was excellent in elasticity, brightness, redness, smoothness, smoothness, and crispness. Therefore, the skin condition improving effect of the foamable skin external preparation of the present invention having a specific component is high, whitening, improving skin quality, tightening the skin, preparing the skin, preparing the texture of the skin, tightening the skin, giving the skin moisture Clearly, it can keep the skin soft, soften the skin, give the skin a smoothness, smooth the skin, and make wrinkles caused by drying inconspicuous.

The following [Evaluation 3] was performed for each of the above Examples and Comparative Examples.
[Evaluation 3] (Turnover test)
The inner side of the forearm of a subject (a healthy female randomly selected in their 20s to 30s) was washed with a face wash and allowed to rest in the measurement room for 15 minutes. Next, a cellophane tape (4 cm × 1.8 cm) was applied to the measurement site on the inner side of the forearm, and after making it adhere with a constant pressure, the operation of peeling the tape was repeated twice. The foamed skin external preparation after mixing was applied to a measurement site in a range of 4 cm × 4 cm and allowed to stand for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. Similarly, the operation of applying the tape → peeling was repeated twice at the measurement site that was not applied before application after 5 minutes.
The first tape was discarded, and a vinyl chloride resin adhesive was thinly applied to the stratum corneum sampling surface of the second tape and attached to a slide glass. After sticking, the slide glass was sufficiently dried, immersed in ethanol for 10 minutes, and dried at room temperature (22 ° C. to 27 ° C.) for 10 minutes or more. Thereafter, it was immersed in xylene until the tape was peeled off. After the tape peeling, the slide glass was further immersed in xylene for 30 minutes to 1 hour. After the slide glass was taken out and dried, it was immersed in a staining solution (gentian violet dissolved in purified water at a concentration of 0.1 w / w% and brilliant green at a concentration of 0.5 w / w%) for 15 minutes. After washing 4-5 times with purified water, it was dried and observed 200 times with an optical microscope. The obtained observation image was subjected to a five-step evaluation according to each of the three items described in Table H according to the evaluation criteria shown in Table H below. Calculate the total value of the three evaluation points (score: 5 to 1 point) for each observation image before and after use of the effervescent skin external preparation, and calculate the score total value before use from the score total value after use. The subtracted value was obtained. All three items in Table H below indicate the degree of skin metabolism (turnover), and the greater the value of the evaluation score, the greater the degree of turnover. The difference before and after use of the score total value calculated | required above is shown in FIGS. Moreover, the observation image of the horny layer cell before and behind use of the foamable skin external preparation of the comparative example 1, Example 1-19, Example 2-3, and Example 4-3 obtained by the said microscope observation is shown in FIG. Shown in

  As shown in FIGS. 14-26, in each Example containing a specific component, the score total value after using a foaming skin external preparation increased by 2 or more from before use. On the other hand, in Comparative Examples 1 to 7, the total score after use of the foamable skin external preparation decreased from before use, or even when increased, the difference from before use remained at 1 or less. In addition, from FIG. 27, the improvement in the stratum corneum form and the array regularity, which are indicators of turnover, after use of the foaming skin external preparation after use is remarkable in the example, whereas in the comparative example, It is clear that this is not possible. Therefore, it is clear that the foamable skin external preparation of each Example is superior in the effect of promoting turnover as compared with each Comparative Example.

The specific component used by this invention was used for the cell activation test of the procedure of the following (1)-(5).
[Cell activation test 1]
(1) Dulbecco's modified Eagle medium (10% by mass FBS-DMEM) containing normal human skin fibroblasts (NHDF) in 10% by mass fetal bovine serum using a 75 cm ² flask in a 37 ° C., 5% by volume CO ₂ incubator. Was cultured.
(2) The cells cultured in (1) were suspended by trypsin treatment, and then seeded at a cell density of 1 × 10 ⁴ cells / well from a 75 cm ² flask to each well of a 96-well plate.
(3) The cells seeded in (2) were pre-cultured in a 10% by mass FBS-DMEM medium at 37 ° C. in a 5% by volume CO ₂ incubator for 24 hours.
(4) After the pre-culture in (3), the medium was removed from each well, washed once with 200 μL / well of serum-free DMEM, and then 200 μL of the test substance-containing medium prepared to a predetermined concentration was added to each well. The cells after adding the test substance-containing medium were cultured for 24 hours in a 5 vol% CO ₂ incubator at 37 ° C.
The test substance-containing medium was prepared as in Preparation Method 1 below.
(Method 1 for preparing test substance-containing medium)
Sodium bicarbonate, malic acid, thickener listed in Table 8 below, and arbutin as a specific component, final concentration of sodium bicarbonate is 62.5 mM, final concentration of malic acid is 20.8 mM, thickener and specified The components were mixed in serum-free DMEM so that the final concentrations of the components were as shown in Table 8 below.

