CN102356874A - Antioxidant health food composition, and its preparation method and application - Google Patents
Antioxidant health food composition, and its preparation method and application Download PDFInfo
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- CN102356874A CN102356874A CN2011102857684A CN201110285768A CN102356874A CN 102356874 A CN102356874 A CN 102356874A CN 2011102857684 A CN2011102857684 A CN 2011102857684A CN 201110285768 A CN201110285768 A CN 201110285768A CN 102356874 A CN102356874 A CN 102356874A
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Abstract
The invention relates to an antioxidant health food composition, and its preparation method and application. The antioxidant health food composition provided in the invention mainly comprises 1 part to 10 parts of haematococcus pluvialis and 5 to 50 parts of coenzyme Q10. The composition in the invention can substantially improve antioxidant capacity of an organism and reduce oxidative damage caused by sports.
Description
Technical field
The present invention relates to field of health care food, be specifically related to a kind of anti-oxidation health food compositions.
Background technology
The biochemical conference of nineteen eighty-three the 5th international movement has provided clear and definite definition to sports fatigue, and " body can not remain on its function a certain specified level, perhaps can not keep a certain predetermined exercise intensity." since the eighties in 19th century, several kinds of theories below the various countries scholar has proposed for the physiological mechanism of exercise induced fatigue: the one, the accumulation of metabolism matrix fatigue products (accumulation hypothesis); The 2nd, the required matrix of moving is exhausted (depleted hypothesis); The 3rd, the plysiochemical state of matrix changes; The 4th, the adjusting of body and coordination function imbalance.
In recent years; Fast development along with subjects such as physiology, biochemistry and sports medical science; The mechanism that the extensive use of new scientific research methods, means and advanced person's experimental instrument and equipment, exercise induced fatigue produce and the researchs of the means of elimination thereof also deepen continuously.Experiment showed, that in a large number free radical is one of them very important factor.Numerous researchs confirm; During motion,, can cause free radical to be piled up in vivo when the clearance rate of interior free yl during less than endogenous free radical production rate; The free radical bulk deposition; Will the attack cells film, mitochondrial membrane, with film in the unsaturated fat acid reaction, cause lipid peroxidation to strengthen, destroy eucaryotic cell structure, cause lipid peroxidation, disturb the eubolism of human body movable, influence locomitivity.A lot of researchs all show; The oxidative stress that big intensity sports cause possibly cause comprising the lipid peroxidation of tissues such as skeletal muscle, heart, liver, red blood cell and blood plasma, and all cells of tissues films of free radical invasion and attack human body make the lipid generation peroxidating of cell membrane; Show as tired generation ahead of time; Be difficult to after the fatigue recover, locomitivity descends, motion back immunity reduction etc.In addition, power exhausts motion and also can cause protein oxidation and dna damage.Have research to show, the muscle damage that free radical causes possibly be one of factor of decision muscle ability, and additional anti-oxidant can reduce oxidation tissue damage.To this type of anti-oxidant, existing research mainly concentrates on carotenoid, vitamin C, ubiquinone, vitamin E, glutathione etc.As a kind of safety, efficient antioxidants, range of application is increasingly extensive respectively for haematococcus pluvialis and Co-Q10, but does not appear in the newspapers as yet as the research that combination is used to alleviate exercise-induced oxidation injury.
Summary of the invention
The purpose of this invention is to provide a kind of the move oxidative damage that causes, anti-oxidation health food compositions that can significantly improve the matrix oxidation resistance of reducing.
Anti-oxidation health food compositions of the present invention mainly comprises the following weight composition:
1～10 part of haematococcus pluvialis
5～50 parts of Co-Q10s.
In addition, said weight item is:
2～8 parts of haematococcus pluvialis
Co-Q10 10-40 part.
In addition, said weight item is:
4～6 parts of haematococcus pluvialis
20～30 parts of Co-Q10s.
Said haematococcus pluvialis is a content astaxanthin at 1.5～10% powder-type or oily concentrated type haematococcus pluvialis.
