CN105919019A - Chitosan oligosaccharide salt and preparation method thereof - Google Patents
Chitosan oligosaccharide salt and preparation method thereof Download PDFInfo
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- CN105919019A CN105919019A CN201610273877.7A CN201610273877A CN105919019A CN 105919019 A CN105919019 A CN 105919019A CN 201610273877 A CN201610273877 A CN 201610273877A CN 105919019 A CN105919019 A CN 105919019A
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- oligochitosan
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- chitosan oligosaccharide
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- 238000002360 preparation method Methods 0.000 title claims description 14
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical class O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 title abstract 8
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 239000012535 impurity Substances 0.000 claims abstract description 5
- 229920001661 Chitosan Polymers 0.000 claims description 62
- 150000003839 salts Chemical class 0.000 claims description 33
- 238000001914 filtration Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 235000013305 food Nutrition 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000012047 saturated solution Substances 0.000 claims description 6
- 230000009514 concussion Effects 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 230000003749 cleanliness Effects 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 238000006392 deoxygenation reaction Methods 0.000 claims description 3
- 239000002274 desiccant Substances 0.000 claims description 3
- 230000007613 environmental effect Effects 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000003828 vacuum filtration Methods 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 2
- 239000010959 steel Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 230000036772 blood pressure Effects 0.000 abstract description 4
- 239000011780 sodium chloride Substances 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 abstract description 2
- 201000008482 osteoarthritis Diseases 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 4
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical group COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960002442 glucosamine Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000003544 deproteinization Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a chitosan oligosaccharide salt. Each 100g of the chitosan oligosaccharide salt comprises 96-96.2g of chitosan oligosaccharide and table salt, 3.8-4g of water and the balance unavoidable impurities in production. A weight ratio of chitosan oligosaccharide to table salt is 1: 10-1: 3. The chitosan oligosaccharide salt realizes easy intake of chitosan oligosaccharide with absorption easiness and a high utilization rate. Clinical and animal test results show that the chitosan oligosaccharide salt has good effects of reducing blood pressure and blood sugar, adjusting blood fat, inhibiting cancer cells, protecting liver, adjusting immunity, preventing and treating bone arthrosis and resisting radiation.
Description
Technical field
The invention belongs to food technology field, be specifically related to a kind of oligochitosan salt and preparation method thereof.
Background technology
Chitin, chitosan, oligochitosan have identical raw material sources, are all to carry from crustaceans body (Carapax Eriocheir sinensis etc.)
The material taken, but product form and technology of preparing, the degree of polymerization are different, and action effect is very different.Chitin be by
The relatively primary product formed after shrimp and crab shells decalcification, deproteinization, its molecular weight at hundreds of thousands between millions of, owing to not dissolving in
Water, is difficult to, insoluble under diluted acid, alkali, ethanol and other organic solvents, generic condition, the utilization that is absorbed by the body；Chitosan is with first
Shell element is raw material, the product after deacetylation, is dissolved in weak acid, and molecular weight is tens thousand of, only micro-by human body alimentary canal
Bio-enzyme degradation just can be absorbed by the body after forming oligochitosan, and utilization rate is the lowest；Oligochitosan be chitosan after bio-enzyme degradation,
The oligo-glucosamine being formed by connecting with β-Isosorbide-5-Nitrae-glycosidic linkage with 2-10 glucosamine, water solublity is high, easily by human body
Absorb, directly participate in the physiological regulation of body, specific can change variation sugar chain structure and function, recover its communication, identification
And regulating and controlling effect.
Oligochitosan has wide spectrum, efficiently, strengthens body immune cytoactive, improves impaired liver cell functioning cell,
Recover the effects such as function of immune system, the rehabilitation of promotion disease, delaying cell aging, and, oligochitosan is unique in natural sugar
A large amount of alkalescence sugar existed, are one of the representatives of sugar bio-engineering research achievement.
In view of the above effect of oligochitosan, the most nontoxic as functional food because of it, safety, a kind of oligochitosan is proposed strong
Relieving dyspepsia product, have huge social meaning and economic implications.Sal is the necessary edible flavouring of people's daily life, at Sal
Middle interpolation oligochitosan is to make that people is stable, long-term, the best mode of oligochitosan safe for ingestion.
