JP2013107859A - Skin cosmetic preparation for external use comprising connarus extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an anti-aging agent and whitening agent for external use based on antioxidative and anti-saccharification properties.SOLUTION: Anti-aging and whitening of the skin are attained by an active ingredient with anti-aging and anti-saccharification properties contained in an extract of Connarus Ruber of the family Connaraceae.

Description

The present invention relates to an external preparation for skin containing an extract of Connarus Rubber, and more particularly to an anti-aging agent based on antioxidant properties and / or anti-glycation properties, and a whitening agent for external use on skin.

<Antioxidation>
Generally, the skin is exposed to the outside, and it is known that wrinkles, dust, texture disappearance, and elasticity decrease due to skin aging due to external components such as oxygen and ultraviolet rays. In addition, ROS (reactive oxygen species) generated in skin cells, especially free radical type active oxygen, is known to cause damage to skin tissue as a result of inducing a chain oxidation reaction with easily oxidizable substrates such as lipids. It has been.

  In particular, ROS caused by ultraviolet rays causes sebum and lipid peroxidation, protein denaturation, enzyme function inhibition, DNA damage, etc., resulting in skin irritation and continued skin aging. It is thought to accelerate and cause various skin diseases and skin cancer.

  In order to deal with such troubles due to active oxygen, for example, the use of free radical supplementing acidic substances such as vitamin C and vitamin E, and synthetic antioxidant substances such as BHT and BHA is known. For example, Patent Document 1 discloses a composition for promoting collagen production, hyaluronidase inhibition, superoxide scavenging, and / or DPPH radical scavenging, which comprises an extract of body bud flowers, peony flowers, and Terminaria arjuna. ing.

<Anti-glycation>
In a glycation reaction of a protein in the body (Maillard reaction between reducing sugars such as glucose), if a hyperglycemic state continues due to diabetes or the like, the degradation reaction becomes difficult to progress due to aging, and the production of glycation products tends to occur. Function is impaired, or glycation products accumulate.

This saccharification product eventually becomes a terminal saccharification product (advanced glycation end products (AGEs)), but the generation of AGEs is an irreversible reaction. The produced AGEs are excreted out of the body by metabolism, but with aging, the metabolic rate becomes slower and AGEs accumulate in each tissue in the living body. AGEs accumulate in various tissues in the living body and cause various symptoms by binding to receptors of AGEs. Typical examples are when AGEs are generated and accumulated in the skin (epidermis, dermis). Of the skin (for example, changes in skin tone such as wrinkles, tarmi, yellowing), reduced translucency, spots, etc.) It is done.

In diabetic patients, AGEs caused by hyperglycemia are known to cause complications such as cataracts, arteriosclerosis, and renal dysfunction, and as a countermeasure, the generated AGEs must be easily discharged out of the body. Don't be.

Conventionally, in order to make it an active ingredient of a cosmetic composition or a food composition, a search for a component that suppresses the generation of AGEs or a component that decomposes AGEs has been performed. For example, Patent Document 2 includes an anti-glycating agent, an anti-aging agent, an inhibitor of skin collagen damage, or a decrease in skin tension or elasticity, or skin wrinkles, containing Budreja axillaris leaf extract as an active ingredient, An agent for inhibiting, preventing, or improving is disclosed.

In Patent Document 3, the skin is treated with an ingredient that inhibits α-glucosidase so that carbohydrates, disaccharides, and 1,4 polysaccharides on the skin surface are not easily metabolized to their constituent sugars, An α-glucosidase inhibitor aimed at reducing monosaccharides contributing to the formation of AGEs on the skin surface and suppressing the generation of AGEs is disclosed.

This is because monosaccharides such as glucose react with free amino groups on the skin surface to form certain intermediates that initiate a cascade of reactions, which eventually become irreversible for skin proteins such as collagen. It has long been known to result in mechanical cross-linking, and as AGEs are formed in the skin due to the increased presence of glucose in the skin and body tissues, collagen is cross-linked, reducing age-related skin wrinkles and aging. Since it will proceed, it is to prevent or improve by inhibiting this.

