CN110279627A - Anti- saccharification composition of one kind and preparation method thereof - Google Patents
Anti- saccharification composition of one kind and preparation method thereof Download PDFInfo
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- CN110279627A CN110279627A CN201910648974.3A CN201910648974A CN110279627A CN 110279627 A CN110279627 A CN 110279627A CN 201910648974 A CN201910648974 A CN 201910648974A CN 110279627 A CN110279627 A CN 110279627A
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- saccharification
- carnosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of anti-saccharification composition and preparation method, the anti-composition that is saccharified includes the component of following weight percentage: moisturizer 3.61~13.1%, chelating agent 0.02~0.1%, antioxidant 0.3~0.6 and surplus water；It further include anti-saccharifying agent, the anti-saccharifying agent includes Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine, and the anti-each ingredient of saccharifying agent is Ganodernaa lucidum extract 0.5~12%, sweet osmanthus flower extract 0.5~12% and carnosine 0.05~0.5% in the weight percentage of anti-saccharification composition.The present invention is compounded by multiple efficacies ingredient, anti- saccharification effect can be effectively improved, prevention, inhibit or improve because of saccharification caused by skin is dark yellow, the colour of skin is uneven problem, while can also bright color, reduce wrinkle of skin, improve dermatoglyph, and restore skin elasticity.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to anti-saccharification composition of one kind and preparation method thereof.
Background technique
" saccharification phenomenon " refers to our vivo proteins in conjunction with the sugar absorbed in diet, and generated physiology is anti-
It answers, and glucose extra after the metabolism of body sugar, it is exactly the arch-criminal of cell senescence, the phenomenon that is saccharified is unsaturated fatty value
It is pushed into the lowest point, causes aging factor physiologically, causes such as saccharification, oxidation, inflammation reaction.Although anti-saccharification makeup in recent years
Product occur successively, but all have that anti-saccharification result is undesirable, and anti-saccharogenic activity ingredient is difficult to the defects of playing its effect.Therefore,
Urgent need develops a kind of safety, non-stimulated, anti-apparent cosmetics of saccharification result.
Summary of the invention
There is provided it is an object of the invention to overcome in place of the shortcomings of the prior art a kind of anti-saccharification composition and its
Preparation method, anti-saccharification composition of the invention are able to solve that the anti-saccharification result of existing product is undesirable, anti-saccharogenic activity ingredient
It is difficult to play the defect of its effect.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of anti-saccharification composition, including following weight hundred
The component of point content: moisturizer 3.61~13.1%, chelating agent 0.02~0.1%, antioxidant 0.3~0.6 and surplus water；
It further include anti-saccharifying agent, the anti-saccharifying agent includes Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine, and the anti-saccharifying agent is each
Ingredient is Ganodernaa lucidum extract 0.5~12%, 0.5~12% and of sweet osmanthus flower extract in the weight percentage of anti-saccharification composition
Carnosine 0.05~0.5%.
Ganoderma lucidum polysaccharide in Ganodernaa lucidum extract of the invention is to the genes table such as LIG1, PKL1, ACTB of skin cell metabolism
Up to there is up-regulation effect, energy DNA plerosis damage promotes cell growth, plays the role of fighting cell ageing.Ganoderma lucidum polysaccharide is to hydroxyl freedom
Base, ultra-oxygen anion free radical have certain Scavenging activity；Sweet osmanthus flower extract is a kind of by extracting from sweet osmanthus (Asia tea olive
Olive) spend the plant-derived plant of middle generation.Active polyphenol containing high concentration provides strong anti-oxidant work for environmental pressure
Property.Inhibit the inflammatory effector of urban air pollution.Inhibit the sugar of skin protein (collagen) and other important biomolecule
Base.Protect Skin Cell (fibroblast) from the toxicity at age.The excellent stability of lasting anti-oxidant anti-inflammatory effect.Osmanthus
The Flavonoid substances contained in spending can effectively remove free radical, superoxide ion, inhibit the external lipid peroxidation of mitochondria, reduce
The oxidativestress damage of Skin Cell, delaying cell aging process reduce skin lines.Carnosine has been shown to have powerful clear
Except free radical, anti-oxidant, anti-aging effects, in addition also there is superior anti-glycosylation, can protect skin collagen.