Summary of the invention
Goal of the invention: it is an object of the invention to provide a kind of Sal containing oligochitosan and manufacture method thereof.
Technical scheme:
A kind of oligochitosan salt, it is characterised in that:
Oligochitosan salt described in every 100g contains following composition:
Oligochitosan and edible salt 96g～96.2g altogether；
Water: 3.8g～4g；
Remaining is impurity inevitable during producing；
Wherein the weight ratio of oligochitosan and edible salt is 1:10～1:3.
Wherein oligochitosan weight is the 17%～20% of edible salt weight.
The preparation method of described oligochitosan salt, it is characterised in that: the method comprises the following steps:
Prefabricated: edible salt ultraviolet-sterilization 45min；Oligochitosan material vacuum lyophilizing is to moisture≤6%；
(1) being dissolved in purified water at a temperature of 21 ~ 35 DEG C by the complete edible salt that sterilizes, stirring, to saturation, is made full
And saline solution.
(2) measure the dehydrated alcohol of saturated common salt water quality described in relative 0.1% to incorporate and saturated solution is sufficiently stirred for mix
Close, stand 10min, take clear liquor stand-by；
(3) take pre-appraisal Sal to add in the Sal saturated solution prepared, be stirred well to no longer have Sal solid to dissolve；
(4) mixture of preparation in step (3) is placed in vacuum filtration equipment, leaches out redundant solution, for ensureing sucking filtration matter
Amount is shaken during sucking filtration；The moistening Sal solid that sucking filtration completes preserves in keeping surface moisture environment；
(5) by being dried the vibration of complete oligochitosan or being ground to epigranular without caking, weigh in the desired amount, insert level medical
Vibrating in rustless steel pallet or ware device, concussion becomes thin uniform layer, thickness≤0.15mm to it；
(6) the wet structure Sal that step (4) prepares is weighed by proportional quantity, be spread in uniform on oligochitosan thin layer, dispensing
Time keep the vibration of pallet, band vibrates and imposes suitable gently grinding simultaneously after dispensing, makes full and uniform being coated on of oligochitosan
Sal surface；
(7) salt product being coated with is placed in freeze-drier removing excessive moisture so that it is water content≤7%；
(8) such as the rare caking of step (7) finished product, can gently grind separation, make manufactured goods granule uniform；
(9) manufactured goods are inserted lucifuge and seals preservation in bag, bag is inserted food desiccant and deoxygenation agent, add food and use
Eliminating smell agent.
The preparation method of described oligochitosan salt, it is characterised in that:
Preparation environmental condition is:
Temperature: 15～26 DEG C；
Relative humidity :≤60%；
Cleanliness factor: D level production environment；
Air pressure: normal pressure or pressure-fired.
Advantage and effect: the present invention can effectively make human body take in easily absorption, and the oligochitosan that utilization rate is high, through clinical and animal
Experiment, for blood pressure lowering, blood sugar lowering, regulation blood fat, anticancer, the liver protecting, regulation immunity, prevents and treats osteoarthritis, anti-
Radiation all has good effect.
Detailed description of the invention:
The present invention is a kind of oligochitosan salt, and it specifically includes that
Oligochitosan salt described in every 100g contains following composition:
Oligochitosan and edible salt 96g～96.2g altogether；
Water: 3.8g～4g；
Remaining is impurity inevitable during producing；
Wherein the weight ratio of oligochitosan and edible salt is 1:10～1:3.
Preferably, oligochitosan weight is the 17%～20% of edible salt weight.
Preparation environmental condition:
Temperature: 15 ~ 26 DEG C
Relative humidity :≤60%
Cleanliness factor: D level production environment
Air pressure: normal pressure or pressure-fired
Prepare solvent:
Anhydrous alcohol for medical use
Medicinal purified water
Prefabricated condition:
Edible salt ultraviolet-sterilization 45min
Oligochitosan material vacuum lyophilizing is to moisture≤6%
Preparation process:
The most prefabricated saturated aqueous common salt；
2. being dissolved in purified water at a temperature of 21 ~ 35 DEG C by the complete edible salt that sterilizes, stirring is to saturation.