Carboxymethylarginine (CMA) is a type of AGE structure that specifically accumulates in collagen, but AGEs of skin collagen are thought to be the main cause of skin aging symptoms such as wrinkles, sagging, and dullness. Patent Document 4 describes that a CMA production inhibitor can inhibit collagen AGEs and can suppress the degeneration of biological proteins such as skin and blood vessels, and is one of the indicators of skin aging. It is described as being useful.

<Whitening>
It is known that due to ultraviolet rays, melanin production in skin pigment cells is promoted by the stimulation, and pigmentation such as stains and buckwheat caused by excessive deposition of melanin on the epidermis occurs. It is thought that it is produced through tyrosine, dopa, dopaquinone, 5,6-hydroxyindophenol and several intermediates by the action of tyrosinase, an enzyme biosynthesized in epidermal pigment cells. There are generally known methods for preventing, treating or ameliorating spots, buckwheat and skin pigmentation by means of suppressing the production process and lightening the produced melanin. For example, use of rattan tea extract, willow bamboo extract, etc., which are herbal medicines having an inhibitory effect on tyrosinase activity, large doses of L-ascorbic acid, subcutaneous injection of glutathione, etc., application of kojic acid, cysteine, hydroxyquinone, etc. to the skin Etc.

  For example, Patent Document 5 discloses an antioxidant, an anti-aging agent, and a whitening agent containing an extract of a plant belonging to the genus Mansoa (genus Mansoa; Genus Pseudocalymmma) as an active ingredient, and Patent Document 6 discloses Scidapitys. Verticillata) An external skin preparation having an antioxidant, anti-glycation, and whitening ability containing an extract as an active ingredient is disclosed.

  In addition, for preventing and improving pigmentation, cosmetics containing extracts such as water-soluble solvents of Dacridium biforme are known.

As described above, effective countermeasures against a wide variety of injuries to the skin have been studied, but natural substances, especially plant extracts, have been studied for many years because of safety considerations. However, the current situation is extremely difficult because the effects are different and cannot be predicted depending on the extraction site and the extraction method. For example, Patent Document 7 includes Costus Spicatus.
spicatus, Costus spiralis, Aniba plant, Myrcia plant, Potomorphe plant, Mirarirara plant, Kenopodium umbrocioide di
A formulation of an extract of a genus Ambrosioides, Polygala Spectabilis, or Arabidoa plant to an external preparation (including cosmetics) is disclosed.

  On the other hand, Connarus (Connarus ruber) is a plant belonging to the American family that grows naturally in the Amazon rainforest, which is known as a treasure trove of medicinal resources. . Therefore, although useful to the living body is expected, as a physiological activity of Connals extract, mutagenicity inhibitory action has been reported by collaborators, but there are still many unclear points about other effectiveness .

The inventors focused on the unknown usefulness of conalus, proceeded with exploration and research on its effects, and proceeded with exploration research on mutagenicity inhibitors of conalus bark extract as in Non-Patent Documents 1 and 2. Surprisingly, in recent years, it has been found that there is an excellent effect of treatment, improvement and prevention of excessive production of active oxygen, glycation, and melanin, which are factors of skin troubles that have been attracting attention. Succeeded in finding out more optimal conditions for the use of the external preparation for skin described in the above in various dosage forms, and completed the invention.

JP 2011-042644 A JP 2011-102270 A Special table 2010-539174 gazette JP 2009-096731 A JP 2011-148708 A JP 2008-074748 A JP 2001-122863 A

Abstracts of Annual Meeting of the Pharmaceutical Society of Japan (Vol.131, No.2, p.224, 2011) Abstracts of Annual Meeting of Japanese Biopharmaceutical Society (Vol.56, p.96, 2009) "2010 editions of known technologies in the cosmetics field" (edited by the Japan Cosmetic Industry Association Patent Committee)

  There is a need for a natural extract-based drug that can respond to a wide range of skin disorders such as wrinkles, stains, loss of texture, loss of elasticity, stains, and freckles, and can prevent, treat, or improve the skin. Yes.