(5) The cultured cells were washed once with PBS 200 μL / well.
150 μL / well of Cell Counting Kit-8 solution diluted 30-fold with serum-free DMEM was added. Thereafter, 37 ° C., was allowed to stand appropriately colored 5 vol% CO ₂ incubator, the absorbance was measured at 450nm.
Based on the obtained absorbance, the cell activation activity (%) was calculated by the following formula. In addition, the data of the reference example 1 was used as Data control in a following formula. Cell activation activity (%) = (Data sample-Data blank) / (Data control-Data blank) × 100

  The results of cell activation activity are shown in FIG. As shown in FIG. 28, it can be seen that the cell activation activity can be enhanced by combining the specific component with the thickener, the acidic component, and the carbon dioxide generating component.

Moreover, the specific components described in Table 9 below were subjected to the following [Cell Activation Test 2].
[Cell activation test 2]
The method for preparing the test substance-containing medium was changed to the following Preparation Method 2. In addition, when calculating the cell activation activity (%), serum-free DMEM without addition of a test substance was used as Data control. Except for these points, the same procedure as in [Cell Activation Test 1] was performed. The results are shown in Table 9 below.
(Method 2 for preparing test substance-containing medium)
The specific components listed in Table 9 below were mixed with serum-free DMEM so that the final concentration was the value shown in Table 9 below. In Table 9 below, when “Carbonate” is described as “Yes”, it is specified so that the final concentration of sodium bicarbonate is 31.2 mM and the final concentration of malic acid is 6.25 mM. Both components were mixed in serum-free DMEM. In the following Table 9, when the term “carbonic acid” is described as “−”, only specific components were mixed in serum-free DMEM, and sodium bicarbonate and malic acid were not used.

  As described above, it has been confirmed that the cell activation activity is increased when the foamable skin external preparation contains the specific component.

Claims (6)

  A carbon dioxide-foaming skin external preparation containing an acidic substance, a carbon dioxide-generating substance that generates carbon dioxide by reacting with the acidic substance and a thickener in the same agent or two or more agents, and further comprising ascorbic acid Glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl Alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, pyridoxine hydrochloride, pyridoxine, oxidation Carbon dioxide foaming topical skin preparation containing at least one selected from lead, arbutin, phosphate-L-ascorbyl magnesium, ascorbyl dipalmitate, placenta, retinol and retinol palmitate (provided that carbon dioxide foaming skin topical preparation is 1 When it is composed of an agent, it is mixed with a water-containing substance at the time of use, and when it is composed of two or more agents, any one of the agents contains water).   Furthermore, the carbon dioxide-foaming skin external preparation of Claim 1 containing a polyhydric alcohol. A first agent which is an acid-containing composition containing an acidic substance and water;
A second agent that is a base-containing composition containing a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide,
A carbon dioxide foaming external preparation for skin, which is a kit for mixing the first agent and the second agent at the time of use, wherein one or both of the first agent and the second agent have a thickener, and
One or both of the first agent and the second agent are ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-acetate Tocopherol, nicotinic acid dl-α-tocopherol, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, hydrochloric acid Pyridoxine, pyridoxine, zinc oxide, arbutin, phosphate-L-ascorbyl magnesium, ascorbyl dipalmitate, placenta, retinol and palmitic acid Carbon dioxide gas foaming skin external preparation containing at least one selected from Chinoru. A first agent that is an acid-containing composition containing an acidic substance;
A second agent that is a base-containing composition containing a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and water, and
A carbon dioxide foaming external preparation for skin, which is a kit for mixing the first agent and the second agent at the time of use, wherein one or both of the first agent and the second agent have a thickener, and
One or both of the first and second agents are allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, nicotinic acid dl-α-tocopherol, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, pyridoxine hydrochloride, pyridoxine, Zinc oxide, arbutin, ascorbic acid glucoside, phosphate-L-ascorbyl magnesium, ascorbyl dipalmitate, placenta, retinol and palmitic acid Carbon dioxide gas foaming skin external preparation containing at least one selected from Chinoru. A first agent that is an acid and base-containing composition, comprising an acidic substance and a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide;
A second agent that is a composition containing water; and a carbon dioxide foaming topical skin preparation that is a kit for mixing the first agent and the second agent at the time of use, wherein the first agent and the second agent One or both have a thickener, and
One or both of the first agent and the second agent are ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-acetate Tocopherol, nicotinic acid dl-α-tocopherol, D-pantothenyl alcohol, pantotenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer 201, phenol, hydrochloric acid Pyridoxine, pyridoxine, zinc oxide, arbutin, phosphate-L-ascorbyl magnesium, ascorbyl dipalmitate, placenta, retinol and palmitic acid Carbon dioxide gas foaming skin external preparation containing at least one selected from Chinoru.   The carbon dioxide-foaming skin external preparation according to any one of claims 3 to 5, wherein one or both of the first agent and the second agent contain a polyhydric alcohol.