JP2010248150A - Agent for preventing, inhibiting, or ameliorating skin aging due to build-up of advanced glycation end products - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new agent for preventing, inhibiting or ameliorating skin deterioration stemming from AGEs build-up, an agent for ameliorating skin stiffness, and an agent for ameliorating skin tints. <P>SOLUTION: The agent for preventing, inhibiting or ameliorating skin deterioration stemming from AGEs build-up, the agent for ameliorating skin stiffness, and the agent for ameliorating skin tints containing (a) lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid and at least one selected from the group consisting of a pharmaceutically-permitted salt thereof, and (b) an advanced glycation end products decomposition agent as an active ingredient are provided. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an agent for preventing, suppressing or improving skin deterioration due to accumulation of advanced glycation end products used as a cosmetic composition, an agent for improving skin tension, and an agent for improving skin color. About.

A saccharification reaction (Maillard reaction) occurs between a reducing sugar such as glucose and a protein, and a saccharification product is generated. Protein saccharification occurs in vivo, but if a hyperglycemic state continues due to diabetes, etc., or if the degradation reaction does not proceed easily due to aging, the production of glycation products tends to occur and the function of the protein is impaired. Saccharification products accumulate. This saccharification product finally becomes a terminal saccharification product (advanced glycation end products; hereinafter abbreviated as “AGEs”), but the generation of AGEs is an irreversible reaction. The generated AGEs are excreted from the body by metabolism, but with aging, the metabolic rate becomes slower and AGEs accumulate in each tissue in the living body.
AGEs cause various symptoms by accumulating in each tissue in the living body or binding to receptors of AGEs. For example, when AGEs are generated and accumulated in the skin (epidermis, dermis), it contributes to the deterioration of the entire skin (for example, changes in skin color such as yellowing, reduction in transparency and tension). In diabetic patients, AGEs caused by hyperglycemia cause complications such as cataracts, arteriosclerosis, and renal dysfunction. Therefore, in order to discharge the generated AGEs to the outside of the body, it is important to decompose the AGEs into a form that can be easily discharged outside the body.

Conventionally, in order to make it an active ingredient of a cosmetic composition or a food composition, a search for a component that suppresses the generation of AGEs and a component that decomposes AGEs has been conducted. For example, Patent Document 1 describes that citrus volatile oils inhibit the production of pentosidine, which is one of AGEs. Patent Document 2 describes that an extract of olive oil in ethanol has an AGEs-decomposing action and suppresses skin dullness.
Patent Document 3 describes a whitening agent containing an unsaturated fatty acid together with a concentration of lactic acid selected from lactic acid, alkali metal lactic acid salt or alkaline earth metal salt, and lactic acid nonmetal compound with a concentration of 5 v / v% or more. Yes.

JP2004-35424 JP 2001-122758 Japanese Patent Laid-Open No.3-106810

  An object of the present invention is to provide a novel agent for preventing, suppressing or improving skin deterioration due to accumulation of AGEs, an agent for improving skin tension, and an agent for improving skin color.

The present inventor repeated research to solve the above problems,
(a) at least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof;
(b) AGEs degrading agents, such as unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable amides thereof (Hereafter, it may be abbreviated as “unsaturated fatty acids and derivatives thereof”), and when used in combination with vegetable oils containing these, plant extracts having an AGEs decomposition effect, etc., AGEs are accumulated due to a synergistic effect. It has been found that skin deterioration due to the above is suppressed very effectively, specifically, (i) skin tension is improved, and (ii) skin color change such as yellowish dullness is improved.
The present invention has been completed based on the above findings, and has been completed further. The following AGEs accumulate to prevent, suppress, or improve skin deterioration due to accumulation of AGEs, skin tension improving agent, and skin color. Provide a taste improver.

Item 1. An agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products, comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent Item 2. Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable Item 2. An agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 1, which is at least one member selected from the group consisting of amides thereof.
Item 3. Item 3. An agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 2, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.
Item 4. Item 4. The skin caused by accumulation of advanced glycation end products according to Item 3, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids. Prevention, suppression, or amelioration of decline.
Item 5. The advanced glycation end product degradation agent according to Item 1, wherein the advanced glycation end product degradation agent is a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof. An agent for preventing, suppressing or improving skin deterioration caused by accumulation of end products.
Item 6. The plant oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea butter, resulting from accumulation of advanced glycation end products according to item 5. Preventing, suppressing, or improving skin deterioration.
Item 7. A skin tension improving agent comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent Section 8. Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable Item 8. The skin tension improving agent according to Item 7, which is at least one selected from the group consisting of amides thereof.
Item 9. Item 9. The skin tension improving agent according to Item 8, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.
Item 10. Item 10. The skin tension improving agent according to Item 9, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.
Item 11. Item 8. The improvement of skin tension according to Item 7, wherein the advanced glycation end product degradation agent is a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof. Agent.
Item 12. Item 12. The skin tension improving agent according to Item 11, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat.
Item 13. A skin tone improving agent comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent Item 14. Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable Item 14. The skin tone improving agent according to Item 13, which is at least one member selected from the group consisting of amides thereof.
Item 15. Item 15. The skin tone improver according to Item 14, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.
Item 16. Item 16. The skin tone improver according to Item 15, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.
Item 17. Item 14. The skin tone according to Item 13, wherein the advanced glycation end product degradation agent is a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof. Improver.
Item 18. Item 18. The skin tone improver according to Item 17, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadowfoam oil, and shea fat.

Item 18. A composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products, comprising the following (a) and (b) as active ingredients:
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced Glication End Products Degrading Agent Item 19. Item 19. A composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 18, wherein the composition is a cosmetic composition.
Item 20. A composition for improving skin tension comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent Item 21. Item 21. The composition for improving skin tension according to Item 20, wherein the composition is a cosmetic composition.
Item 22. A composition for improving skin color, comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent Item 23. Item 21. The composition for improving skin color according to Item 20, wherein the composition is a cosmetic composition.

  When at least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof, and an AGEs decomposing agent are used in combination, the elasticity of the skin And the return of deformed skin is improved, and the color of the skin is improved. Thereby, the impression of the whole skin is kept young and a youthful appearance is obtained. Therefore, these compositions can be suitably used as a cosmetic composition.

It is a figure which shows the change of b * value of the skin by application | coating of a test sample. It is a figure which shows the meaning of Uf, Ua, Ue, Ur. It is a figure which shows the change of the elasticity of the skin by application | coating of a test sample. It is a figure which shows the change of the moisture content of the skin by application | coating of a test sample.

