JP6108363B2 - Skin preparation kit - Google Patents

Description

  The present invention is a kit for obtaining a foamable skin external preparation, wherein the first agent contains an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. The kit is characterized in that the second agent is a composition containing water and / or a humectant.

When carbon dioxide acts on the skin, there is an effect of promoting blood circulation in the skin. Therefore, various skin external preparations using carbon dioxide have been proposed. Many of these generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. For example, in order to maintain the effect of the generated carbon dioxide gas, a method of mixing a hydrous viscous composition containing an acidic substance, water and a thickener and a solid carbon dioxide gas generating substance immediately before use has been proposed. (Patent Document 1). In addition, it is mixed with water immediately before use in a granular material containing a substance that is hydrolyzed to produce an acid, carbonate, thickener, gelling agent that gels with calcium ions, and water-insoluble or poorly water-soluble calcium salt. A method of use has been proposed (Patent Document 2).

WO99 / 24043 WO 2006/80398

  However, when carbon dioxide is generated by the method described in Patent Document 1, it is difficult to uniformly mix the hydrous viscous composition and the solid carbon dioxide-generating substance, and foaming due to carbon dioxide tends to cause unevenness. Takes time to start. In addition, the method described in Patent Document 2 is troublesome for the user because it takes time to measure water, and the viscosity and carbon dioxide generation amount during use are not constant depending on the quality of the water used. The effect will be different for each use.

  The present invention has been made in view of the above circumstances, is easily mixed uniformly during mixing, generates carbon dioxide gas evenly, and has a constant quality foaming skin regardless of the user's measuring effort and the quality of water used. The purpose is to provide a kit for obtaining an external preparation.

The present invention provides a kit for obtaining the following foamable skin external preparation (hereinafter also referred to as a kit of the present invention).
<1> A kit for obtaining an external preparation for foaming skin, wherein the first agent is an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. And the second agent is a composition containing water and / or a humectant.
<2> The kit according to <1>, wherein the first agent is a solid composition.
<3> The kit according to either <1> or <2>, wherein the acidic substance of the first agent and the carbon dioxide generating substance coexist so as not to contact each other.
<4> The kit according to any one of <1> to <3>, wherein the acidic substance and / or carbon dioxide generating substance of the first agent has a coat layer.
<5> The kit according to <1>, wherein the second agent is a liquid composition.
<6> The kit according to any one of <1> or <5>, wherein the second agent contains water and a humectant.
<7> The first agent and the second agent are mixed and used at a weight ratio in the range of 1: 0.1 to 1:30, according to any one of <1> to <6> kit.

  According to the present invention, it is easy for a user to mix evenly during mixing, carbon dioxide gas is generated immediately without unevenness, and a constant-quality foaming skin external preparation is used regardless of the user's measuring effort and the quality of water used. A kit for obtaining can be provided. In particular, when an acidic substance and a carbon dioxide generating substance are blended in the first agent at the same time, foaming with carbon dioxide gas at the time of mixing with the second agent can be performed efficiently. In addition, since the second agent does not contain an acidic substance or carbon dioxide generating substance, the acidic substance or carbon dioxide generating substance in the second agent does not react with other substances. Other active ingredients can be used without limitation. Furthermore, even if only the second agent is mistakenly used on the skin, no irritation is given, so that it can be used safely. Moreover, skin can be kept white and fresh by using the foamable skin external preparation obtained by using the kit of the present invention.

The increase rate of the volume by the carbon dioxide gas of the foamable skin external preparation obtained using the kit of this invention is shown.

  The present invention is a kit for obtaining a foamable skin external preparation, wherein the first agent contains an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. The kit is characterized in that the second agent is a composition containing water and / or a humectant.

  In the kit of the present invention, the user can use the first agent and the second agent by mixing the first agent and the second agent as appropriate to cause foaming due to the generation of carbon dioxide gas and apply it to the skin. The kit of the present invention is characterized by good storage stability by being divided into the first agent and the second agent, and is easy for the user to handle during use. Hereafter, each component contained in the foamable skin external preparation obtained using the kit of this invention and the kit of this invention, and its manufacturing method are demonstrated.