Present inventor's discovery compounds Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine, by comparing also found, in anti-sugar
Under the additive amount unanimous circumstances of agent, while when use Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine three, wrinkle is subtracted
Less, dermatoglyph improves, skin elasticity improves and pigment reduction has remarkable result.Illustrate between each ingredient of anti-saccharification composition
There is synergistic function.
Preferably, the anti-saccharifying agent includes the component of following weight percentage: Ganodernaa lucidum extract 4~12%, sweet osmanthus
Flower extract 4~12% and carnosine 0.2~0.5%.Anti- saccharifying agent is in the weight percent ranges, and anti-saccharification result is more
It is good.
Preferably, the anti-saccharifying agent includes the component of following weight percentage: Ganodernaa lucidum extract 4%, sweet osmanthus mention
Take object 4% and carnosine 0.2%.For each ingredient when this content matches, anti-saccharification result reaches best.
Preferably, the weight ratio of the Ganodernaa lucidum extract and sweet osmanthus flower extract is 1:1.
Preferably, the moisturizer includes the glycerol of the butanediol of 2~6 weight percentages, 1~5 weight percentage
Polyethers -26, the Sodium Hyaluronate of 0.01~0.3 weight percentage, 0.3~0.8 weight percentage by decoyl hydroximic acid,
1,2 hexylene glycols of compound, 0.3~1 weight percentage that glycerol caprylate, 1,2- pentanediol and propylene glycol form；It is described
Chelating agent is EDETATE SODIUM；The antioxidant is parahydroxyacet-ophenone.
Preferably, anti-saccharification composition further includes skin conditioning agent, anti-inflammatory Shu Min agent, and the skin conditioning agent includes 0.5
The extract of magnolia sieboldii of~6 weight percentages, the purslane extract of 0.5~8 weight percentage and 1~8 weight hundred
Divide the seawater of content；The anti-inflammatory Shu Min agent includes the gentian root extract and 0.5~6 weight of 0.5~5 weight percentage
Percentage composition is extracted by Gotu Kola P.E, polygonum cuspidate root extract, Baical Skullcap root P.E, glycyrrhiza glabra root extract, Flos Chrysanthemi
The compound that object, tea extract, rosemary leaf extract form.
Preferably, anti-saccharification composition further includes essence and Cremophor RH40.
Preferably, anti-saccharification composition includes the component of following weight percentage: Ganodernaa lucidum extract 5%, sweet osmanthus mention
Take object 5%, carnosine 0.2%, butanediol 4%, glycerin polyether -26 4%, parahydroxyacet-ophenone 0.5%, EDETATE SODIUM 0.05%,
Sodium Hyaluronate 0.1%, extract of magnolia sieboldii 5%, purslane extract 5%, seawater 4%, gentian root extract 3%,
It is extracted by Gotu Kola P.E, polygonum cuspidate root extract, Baical Skullcap root P.E, glycyrrhiza glabra root extract, german chamomile flower extract, tealeaves
Object, rosemary leaf extract composition compound 3%, essence 0.0005%, Cremophor RH40 0.0025%, by decoyl
Compound 0.5%, 1,2 hexylene glycols 0.5% and the surplus that hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol form
Water.
The present invention also provides the preparation methods of the anti-saccharification composition, comprising the following steps:
1) water, butanediol, glycerin polyether -26, parahydroxyacet-ophenone, EDETATE SODIUM are mixed and heated to 80 DEG C, dissolved
Entirely, stirring cooling；60 DEG C are down to hereinafter, again by Sodium Hyaluronate, extract of magnolia sieboldii, purslane extract, sea to temperature
Water, gentian root extract, Ganodernaa lucidum extract, sweet osmanthus flower extract, carnosine, by Gotu Kola P.E, polygonum cuspidate root extract, Huang
The compound that a kind of reed mentioned in ancient books extract, glycyrrhiza glabra root extract, german chamomile flower extract, tea extract, rosemary leaf extract form
It is added, continues stirring cooling；
2) 45 DEG C or less are down to temperature to continue to stir by essence, Cremophor RH40 addition, keep its evenly dispersed；
3) add the compound being made of decoyl hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol, 1,2 oneself
Glycol stirs evenly, and is down to room temperature, discharging.
The beneficial effects of the present invention are: the present invention is compounded by multiple efficacies ingredient, can effectively improve anti-sugar
Change effect, prevention, inhibit or improve because of saccharification caused by skin is dark yellow, the colour of skin is uneven problem, while can also bright color,
It reduces wrinkle of skin, improve dermatoglyph, and restore skin elasticity.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Each raw material effect involved by following embodiment is all made of the commodity sold on the market unless otherwise instructed.