Hereinafter, the present invention will be described in detail.
The agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs of the present invention, the agent for improving skin tension, and the agent for improving skin color include the following (a) and (b) as active ingredients: .
(a) at least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof
(b) AGEs degradation agent
Examples of the (b) AGEs decomposing agent include the following (bi), (b-ii), or (b-iii).
(bi) selected from the group consisting of unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable amides thereof At least one
(b-ii) A vegetable oil containing at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable derivatives thereof
(b-iii) Plant extract having AGEs-degrading effect In other words, the components in (a) and (b) above are also anti-glycation agents, anti-aging agents based on anti-glycation action, or active ingredients of anti-aging agents. .
Prevention, suppression of skin deterioration due to accumulation of AGEs containing as an active ingredient (a) and two or more selected from the group consisting of (bi), (b-ii), and (b-iii), Alternatively, an improving agent, an improving agent for skin tension, and an improving agent for skin tone are also included in the present invention.

Lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof Examples of pharmaceutically acceptable salts include alkali metal salts such as sodium salt and potassium salt; calcium Salts, alkaline earth metal salts such as magnesium salts; ammonium salts and the like. Among lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof, lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid are preferred, and lactic acid, sodium lactate Is more preferable.
Lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof can be used alone or in combination of two or more.

As unsaturated fatty acid and its derivative unsaturated fatty acid, C16-24 unsaturated fatty acid is mentioned, for example. Specifically, crotonic acid (C4: 1 (2)), myristoleic acid (C14: 1 (9)), palmitoleic acid (C16: 1 (9)), oleic acid (C18: 1 (9)), Elaidic acid (C18: 1 (9)), vaccenic acid (C18: 1 (11)), gadoleic acid (C20: 1 (9)), eicosenoic acid (C20: 1 (11)), erucic acid (C22: 1 (13)), monoene unsaturated fatty acids such as nervonic acid (24: 1 (15)); linoleic acid (C18: 2 (9,12)), 8,11-icosadienoic acid (C20: 2 (8,11 ), Diene unsaturated fatty acids such as docosadienoic acid (C22: 2 (13,16)); (9,12,15) -linolenic acid (α-linolenic acid, C18: 3 (9,12,15)), (6,9,12) -linolenic acid (γ-linolenic acid, C18: 3 (6,9,12)), eleostearic acid (C18: 3 (9,11,13)), 5,8,11 -Triene unsaturated fatty acids such as icosatrienoic acid (C20: 3 (5,8,11)); arachidonic acid (C20: 4 (5,8,11,14), stearidonic acid (C18: 4 (6,9, 12,15)) tetraene unsaturated fatty acids; eicosapentaenoic acid (C20: 5 (5,8,11,14,17)), Unsaturated pentaene fatty acids such as eagle acid (C22: 5 (7,10,13,16,19)); docosahexaenoic acid (DHA, C22: 6 (4,7,10,13,16,19)) These fatty acids are commercially available.
Of these, unsaturated fatty acids having 16 to 20 carbon atoms are preferable, unsaturated fatty acids having 18 to 20 carbon atoms are more preferable, and unsaturated fatty acids having 18 carbon atoms are even more preferable in view of high AGE decomposition activity. As for the degree of unsaturation, a diene unsaturated fatty acid or a triene unsaturated fatty acid is preferable in terms of high AGE decomposition activity. In particular, a diene or triene unsaturated fatty acid having 18 carbon atoms is preferred.

In the present invention, pharmaceutically acceptable derivatives of unsaturated fatty acids can also be used. Derivatives include salts, glycerides, esters, and amides.
Examples of pharmaceutically acceptable salts of unsaturated fatty acids include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts and the like.
The pharmaceutically acceptable glyceride of the unsaturated fatty acid may be any of monoglyceride, diglyceride and triglyceride. The monoglyceride may be any of 1-acyl glyceride, 2-acyl glyceride and 3-acyl glyceride. The diglyceride may be any of 1,2-acyl glyceride, 1,3-acyl glyceride and 2,3-acyl glyceride.

When the glyceride of the unsaturated fatty acid is diglyceride or triglyceride, at least one of the constituent fatty acids may be an unsaturated fatty acid, and the ratio of the unsaturated fatty acid in the fatty acid constituting the glyceride is preferably 30% by weight or more. 50 wt% is more preferable, and 65 wt% or more is even more preferable. Moreover, when it is a diglyceride or a triglyceride, the unsaturated fatty acid may be the same or different.
Examples of pharmaceutically acceptable esters of unsaturated fatty acids include esters with aliphatic alcohols having 1 to 20 carbon atoms.
Examples of pharmaceutically acceptable amides of unsaturated fatty acids include ammonia, alkylamine (alkyl group having 1 to 4 carbon atoms), dialkylamine (alkyl group having 1 to 4 carbon atoms), trialkylamine (alkyl group). May be an amide of an unsaturated fatty acid with an alkanolamine (carbon number of the alkyl group is 1 to 4).
An unsaturated fatty acid and its derivative can be used individually by 1 type or in combination of 2 or more types.

Vegetable oils As vegetable oils, vegetable oils containing at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof, specifically evening primrose oil, cario carbaziriense fruit oil, meadow foam oil , Shea fat, avocado oil, olive oil, persic oil, cucumber nut oil, grape seed oil, safflower oil, almond oil, corn oil, pistachio seed oil, sunflower oil, hazelnut oil, macadamia nut oil, rosehip oil, soybean oil, sesame oil , Wheat germ oil, rapeseed oil, cottonseed oil, rice bran oil and the like. Among them, evening primrose oil, cario carbagiriense fruit oil, meadow foam oil, and shea fat are preferable, evening primrose oil and cario carbagiriense fruit oil are more preferable, and evening primrose oil is even more preferable. Evening primrose oil is a fatty oil obtained from the seeds of evening primrose (Akabanae evening primrose) or a plant belonging to the same genus, and Cariocarbrasiliense fruit oil is a fatty oil obtained from the pulp of Cariocarbrasiliense.

  These vegetable oils can be produced by known methods. For example, the crude oil can be obtained by mechanically squeezing seeds and the like to squeeze out the oil, further extracting the remaining oil with a solvent such as hexane, and then completely removing the solvent by distillation. The crude oil is then obtained by adding water to the crude oil to separate the gum and removing it with a centrifuge. Phosphoric acid is added to this crude oil to remove the remaining gum, sodium hydroxide is added to remove free fatty acids, water is washed, and then activated clay is added and stirred to adsorb pigments such as chlorophyll. Filtered to remove white clay, then cooled to remove the solid oil and wax that precipitates and remove odorous components by steam distillation under high temperature and vacuum to obtain a refined vegetable oil. It is done.

In the present invention, any of crude oil, crude oil, and refined oil can be used as an active ingredient for preventing, suppressing, or improving the deterioration of skin due to accumulation of AGEs and AGEs.
Moreover, refined evening primrose oil can be purchased from, for example, Oriza Oil Chemical Co., Ltd., Nisshin Oillio Group, etc., and refined Cario carbagiriense fruit oil can be purchased from, for example, Croda Japan.
A vegetable oil having a ratio of unsaturated fatty acids having 18 carbon atoms of 90% by weight or more based on the total fatty acids can also be used as an active ingredient of the AGEs degradation inhibitor. Examples of such vegetable oil include evening primrose oil.
A vegetable oil can be used individually by 1 type or in combination of 2 or more types.