<First Agent>
The first agent in the kit of the present invention (hereinafter also referred to as the first agent) contains an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. The first agent is preferably a solid composition, and more preferably in the form of granules, fine particles, and powder. Moreover, it is preferable that water is not included substantially from a viewpoint of storage stability. Specifically, the water content in the first agent is preferably 15% or less, more preferably 10% or less, and even more preferably 8% or less.

≪Acid substances≫
The acidic substance used in the first agent of the present invention may be either an organic acid or an inorganic acid, and one or more of these are used. Moreover, the acidic substance to be used is preferably in a solid form, more preferably in a granular form, a fine granular form, or a powder form.

  Examples of organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid and valeric acid or salts thereof, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid Acids, dicarboxylic acids such as isophthalic acid and terephthalic acid or salts thereof, acidic amino acids such as glutamic acid and aspartic acid or salts thereof, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glycerin Examples include acids, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and other oxyacids or salts thereof, and inorganic acids include phosphoric acid, sulfurous acid and other inorganic acids or salts thereof, These 1 type (s) or 2 or more types can be used. Of these, citric acid or a salt thereof, ascorbic acid or a salt thereof, malic acid or a salt thereof, succinic acid or a salt thereof is preferable, and citric acid or a salt thereof is more preferable from the viewpoints of safety and solubility in the second agent. preferable.

  Various materials can be used without particular limitation as the carbon dioxide generating material used in the first agent of the present invention. Further, the carbon dioxide generating substance to be used is preferably in a solid form, and more preferably in a granular form, a fine granular form or a powder form.

≪Carbon dioxide generating substance≫
Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Of these, sodium hydrogen carbonate is more preferable, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The acidic substance or the carbon dioxide generating substance can be used in the first agent as a mixture with other components. Here, when granulating the acidic substance or the carbon dioxide generating substance and other components to obtain granules of the acidic substance or the carbon dioxide generating substance, other components (however, the acidic substance or the carbon dioxide gas) In the case of covering the generated substance, the content of the coating layer is not particularly limited, but is preferably less than 90% by mass in the granule. When other components are present in a content exceeding 90% by mass, foaming properties are lowered, which is not preferable.

  The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc. It can be produced according to a conventional method.

  For example, in the production of granules, a matrix substrate having functions such as granule molding may be used. When a low melting point compound is used as the matrix base, the acidic substance or the carbon dioxide generating substance is added to the low melting point compound melted by heating in a container such as a beaker, and sufficiently stirred and mixed. You may add an appropriate additive to this as needed. The mixture is further stirred while being cooled at room temperature, and left to solidify. If it hardens to some extent, it may be cooled rapidly in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide generating substance is dissolved or dispersed in this. After thoroughly mixing, heat in an oven to remove the solvent and dry. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.

  As the shape of the acidic substance or the carbon dioxide generating substance, for example, an irregular shape, a planar shape, a polyhedron shape, a spherical shape, a drop shape, a fiber shape, a columnar shape, a fine powder shape, and the like can be employed without particular limitation. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm or less are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

  In the present invention, the acidic substance and the carbon dioxide generating substance are contained in the same agent, and the acidic substance and the carbon dioxide generating substance are blended and coexist in the same agent so as not to physically contact each other. It is preferable. The coexistence means is not particularly limited and can be widely applied.

  When blending so that the acidic substance and the carbon dioxide generating substance do not come into physical contact with each other, for example, a coating layer is provided on either or both of the acidic substance and the carbon dioxide generating substance. Alternatively, either one or both of the acidic substance and the carbon dioxide generating substance may be encapsulated. In addition, a layer that does not contain the acidic substance and the carbon dioxide generating substance may be sandwiched between the acidic substance and the carbon dioxide generating substance so that they do not come into direct contact with each other, and compression molding may be performed.