3. measure the dehydrated alcohol of relative 0.1% saturated common salt water quality to incorporate in saturated solution and be thoroughly mixed, stand
10min, takes clear liquor stand-by.
4. take pre-appraisal Sal to add in the Sal saturated solution prepared, be stirred well to no longer have Sal solid molten
Solve.
5. by mixture as in vacuum filtration equipment, leach out redundant solution, for ensureing that sucking filtration quality is it is contemplated that sucking filtration
During the most suitable concussion.The moistening Sal solid that sucking filtration completes is keeping in surface moisture environment (sealing, moisturizing) as early as possible
Use.
6., by being dried the vibration of complete oligochitosan or being ground to epigranular without caking, weigh in the desired amount, insert level
Vibrating in medical stainless steel pallet or ware device, concussion is to thin uniform layer, thickness≤0.15.
7. the wet structure Sal prepared is weighed by proportional quantity, be spread in uniform on oligochitosan thin layer, protect when dispensing
Holding the vibration of pallet, band vibrates after dispensing and imposes suitable gently grinding simultaneously, make oligochitosan full and uniform be coated on Sal
Surface.
8., by the salt product being coated with as freeze-drier is gone out excessive moisture, make water content≤7%.
9. enter the rare caking of manufactured goods, can gently grind separation, be formed into product granule uniform.
10. insert lucifuge and seal preservation in bag, bag is inserted food desiccant and deoxygenation agent, and advises separately adding food
Product eliminating smell agent.
11. pot-lives are with the oligochitosan shelf-life as standard.
Can uniform solid bag between 1/10-1/3 by above-mentioned technique, oligochitosan and Sal ratio range (mass unit)
Covering, wherein about 1/5 be evenly coated, visual effect is preferable, ties grain good dispersion degree.Deepening more than 1/3 color and luster, caking situation is bright
Aobvious.
The ratio of oligochitosan and salt, between 0.075 ~ 0.35, can refer to this standard and carries out proportioning, it is proposed that by 0.2 during preparation
Proportions.
At present oligochitosan general recommendations day amount is not more than 3g, and no less than 1g, Sal day, amount was less than 8g, China
Reality intake per capita is about between 10 ~ 12g.
Oligochitosan individually stores time variation and influence factor with reference to oligochitosan enterprise production standard, as a example by current sample presentation,
Take homogeneous and prepare sample respectively-18 ,-5,0,5,15,20,25,30,45 DEG C, relative humidity 20%, 40%, 60%, 80% 100%,
120% time, do in 8h, the time-varying of 24h, 48h, 148h time and influence factor's experiment, result such as following table:
√ check mark representative has an impact.
Result is this oligochitosan melange at present, and sensitive to moisture and temperature, temperature is substantially deepened higher than 28 DEG C of color and lusters, >=
Melanism when 60 DEG C, taste is unchanged with dissolubility, and humidity >=80% variable color is obvious, and two kinds of factors all can cause brownization obvious.
The examining report provided according to mark technology (Qingdao) research and development centre of section:
(bullets: SCT-D20151223-002N), in the oligochitosan salt sample of 100g censorship
There may be impurity to include:
Nitrite ＜ 1 mg/kg
Total arsenic 0.011 mg/kg
Lead 0.029 mg/kg
Copper 0.26 mg/kg
Every ＜ 0.01 mg/kg
Total mercury 0.015 mg/kg
Ph value 5.52
Fluorine 0.71 mg/kg
Sulfate 1783 mg/kg
Barium 0.51 mg/kg
Moisture 3.86%
Examining report shows, above-mentioned each component content all meets relevant national standard.
Oligochitosan clinical application effect:
According to Xiyuan Hospital, Chinese Medicine Academy of China (Beijing 100091) research report:
Select hyperpietic's ratio of being in hospital, divide two groups at random:
First group: oligochitosan group 30 example I phase 15 example II phase 15 example
(age is all in 36-69 year)
Second group: nifedipine group 30 example I phase 14 example II phase 14 example
(age is all in 34-69 year)
First group: oligochitosan group each 0.4g every day 2 times
Second group: each 10mg of nifedipine group is three times a day
Two groups all serve on 25 days.
