CN110279627B - Anti-saccharification composition and preparation method thereof - Google Patents
Anti-saccharification composition and preparation method thereof Download PDFInfo
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- CN110279627B CN110279627B CN201910648974.3A CN201910648974A CN110279627B CN 110279627 B CN110279627 B CN 110279627B CN 201910648974 A CN201910648974 A CN 201910648974A CN 110279627 B CN110279627 B CN 110279627B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses an anti-saccharification composition and a preparation method thereof, wherein the anti-saccharification composition comprises the following components in percentage by weight: 3.61-13.1% of humectant, 0.02-0.1% of chelating agent, 0.3-0.6% of antioxidant and the balance of water; the anti-saccharification agent comprises 0.5-12 wt% of ganoderma lucidum extract, 0.5-12 wt% of osmanthus flower extract and 0.05-0.5 wt% of carnosine. According to the invention, by compounding various functional components, the anti-glycation effect can be effectively improved, the problems of dark yellow skin and uneven skin color caused by glycation can be prevented, inhibited or improved, and simultaneously the skin color can be brightened, the skin wrinkles can be reduced, the skin texture can be improved, and the skin elasticity can be recovered.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-saccharification composition and a preparation method thereof.
Background
The "glycation phenomenon" refers to the physiological reaction generated by the combination of proteins in our body and sugar ingested in the diet, and the excess glucose after the sugar metabolism of the body is the very cause of cell aging, and the glycation phenomenon pushes the value of unsaturated fat to the bottom of the grain, so as to trigger physiological aging factors, and cause reactions such as glycation, oxidation, inflammation and the like. Although anti-glycation cosmetics have been developed in recent years, they have drawbacks such as unsatisfactory anti-glycation effect and difficulty in exerting their effects as anti-glycation active ingredients. Therefore, it is urgently needed to research a cosmetic which is safe, non-irritant and has an obvious anti-saccharification effect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an anti-saccharification composition and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: an anti-saccharification composition comprises the following components in percentage by weight: 3.61-13.1% of humectant, 0.02-0.1% of chelating agent, 0.3-0.6% of antioxidant and the balance of water; the anti-saccharification composition further comprises an anti-saccharification agent, wherein the anti-saccharification agent comprises 0.5-12% of ganoderma lucidum extract, 0.5-12% of osmanthus flower extract and 0.05-0.5% of carnosine in percentage by weight.
The ganoderma lucidum polysaccharide in the ganoderma lucidum extract has an up-regulation effect on gene expressions such as LIG1, PKL1 and ACTB of skin cell metabolism, can repair DNA damage, promote cell growth and has an effect of resisting cell aging. The ganoderan has certain scavenging ability for hydroxyl free radical and superoxide anion free radical; the osmanthus flower extract is a plant-derived plant produced from osmanthus flowers (asian tea olives) by extraction. Contains high-concentration active polyphenol, and provides strong antioxidant activity for environmental stress. Inhibiting the inflammatory effect of urban air pollution. Inhibiting glycosylation of skin proteins (collagen) and other important biomolecules. Skin cells (fibroblasts) are protected from the toxicity of age. Excellent stability of durable antioxidant and anti-inflammatory effects. The flavonoids substances contained in the sweet osmanthus can effectively remove free radicals and superoxide ions, inhibit in-vitro lipid peroxidation of mitochondria, reduce oxidative stress injury of skin cells, delay the aging process of cells and reduce fine wrinkles of the skin. Carnosine has been shown to have strong free radical scavenging, antioxidant, anti-aging effects, and also has excellent anti-glycosylation effects, and can protect collagen of skin. The inventor of the application finds that the ganoderma lucidum extract, the osmanthus flower extract and the carnosine are compounded, and also finds that under the condition that the addition amount of the anti-saccharification agent is consistent, the ganoderma lucidum extract, the osmanthus flower extract and the carnosine are used simultaneously, the effects of reducing wrinkles, improving skin textures, improving skin elasticity and reducing pigments are remarkable. The synergistic effect of the components of the anti-saccharification composition is shown.
Preferably, the anti-glycation agent comprises the following components in percentage by weight: 4-12% of ganoderma lucidum extract, 4-12% of osmanthus flower extract and 0.2-0.5% of carnosine. Within the weight percentage content range, the anti-saccharification agent has better anti-saccharification effect.
Preferably, the anti-glycation agent comprises the following components in percentage by weight: 4% of ganoderma lucidum extract, 4% of osmanthus flower extract and 0.2% of carnosine. Under the condition of the content ratio of each component, the anti-saccharification effect reaches the best.
Preferably, the weight ratio of the ganoderma lucidum extract to the osmanthus flower extract is 1: 1.