  Hereinafter, the coexistence means of the acidic substance and the carbon dioxide generating substance in the same agent will be specifically described, but the invention is not limited thereto.

[Coat layer formation]
As a coating layer forming method, for example, a method of forming a coating layer in at least one of an acidic substance and a carbon dioxide generating substance may be used. By providing a coat layer, even if it coexists with the acidic substance, the carbon dioxide generating substance and other components in the same agent, there is no risk of unexpected carbon dioxide generation during its production or storage, so stability, It is preferable from the viewpoint of durability.

  A preferable coating agent for constituting the coating layer can be used without particular limitation as long as it has low reactivity with the acidic substance or the carbon dioxide generating substance. For example, fats and oils, fatty acids, fatty acid salts, acetylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, hydroxypropylmethylcellulose, methyl methacrylate-methacrylic acid copolymer, ethyl acrylate-methacrylic acid Copolymers, gum arabic, sodium alginate, soluble starch, hydroxypropylcellulose, wheat starch, polysaccharides (eg sucrose, lactose, etc.), citrate and the like can be mentioned. In particular, when an acidic substance such as citric acid is coated, it is preferable to employ a citrate such as calcium citrate. Moreover, you may form a coat layer using solid hydrocarbon wax, solid fats, etc. which melt | dissolve at temperature more than fixed by heating.

  The amount of the coating agent used for the acidic substance and / or carbon dioxide generating substance is preferably 1 to 20% (w / w), more preferably 1 to 10% (w / w) based on the acidic substance or carbon dioxide generating substance. w) About.

  The coating layer may be coated by any method as long as it is usually used for coating particles. For example, it may be coated at the same time as granulation by spray granulation or tumbling granulation, etc., and the powder or granulated product is coated with oil and fat, granulation coating, transport layer method, pan coating, rolling coating, fluid coating or You may coat | cover using methods, such as dry coating. When excessive heat or physical force is applied during coating, the acidic substance or the carbon dioxide generating substance is destroyed and the generated film is broken, and the surface of the acidic substance or the carbon dioxide generating substance is broken. Not only is it difficult to uniformly coat the lipid powder on the whole, but the acidic substance or the carbon dioxide generating substance leaks out on the surface and solidifies due to moisture absorption, or it may cause adverse effects on other components during compounding. The coating conditions must be such that the coating layer and the coating object are not destroyed.

[Encapsulation]
When an acidic substance and / or a carbon dioxide generating substance is encapsulated, a known method may be employed without any particular limitation.

  As the encapsulation method, a known method can be applied without any particular limitation. Examples of the encapsulation material include gelatin, starch, gum arabic, methylcellulose, acrylic acid ester, methacrylic acid ester, vinyl acetate, Polyvinyl alcohol, silicone resin, solid wax, polyethylene, fatty acid, higher alcohol, and the like, and those formed with a multilayer of surfactants such as liposomes are included, but can be widely used without being limited thereto. For example, the basic structure of the capsule is composed of a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate, and styrene, or the monomer and acrylic acid, methacrylic acid, divinyl A resin capsule made of a copolymer formed from a monomer selected from benzene and ethylene glycol dimethacrylate is also preferable. In such a microcapsule, the contents and the polymer constituent monomer constituting the capsule shell are emulsified in a reaction solvent such as water, and polymerization of azobisisobutyronitrile, benzoyl peroxide, etc. is started. What is necessary is just to add an agent and to perform emulsion polymerization. As a surface active component used for such emulsification, for example, hexlite sold under the name of “Laponite XLG” can be suitably exemplified. The produced microcapsules are separated by means such as centrifugation, and washed if desired, whereby the microcapsules of the present invention can be produced.