Plant extract with AGEs decomposition effect
A well-known thing can be used for the plant extract which has an AGEs decomposition effect without a restriction | limiting. Known plant extracts having an AGEs-degrading effect include, for example, olive extract (Japanese Patent Laid-Open No. 2001-122758); cypress extract (Japanese Patent Laid-Open No. 2001-131051); Japanese Unexamined Patent Publication No. 2007-161663); Polar Solvent Extract of Rosaceae (Japanese Unexamined Patent Publication No. 2007-161662); Polar Solvent Extract of Rooibos Plant (Japanese Unexamined Patent Publication No. 2007-161661); Polar solvent extract of plant body (JP 2007-161660); salamander soft extract, turmeric extract, saffron tincture, peppermint soft extract, ginger extract, carrot extract, lotus leaf extract, red pepper extract, coleus forss Kori extract, twilight leaf extract, hihitsu extract, sunflower flower powder, hikikoshi extract, shikwasa extract, kudzu root extract, pu-erh tea extract, licorice extract, black rice extract, evening primrose , Guava leaf extract, loquat leaf extract, onion hull extract, green flower extract, mulberry leaf extract, cod bud extract, chorogi extract, white kidney bean extract, rabu hemp extract, kumazasa extract, bitter gourd extract, barley leaf extract, barley young leaf extract , Brown algae extract, konjac koji extract, coffee bean extract, grape seed extract, apple extract, olive leaf extract, kombu extract, ashitaba powder, catechin, kumquat soft extract, koji extract, kumquat extract, citrus extract, yuzu powder and crust extract (Above, JP-A-2007-119373); American witch hazel, apricots, Ichiyakusou, waurusushi, oren, giant crape myrtle, ganbeeroki, genus shoko, kohone, pomegranate, peonies, sunflower, dio, chanoki, chojino Citrus volatile oils of citrus fruits, chimney berry senna, tencha, toccoli strawberry, tormentilla, rose, button, yak salvia, chalcedony, bayberry, eucalyptus, logwood, walnut mulberry (above, JP 2002-241299) (Japanese Patent Laid-Open No. 2004-35424). Among them, extracts derived from plants such as mugwort, saxifrage, carrot, hikiokoshi, brown algae, grape seed, apple, maronnier, and neem are preferable.
The plant extract which has an AGEs decomposition effect can be used individually by 1 type or in combination of 2 or more types.

Cosmetic composition Preventing, suppressing, or improving skin deterioration due to accumulation of AGEs of the present invention, an agent for improving skin tension, and an agent for improving skin tone are the above-described effective ingredients, cosmetic ingredients. Can be mixed with a known base or carrier acceptable as a cosmetic composition.
Each agent of the present invention may be formulated as a single composition containing the component (a) and the component (b), and the component (a) and the component (b) are formulated as separate compositions. It may be a formulation in which these compositions are combined. Moreover, when using 2 or more types of said (a) component, or 2 or more types of said (b) component, they are good also as a mutually different composition.
The form of the cosmetic composition is not particularly limited. For example, lotion, milky lotion, cream, cosmetic liquid, sunscreen cosmetics, basic cosmetics such as packs, hand creams, body lotions, body creams; Cosmetics for cleaning such as makeup remover and body shampoo; makeup cosmetics such as foundation, makeup base, lip balm, lipstick and teak color; bathing agent and the like.

The content of (a) lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid and pharmaceutically acceptable salts thereof in the cosmetic composition is, for example, about 0.0001 to 50% by weight. What is necessary is just about 0.001 to 50 weight%, and about 0.05 to 25 weight% is more preferable.
Further, the pH of the cosmetic composition containing (a) lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof may be, for example, 5.5 or less, The number is preferably 4 or less, and may be 2 or more, for example, and preferably 3 or more. When the cosmetic composition contains the component (a) and the component (b), the pH of the composition may be in the above range, and the composition containing the component (a) and the component (b) When the composition containing is a different composition, the pH of the composition containing the component (a) may be in the above range.

The content of the (b) AGEs decomposing agent in the cosmetic composition may be, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 10% by weight, and more preferably about 0.001 to 5% by weight. When two or more of the above (bi), (b-ii), and (b-iii) are included, the total amount thereof may be in the above range.
Also, a cosmetic composition comprising (a) lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, and phytic acid, and pharmaceutically acceptable salts thereof, and (b) an AGEs decomposing agent. The ratio (component (a): component (b)) in this case is preferably about 1: 0.0000002 to 200,000, more preferably about 1: 0.000002 to 10000, and even more preferably about 1: 0.00004 to 100 by weight. When the component (a) and the component (b) are combined as separate compositions, the combination ratio (component (a): component (b)) may be within the above range.
If it is the said range, the improvement effect of sufficient skin tension and the improvement effect of skin tone will be acquired with the normal usage-amount of cosmetics.

  Bases or carriers include paraffin, liquid paraffin, squalane, white wax, gelled hydrocarbon (such as plastic base), ozokerite, ceresin, petrolatum, hard fat, microcrystalline wax, α-olefin oligomer, light liquid paraffin, etc. Hydrocarbons; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; such as glyceryl tri-2-ethylhexanoate (trioctanoin), tri (caprylic acid / capric acid) glyceryl Tri-fatty acid glycerides; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol; methyl polysiloxanes, highly polymerized methyl polysiloxanes, dimethylsiloxane methyl (polyoxyethylene) siloxane methyl Polyoxypropylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene-methylpolysiloxane copolymer, poly ( Oxyethylene / oxypropylene) / methylpolysiloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methyl Polysiloxane, cross-linked methylphenyl polysiloxane, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, cross-linked alkyl-modified silicone, decamethylcyclopenta Silicone such as siloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane network polymer, polyoxyethylene-methylpolysiloxane copolymer, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethylpolysiloxane Oils; glycol acetates such as ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2-propene-1,1-diol diacetate Tart; Triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanediol diisobut Glycol esters such as acrylates; such as ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate Glycol acrylates; glycol dinitrates such as ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and propylene glycol dinitrate; 2,2 '-[1,4-phenylenedioxy] diethanol; ethylcellulose, hydroxy Cellulose derivatives such as propylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; Diethylene; butylene glycol adipic acid polyester; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate; dextrin, malto Polysaccharides such as dextrin; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether , Propylene glycol Examples thereof include glycol ethers such as no ethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether and dipropylene glycol monopropyl ether; and aqueous bases such as water.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), tri fatty acid glycerides (especially glyceryl tri-2-ethylhexanoate, tri (caprylic acid / capric acid) glyceryl), higher alcohols ( In particular, cetanol, stearyl alcohol, behenyl alcohol), silicone oil (especially methylpolysiloxane, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, Methyl siloxane network polymer, polyoxyethylene / methyl polysiloxane copolymer, methyl hydrogen polysiloxane, triethoxysilylethyl polydimethylsiloxyethylhexyl dimethicone, dimethicone Polypolysiloxane), esters (especially isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol monoethyl ether), water are preferred. .
A base or a carrier can be used alone or in combination of two or more.

