JP2010248148A - Breakdown agent of advanced glycation end product - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new AGEs (advanced glycation end products) breakdown agent, and to provide an agent for preventing, inhibiting, or ameliorating skin deterioration stemming from AGEs buildup. <P>SOLUTION: The AGEs breakdown agent, and the agent for preventing, inhibiting, or ameliorating the skin deterioration stemming from the AGEs buildup contain the following (i) or (ii), as an active ingredient: (i) at least one kind selected from the group consisting of an unsaturated fatty acid and a pharmaceutically-permitted salt, ester, amide, and glyceride thereof; and (ii) a vegetable oil (evening primrose oil, pequi oil, meadowfoam oil, shea oil, etc.) that contains at least one kind selected from the group consisting of an unsaturated fatty acid and/or a glyceride thereof. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an advanced glycation end product degradation agent used as a cosmetic composition or a food composition, and prevention, suppression, or improvement of skin deterioration due to accumulation of advanced glycation end products. It relates to the agent.

  A saccharification reaction (Maillard reaction) occurs between a reducing sugar such as glucose and a protein, and a saccharification product is generated. Protein saccharification occurs in vivo, but if a hyperglycemic state continues due to diabetes, etc., or if the degradation reaction does not proceed easily due to aging, the production of glycation products tends to occur and the function of the protein is impaired. Saccharification products accumulate. This saccharification product finally becomes a terminal saccharification product (advanced glycation end products; hereinafter abbreviated as “AGEs”), but the generation of AGEs is an irreversible reaction. The generated AGEs are excreted from the body by metabolism, but with aging, the metabolic rate becomes slower and AGEs accumulate in each tissue in the living body.

AGEs cause various symptoms by accumulating in each tissue in the living body or binding to receptors of AGEs. For example, when AGEs are generated and accumulated in the skin (epidermis, dermis), it contributes to the deterioration of the entire skin (for example, changes in skin color such as yellowing, reduction in transparency and tension). In diabetic patients, AGEs caused by hyperglycemia cause complications such as cataracts, arteriosclerosis, and renal dysfunction. Therefore, in order to discharge the generated AGEs to the outside of the body, it is important to decompose the AGEs into a form that can be easily discharged outside the body.
Conventionally, in order to make it an active ingredient of a cosmetic composition or a food composition, a search for a component that suppresses the generation of AGEs and a component that decomposes AGEs has been conducted. For example, Patent Document 1 describes that citrus volatile oils inhibit the production of pentosidine, which is one of AGEs. Patent Document 2 describes that an extract of olive oil in ethanol has an AGEs-decomposing action and suppresses skin dullness.

JP2004-35424 JP 2001-122758

  An object of the present invention is to provide a novel agent for degrading AGEs and an agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs.

The present inventor has conducted research to solve the above problems, and unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and pharmacological agents. (I) AGEs are decomposed, and (ii) skin tone such as yellowish darkness. It was found to improve the change and (iii) improve skin firmness.
The present invention has been completed by further research based on the above findings, and provides the following AGEs decomposing agent and an agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs.

Item 1. Unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and at least one selected from the group consisting of pharmaceutically acceptable amides thereof Advanced glycation end products degradation agent containing as an active ingredient.
Item 2. Item 2. The advanced glycation end product degradation agent according to Item 1, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.
Item 3. Item 3. The advanced glycation end product degradation agent according to Item 2, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.
Item 4. An advanced glycation end product degradation agent comprising, as an active ingredient, a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof.
Item 5. Item 5. The advanced glycation end products decomposer according to item 4, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cariocarbradiriense fruit oil, meadowfoam oil, and shea fat.
Item 6. Unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and at least one selected from the group consisting of pharmaceutically acceptable amides thereof An agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products, comprising as an active ingredient.
Item 7. Item 7. The agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 6, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.
Item 8. Item 8. The skin resulting from accumulation of advanced glycation end products according to Item 7, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids. An agent for preventing, suppressing, or improving the decline of
Item 9. Prevention of skin deterioration due to accumulation of advanced glycation end products, comprising as an active ingredient a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof, Inhibitor or improver.
Item 10. Item 10. The result of accumulation of advanced glycation end products according to Item 9, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat Preventing, suppressing, or improving skin deterioration.
Item 11. Item 11. The advanced glycation end products according to any one of items 6 to 10, wherein the deterioration of the skin caused by accumulation of advanced glycation end products is a change in skin color or a decrease in elasticity. An agent for preventing, suppressing or improving skin deterioration caused by accumulation.