[Compression molding]
As a compression molding method, a substance other than the acidic substance and the carbon dioxide generating substance (so that they do not directly contact between the first layer containing the acidic substance and the second layer containing the carbon dioxide generating substance ( For example, a method in which a third layer made of an excipient, a thickener, etc.) is sandwiched and compression molded may be employed. The compression-molded dosage form may be any dosage form as long as it is solid, such as a tablet, sphere, or plate. Here, the acidic substance to be used and the carbon dioxide generating substance may be used as they are, or the acidic substance in which a coating layer is provided by the above-described method on either one of the first layer and the second layer, or A carbon dioxide generating substance, the encapsulated acidic substance or the carbon dioxide generating substance may be used. The compression molding method is not particularly limited, and a known method can be applied.

  The acidic substance and the carbon dioxide generating substance contained in the first layer and the second layer may be used as they are, or in addition, excipients, thickeners and the like may be mixed and used. . As the excipient, thickener and the like used for the first layer, the second layer and the third layer, those described in the description of the granule can be used without any particular limitation.

  The acidic substance and the carbon dioxide generating substance are preferably contained in the first agent in a ratio of 1: 0.1 to 1:40, and preferably in a ratio of 1: 0.5 to 1:20. Is more preferable, and it is still more preferable to contain in the ratio of 1: 1-1: 10. When the above range is exceeded, the pH when used as an effervescent skin external preparation becomes strongly acidic or strongly basic, and irritation to the skin becomes strong.

≪Thickener≫
The thickener used in the first agent of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, topical medicines, quasi drugs, etc. Molecules, natural polymers, viscous minerals, etc. can be used.

Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cation And hydrophilic synthetic polymers such as fluorinated cellulose and pluronic.

Examples of the semisynthetic polymer include cellulose derivatives such as carboxymethylcellulose or salts thereof, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and sulfonated cellulose derivatives. Examples of other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide, and the like.

Natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, mannan, curdlan, alginic acid or salts thereof, gum arabic Pectin, quinseed, starch, alge colloid, chondroitin sulfate or salts thereof, chito acid and derivatives thereof. Examples of other natural polymers include nucleic acids or salts thereof, ribonucleic acids or salts thereof, albumin, gelatin, silk fibroin and the like.

Examples of the clay mineral include laponite, bentonite, smectite kaolinite, and montmorillonite.

  Among the above thickeners, the use of one having high solubility in the second agent makes it possible to dissolve the first agent uniformly without causing lumps, and to feel the rough surface of the skin due to undissolved components. This is preferable because it can be relaxed. Here, the solubility in the second agent is determined by the fact that when the second agent at room temperature is added and agitated, the skin external preparation instantly dissolves in water or a moisturizing agent and uniformly dissolves to hold carbon dioxide gas. It can be judged from the fact that it has a sufficient viscosity to do so and that no lumps are produced during dissolution.

  Examples of such a thickener include carboxyvinyl polymer, carboxymethyl cellulose or salts thereof, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust Examples include bean gum, celluloses, galactan, gum arabic, tragacanth gum, mannan, curdlan, alginic acid or salts thereof, albumin and the like. Carboxymethyl cellulose or salts thereof, xanthan gum, carrageenan and albumin are preferably used. Although the said thickener can use 1 type (s) or 2 or more types, it is preferable to use 2 or more types. Moreover, it is preferable to use albumin from the viewpoint of retention of generated carbon dioxide gas and foam quality by carbon dioxide gas.

  The thickener is preferably contained in the first agent in an amount of 1 to 40% by mass, more preferably 5 to 35% by mass, and still more preferably 10 to 30% by mass. 25% by mass is particularly preferred. When the content is small, a feeling of roughness due to undissolved components is likely to occur during mixing of the first agent and the second agent, so that the feeling in use is impaired. In addition, it tends to sag during use and lacks adhesion to the skin, and also has a poor ability to retain the generated carbon dioxide gas, so that a sufficient blood circulation promoting effect cannot be obtained. On the other hand, if the content of the thickener exceeds the above range, the solubility in the second agent is inferior, causing lumps and causing discomfort when applied to the skin, and the viscosity is too high. It becomes difficult to apply or wash off. In addition, unevenness occurs in the generation of carbon dioxide gas, and the ability to retain the generated carbon dioxide gas is not so high, so that a sufficient blood circulation promoting action cannot be obtained.