In order to solve the above problems, in the present invention, a polar solvent extract of Connalus (Connalus Rubber) is used as an anti-aging agent, a whitening agent, and a cosmetic containing the agent.

Since the present invention is an anti-skin aging agent for skin use or / and a whitening agent for skin use containing an extract of Connarus (scientific name Connarus Rubber), the extract has excellent DPPH radical scavenging activity, lysozyme, and inhibition of crosslinking reaction. By inhibiting melanin production, it can be applied to cosmetics and the like by blending alone as an anti-aging agent and / or whitening agent or as a raw material component.

The topical skin preparation such as an antioxidant, whitening agent, anti-aging agent or anti-inflammatory agent of the present invention contains an extract of the genus Connarus Rubber as an active ingredient.
Here, the extract of Conus includes an extract, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a crude extract or a purified product, and a supercritical extract or subcritical extract. Any of the objects may be included.

The extraction part of the conus that can be used as the extraction raw material is not particularly limited, and for example, the above-ground part, the root part, or a mixed part thereof can be used. It is also preferable for increasing the efficiency. As the above-mentioned ground part, it is preferable to use a leaf part, a branch part, a bark part, a stem part, a fruit part, etc., and it is particularly preferable to use a bark part.

  Details of active oxygen inhibitory substances, radical scavenging substances, lipid oxidation inhibitors, tyrosinase activity inhibitors, melanin production inhibitors, elastase activity inhibitors or β-hexosaminidase activity inhibitors contained in the active ingredient of Connals The name of the chemical substance is unknown.

However, the active ingredient of conalus can be obtained by the extraction method using water, aqueous solvent or hydrophilic organic solvent generally used for the extraction operation from plants, and this includes active oxygen scavenging action, radical scavenging action, lipid oxidation. It can be confirmed that it has an inhibitory action, a tyrosinase activity inhibitory action, a melanin production inhibitory action, an elastase activity inhibitory action, or a β-hexosaminidase activity inhibitory action. For example, after drying the connals, the extract having the above-described action can be obtained by pulverization as it is or using a coarse crusher and subjecting it to extraction with an extraction solvent. Drying may be performed in the sun or using a commonly used dryer. Further, after pretreatment such as degreasing with a nonpolar solvent such as hexane, it may be used as an extraction raw material. By performing pretreatment such as degreasing, extraction with a solvent can be performed efficiently.

  As the extraction solvent, it is preferable to use a polar solvent, and examples thereof include water, an aqueous solvent, a hydrophilic organic solvent, and the like. These may be used alone or in combination of two or more at room temperature or a temperature below the boiling point of the solvent. Is preferred. In addition to pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, water that can be used as the extraction solvent includes those subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, filtration, ion exchange, osmotic pressure adjustment, buffering, and the like. Therefore, the water that can be used as the extraction solvent in the present invention includes purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline, supercritical water, subcritical water, and the like. included. The aqueous solvent refers to an aqueous solution in which a substance other than the hydrophilic organic solvent (for example, water-soluble salts such as sodium chloride) is dissolved in such water at a concentration that does not lose the properties as an extraction solvent.

  Examples of hydrophilic organic solvents that can be used as the extraction solvent include lower aliphatic alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; -C2-C5 polyhydric alcohols, such as butylene glycol, propylene glycol, and glycerol, etc. are mentioned.

When the above-mentioned mixed solution of two or more polar solvents is used as the extraction solvent, the mixing ratio can be adjusted as appropriate. For example, when using a mixed solution of water and a lower aliphatic alcohol which is a hydrophilic organic solvent, it is preferable to mix 1 to 90 parts by weight of a lower aliphatic alcohol with respect to 10 parts by weight of water, When using a mixed liquid with a lower aliphatic ketone, it is preferable to mix 1 to 40 parts by weight of a lower aliphatic ketone with respect to 10 parts by weight of water, and a mixed liquid of water and a polyhydric alcohol is used. In this case, polyhydric alcohol 1 to 10 parts by mass of water
It is preferable to mix 90 parts by mass.