In addition, said composition also contains 10～500 parts filler or in the adhesive one or more.
Wherein, said filler is selected from one or more in soybean oil, lecithin, starch, lactose, sucrose, xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, microcrystalline cellulose, the dolomol; Said adhesive is selected from one or more in Hydroxypropyl methylcellulose, PVP, starch, the dextrin.
The present invention also provides a kind of method for preparing above-mentioned composition, and it comprises the steps:
Whole raw materials are mixed; Add pharmaceutically acceptable carrier or diluent, mix, be prepared into conventional formulation.
In addition, the present invention also provides the application of a kind of said composition in preventing exercise-induced oxidation injury.
Wherein said being applied as made capsule, soft capsule or tablet with said composition.
Haematococcus pluvialis (aematoccocus pluvialis) is a kind of monoplast green alga of uniqueness, and be confirmed to be is the biology that occurring in nature can synthesize and accumulate astaxanthin in a large number at present, and it has the strongest non-oxidizability.Can haematococcus pluvialis algae kind be propagated artificially, the spore of haematococcus pluvialis of gathering is processed the haematococcus pluvialis powder through technologies such as broken wall, dryings; Also can the haematococcus pluvialis powder be dissolved extraction through oil and obtain oily concentrated type haematococcus pluvialis.The inventor discovers that preparing health-care food composition with haematococcus pluvialis has certain effect to alleviating exercise-induced oxidation injury.
Co-Q10 is preventing to have good effect aspect the lipid peroxidation, and existing research shows that additional Co-Q10 can weaken the Myocardial Lipid Peroxidation due to the motion, nucleus and mitochondrial lipid peroxidation, and skeletal muscle oxidisability egg white injury.
Composition of the present invention can significantly improve the oxidation resistant ability of body, reduces the oxidative damage that motion causes.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Oily concentrated type haematococcus pluvialis and powder-type haematococcus pluvialis are all available from Shanghai Lay sparrow bio tech ltd among the embodiment; Co-Q10 is available from Zhejiang NHU Company Ltd.
Embodiment 1
With oily concentrated type haematococcus pluvialis 500g (content astaxanthin 10%), Co-Q10 250g, soybean oil 4200g, lecithin 50g, mixing, with rotating the Zhanang machine automatically, the pressing moulding gets 5000 soft capsules.
Embodiment 2
Adopt embodiment 1 same process to prepare soft capsule, wherein oily concentrated type haematococcus pluvialis 10g (content astaxanthin 10%), Co-Q10 50g, soybean oil 4900g, lecithin 40g.
Embodiment 3
Take by weighing powder-type haematococcus pluvialis 1kg (content astaxanthin 1.5%) respectively, Co-Q10 10kg, starch 13kg, dolomol 1kg mixes, and is filled in the capsule, makes 50000 seed lac wafers.
Embodiment 4
Take by weighing powder-type haematococcus pluvialis 0.5kg (content astaxanthin 1.5%) respectively, Co-Q10 25kg, lactose 5kg, starch 7kg; Microcrystalline cellulose 2.1kg mixes, and as adhesive, makes softwood with the 2% PVP aqueous solution; Above-mentioned softwood is processed particle through waving of 14 eye mesh screens in the granulator, particle is inserted in the multi-functional boiling drier, about 40 minutes of 50 ℃ of fluidized dryings; The control pellet moisture is 5%, and whole grain adds the 0.4kg dolomol then in particle; Total mixing, compressing tablet prepares 100000;
Embodiment 5
Take by weighing powder-type haematococcus pluvialis 0.5kg (content astaxanthin 3.5%) respectively, Co-Q10 3.5kg, starch 4.5kg, microcrystalline cellulose 4kg, lactose 4.4kg, dolomol 0.1kg mix, and are filled in the capsule, make 50000 seed lac wafers.