  As the first agent, an excipient can be used as necessary. As the excipient that can be used, an excipient that can be used in cosmetics, external medicines, quasi drugs, and the like can be used. Specific examples include glucose, maltitol, lactose, dextrin, starch, talc, silica and the like, and glucose and dextrin are preferred.

<Second agent>
The second agent in the kit of the present invention contains water and / or a humectant. Preferably, water and a humectant are contained.

  As water that can be used as the second agent, water that can be used in cosmetics, topical medicines, quasi drugs, and the like can be used, but purified water, distilled water, membrane filtered water, and ion exchange water are preferable.

≪Humectant≫
As the humectant used in the second agent, a humectant that can be used in cosmetics, external medicines, quasi drugs, and the like can be used. Specific examples include, for example, polyglycerin such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1, Examples thereof include polyhydric alcohols such as 3-propanediol, sorbitol, and polyglycerin derivatives, polyoxyalkylene alkyl glucoside, sodium lactate, and sodium pyrrolidone carboxylate. Of these, glycerin, diglycerin, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, and polyethylene glycol are particularly preferable. The blending amount is slightly different depending on the type of humectant, but is preferably 0.01 to 80% by mass, more preferably 0.5 to 60% by mass, and still more preferably 1 to 40% by mass.

The second agent of the present invention is preferably a liquid composition, and more preferably has a low viscosity. Specifically, the viscosity at 25 ° C. is preferably 3000 mPa · s or less, more preferably 1000 mPa · s or less, and particularly preferably 100 mPa · s or less. It is preferable that a thickener is not included substantially. When the viscosity exceeds 3000 mPa · s, it becomes difficult to uniformly disperse the first agent in the second agent, which is a viscous composition, when mixing with the first agent, and unevenness in foaming by carbon dioxide gas tends to occur. In addition, it takes time to start foaming. At this time, the thickener is the same as that contained in the first agent.

<External preparation for skin>
In addition to the components contained in the first agent and the second agent, the foamable type skin external preparation produced using the kit of the present invention has other active ingredients, preservatives, pH adjusters, fats and oils, depending on the purpose and purpose , Fragrance, colorant, antioxidant, antibacterial and antifungal agent, alcohol, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, inorganic salt, lubricant, solvent, etc. One or more components that are usually used in external preparations for skin can be used. In this case, the component to be added can be used for either the first agent or the second agent, or may be used for either agent.

  Hereinafter, typical components other than the acidic substance, the carbon dioxide gas generating substance, the thickener, and the humectant contained in the foamable external skin preparation produced using the kit of the present invention will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs, plants and the like used in cosmetics, external medicines, quasi drugs and the like can be used according to the purpose. Typical examples include glycyrrhizic acid or derivatives thereof, whitening agents such as placenta extract, plant components such as licorice, and the like. As plant components, the whole plant, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc. are used as they are. These can be used after being cut, crushed, crushed or exploited, or dried or powdered. The active ingredient used in the present invention can be used for either the first agent or the second agent, but from the viewpoint of solubility during mixing, it is preferably dissolved in advance in the second agent.

<Usage form of effervescent skin external preparation>
When using the kit of the present invention to obtain a foamable skin external preparation, foaming by carbon dioxide gas is caused by mixing an appropriate amount of a first agent and a second agent in a container. The first agent and the second agent are preferably mixed at a ratio of 1: 0.1 to 1:30, more preferably mixed at a ratio of 1: 0.5 to 1:10, and 1: 1 to 1 : It is particularly preferable to mix at a ratio of 5.

  As a method for preserving the kit of the present invention, a method for preserving cosmetics, external medicines, quasi drugs, etc. can be used, and there is no particular limitation. Good to have been. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, but is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

<Use of foaming skin external preparation>
The effervescent skin external preparation obtained using the kit of the present invention promotes an increase in skin blood flow, and is intended for whitening, improvement of skin quality, improvement of freckles, skin rejuvenation, skin tightening, and partial skin thinning. In addition to cosmetics such as cosmetics, emulsions, creams, packs, and peeling agents, it can be suitably used for pharmaceuticals such as quasi drugs and drugs.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples.