  The extraction treatment is not particularly limited as long as the soluble component contained in the extraction raw material can be eluted in the extraction solvent, and can be performed according to a conventional method. For example, the extraction raw material is immersed in an extraction solvent in an amount 5 to 15 times (mass ratio) of the extraction raw material, and the soluble component is extracted at room temperature, reflux heating, supercritical or subcritical, and then filtered to obtain an extraction residue. An extract can be obtained by removing.

The obtained extract may be subjected to treatments such as dilution, concentration, drying, and purification according to a conventional method, and a concentrated solution, a dried product, and a crude or purified product thereof are obtained. Purification can be performed by, for example, activated carbon treatment, adsorption resin treatment, ion exchange resin treatment, or the like. The obtained extract can be used as it is as an active ingredient of an antioxidant, but it may be a concentrated solution or a dried product.

Here, more specific examples of the antioxidant action of the active ingredient of Connals include, for example, an active oxygen scavenging action, a radical scavenging action and / or a lipid oxidation inhibiting action, and particularly limited thereto. is not. Here, “active oxygen” includes superoxide, hydrogen peroxide, hydroxy radical, singlet oxygen, lipid peroxide, and the like. The “radical” means a molecule or atom having one or more unpaired electrons, and includes superoxide, hydroxy radical, DPPH and the like.

  Further, regarding the whitening action of the active ingredient of Connals, the more specific action is, for example, tyrosinase activity inhibitory action and / or melanin production inhibitory action, but is not particularly limited to these specific actions. . Furthermore, regarding the anti-aging action of the active ingredient of Connals, a more specific action is, for example, an elastase activity suppressing action, but is not particularly limited to these specific actions. Further, regarding the anti-inflammatory action that the active ingredient of Connals has, more specific action is, for example, β-hexosaminidase activity suppressing action, but it is not particularly limited to these specific actions.

In addition, the active oxygen scavenging action, radical scavenging action, lipid oxidation inhibitory action, tyrosinase activity inhibitory action, melanin production inhibitory action, elastase activity inhibitory action or β-hexosaminidase activity inhibitory action possessed by the active ingredient of the above-mentioned connals is utilized. , Active oxygen scavengers, radical scavengers, lipid oxidation inhibitors, tyrosinase activity inhibitors, melanin production inhibitors, elastase activity inhibitors or anti-inflammatory agents. The antioxidant, whitening agent, anti-aging agent or anti-inflammatory agent of the present invention may be composed of only the above-mentioned active ingredient of the connals, or may be formulated from the above-mentioned active ingredient.

  The active ingredient of the above connals is formulated into an arbitrary dosage form such as powder, granule, liquid etc. according to a conventional method using a pharmaceutically acceptable carrier such as dextrin and cyclodextrin and any other auxiliary agent. In addition to being able to be used by blending with other compositions (for example, skin cosmetics to be described later), it can be used as an ointment, a liquid for external use, a patch and the like. In this case, as an auxiliary agent, for example, an excipient, a binder, a disintegrant, a lubricant, a stabilizer, a flavoring agent and the like can be used.

The antioxidant of the present invention can eliminate excessively produced active oxygen and in vivo radicals through the active oxygen scavenging action, radical scavenging action and / or lipid oxidation inhibiting action of the active ingredient of Connals. As a result, it is possible to prevent, treat, or improve skin aging such as wrinkles, disappearance of texture, and skin elasticity. However, the antioxidant of the present invention can be used for all purposes other than these uses, which are meaningful for exerting an active oxygen scavenging action, a radical scavenging action and / or a lipid oxidation inhibiting action.

  In addition, the whitening agent of the present invention can prevent, treat, or improve skin darkening, spots, etc. through the tyrosinase activity inhibitory action and / or melanin production inhibitory action of the active ingredient of Connals. However, the whitening agent of the present invention can be used for all uses other than these uses, which are meaningful for exhibiting a tyrosinase activity inhibitory action and / or a melanin production inhibitory action.