In addition, the cosmetic composition is a known additive that is added to the cosmetic, for example, a surfactant, a thickener, a preservative, a pH adjuster, a chelating agent, a stable agent, as long as the effects of the present invention are not impaired. An agent, an irritation reducing agent, a preservative, a coloring agent, a dispersing agent, a fragrance and the like can be added. An additive can be used individually by 1 type or in combination of 2 or more types.
Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters; glyceryl fatty acids such as glyceryl monostearate and glyceryl monostearate; polyglyceryl fatty acids such as polyglyceryl monostearate, polyglyceryl monoisostearate and polyglyceryl diisostearate; propylene glycol monostearate Propylene glycol fatty acid esters such as: polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor Cured castor oil derivatives such as oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80; polylauric acid monolaurate (20) sorbitan (polysorbate 20), Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; Polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; stearylamine, oleyl Amines such as tromethamine, polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and the like silicone-based surfactants such as PEG-9 polydimethylsiloxyethyl dimethicone.

  Among them, glycerin fatty acids (particularly glyceryl monostearate), polyglycerin fatty acids (particularly polyglyceryl monostearate), hardened castor oil derivatives (particularly polyoxyethylene hardened castor oil 50 (HCO-50), polyoxyethylene) Hydrogenated castor oil 60 (HCO-60)), polyoxyethylene sorbitan fatty acid esters (particularly polyoxyethylene (20) sorbitan isostearate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60)), polyoxyalkylene Alkyl ether (especially polyoxyethylene cetyl ether), silicone surfactant (especially polyoxyethylene methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethyl) Lucyloxyethyl dimethicone) is preferred.

  Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, dextran, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium alginate, propylene glycol alginate, polyvinyl Alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxy vinyl polymer, alkyl methacrylate copolymer, sodium polyacrylate, polyethylene glycol, bentonite, dextrin fatty acid ester, pectin, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer The Chill distearyl ammonium hectorite, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, polyethylene glycol distearate, triisostearate, ethylene glycol, triisostearate, polyoxyethylene (20) and the like methyl glucoside. Among them, xanthan gum, alkyl methacrylate methacrylate copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, carboxyvinyl polymer, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, dimethyl distearyl ammonium hectorite (Acryloyl dimethyl taurate ammonium / vinyl pyrrolidone) copolymer, polyethylene glycol distearate, ethylene glycol triisostearate, polyoxyethylene (20) methyl glucoside triisostearate.

Preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid Examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol. Of these, methyl paraoxybenzoate, propyl paraoxybenzoate, and phenoxyethanol are preferable.
Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, Oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic base (sodium bicarbonate, sodium carbonate, hydroxylation) Potassium, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.) and organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Among these, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide, and sodium hydroxide are preferable.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metalin An acid etc. are mentioned. Of these, sodium edetate is preferable.
Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.
Examples of the irritation reducing agent include licorice extract and sodium alginate.
Examples of the colorant include inorganic pigments and natural pigments.
In addition, the cosmetic composition can improve, suppress, and reduce the deterioration of the entire skin caused by accumulation of AGEs in the skin (for example, change in skin color such as yellowish blur, reduction in firmness and transparency), Alternatively, known anti-glycation components that can be added to cosmetics can be blended for the purpose of further enhancing the effects of the present invention, such as prevention and slowing down the progress (speed) of the deterioration of the entire skin. Known anti-glycation components can be used singly or in combination of two or more.

  Known anti-glycation components include, for example, Amler fruits, fruit juices or extracts thereof (JP 2006-028090, JP 2006-62989, etc.); L-arginine, L-lysine, hydrolyzed casein (above, JP 2001-039816); Hydrolyzable tannin (JP 9-40519); Carnosine, α-lipoic acid (above, “Latest skin diagnostic manual for beauty”, Fragrance Journal, August 15, 2006 Issued): Western rose flower / ovary, hybrid rose flower / ovary / gaku / leaf / stem, age, grape leaf, oyster leaf, apple leaf, marigold flower, magnolia leaf extract Open 2006-273811); button genus plant extract, seaweed genus plant extract, genus genus plant extract, sunflower plant extract, aloe genus plant extract, amadokoroko genus plant extract, flax genus plant extract, Rose plant extract , Linden plant extract, kangwei plant extract, genus plant extract, kanto plant extract, burdock plant extract, mint plant extract, elder plant extract (above, JP 2003-212749 A) No.); an extract of Odaka Ryo (Japanese Patent Laid-Open No. 2006-62987); Asunaro, Asenyaku, Itadori, Ichiyakusou, Apricots, Keikanka, Hakukayumatou, Birch, Hawthorn, Achillea millefolium, Tarayo, Dokudami, Torumenchira, Bakumondo, Hiba, Extracts of grapes, green willow, mugwort, mocca, litchi, roman chamomile (above, JP-A-2003-212770); American witch hazel, apricots, Ichiyakusou, Owaurushi, Ouren, Greater Salve, Gambier, Gennoshiko, Kouhone, Pomegranate, Peonies, Natsuyukisou, die Extract of cormorant, chanoki, cinnamon, cinneberry senna, tencha, toccoli strawberry, tormentilla, rose, button, salamander, yachabushi, bayberry, eucalyptus, logwood, walmok (above, JP 2002-241299); Extracts of aloe, apricot, hippopotamus, cypress, trash, sanchinin carrot, sardine carrot, narco lily, chickweed, scallop, bukuro, yuzu (above, JP-A-2002-241293); calcade, hibiscus, shazenshi, tonin, maronier, keishi , Trash, sicon, senna, toshishi, beakkyu extract (above, JP 11-106336); jujube fruit kernel (acid jinjin), MACJONG fruit, pumpkin seeds, eucommia leaves, salacia root, ooh Extract of leaf of Umegasao (above, JP 2007-254345); Achacha, Enishida Snow lotus flower, devils crow, Ezoukogi, Rosea, Ercampure extract (above, JP 2007-254344); Papaya extract (JP 2006-298812); Simonil extract (JP 2006-219447) An extract of a genus genus (Japanese Patent Laid-Open No. 2006-117700); agrimony, ashwagandha, anise, amachazal, sweet candy, ginkgo, fennel, witch hazel, turmeric, echinacea, elephant, elder, elba mate, plantain Olive, oregano, orange, persimmon, persimmon, chamomile, guarana, cocoon grass, chrysanthemum, gymnema, cat's claw, catnip, killaway, goldfish, guava, cucumber, zakuza, cumixtin, black soybeans, wrinkles, cinnamon, tsutsumeishi, bitter gourd, Cola nut, gokahi, tsutsukora, coriander, comfrey, saximaso Cormorant, safflower, salacia oblonga, hawthorn, sanitary carrot, perilla, juyaku, juniper berry, ginger, cedar, horsetail, stevia, spearmint, sage, savory, hawthorn, sanctuary, thyme, tahibo, dandelion, chervil , Chanoki, chabodia, clove, daisy, dill, eucommia, nutmeg, nanban, nettle, hibiscus, white birch, white flower snake tongue grass, cabbage, basil, lotus, half-branch, heath, peach, hyssop, wisteria Fever-Fu, Fukugi, Wisteria, Plantago Thyrium, Blueberry, Blue Mallow, Penny Royal, Safflower, Peppermint, Hop, Poligi, Pound Apple, Marshmallow, Marjoram, Marigold, Mullin, Marlow Mall, Marlow Bull , Mifuragi, Milk Thistle, Megurinoki, Medu Sweet, Mokka, Yaeyama Aoki, Yakurakugi, Yarrow Flower, Eucalyptus, Yakuinin, Mugwort, Raspberry, Lavender, Linden, Rooibos, Lemongrass, Lemon Thyme, Lemon Verbena, Lemon Balm, Rosehip, Rose Pink Butts , Rosemary, Rose Red, Laurel, Rafu, Wild Strawberry extract (above, JP-A-2004-250445); Extract of Akamegashiwa, Oyster, Mulberry, Hypericum perforatum, Azalea, Yakuyo garage, Yaba Santa, Rosehip (above) , JP 2004-189663); extract of cherry, red scenic heaven, blueberry, bearberry, white peach, chickweed, tiger weevil, henna, and larea (above, JP 2001-316221); Extracts of king spider, goldfish, bay bay, sorghum, peony, swordfish, baimo, potato mulberry (above, JP-A-8-259431); carrot leaf extract (JP-A-2004-51580); Extract of hawthorn, chanoki, cinnamon, dokudami, tormentilla, rose, grape, maronnier, roman chamomile (above, JP 2005-35911); aminoguanidine or its salt (latest medicine, 49-2, p78-83) 1994); black soybean seed coat, mate tea leaves (green), linden flowers, radish leaves, black rice seeds, willow bark and shoots, Ibright aboveground, black cohosh root, agni fruit, artichoke leaves, litchi seeds, cutlet bark, auto Above-ground wheat, passion flower leaves, chadebugure leaves, buckwheat leaves, maria thistle fruit, tomorrow Leaf, devil's claw root, ipe bark, agaricus mycelium, paffia root, acai fruit, mozuku whole plant and processed product of cypress stem and leaf (above, JP 2008-088102); neem extract; aristine; glucosamine, etc. It is done. Among them, ingredients derived from plants such as Amler, lychee, rose, maroonier, Maria thistle, Neem (especially Amler extract, lychee seed extract, rose petal extract, Maronier extract, Maria Thistle extract, Neem extract); hydrolysis Sexual tannins (particularly derived from chestnut astringent skin); L-arginine or a salt thereof; lysine or a salt thereof; carnosine; α-lipoic acid; aminoguanidine or a salt thereof;