<Manufacture of effervescent skin external preparation>
According to the composition shown in Table 1, the kit of the present invention was produced.

Examples 1-5, Comparative Example 2
[First agent]
The raw materials described in the first agent were mixed to obtain the first agent.
[Second agent]
Purified water was added to the beaker, then the ingredients described in the second agent were added and stirred to obtain the second agent.
Comparative Example 1
[First agent]
The raw materials described in the first agent were mixed to obtain the first agent.
[Second agent]
Purified water was put into a beaker, and then a thickener was added and stirred to obtain a viscous composition.

<Characteristic evaluation of effervescent skin external preparation>
The characteristics of the foamable skin external preparation obtained in the above examples were evaluated according to the following procedures.
[Evaluation Example 1. Second agent viscosity]
For the second agent listed in Table 1, the viscosity was evaluated by the method described in JP-A-2000-319187. That is, on the edge of a glass plate having a smooth surface of 40 cm in length, 1 g of the second agent obtained in Examples 1 to 5 and Comparative Examples 1 and 2 was applied in the shape of a disk having a diameter of 1 cm, and the disk comes up. Thus, the moving distance after 5 seconds was measured at an angle of 60 degrees with respect to the horizontal plane. Evaluation was made with a moving distance of 30 cm or more after 5 seconds as ◯, a moving distance of 15 cm or more but less than 30 cm as Δ, and a moving distance of less than 15 cm as x. The obtained results are shown in Table 2. Moreover, as a result of measuring the viscosity of Examples 1-5 using the viscometer (Brookfield RVT type | mold), the value below the lower limit (10 mPa * s) of a viscometer was shown.

[Evaluation Example 2. Evaluation of foam volume]
Examples 1-5
15 g of the second agent was put in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 5 g of the first agent was added thereto, and stirred 20 times for 10 seconds. Immediately after stirring, the volume after 1 minute, 10 minutes, and 20 minutes was measured, and the volume increase rate relative to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas 20 minutes after was made into the holdable carbonic acid amount.

Comparative Example 1
18.93 g of the second agent was placed in a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 1.07 g of the first agent was added thereto, and the mixture was stirred 20 times for 10 seconds. Immediately after stirring, the volume after 1 minute, 10 minutes, and 20 minutes was measured, and the volume increase rate relative to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas 20 minutes after was made into the holdable carbonic acid amount.

[Evaluation Example 3. Evaluation of Usability of Effervescent Skin Topic Agent]
A foamable skin external preparation was prepared using the kits of the present invention obtained in Examples 1 and 5 and Comparative Examples 1 and 2, and the resulting foamable skin external preparation was used at and after use. The items shown in 3 were evaluated.
First, the inside of the forearm of subjects (3 women in their 20s to 30s) was washed with a face wash. Next, measurement was performed before using the foamable skin external preparation. Next, the said foamable skin external preparation was apply | coated to the measurement site | part, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. After 15 minutes from washing, the measurement after using the foamable skin external preparation was performed. The subject was resting in the measurement room during the measurement.