  Furthermore, the anti-aging agent of this invention can suppress that the elastase derived from a fibroblast decomposes | disassembles elastin more than necessary through the elastase activity suppression effect which the active ingredient of a conus has. As a result, it is possible to prevent, treat, or improve skin aging such as wrinkles, disappearance of texture, and skin elasticity. However, the anti-aging agent of this invention can be used for all uses other than these uses, which are meaningful for exerting an elastase activity inhibitory action.

Furthermore, the anti-inflammatory agent of this invention can suppress the activity of β-hexosaminidase released together with histamine through the β-hexosaminidase activity suppressing action of the active ingredient of Connals. As a result, allergic diseases and the like can be prevented and improved by substances that inhibit or suppress histamine release.
However, the anti-inflammatory agent of this invention can be used for all uses other than these uses that are meaningful for exerting an anti-inflammatory action.

[Skin cosmetic]
The extract from the above connals is suitable for blending into a skin cosmetic because it is excellent in use feeling and safety when applied to the skin. In this case, the extract of Conals may be blended as it is, or an antioxidant, a whitening agent, an anti-aging agent or an anti-inflammatory agent formulated from the extract may be blended.

  Skin cosmetics that can be blended with the above extract of Connars are not particularly limited. For example, emulsion, soap, facial cleanser, bath preparation, cream, lotion, eau de cologne, shaving cream, shaving lotion. , Cosmetic oil, sunscreen lotion, funny powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner lipstick, lip balm, shampoo, rinse, dye Examples thereof include hairs, dispersions, and cleaning materials.

  In the case of blending the above extract of Conalus into skin cosmetics, the amount of the cosmetics can be adjusted as appropriate depending on the type of skin cosmetics, etc. A suitable blending ratio that acts is about 0.0001 to 10% by mass in terms of a standard extract (dry matter), and a particularly suitable blending ratio is in terms of a standard extract (dry matter). And about 0.001 to 1% by mass.

  In addition to the above essential components, the skin external preparation of the present invention, as long as the effects of the present invention are not impaired, are incorporated into skin external preparations such as cosmetics and quasi drugs, oils, higher alcohols , Fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols, sugars, polysaccharides, amino acids, peptides, proteins, polymer compounds, bioactive ingredients, solvents, antioxidants, fragrances, preservatives, etc. Can be blended. In this case, even if there is an influence that impairs a part of the functions of the present invention, the effect of the invention is essentially impaired if the other functions are not affected or remain insignificant. It should be noted that there is no point.

  Examples of the solvent include water, ethanol, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, and next-generation fluorocarbon.

  In addition, the external preparations for skin of the present invention, such as antioxidants, whitening agents, anti-aging agents, anti-inflammatory agents, and cosmetics, are applied to humans and are applied to animals other than humans (companion animals, domestic animals, etc.). It can also be applied to.

Below, the manufacture example, various test examples, etc. of a Connals extract and the skin external preparation containing it are demonstrated.
<Production Example 1>
After 1 kg of dry connals bark was immersed in 50% 1,3-butylene glycol for 24 hours at room temperature, it was filtered to obtain an extract.

<Radical scavenging action test (antioxidation effect confirmation test)>
Reactive oxygen species (ROS) generated in the living body by ultraviolet rays or stress induces oxidative damage of DNA, protein denaturation, etc., and is considered to be one of the causes of wrinkles and spots. Therefore, suppression of oxidation is useful as an anti-aging material.

1-diphenyl-2-picryl-hydrazyl (DPPH), which is a stable radical substance having a maximum absorption at 520 nm, is contained in the Connals extract. Antioxidant ability was evaluated by catching a decrease in absorbance at 520 nm caused by reduction by an antioxidant.