The amount of the known anti-glycation component used is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, more preferably about 0.001 to 5% by weight, based on the total cosmetic composition. is there. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Furthermore, the cosmetic composition has an antioxidant component, an anti-aging component, an anti-inflammatory component, a whitening component, a keratin softening component, a cell activation component, vitamins, a blood circulation promoting component, as long as the effects of the present invention are not hindered. Other medicinal ingredients that can be added to cosmetics, such as moisturizing ingredients, ingredients that prevent and / or repair DNA damage, UV-absorbing ingredients, UV-scattering ingredients, cleaning ingredients, antibacterial ingredients, and astringent ingredients it can. Other medicinal ingredients can be used alone or in combination of two or more.

  Antioxidant components include components derived from plants (eg, grape, ginseng, comfrey, etc.); proanthocyanidins, tocopherols and derivatives thereof, ascorbic acid and derivatives thereof, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, Examples include erythorbic acid and salts thereof, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, and hypotaurine. Among them, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, tocopherol and its derivatives (particularly δ-tocopherol, α-tocopherol), ascorbic acid and its derivatives (particularly ascorbic acid, ascorbic acid) Sodium phosphate ester, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin and ergothioneine are preferred.

The amount used in the case of using an antioxidant component is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, and more preferably about 0.001 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Antiaging components include hydrolyzed soy protein, retinoids (retinol and derivatives thereof, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L- Examples include serine and mevalonolactone. Of these, hydrolyzed soy protein, retinol, retinol acetate, and retinol palmitate are preferred.
When the anti-aging component is used, the amount used is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition.

Anti-inflammatory components include components derived from plants (eg Comfrey); allantoin, calamine, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin , Salicylic acid or a derivative thereof. Of these, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate are preferable.
The amount used in the case of using the anti-inflammatory component is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.

Examples of whitening ingredients include arbutin; hydroquinone; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; ascorbic acid or a derivative thereof; vitamin E or a derivative thereof; pantothenic acid or a derivative thereof; Plant components (for example, plant extracts and essential oils) having Among these, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetracordylhexyldecanoate) and tranexamic acid are preferable.
When the whitening component is used, the amount used is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used when using a plant component having a whitening effect as the whitening component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to the total amount of the cosmetic composition, in terms of an extract such as an extract or an essential oil It is 15% by weight, more preferably about 0.001 to 10% by weight.

Examples of the keratin soft component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid and the like. Of these, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferred.
The amount used when the keratin softening component is used is, for example, 0.0001 to 15% by weight, preferably about 0.001 to 10% by weight, based on the whole cosmetic composition.
Cell activation components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; vitamins such as retinol and its derivatives, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids Α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoins, and photosensitizer 301. Among them, bilberry leaf extract, retinol, retinol acetate, and retinol palmitate are preferable.

The amount used in the case of using the cell activating component is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Vitamins include retinol, retinol acetate, retinol palmitate, etc., retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl retinoate Vitamins such as β-tocopheryl retinoate; provitamins A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, echinone; δ-tocopherol, α- Vitamin Es such as tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin Vitamin B2 such as denine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate; nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinamide; stearic acid Ascorbyl, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbic acid Vitamin Cs such as glucoside; Vitamin Ds such as methyl hesperidin, ergocalciferol, cholecalciferol; Vitamin Ks such as dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, Vitamin B1 such as thiamine triphosphate, thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride , Vitamin B6 such as pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin Folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-panthetin, coenzyme A, pantothenyl ethyl ether; biotin and biocytin In addition, vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol and the like can be mentioned.

Among them, vitamin A such as retinol, retinol acetate, retinol palmitate, etc .; vitamin C such as ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate) Vitamin E such as δ-tocopherol and tocopherol nicotinate; nicotinic acid such as nicotinamide is preferred.
The amount of vitamins to be used can be appropriately selected in consideration of the feeling of use and effects on the skin. % By weight, more preferably about 0.5 to 20% by weight.