[Evaluation Example 4. Skin condition measurement before and after use]
Using the kits of the present invention obtained in Examples 1 and 5 and Comparative Examples 1 and 2 above, a foamable skin external preparation was prepared, and the skin color difference before and after use of the obtained foamable skin external preparation (measuring instrument) : Color difference meter), moisture transpiration (measuring instrument: Tewmeter TM300), stratum corneum moisture (measuring instrument: SKICON-200EX), and elasticity (measuring instrument: Cutometer MPA580).
First, the inside of the forearm of subjects (3 women in their 20s to 30s) was washed with a face wash. Next, measurement was performed before using the foamable skin external preparation. Next, the said foamable skin external preparation was apply | coated to the measurement site | part, and it left still for 10 minutes. Next, the foamable skin external preparation was removed and washed with water. After 15 minutes from washing, the measurement after using the foamable skin external preparation was performed. The subject was resting in the measurement room during the measurement.
Tables 4 and 5 show the skin condition measurement results after use. Table 4 shows the skin color difference, and Table 5 shows the results of measurement of moisture transpiration, stratum corneum moisture, and elasticity. Tables 4 and 5 show comparative values with 1 before using the foamable skin external preparation. The color difference indicates that the larger the value, the whiter the color is; the smaller the value, the better the barrier function, and the higher the value, the better the stratum corneum moisture value. The elasticity indicates that the larger the value, the better.

From Table 2, it can be seen that Examples 1 to 5 are liquid compositions having no fluidity in the second agent and exhibiting excellent fluidity. From FIG. 1, the amount of carbon dioxide foaming is as follows: Example 1, 2> Examples 3, 4, 5> Comparative Example 1 immediately after stirring, and Example 2, 4> Example 1 after 20 minutes. 3, 5> Comparative Example 1. From this, it can be seen that Examples 1 to 5 produced a larger amount of carbonic acid than Comparative Example 1, and well retained carbon dioxide.
From Table 3, it can be seen that the effervescent skin external preparation obtained using the kit of the present invention has a higher evaluation in use than Comparative Examples 1 and 2. In particular, it has good elongation during use, is easy to remove after use, and has the effect of moisturizing, smoothing and brightening the skin, making it easy for users to use and to the skin It turns out that the effect of is high.
Moreover, as for the state of the skin after use from Table 4, the color difference is good in the order of Examples 2-5 ≧ Example 1> Comparative Example 2> Comparative Example 1. From Table 5, the amount of water transpiration, the stratum corneum Good results were obtained in the order of Example 5> Example 1> Comparative Example 1> Comparative Example 2 for both moisture content and elasticity. That is, it can be seen that Examples 1 and 5 are more effective in improving the state after use than Comparative Examples 1 and 2, and the effect is particularly enhanced by using water and a moisturizer in combination, that is, the skin is whitened. , You can keep fresh.

Below, the formulation example of the kit of this invention is shown. Both the first agent and the second agent can be produced by the same production method as in Example 1.

Formulation Example 1

In Table 5, the citric acid that is an acidic substance was pre-coated with calcium citrate. Others were produced in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 1: 3, an effervescent skin external preparation can be obtained.

Formulation Example 2

In Table 6, ascorbic acid which is an acidic substance was pre-coated with sodium ascorbate. Others were produced in the same manner as in Example 1. When the 1st agent and 2nd agent of the obtained kit are mixed by 1: 1, a foamable skin external preparation can be obtained.

Formulation Example 3

When the 1st agent and 2nd agent of the obtained kit are mixed by 1:10, a foamable skin external preparation can be obtained.

Formulation Example 4

When the 1st agent and 2nd agent of the obtained kit are mixed by 1: 5, a foamable skin external preparation can be obtained.

  As is clear from the above study, the kit of the present invention is easy to mix uniformly, and produces the effect that carbon dioxide gas is generated evenly during use. Furthermore, it turns out that there exists an effect of keeping skin white and fresh by using the foamable skin external preparation obtained using the kit of the present invention.

Claims (5)

A kit for obtaining a foaming skin external preparation for whitening , wherein the first agent comprises an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. A kit, wherein the second agent is a liquid composition containing water and a humectant.   The kit according to claim 1, wherein the first agent is a solid composition.   The kit according to claim 1, wherein the acidic substance of the first agent and the carbon dioxide generating substance coexist so as not to contact each other.   The kit according to any one of claims 1 to 3, wherein the acidic substance and / or carbon dioxide generating substance of the first agent has a coat layer.   The kit according to any one of claims 1 to 4, wherein the first agent and the second agent are mixed and used in a weight ratio ranging from 1: 0.1 to 1:30.

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