The Conalus extract was diluted in ethanol and used as a sample. The sample was put in a 96-well plate, and 1.5 × 10 ⁻⁴ mol / L DPPH solution was added and reacted at 25 ° C. for 30 minutes, and the absorbance at 520 nm was measured. The result was shown as DPPH radical elimination rate shown in the following formula.
DPPH radical scavenging rate (%) = {1− (A−B) / (C−D)} × 100
(In the formula, A, B, C and D represent the following measured values. A: Absorbance of the reaction solution in the sample solution of each concentration, B: Absorbance of the adjustment solution in the sample solution of each concentration, C: No sample added Absorbance of reaction solution in D, D: Absorbance of adjustment solution without addition of sample)

It was confirmed that the Connals extract was superior to ascorbic acid known to have a DPPH radical scavenging action.

<Crosslinking reaction inhibition test (anti-glycation effect test)>
It is known that saccharification is a non-enzymatic reaction between sugar and protein and ultimately forms terminal glycation products (AGEs). In recent years, it has been suggested that increased glycation stress in the skin greatly affects aging, such as the cross-linking of collagen accompanying glycation causes a decrease in skin elasticity. Therefore, suppression of saccharification can be expected as an anti-aging material.

The Connals extract was mixed with 20 mM D-ribose and 25 mg / ml lysozyme and allowed to stand at 37 ° C. for 7 days. Thereafter, a sample buffer was added to the reaction solution, followed by electrophoresis, and bands were visualized by Coomassie brilliant blue staining. The band size of the lysozyme dimer produced was evaluated as an index of saccharification.

It was confirmed that the Connals extract was significantly superior to aminoguanidine, which is known to have an anti-glycation effect by inhibiting lysozyme crosslinking.

<Melanin production inhibitory action test (whitening effect confirmation test)>
Melanin produced excessively by ultraviolet rays or the like causes skin dullness. Therefore, the production effect of melanin production can be expected as a whitening agent.

B16 mouse melanoma cells cultured in 10% FBS-containing MEM medium were used. This culture was all performed at 37 ° C. in the presence of 5% CO ₂ . The Conalus extract was diluted with MEM medium containing 10% FBS to prepare a sample. Specifically, 1.5 × 10 ⁵ B16 mouse melanoma cells were seeded in a 35 mm plastic petri dish and cultured for 24 hours. Then, it replaced | exchanged for the fresh culture medium and added the test sample. Forty-eight hours after adding the sample, the medium was removed, the cells were lysed with 0.85N potassium hydroxide solution, and the absorbance at 420 nm was measured. Moreover, the melanin production rate at the time of sample addition was computed by making the melanin production rate of the cell without a sample 100%.

It was confirmed that the Connals extract was remarkably superior to arbutin known to have a melanin production inhibitory action.

  Formulation examples of external preparations for skin (cosmetics) that could be formulated as embodiments of the present invention are listed below. In addition to these, for example, formulation examples introduced in Non-Patent Document 3 can be easily formulated. can do. In addition, all the mixture ratios shown following a component are weight%.

[Formulation Example 1; lotion]
Cetyl alcohol 5
Glycerin 2
1,3-butylene glycol 5
Trimethylglycine 1
Sodium polyaspartate 0.1
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.25
α-Tocopherol 2-L-ascorbic acid phosphate diester potassium 0.1
HEDTA3 sodium 0.1
Kouyamaki extract (sample 2) 0.1
Sodium hexametaphosphate 0.003
Carboxyvinyl polymer 0.05
Potassium hydroxide 0.025
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Formulation Example 2; lotion]
Glycerin 2.5
1,3-butylene glycol 4
Erythritol 1.5
Polyoxyethylene methyl glucoside 1
Polyoxyethylene hydrogenated castor oil 0.5
Kouyamaki extract (sample 2) 0.1
Citric acid 0.02
Sodium citrate 0.08
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Prescription Example 3; Emulsion]
Dimethylpolysiloxane 2.5
Decamethylcyclopentasiloxane 23
Dodecamethylcyclohexasiloxane 15
Polyoxyethylene / methylpolysiloxane copolymer 1.5
Trimethylsiloxysilicic acid 1
1,3-butylene glycol 5
Squalane 1.5
Talc 6
Dipotassium glycyrrhizinate 0.1
Kouyamaki extract (sample 2) 0.1
Tocopherol acetate 0.1
Edetate trisodium 0.05
2-methoxyhexyl paramethoxycinnamate 5
Silicone coated fine particle titanium oxide 4
Dimethyl distearyl ammonium hectorite 0.5
Spherical polyethylene powder 3
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Prescription Example 4; Cream]
Liquid paraffin 9
Vaseline 2
Dimethylpolysiloxane 2
Stearyl alcohol 4
Behenyl alcohol 2
Glycerin 5
Dipropylene glycol 4
Xylitol 1
Tetra-2-ethylhexanoic acid pentaerythrit 4
Lipophilic glyceryl monostearate 2
Polyisoethylene glyceryl monoisostearate 2
Polyoxyethylene glyceryl monostearate 1
Citric acid 0.05
Sodium citrate 0.05
Sodium hydroxide 0.015
Oil-soluble licorice extract 0.1
Tocopherol acetate 0.1
Kouyamaki extract (sample 2) 0.1
P-Hydroxybenzoate appropriate amount phenoxyethanol appropriate amount edetate trisodium 0.05
Polyvinyl alcohol 0.5
Hydroxyethyl cellulose 0.5
Carboxyvinyl polymer 0.05
Purified water Residual fragrance Appropriate amount