Preferably, the moisturizer comprises 2-6 weight percent of butanediol, 1-5 weight percent of glyceryl polyether-26, 0.01-0.3 weight percent of sodium hyaluronate, 0.3-0.8 weight percent of a compound consisting of caprylyl hydroximic acid, glyceryl caprylate, 1, 2-pentanediol and propylene glycol, and 0.3-1 weight percent of 1, 2-hexanediol; the chelating agent is EDTA disodium; the antioxidant is p-hydroxyacetophenone.
Preferably, the anti-saccharification composition further comprises a skin conditioner and an anti-inflammatory and soothing agent, wherein the skin conditioner comprises 0.5-6 wt% of magnolia sieboldii extract, 0.5-8 wt% of purslane extract and 1-8 wt% of seawater; the anti-inflammatory and allergy-relieving agent comprises 0.5-5 weight percent of Gentiana lutea root extract and 0.5-6 weight percent of a compound consisting of a centella asiatica extract, a polygonum cuspidatum root extract, a scutellaria baicalensis extract, a glycyrrhiza glabra root extract, a chamomile flower extract, a tea leaf extract and a rosemary leaf extract.
Preferably, the anti-glycation composition further comprises a perfume and PEG-40 hydrogenated castor oil.
Preferably, the anti-glycation composition comprises the following components in percentage by weight: 5% of ganoderma lucidum extract, 5% of osmanthus flower extract, 0.2% of carnosine, 4% of butanediol, glyceryl polyether-264%, 0.5% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 0.1% of sodium hyaluronate, 5% of magnolia sieboldii extract, 5% of purslane extract, 4% of seawater, 3% of gentiana lutea root extract, 3% of a complex consisting of centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis extract, glycyrrhiza glabra root extract, chamomile flower extract, tea leaf extract and rosemary leaf extract, 0.0005% of essence, 0.0025% of PEG-40 hydrogenated castor oil, 0.5% of a complex consisting of caprylic hydroxamic acid, glyceryl caprylate, 1, 2-pentanediol and propylene glycol, 0.5% of 1, 2-hexanediol and the balance of water.
The invention also provides a preparation method of the anti-saccharification composition, which comprises the following steps:
1) mixing water, butanediol, glyceryl polyether-26, p-hydroxyacetophenone and EDTA disodium, heating to 80 ℃, dissolving completely, stirring and cooling; cooling to below 60 deg.C, adding sodium hyaluronate, Magnolia sieboldii extract, herba Portulacae extract, seawater, radix Gentianae extract, Ganoderma lucidum extract, flos Osmanthi Fragrantis extract, carnosine, and a composition comprising herba Centellae extract, rhizoma Polygoni Cuspidati extract, Scutellariae radix extract, radix Glycytthizae extract, flos Matricariae Chamomillae extract, folium Camelliae sinensis extract, and herba Rosmarini officinalis extract, stirring, and cooling;
2) adding essence and PEG-40 hydrogenated castor oil when the temperature is reduced to below 45 deg.C, and stirring to disperse uniformly;
3) adding compound composed of caprylyl hydroximic acid, glyceryl caprylate, 1, 2-pentanediol and propylene glycol, and 1, 2-hexanediol, stirring, cooling to normal temperature, and discharging.
The invention has the beneficial effects that: according to the invention, by compounding various functional components, the anti-glycation effect can be effectively improved, the problems of dark yellow skin and uneven skin color caused by glycation can be prevented, inhibited or improved, and simultaneously the skin color can be brightened, the skin wrinkles can be reduced, the skin texture can be improved, and the skin elasticity can be recovered.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
The following examples are given for the purpose of using commercially available raw materials unless otherwise specified.
The trade name of the compound consisting of butylene glycol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract in the invention is called CalmYang.
Examples 1 to 7 and comparative examples 1 to 5
Examples 1 to 7 are anti-glycation compositions according to the present invention, and the weight percentage formulation of the anti-glycation compositions of examples 1 to 7 and comparative examples 1 to 5 is shown in table 1.
TABLE 1 EXAMPLES 1 TO 7 AND COMPARATIVE EXAMPLES 1 TO 5 ANTI-GLYCERING COMPOSITION FORMULATIONS
The preparation method of the anti-saccharification composition comprises the following steps:
1) heating water, butanediol, glyceryl polyether-26, p-hydroxyacetophenone and EDTA disodium to 80 ℃, dissolving completely, stirring and cooling; cooling to below 60 deg.C, adding sodium hyaluronate, Magnolia sieboldii extract, herba Portulacae extract, seawater, radix Gentianae extract, Ganoderma lucidum extract, flos Osmanthi Fragrantis extract, carnosine, and a composition comprising herba Centellae extract, rhizoma Polygoni Cuspidati extract, Scutellariae radix extract, radix Glycytthizae extract, flos Matricariae Chamomillae extract, folium Camelliae sinensis extract, and herba Rosmarini officinalis extract, stirring, and cooling;
2) adding essence and PEG-40 hydrogenated castor oil when the temperature is reduced to below 45 deg.C, and stirring to disperse uniformly;
3) adding compound composed of caprylyl hydroximic acid, glyceryl caprylate, 1, 2-pentanediol and propylene glycol, and 1, 2-hexanediol, stirring, cooling to normal temperature, and discharging.