Examples of the blood circulation promoting component include plants (e.g. ginseng, ashitaba, arnica, ginkgo, fennel, enmelio, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, sorghum, nematode, Assembly, thyme, clove, chimney, spruce, spruce, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokuinin, rosemary, rosehip, chimpi, touki, spruce, peach, apricot, walnut , A component derived from corn); tocopherol nicotinate, glucosyl hesperidin, hesperidin. Among these, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, and hesperidin are preferable.
The amount of the blood circulation promoting component is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, and more preferably about 0.001 to 4% by weight, based on the entire cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.

  As moisturizing ingredients, ingredients derived from plants (eg, Tigaya); amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, theanine and derivatives thereof; collagen, gelatin, elastin Such proteins and peptides, hydrolysates thereof; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, dipropylene glycol, diglycerin; sugar alcohols such as sorbitol; lecithin, hydrogenated lecithin Phospholipids such as: hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, heparin, chondroitin mucopolysaccharides; lactic acid, sodium pyrrolidone carboxylate NMF-derived components such as urea and urea; polyglutamic acid; polymers having a phospholipid polar group such as MPC polymer (for example, LIPIDURE (registered trademark)); polyoxypropylene methyl glucoside; trimethylglycine (betaine); hydroxyethyl Urea; acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer; sorbitol and the like. Among them, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethyl glycine (betaine), hydroxyethyl urea Acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, and sorbitol are preferred.

When the moisturizing component is used, the amount used is, for example, 0.001 to 10% by weight, preferably about 0.01 to 5% by weight, and more preferably about 0.1 to 5% by weight, based on the entire cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
The component having the action of preventing and / or repairing DNA damage includes components derived from animals (eg, Artemia); components derived from plants (eg, cat's claw); DNA, DNA salts, RNA, RNA salts, etc. Examples include nucleic acid components. Of these, artemia extract and DNA-Na are preferred.

The amount of the component having an effect of preventing and / or repairing DNA damage is, for example, about 0.001 to 3% by weight, preferably about 0.01 to 1% by weight, based on the whole cosmetic composition. When animal components are used, the amount used is about 0.00001 to 0.1% by weight, preferably about 0.0001 to 0.01% by weight, based on the total amount of the cosmetic composition, in terms of extracts such as extracts.
Examples of ultraviolet ray absorbing components include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) ) Anilino] -1,3,5-triazine, dimethoxybenzylideneoxoimidazolidinepropionate 2-ethylhexyl, 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6 (4-methoxyphenyl) -1,3,5-triazine and the like. Among them, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino]- 1,3,5-triazine is preferred.

The amount used in the case of using the ultraviolet absorbing component is, for example, about 0.01 to 20% by weight, preferably about 0.1 to 15% by weight, based on the whole cosmetic composition.
Ultraviolet scattering components include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silicic acid, and those inorganic compounds Coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, or compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, silicon oil and fatty acid aluminum salts, etc. And the like processed with. Among these, inorganic compounds such as zinc oxide, titanium oxide and iron oxide, and those inorganic compounds coated with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica and talc, and silicon oil are preferable.

The amount used in the case of using the ultraviolet scattering component is, for example, about 0.001 to 35% by weight, preferably about 0.1 to 25% by weight, based on the whole cosmetic composition.
As washing components, polyoxyalkylene alkyl (or alkenyl) ether sulfate, alkyl (or alkenyl) sulfate, higher fatty acid salt, ether carboxylate, amide ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid Anionic surfactants such as salts, polyoxyalkylene fatty acid amide ether sulfates, acylated isethionates, acylated taurates;
Nonionic surfactants such as amine oxides, glycerin fatty acid esters, sorbitan fatty acid esters, alkyl saccharides, polyoxyalkylene alkyl ethers, fatty acid alkanolamides, polyoxyalkylene hydrogenated castor oil; linear chains which may be added with alkylene oxide Or cationic surfactants such as mono- or di-long-chain alkyl quaternary ammonium salts having branched long-chain alkyl groups; amphoteric surfactants such as carbobetaine, sulfobetaine, imidazolinium betaine, and amide betaine .

  Of these, anionic surfactants, nonionic surfactants, and amphoteric surfactants are preferred. Anionic surfactants include higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid) are preferred. Among the nonionic surfactants, fatty acid alkanolamides (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide) and amine oxides (especially coconut oil alkyldimethylamine oxide, lauryldimethylamine oxide) are preferable. Amphoteric surfactants include imidazolinium betaines (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium. ) Is preferred.

The blending amount of the cleaning component is about 0.01 to 80% by weight, preferably about 0.1 to 60% by weight, based on the whole cosmetic composition.
Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101 Photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride and the like. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride Are preferred, and benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol are more preferred.

When the antibacterial component is used, the amount used is preferably about 0.0003 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition.
Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Among these, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferable.

When the astringent component is used, the amount used is, for example, about 0.0003 to 10% by weight, preferably about 0.01 to 5% by weight, more preferably about 0.01 to 5% by weight, based on the entire cosmetic composition.
The cosmetic composition of the present invention can be prepared by mixing and stirring each component according to a conventional method. For example, an ingredient insoluble in a cosmetic base and an oil component can be mixed and stirred in advance, and then an aqueous component can be blended and mixed and stirred again. A stirrer such as a homomixer may be used to facilitate the dispersion of components insoluble in the base.

Preferred combinations of components Examples of preferred combinations of the active ingredient of the present invention and other active ingredients include the following combinations.
When it contains a known anti-glycation component, Amlar extract, lychee seed extract, rose petal extract, maronier extract, maria thistle extract, neem extract, hydrolyzable tannin, L-arginine or salt thereof, lysine or salt thereof, Carnosine, α-lipoic acid, aminoguanidine or a salt thereof, aristine, or glucosamine;
When antioxidant components are included, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, δ-tocopherol, α-tocopherol, ascorbic acid, sodium ascorbate phosphate, ascorbate phosphate ester Magnesium, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin, or ergothioneine;

When it contains an anti-aging ingredient, hydrolyzed soy protein, retinol, retinol acetate, or retinol palmitate,
When containing an anti-inflammatory component, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, or stearyl glycyrrhetinate
When containing a whitening component, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), or tranexamic acid,
When containing a cell activation component, bilberry leaf extract, retinol, retinol acetate, or retinol palmitate,
When vitamins are included, vitamins A (retinol, retinol acetate, retinol palmitate), vitamins C (ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetra 2) -Ascorbyl hexyldecanoate)), vitamin Es (δ-tocopherol, tocopherol nicotinate), nicotinic acids (nicotinamide),

When containing a blood circulation promoting component, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, or hesperidin,
When moisturizing ingredients are included, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methylglucoside, trimethylglycine (betaine) ), Hydroxyethylurea, acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, or sorbitol,
When it contains a component having an action of preventing and / or repairing DNA damage, Artemia extract or DNA-Na,

  When an ultraviolet absorbing component or an ultraviolet scattering component is included, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, or 2,4,6-tris [4 -(2-Ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, zinc oxide, titanium oxide, iron oxide, inorganic powders of these inorganic compounds (aluminum hydroxide, hydrous silicic acid, mica, or talc) Or coated with silicone oil,

When it contains a cleaning component, higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide) / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid), fatty acid alkanolamide (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide), amine oxide (especially coconut oil alkyldimethyl) Amine oxide, lauryl dimethylamine oxide), imidazolinium betaine (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl) Ru-N-carboxymethylethylenediamine disodium),
When it contains an antibacterial component, benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, or isopropylmethylphenol,
In the case of containing an astringent component, examples include alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, or a combination with tannic acid.
Of these, it is preferable to combine known anti-glycation components, antioxidant components, anti-aging components, anti-inflammatory components, cell activation components, vitamins, and moisturizing components. Among these, it is more preferable to combine known anti-glycation components, anti-aging components, and antioxidant components.