[Prescription Example 5; Gel]
Glycerin 2
1,3-butylene glycol 4
Sodium hydroxide 0.2
Edetate trisodium 0.05
Kouyamaki extract (sample 2) 0.1
Carboxyvinyl polymer 0.25
P-Hydroxybenzoate appropriate amount purified water remaining

[Prescription Example 6; Emulsification Foundation]
Behenyl alcohol 0.5
Dipropylene glycol 6
Stearic acid 1.5
Glycerol monostearate 1
Sodium hydroxide 0.15
Triethanolamine 0.6
Tocopherol acetate 0.1
P-Hydroxybenzoic acid ester Appropriate amount of yellow iron oxide 1
Dimethylpolysiloxane (6cs) 2
Dimethylpolysiloxane (100cs) 5
Stearyl alcohol 1.5
Isostearic acid 1.5
Behenic acid 0.5
Cetyl 2-ethylhexanoate 10
Polyoxyethylene glyceryl monostearate 1
Titanium oxide 3
Surface-treated titanium oxide 10
Polyalkyl acrylate coated mica titanium 0.5
Black iron oxide appropriate amount Silicic anhydride 6
2-methoxyhexyl paramethoxycinnamate 2
Bengala appropriate amount ultramarine blue appropriate amount legal dye appropriate amount xanthan gum 0.1
Bentonite 1
Carboxymethylcellulose 0.1
Kouyamaki extract (sample 2) 0.1
Purified water Residual fragrance Appropriate amount

[Prescription Example 7; Solid Foundation]
Talc 43
Kaolin 15
Sericite 10
Zinc 7
Titanium oxide 4
Yellow iron oxide 3
Black iron oxide Appropriate amount Bengala Appropriate amount Squalane 8
Isostearic acid 4
Monooleic acid POE sorbitan 3
Isocetyl octoate 2
Kouyamaki extract (sample 2) 0.5
P-Hydroxybenzoate ester

It is possible to provide a blended raw material such as cosmetics having high effect and safety, mainly having anti-oxidation, anti-glycation and whitening functions, or the drug itself.