Embodiment 6
Take by weighing powder-type haematococcus pluvialis 0.7kg (content astaxanthin 1.5%) respectively, Co-Q10 1.8kg, starch 14.5kg, microcrystalline cellulose 7kg, lactose 5.9kg, dolomol 0.1kg mix, and are filled in the capsule, make 50000 seed lac wafers.
Experimental example human efficiency test
1 laboratory sample and method
1.1 laboratory sample
The soft capsule content of getting embodiment 2 gained is an experiment product, and is subsequent use with 10 times of olive oil dilutions.
1.2 experimental subjects
Select 100 of SD rats for use, body weight 220 ± 18g at about 3 monthly ages, is divided into control group and experimental group, each 50 at random.
1.3 experimental technique
The foundation of experimental model: the adjusting glass jar depth of water is 115 times of rat length overall (height+tail is long), water temperature 32-34 ℃.Experimental rat is in experiment preadaptation property swimming 2d, every day 20min, after the formal experiment beginning; Experimental rat bears a heavy burden 5% swimming to exhausting near power every day, and power exhausts standard: obviously imbalance of heavy burden rats'swimming action, and can not adhere to or sink under water above 3s again can not backwater surface be that power exhausts; If above-mentioned situation occurs, in time pick up, note warming; Swim 1 time behind the 8:00 morning every day, continuously 21d.
After the formal experiment beginning, experimental group with contained haematococcus pluvialis 5mg/kgbw and 2 dose groups of 10mg/kgbw, is irritated stomach with the amount of laboratory sample, and control group is with equivalent olive oil filling stomach, every day 1 time.Each is organized, and rat is all conventional to be raised, experiment beginning back 1d, 7d, 14d, 21d, every morning the 7:00-8:00 experimental rat under the empty stomach state, every group of 8 of sacrificed by decapitation are respectively got blood and are used EDTANa
2Anti-freezing, separated plasma ,-20 ℃ are frozen, to be checked.
The instrument of index test, reagent and method: use German eppendorfEcom-F6124 semi-automatic biochemical analyzer; Measure the content of blood plasma MDA (MDA) and the activity of superoxide dismutase (SOD), (MDA is that TBA method, SOD are xanthine oxidase).
1.4 result's statistics
Data are handled with the SPSS1110 statistical software, adopt the t check that test data is carried out statistical analysis, represent with mean ± SD.
2 experimental results
2.1 plasma malonaldehyde content relatively
Table 1 experimental rat blood plasma MDA (nmol/L) content relatively
* compare P＜0.05 with control group; * and control group compare, P＜0.01
MDA is the product that the body lipid peroxidating obtains, and motion causes plasma malonaldehyde content to raise, and the variation of therefore measuring mda content is an important indicator of estimating antioxidant effect.Visible by table 1, the experiment beginning after 7 days 5mg/kgbw dose groups MDA content significantly be lower than control group, wherein have the utmost point significance difference opposite sex after 21 days; 10mg/kgbw dose groups MDA content significantly is lower than control group, wherein has the utmost point significance difference opposite sex after 14 days, 21 days.
2.2 the peroxide plasma dismutase activity relatively
Table 2 experimental rat plasma SOD (nU/L) specific activity
* compare P＜0.05 with control group; * and control group compare, P＜0.01
Visible by table 2, experiment beginning back 1d, two dose groups rat plasma SOD activity do not have significant difference, and 5mg/kgbw dose groups 7d (P＜0.05), 14d (P＜0.05) and 21d (P＜0.01) SOD activity all are higher than control group, and have significant difference; 10mg/kgbw dose groups 7d (P＜0.05), 14d (P＜0.01) and 21d (P＜0.01) SOD activity all are higher than control group, and have significant difference
3 conclusions
After the training of exhausting property of power, haematococcus pluvialis and Co-Q10 composition that the present invention obtains are taken in the aggravation of the radical damage of body, can significantly improve the oxidation resistant ability of body, reduce the oxidative damage that motion causes.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (9)
1. an anti-oxidation health food compositions is characterized in that, mainly comprises the following weight composition:
1～10 part of haematococcus pluvialis
5～50 parts of Co-Q10s.