How to Use The cosmetic composition may be applied in the usual manner of use and the number of uses. Also, (1) use of a composition containing the component (a) and the component (b), (2) a composition containing the component (a) and a composition containing the component (b) Any use mode of the combined use is suitable.
The subject of use of the agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs and AGEs of the present invention is not particularly limited, but the cosmetic composition is caused by the elderly, generation of AGEs, and accumulation Suitable subjects include humans in whom the overall skin has declined, humans in whom the entire skin has a tendency to decline due to the generation and accumulation of AGEs. In addition, for food compositions, there are other elderly people, humans with a decline in the whole skin due to the generation and accumulation of AGEs, humans with a tendency to decline in the whole skin due to the generation and accumulation of AGEs. , Diabetics (especially those causing complications such as cataracts, arteriosclerosis, renal dysfunction, retinopathy, neuropathy), arteriosclerosis patients, malignant tumor patients, bone disease patients, Alzheimer's disease patients, Parkinson's disease Patients and the like are suitable targets. In addition, in any case of the cosmetic composition and the food composition, healthy people can also be targeted, thereby preventing or declining the deterioration of the entire skin due to the generation and accumulation of AGEs due to aging and the like. Can slow down.

In addition, the present invention includes the following aspects.
(i) A method for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs administered to a human or non-human mammal, an effective amount of the active ingredient described above, a method for improving skin tension, or a skin color How to improve.
(ii) The above-mentioned active ingredient for preventing, suppressing or improving skin deterioration due to accumulation of AGEs, improving skin tension, or improving skin color.
(iii) Use of the above-described active ingredient for the production of an agent for preventing, suppressing or improving skin deterioration due to accumulation of AGEs, an agent for improving skin tension, or an agent for improving skin tone.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples.
Test Sample Lactic acid and sodium lactate-containing lotion having the composition shown in Table 1 below were prepared by a conventional method.

Lactic acid and sodium lactate were purchased from Pulac Japan. Evening primrose oil was purchased from Nissin Oilio Group.
In the following examples, there were provided a group in which only the skin lotion was applied, a group in which only evening primrose oil was applied, and a group in which evening primrose oil was applied after the skin lotion was applied.
Example 1 (Examination of the effect on skin color)
Test sites were marked by marking 2 cm x 2 cm sections on the forearm of adults in their 20s and 40s (4 people per group). The test sample was applied to four test sites twice a day (morning and evening), with a lotion of 0.05 ml / compartment and 0.05 ml of evening primrose oil / compartment. The forearm area where nothing was applied in each subject was used as a control. The skin color (b * value) was measured using a spectrocolorimeter (Minolta, CM-2002) before the start of application and after 28 days of application. The b * value is an index of chromaticity, and the larger the value, the stronger the yellowness, and the smaller the value, the stronger the blueness.
The amount of change in the b * value after 28 days of application of the test sample is shown in Table 2 below and FIG. The numerical values in Table 2 and FIG. 1 are average values of changes in b * values derived from four measured values (total of 16 measured values) of four subjects.

表２、及び図１から、乳酸（ナトリウム）と月見草油とを併用することにより、b*値が大きく減少し、肌の黄色みが低減したことが分かる。また、b*の減少幅は、乳酸（ナトリウム）と月見草油とを併用した場合、月見草油、及び乳酸(ナトリウム)をそれぞれ単独で使用した場合に比べて、相乗効果が認められた。

From Table 2 and FIG. 1, it can be seen that the combined use of lactic acid (sodium) and evening primrose oil significantly reduced the b * value and reduced the yellowness of the skin. In addition, the b * decrease range showed a synergistic effect when lactic acid (sodium) and evening primrose oil were used in combination, compared to when primrose oil and lactic acid (sodium) were each used alone.

Example 2 (Examination of the effect on skin elasticity)
In the same manner as in Example 1, the test sample was applied to the subject's forearm. Before the start of application and after application for 14 days, using a skin viscoelasticity measuring device (Integral Co., Ltd., Cutometer SEM575), the applied part of the skin is aspirated for 2 seconds at a pressure of 300 mbar and then opened for 2 seconds. Skin elasticity was evaluated by measuring the change in thickness.
The ratio (Ua / Uf) of the height recovery due to opening (Ua) to the skin height (Uf) at the time of maximum suction was used as an index indicating the elasticity of the skin. In addition, the ratio (Ur / Ue) of the height recovery (Ur) 0.1 seconds after release to the skin height (Ue) after 0.1 seconds of suction, the ease of return of the skin condition by suction and release It was used as an indicator. The meaning of Uf, Ua, Ue, Ur is illustrated in FIG. Moreover, the average value of each group 14 days after application | coating is shown in the following Table 3 and FIG.

表３、及び図３から明らかなように、月見草油と乳酸(ナトリウム)とを併用することにより、皮膚の弾力性（Ua/Uf）及び皮膚の状態の戻り易さ（Ur/Ue）の何れも、コントロールに比べて向上した。また、月見草油、及び乳酸(ナトリウム)をそれぞれ単独で使用した場合に比べて、相乗効果が認められた。

As is apparent from Table 3 and FIG. 3, by using evening primrose oil and lactic acid (sodium) in combination, either the elasticity of the skin (Ua / Uf) or the ease of return of the skin condition (Ur / Ue) Also improved compared to the control. Moreover, a synergistic effect was recognized compared with the case where evening primrose oil and lactic acid (sodium) were used alone.

Example 3 (Examination of influence on moisture content of skin)
In the same manner as in Example 1, the test sample was applied to the subject's forearm. Before the start of application and after 14 days of application, the moisture content of the skin at the application part was measured using an impedance meter (IBS, Skicon-200).
The results are shown in FIG. It can be seen that the amount of moisture in the skin was increased by the application of the skin lotion containing lactic acid and evening primrose oil as compared with the control.