Example 8 efficacy verification
The test method comprises the following steps: the efficacy evaluation was performed on the anti-glycation compositions of examples 1 to 7 and comparative examples 1 to 5. The specific test method is as follows: by using VISIA tester, 120 subjects were divided into 12 groups of 10 persons, aged 35-55 years, with the skin showing phenomena of laxity, roughness, dullness, yellowing, and deep and multiple wrinkles. The skin care product is healthy, has no dermatosis and anaphylactic disease history, is not sensitive to skin, can use cosmetics according to a range, is matched with workers to finish evaluation work according to requirements, has certain expression capability, and can truly feed back the feeling after use. The samples of examples 1 to 7 of the present invention and comparative examples 1 to 5 were sprayed on the face in the form of a spray, once a day, in the morning and in the evening. The data of 84 continuous days, 0 th day and 84 th day are compared, and the pictures are archived. And calculates the reduction rate thereof.
The results of the tests are shown in table 2:
TABLE 2
As can be seen from table 2, the anti-glycation composition of the present invention has more excellent anti-glycation effect than the commercially available products, and the anti-glycation composition of the present invention has significant effects on wrinkle reduction, skin texture improvement, skin elasticity improvement, and pigment reduction. As can be seen from the comparison of example 4 with comparative examples 1 to 5, the anti-glycation composition has the best effect only when the ganoderma lucidum extract, the osmanthus flower extract and the carnosine are used simultaneously, which indicates that the ganoderma lucidum extract, the osmanthus flower extract and the carnosine have a synergistic effect.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (2)
1. An anti-saccharification composition comprises the following components in percentage by weight: 4% of ganoderma lucidum extract, 4% of osmanthus flower extract, 0.15% of carnosine, 4% of butanediol, 4% of glyceryl polyether-264%, 0.5% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 0.1% of sodium hyaluronate, 5% of magnolia sieboldii extract, 5% of purslane extract, 4% of seawater, 3% of gentiana lutea root extract, 4% of a complex consisting of centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis extract, glycyrrhiza glabra root extract, chamomile flower extract, tea leaf extract and rosemary leaf extract, 0.0005% of essence, 0.0025% of PEG-40 hydrogenated castor oil, 0.5% of a complex consisting of caprylic hydroxamic acid, caprylate, 1, 2-pentanediol and propylene glycol, 0.5% of 1, 2-hexanediol and the balance of water.
2. A method for preparing an anti-glycation composition according to claim 1, comprising the steps of:
1) heating water, butanediol, glyceryl polyether-26, p-hydroxyacetophenone and EDTA disodium to 80 ℃, dissolving completely, stirring and cooling; cooling to below 60 deg.C, adding sodium hyaluronate, Magnolia sieboldii extract, herba Portulacae extract, seawater, radix Gentianae extract, Ganoderma lucidum extract, flos Osmanthi Fragrantis extract, carnosine, and a composition comprising herba Centellae extract, rhizoma Polygoni Cuspidati extract, Scutellariae radix extract, radix Glycytthizae extract, flos Matricariae Chamomillae extract, folium Camelliae sinensis extract, and herba Rosmarini officinalis extract, stirring, and cooling;
2) adding essence and PEG-40 hydrogenated castor oil when the temperature is reduced to below 45 deg.C, and stirring to disperse uniformly;
3) adding compound composed of caprylyl hydroximic acid, glyceryl caprylate, 1, 2-pentanediol and propylene glycol, and 1, 2-hexanediol, stirring, cooling to normal temperature, and discharging.
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| CN110664868A (en) * | 2019-10-15 | 2020-01-10 | 无限极（中国）有限公司 | Composition with anti-glycosylation effect and application thereof |
| WO2021243359A1 (en) * | 2020-05-27 | 2021-12-02 | Mary Kay Inc. | Topical compositions and methods |
| CN115778837B (en) * | 2022-11-21 | 2024-04-02 | 安徽品赫生物科技有限公司 | Synergistic skin-brightening and repairing freeze-dried powder and preparation method and application thereof |
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| JP2011102270A (en) * | 2009-11-11 | 2011-05-26 | Rohto Pharmaceutical Co Ltd | Anti-saccharification agent |
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
| CN105147563B (en) * | 2015-09-29 | 2017-11-28 | 珀莱雅化妆品股份有限公司 | A kind of anti-saccharification particle for powder class cosmetics and preparation method thereof |
| CN105726421A (en) * | 2016-04-28 | 2016-07-06 | 四川力久知识产权服务有限公司 | Cosmetic anti-aging traditional Chinese medicine composition containing ganoderma lucidum |
| CN108392444A (en) * | 2018-03-21 | 2018-08-14 | 张奕晶 | Micro- whole all-round aquation cosmetic of one kind and preparation method thereof |
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