Being extracted by butanediol, water, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tealeaves in the present invention
Object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract composition the product name of compound be
CalmYang。
Examples 1 to 7 and comparative example 1~5
Examples 1 to 7 is a kind of anti-saccharification composition of the present invention, described in Examples 1 to 7 and comparative example 1~5
It is a kind of it is anti-saccharification composition weight percentage formula be shown in Table 1.
1 Examples 1 to 7 of table and the anti-saccharification composite formula of comparative example 1~5
The preparation method of anti-saccharification composition of the invention, comprising the following steps:
1) water, butanediol, glycerin polyether -26, parahydroxyacet-ophenone, EDETATE SODIUM are heated to 80 DEG C, dissolution completely, is stirred
Mix cooling；60 DEG C are down to hereinafter, again by Sodium Hyaluronate, extract of magnolia sieboldii, purslane extract, seawater, Huang to temperature
Rough gentian root extract, sweet osmanthus flower extract, carnosine, is mentioned by Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae Ganodernaa lucidum extract
The compound of object, glycyrrhiza glabra root extract, german chamomile flower extract, tea extract, rosemary leaf extract composition is taken to be added,
Continue stirring cooling；
2) 45 DEG C or less are down to temperature to continue to stir by essence, Cremophor RH40 addition, keep its evenly dispersed；
3) add the compound being made of decoyl hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol, 1,2 oneself
Glycol stirs evenly, and is down to room temperature, discharging.
8 efficacy validation of embodiment
Test method: efficacy assessments are carried out to the anti-saccharification composition of embodiment 1-7 and comparative example 1-5.Specific test side
Method is as follows: utilizing VISIA tester, chooses 120 subjects and be divided into 12 groups of every group of 10 people, the age 35-55 years old, skin existed
Loose, coarse, dull, yellowing, wrinkle are deepened to become more phenomenons.Health, no skin disease and allergy medical history, non-sensitive skin,
Cosmetics can be used by model, and cooperating personnel complete appraisal as required, have certain expressive faculty, it can be really anti-
Impression after presenting use.The sample of 1-7 of the embodiment of the present invention and comparative example 1-5 are sprayed on face with Sprayable, sooner or later daily
It is each primary.Continuous 84 days, the 0th day and the comparison of the 84th day data, photo archive.And calculate its slip.
The results are shown in Table 2 for test result:
Table 2
As can be seen from Table 2, anti-saccharification composition of the invention has superior anti-saccharification effect relative to commercial product
Fruit, anti-saccharification composition of the invention reduces wrinkle, dermatoglyph improves, skin elasticity improves and pigment reduction has significantly
Effect.Embodiment 4 and comparative example 1-5 are compared as it can be seen that anti-saccharification composition is only extracted using Ganodernaa lucidum extract, sweet osmanthus simultaneously
Just there is optimal effect when object and carnosine, illustrate have collaboration to increase between Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine ingredient
Effect effect.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (9)
1. a kind of anti-saccharification composition, the component including following weight percentage: moisturizer 3.61~13.1%, chelating agent
0.02~0.1%, the water of antioxidant 0.3~0.6 and surplus；It is characterized in that, further include anti-saccharifying agent, the anti-saccharifying agent
Including Ganodernaa lucidum extract, sweet osmanthus flower extract and carnosine, weight hundred of the anti-each ingredient of saccharifying agent in anti-saccharification composition
Dividing content is Ganodernaa lucidum extract 0.5~12%, sweet osmanthus flower extract 0.5~12% and carnosine 0.05~0.5%.
2. anti-saccharification composition according to claim 1, which is characterized in that the anti-saccharifying agent includes following weight percent
The component of content: Ganodernaa lucidum extract 4~12%, sweet osmanthus flower extract 4~12% and carnosine 0.2~0.5%.
3. anti-saccharification composition according to claim 2, which is characterized in that the anti-saccharifying agent includes following weight percent
The component of content: Ganodernaa lucidum extract 4%, sweet osmanthus flower extract 4% and carnosine 0.2%.
4. anti-saccharification composition according to claim 1, which is characterized in that the Ganodernaa lucidum extract and sweet osmanthus flower extract
Weight ratio be 1:1.