[Formulation Example 1; lotion]
Cetyl alcohol 5
Glycerin 2
1,3-butylene glycol 5
Trimethylglycine 1
Sodium polyaspartate 0.1
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.25
α-Tocopherol 2-L-ascorbic acid phosphate diester potassium 0.1
HEDTA3 sodium 0.1
Conalus extract 0.1
Sodium hexametaphosphate 0.003
Carboxyvinyl polymer 0.05
Potassium hydroxide 0.025
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Formulation Example 2; lotion]
Glycerin 2.5
1,3-butylene glycol 4
Erythritol 1.5
Polyoxyethylene methyl glucoside 1
Polyoxyethylene hydrogenated castor oil 0.5
Conalus extract 0.1
Citric acid 0.02
Sodium citrate 0.08
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Prescription Example 3; Emulsion]
Dimethylpolysiloxane 2.5
Decamethylcyclopentasiloxane 23
Dodecamethylcyclohexasiloxane 15
Polyoxyethylene / methylpolysiloxane copolymer 1.5
Trimethylsiloxysilicic acid 1
1,3-butylene glycol 5
Squalane 1.5
Talc 6
Dipotassium glycyrrhizinate 0.1
Conalus extract 0.1
Tocopherol acetate 0.1
Edetate trisodium 0.05
2-methoxyhexyl paramethoxycinnamate 5
Silicone coated fine particle titanium oxide 4
Dimethyl distearyl ammonium hectorite 0.5
Spherical polyethylene powder 3
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

[Prescription Example 4; Cream]
Liquid paraffin 9
Vaseline 2
Dimethylpolysiloxane 2
Stearyl alcohol 4
Behenyl alcohol 2
Glycerin 5
Dipropylene glycol 4
Xylitol 1
Tetra-2-ethylhexanoic acid pentaerythrit 4
Lipophilic glyceryl monostearate 2
Polyisoethylene glyceryl monoisostearate 2
Polyoxyethylene glyceryl monostearate 1
Citric acid 0.05
Sodium citrate 0.05
Sodium hydroxide 0.015
Oil-soluble licorice extract 0.1
Tocopherol acetate 0.1
Conalus extract 0.1
P-Hydroxybenzoate appropriate amount phenoxyethanol appropriate amount edetate trisodium 0.05
Polyvinyl alcohol 0.5
Hydroxyethyl cellulose 0.5
Carboxyvinyl polymer 0.05
Purified water Residual fragrance Appropriate amount

[Prescription Example 5; Gel]
Glycerin 2
1,3-butylene glycol 4
Sodium hydroxide 0.2
Edetate trisodium 0.05
Conalus extract 0.1
Carboxyvinyl polymer 0.25
P-Hydroxybenzoate appropriate amount purified water remaining

[Prescription Example 6; Emulsification Foundation]
Behenyl alcohol 0.5
Dipropylene glycol 6
Stearic acid 1.5
Glycerol monostearate 1
Sodium hydroxide 0.15
Triethanolamine 0.6
Tocopherol acetate 0.1
P-Hydroxybenzoic acid ester Appropriate amount of yellow iron oxide 1
Dimethylpolysiloxane (6cs) 2
Dimethylpolysiloxane (100cs) 5
Stearyl alcohol 1.5
Isostearic acid 1.5
Behenic acid 0.5
Cetyl 2-ethylhexanoate 10
Polyoxyethylene glyceryl monostearate 1
Titanium oxide 3
Surface-treated titanium oxide 10
Polyalkyl acrylate coated mica titanium 0.5
Black iron oxide appropriate amount Silicic anhydride 6
2-methoxyhexyl paramethoxycinnamate 2
Bengala appropriate amount ultramarine blue appropriate amount legal dye appropriate amount xanthan gum 0.1
Bentonite 1
Carboxymethylcellulose 0.1
Conalus extract 0.1
Purified water Residual fragrance Appropriate amount

[Prescription Example 7; Solid Foundation]
Talc 43
Kaolin 15
Sericite 10
Zinc 7
Titanium oxide 4
Yellow iron oxide 3
Black iron oxide Appropriate amount Bengala Appropriate amount Squalane 8
Isostearic acid 4
Monooleic acid POE sorbitan 3
Isocetyl octoate 2
Conalus extract 0.5
P-Hydroxybenzoate ester

Claims (5)

  External skin anti-aging agent containing an extract of Connarus Rubber   The anti-skin aging agent for external use according to claim 1, wherein the anti-skin aging active ingredient is an active ingredient based on antioxidant or / and anti-glycation properties.   Skin whitening agent containing an extract of Connarus Rubber   An external cosmetic comprising the external skin anti-aging agent according to claim 1. Cosmetics for external use containing the whitening agent for external use according to claim 3