Formulation Example The unit of the numerical value in the formulation example of the cosmetic composition below is “% by weight”.
Formulation Example 1 Latex Lactic acid 6
Sodium lactate 4
Salicylic acid 0.1
Evening primrose oil 0.1
Meadow foam oil 0.5
Apple extract 0.1
Grape seed extract 0.01
Polyoxypropylene methyl glucoside 2
1,3-butylene glycol 8
Alkyl methacrylate methacrylate copolymer 1.2
Hydroxypropyl methylcellulose 0.5
Polyoxyethylene hydrogenated castor oil 1.6
Glyceryl monostearate0.8
Glyceryl tri-2-ethylhexanoate 3
Decamethylcyclopentasiloxane 2
Ethanol 4
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance <br/> Total 100

Formulation Example 2 Transparent lotion Glycolic acid 0.5
Sodium lactate 5
Salicylic acid 0.05
Cariocarbrasiliense fruit oil 0.1
γ-linolenic acid (Mortierella oil) 0.05
Carrot extract 0.1
Neem extract 0.001
Arbutin 1
Hydrolyzed soy protein 0.5
MPC polymer 0.05
Bilberry leaf extract 0.01
Amler extract 0.01
Diglycerin 2
Polyoxypropylene methyl glucoside 2
Dipropylene glycol 8
Polyoxyethylene hydrogenated castor oil 0.5
Preservatives (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount Perfume Appropriate amount
Water balance <br/> Total 100

Formulation Example 3 Latex Lactic acid 2.5
Sodium lactate 1.5
Phytic acid 0.5
Evening primrose oil 0.5
Cariocarbrasiliense fruit oil 0.1
Grape seed oil 0.1
Apple extract 0.1
Dipropylene glycol 8
Lychee seed extract 0.2
Hydrolyzed soy protein 0.5
d-δ-tocopherol 0.01
Ascorbyl magnesium phosphate 0.001
Nicotinamide 1
Hydrolyzed collagen 0.05
Comfrey leaf extract 0.1
Maronier extract 0.001
POE sorbitan monostearate (polysorbate 60) 0.8
Tri (caprylic / capric) glyceryl 3
Glyceryl tri-2-ethylhexanoate 2
Liquid paraffin 0.5
Dimethylpolysiloxane 0.5
Cetanol 0.2
Alkyl methacrylate methacrylate copolymer 1.5
Xanthan gum 0.2
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance <br/> Total 100

Formulation Example 4 Cream Salicylic acid 0.1
Citric acid 0.4
Sodium citrate 0.1
Evening primrose oil 1
Shea fat 1
Meadow foam oil 0.5
Avocado oil 0.001
d-δ-tocopherol 0.1
Nicotinamide 0.5
Hydrolyzed collagen 0.01
Carnosine 0.1
Brown algae extract 0.1
Neem extract 0.001
Tri (caprylic / capric) glyceryl 5
Tetra-2-ethylhexanoic acid pentaerythrit 3
Squalane 1
Behenyl alcohol 1
Stearyl alcohol 0.8
Alkyl methacrylate methacrylate copolymer 1.2
Hydroxypropyl methylcellulose 0.2
Hydrogenated soybean phospholipid 0.3
Polyoxyethylene sorbitan isostearate 3
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance <br/> Total 100

Formulation Example 5
(A) Transparent lotion lactic acid containing component 10
Glycolic acid 1
Phytic acid 0.2
Hydroquinone 0.5
Hydroxypropyl cellulose 0.1
Diglycerin 2
1,3-butylene glycol 5
Chelating agent
Water balance <br/> Total 100

(B) Latex evening primrose oil containing ingredients 1
Cario Calbrasiliense fruit oil 1
Meadow foam oil 0.3
Olive oil 0.1
Grape Seed Extract 0.5
Methyl polysiloxane 5
Decamethylcyclopentasiloxane 30
2-Ethylhexyl paramethoxycinnamate 5
Dimethyl distearyl ammonium hectorite 1
Polyoxyethylene / methylpolysiloxane copolymer 4
1,3-butylene glycol 10
Sodium hyaluronate 0.01
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance <br/> Total 100
Use the clear lotion and emulsion together.

Formulation Example 6
(A) Cosmetic lactic acid containing ingredients 1
Sodium lactate 0.8
Ascorbic acid 5
Diethylene glycol monoethyl ether 50
Propylene glycol 15
Dipropylene glycol 15
Diglycerin 5
Chelating agent appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance <br/> Total 100

(B) Cream evening primrose oil containing ingredients 2
Meadow foam oil 1
Shea fat 3
Toad extract 0.1
Glycerin 5
1,3-butylene glycol 5
Vaseline 5
Liquid paraffin 2
Glyceryl tri-2-ethylhexanoate 2
Tetra-2-ethylhexanoic acid pentaerythrit 4
Polyoxyethylene hydrogenated castor oil 1.8
Glyceryl monostearate 1.2
Carboxyvinyl polymer 0.3
Stearyl alcohol 2
Behenyl alcohol 2
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance <br/> Total 100
Use the above serum and cream together.

  A mixture of (a) lactic acid and / or a salt thereof and (b) AGEs degrading agent improves the elasticity of the skin, improves the return of deformed skin, and improves the skin tone such as yellowing. Improve and increase the moisture content of the skin. Therefore, the composition containing the mixture can be suitably used as a cosmetic composition.

Claims (18)

An agent for preventing, suppressing or improving skin deterioration caused by accumulation of advanced glycation end products, comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent   Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable The agent for preventing, suppressing or improving skin deterioration caused by accumulation of advanced glycation end products according to claim 1, which is at least one member selected from the group consisting of amides thereof.   The agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to claim 2, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.   The skin resulting from accumulation of advanced glycation end products according to claim 3, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids. An agent for preventing, suppressing, or improving the decline of   The advanced glycation end product degradation agent is an advanced glycation according to claim 1, which is a vegetable oil comprising at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof.・ An agent for preventing, suppressing or improving skin deterioration caused by accumulation of end products.   6. The accumulation of advanced glycation end products according to claim 5, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat. An agent for preventing, suppressing, or improving the deterioration of the skin caused by it. A skin tension improving agent comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent   Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable The skin tension improving agent according to claim 7, which is at least one selected from the group consisting of amides thereof.   The skin tension improving agent according to claim 8, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.   The skin tension improving agent according to claim 9, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.   The advanced glycation end product degrading agent is a vegetable oil comprising at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof. Improver.   The skin tension improving agent according to claim 11, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat. A skin tone improving agent comprising the following (a) and (b) as active ingredients.
(a) At least one selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and pharmaceutically acceptable salts thereof
(b) Advanced glycation end products degradation agent   Advanced glycation end product degradation agents include unsaturated fatty acids and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable The skin tone improving agent according to claim 13, which is at least one selected from the group consisting of amides thereof.   The skin tone improving agent according to claim 14, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.   The skin color improving agent according to claim 15, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.   The skin tone according to claim 13, wherein the advanced glycation end product degrading agent is a vegetable oil comprising at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof. Improver.   18. The skin tone improver according to claim 17, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat.

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