Result: observation index:
1. related symptoms impact (table 1)
Table 1 related symptoms affects
2. the impact on blood pressure
The change of II phase hypertension:
Oligochitosan group 15 example, effective 3 examples, effective 5 examples, invalid 7 examples, effective percentage 53.3%.
Nifedipine group 16 example, effective 5 examples, effective 7 examples, invalid 4 examples, effective percentage 75%.
Although oligochitosan group is less than nifedipine group to the blood pressure lowering effective percentage of II phase hypertension, but it does not has any secondary work
With, it is to merit attention.
3. the impact (table 2) on blood fat
The impact on hypertension blood fat of table 2 oligochitosan
Claims (4)
1. an oligochitosan salt, it is characterised in that:
Oligochitosan salt described in every 100g contains following composition:
Oligochitosan and edible salt 96g～96.2g altogether；
Water: 3.8g～4g；
Remaining is impurity inevitable during producing；
Wherein the weight ratio of oligochitosan and edible salt is 1:10～1:3.
Oligochitosan salt the most according to claim 1, it is characterised in that: wherein oligochitosan weight is the 17% of edible salt weight
～20%.
3. the preparation method of an oligochitosan salt as claimed in claim 1 or 2, it is characterised in that: the method includes following step
Rapid:
Prefabricated: edible salt ultraviolet-sterilization 45min；Oligochitosan material vacuum lyophilizing is to moisture≤6%；
(1) being dissolved in purified water at a temperature of 21～35 DEG C by the complete edible salt that sterilizes, stirring, to saturation, is made full
And saline solution；
(2) measure the dehydrated alcohol of saturated common salt water quality described in relative 0.1% to incorporate in saturated solution and be thoroughly mixed, quiet
Put 10min, take clear liquor stand-by；
(3) take pre-appraisal Sal to add in the Sal saturated solution prepared, be stirred well to no longer have Sal solid to dissolve；
(4) mixture of preparation in step (3) is placed in vacuum filtration equipment, leaches out redundant solution, for ensureing sucking filtration matter
Amount is shaken during sucking filtration；The moistening Sal solid that sucking filtration completes preserves in keeping surface moisture environment；
(5) by being dried the vibration of complete oligochitosan or being ground to epigranular without caking, weigh in the desired amount, insert level medical
Vibrating in rustless steel pallet or ware device, concussion becomes thin uniform layer, thickness≤0.15mm to it；
(6) the wet structure Sal that step (4) prepares is weighed by proportional quantity, be spread in uniform on oligochitosan thin layer, dispensing
Time keep the vibration of pallet, band vibrates and imposes suitable gently grinding simultaneously after dispensing, makes full and uniform being coated on of oligochitosan
Sal surface；
(7) salt product being coated with is placed in freeze-drier removing excessive moisture so that it is water content≤7%；
(8) such as the rare caking of step (7) finished product, can gently grind separation, make manufactured goods granule uniform；
(9) manufactured goods are inserted lucifuge and seals preservation in bag, bag is inserted food desiccant and deoxygenation agent, add food and use
Eliminating smell agent.
The preparation method of oligochitosan salt the most according to claim 3, it is characterised in that:
Preparation environmental condition is:
Temperature: 15～26 DEG C；
Relative humidity :≤60%；
Cleanliness factor: D level production environment；
Air pressure: normal pressure or pressure-fired.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610273877.7A CN105919019A (en) | 2016-04-28 | 2016-04-28 | Chitosan oligosaccharide salt and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610273877.7A CN105919019A (en) | 2016-04-28 | 2016-04-28 | Chitosan oligosaccharide salt and preparation method thereof |
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Family
ID=56837322
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719932A (en) * | 2017-04-24 | 2018-11-02 | 罗成 | A kind of functionality edible salt/Cardia Salt and its application |
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| 张禄梅: "《化学原理实验技术》", 31 August 2015, 重庆大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719932A (en) * | 2017-04-24 | 2018-11-02 | 罗成 | A kind of functionality edible salt/Cardia Salt and its application |
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