5. anti-saccharification composition according to claim 1, which is characterized in that the moisturizer includes that 2~6 weight percents contain
The butanediol of amount, the glycerin polyether -26 of 1~5 weight percentage, 0.01~0.3 weight percentage Sodium Hyaluronate,
The compound of 0.3~0.8 weight percentage being made of decoyl hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol,
1,2 hexylene glycols of 0.3~1 weight percentage；The chelating agent is EDETATE SODIUM；The antioxidant is para hydroxybenzene second
Ketone.
6. anti-saccharification composition according to claim 1, which is characterized in that it further include skin conditioning agent, anti-inflammatory Shu Min agent,
The skin conditioning agent includes the dent of the extract of magnolia sieboldii of 0.5~6 weight percentage, 0.5~8 weight percentage
The seawater of amaranth extract and 1~8 weight percentage；The anti-inflammatory Shu Min agent includes the gentian of 0.5~5 weight percentage
Root extract and 0.5~6 weight percentage by Gotu Kola P.E, polygonum cuspidate root extract, Baical Skullcap root P.E, glycyrrhiza glabra
The compound that root extract, german chamomile flower extract, tea extract, rosemary leaf extract form.
7. anti-saccharification composition according to claim 1, which is characterized in that further include essence and PEG-40 hydrogenated castor
Oil.
8. anti-saccharification composition according to claim 1, which is characterized in that the component including following weight percentage:
Ganodernaa lucidum extract 5%, sweet osmanthus flower extract 5%, carnosine 0.2%, butanediol 4%, glycerin polyether -26 4%, para hydroxybenzene second
Ketone 0.5%, EDETATE SODIUM 0.05%, Sodium Hyaluronate 0.1%, extract of magnolia sieboldii 5%, purslane extract 5%, seawater
4%, gentian root extract 3%, by Gotu Kola P.E, polygonum cuspidate root extract, Baical Skullcap root P.E, glycyrrhiza glabra root extract
Compound 3%, the essence 0.0005%, PEG-40 that object, german chamomile flower extract, tea extract, rosemary leaf extract form
Rilanit special 0.0025%, the compound being made of decoyl hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol
0.5%, the water of 1,2 hexylene glycols 0.5% and surplus.
9. a kind of preparation method of anti-saccharification composition as claimed in claim 8, which comprises the following steps:
1) water, butanediol, glycerin polyether -26, parahydroxyacet-ophenone, EDETATE SODIUM are heated to 80 DEG C, completely, stirring is dropped for dissolution
Temperature；60 DEG C are down to hereinafter, again by Sodium Hyaluronate, extract of magnolia sieboldii, purslane extract, seawater, gentian to temperature
Root extract, Ganodernaa lucidum extract, sweet osmanthus flower extract, carnosine, by Gotu Kola P.E, polygonum cuspidate root extract, Baical Skullcap root P.E,
The compound addition of glycyrrhiza glabra root extract, german chamomile flower extract, tea extract, rosemary leaf extract composition, continues
Stirring cooling；
2) 45 DEG C or less are down to temperature to continue to stir by essence, Cremophor RH40 addition, keep its evenly dispersed；
3) compound, 1,2 hexylene glycols by decoyl hydroximic acid, glycerol caprylate, 1,2- pentanediol and propylene glycol composition are added,
It stirs evenly, is down to room temperature, discharge.
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| CN110664868A (en) * | 2019-10-15 | 2020-01-10 | 无限极（中国）有限公司 | Composition with anti-glycosylation effect and application thereof |
| US20210369596A1 (en) * | 2020-05-27 | 2021-12-02 | Mary Kay Inc. | Topical compositions and methods |
| CN115778837A (en) * | 2022-11-21 | 2023-03-14 | 安徽品赫生物科技有限公司 | Synergistic skin-brightening repair freeze-dried powder and preparation method and application thereof |
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| US20210369596A1 (en) * | 2020-05-27 | 2021-12-02 | Mary Kay Inc. | Topical compositions and methods |
| US11696888B2 (en) * | 2020-05-27 | 2023-07-11 | Mary Kay Inc. | Topical compositions and methods |
| CN115778837A (en) * | 2022-11-21 | 2023-03-14 | 安徽品赫生物科技有限公司 | Synergistic skin-brightening repair freeze-dried powder and preparation method and application thereof |
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| CN110279627B (en) | 2022-02-18 |
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