2. composition according to claim 1 is characterized in that, said weight item is:
2～8 parts of haematococcus pluvialis
10～40 parts of Co-Q10s.
3. composition according to claim 2 is characterized in that, said weight item is:
4～6 parts of haematococcus pluvialis
20～30 parts of Co-Q10s.
4. according to any described composition of claim 1～3, it is characterized in that said haematococcus pluvialis is a content astaxanthin at 1.5～10% powder-type or oily concentrated type haematococcus pluvialis.
5. according to any described composition of claim 1～4, it is characterized in that said composition also contains 10～500 parts filler or in the adhesive one or more.
6. according to the said composition of claim 5; It is characterized in that said filler is selected from one or more in soybean oil, lecithin, starch, lactose, sucrose, xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, microcrystalline cellulose, the dolomol; Said adhesive is selected from one or more in Hydroxypropyl methylcellulose, PVP, starch, the dextrin.
7. one kind prepares any said method for compositions of claim 1～6, it is characterized in that, comprises the steps:
Whole raw materials are mixed; Add filler and adhesive, mix, be prepared into conventional formulation.
8. one kind according to any application of said composition in preventing exercise-induced oxidation injury of claim 1～6.
9. application according to claim 8 is characterized in that, said composition is made capsule, soft capsule or tablet.
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Cited By (8)
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| CN102793184A (en) * | 2012-09-04 | 2012-11-28 | 郭威 | Compound antioxidant nutrition supplement and processing method thereof |
| CN103494202A (en) * | 2013-10-18 | 2014-01-08 | 济南老来寿生物股份有限公司 | Healthcare food with antioxidant function |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN105918591A (en) * | 2016-05-13 | 2016-09-07 | 上海艾苛密进出口有限公司 | Haematococcus candy tablet and preparation method thereof |
| CN110237105A (en) * | 2019-07-05 | 2019-09-17 | 湖北真福医药有限公司 | A kind of potent oxidation resisting soft capsule and preparation method thereof |
| CN111194918A (en) * | 2020-01-07 | 2020-05-26 | 杭州鑫伟低碳技术研发有限公司 | Nutrient composition for improving mitochondrial metabolism and relieving sports fatigue |
| CN111297916A (en) * | 2020-02-18 | 2020-06-19 | 杭州鑫伟低碳技术研发有限公司 | Method for preventing and treating organ damage caused by huge free radical generated by immune overstimulation |
| CN111617051A (en) * | 2020-07-15 | 2020-09-04 | 上海普康药业有限公司 | Coenzyme Q10 raw material crushing process and pharmaceutical composition preparation thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793184A (en) * | 2012-09-04 | 2012-11-28 | 郭威 | Compound antioxidant nutrition supplement and processing method thereof |
| CN103494202A (en) * | 2013-10-18 | 2014-01-08 | 济南老来寿生物股份有限公司 | Healthcare food with antioxidant function |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN105918591A (en) * | 2016-05-13 | 2016-09-07 | 上海艾苛密进出口有限公司 | Haematococcus candy tablet and preparation method thereof |
| CN110237105A (en) * | 2019-07-05 | 2019-09-17 | 湖北真福医药有限公司 | A kind of potent oxidation resisting soft capsule and preparation method thereof |
| CN111194918A (en) * | 2020-01-07 | 2020-05-26 | 杭州鑫伟低碳技术研发有限公司 | Nutrient composition for improving mitochondrial metabolism and relieving sports fatigue |
| CN111297916A (en) * | 2020-02-18 | 2020-06-19 | 杭州鑫伟低碳技术研发有限公司 | Method for preventing and treating organ damage caused by huge free radical generated by immune overstimulation |
| CN111617051A (en) * | 2020-07-15 | 2020-09-04 | 上海普康药业有限公司 | Coenzyme Q10 raw material crushing process and pharmaceutical composition preparation thereof |
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Application publication date: 20120222 |