Item 12. Unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and at least one selected from the group consisting of pharmaceutically acceptable amides thereof A composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products, comprising as an active ingredient.
Item 13. Item 13. The composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 12, wherein the composition is a cosmetic composition.
Item 14. Item 13. A composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 12, wherein the composition is a food composition.
Item 15. Prevention of skin deterioration due to accumulation of advanced glycation end products, comprising as an active ingredient a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof, A composition for suppressing or improving.
Item 16. Item 16. The composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 15, wherein the composition is a cosmetic composition.
Item 17. Item 16. A composition for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products according to Item 15, wherein the composition is a food composition.

Unsaturated fatty acids and derivatives thereof have an action of degrading AGEs. This action improves, suppresses and / or prevents the deterioration of the entire skin caused by the accumulation of AGEs in the skin (for example, changes in skin color such as yellowish dullness, decreased transparency and elasticity) It is possible to slow down the progress of the overall skin decline.
Vegetable oils rich in unsaturated fatty acids and their derivatives have similar effects.
More specifically, the improvement, suppression and / or prevention of the deterioration of the entire skin caused by the accumulation of AGEs will be described. Unsaturated fatty acids and their derivatives, and vegetable oils containing these (for example, evening primrose oil, Cariocarbra gliense fruit) By applying a cosmetic composition containing oil, Meadowfoam oil, shea fat, etc.) to the skin or ingesting a food composition containing these, the yellowness of the skin color is suppressed, and the transparency is increased. Improves skin firmness. Thereby, the impression of the whole skin is kept young and a youthful appearance is obtained.
Also, prevent or improve various diseases caused by AGEs (diabetic complications (cataract, arteriosclerosis, renal dysfunction, retinopathy, neuropathy, etc.), arteriosclerosis, malignant tumor, bone disease, Alzheimer's disease, Parkinson's disease, etc. Is expected to do.

It is a figure which shows the change of b * value of the skin by application of evening primrose oil. It is a figure which shows the meaning of Uf, Ua, Ue, Ur in Example 3. It is a figure which shows the change of the elasticity of the skin by application | coating of evening primrose oil. It is a figure which shows the change of the moisture content of the skin by application | coating of evening primrose oil.

Hereinafter, the present invention will be described in detail.
The AGEs decomposition agent of the present invention, and the prevention, suppression, or improvement agent of skin deterioration due to accumulation of AGEs,
(i) selected from the group consisting of unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and pharmaceutically acceptable amides thereof At least one, or
(ii) A vegetable oil containing at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof is included as an active ingredient.
In other words, the components (i) and (ii) above are also anti-glycation agents, anti-aging agents based on anti-glycation action, or active ingredients of anti-aging agents.
AGEs decomposing agents containing both (i) and (ii) as active ingredients, and agents for preventing, suppressing or improving skin deterioration due to accumulation of AGEs are also included in the present invention.

As unsaturated fatty acid and its derivative unsaturated fatty acid, C16-24 unsaturated fatty acid is mentioned, for example. Specifically, crotonic acid (C4: 1 (2)), myristoleic acid (C14: 1 (9)), palmitoleic acid (C16: 1 (9)), oleic acid (C18: 1 (9)), Elaidic acid (C18: 1 (9)), vaccenic acid (C18: 1 (11)), gadoleic acid (C20: 1 (9)), eicosenoic acid (C20: 1 (11)), erucic acid (C22: 1 (13)), monoene unsaturated fatty acids such as nervonic acid (24: 1 (15)); linoleic acid (C18: 2 (9,12)), 8,11-icosadienoic acid (C20: 2 (8,11 ), Diene unsaturated fatty acids such as docosadienoic acid (C22: 2 (13,16)); (9,12,15) -linolenic acid (α-linolenic acid, C18: 3 (9,12,15)), (6,9,12) -linolenic acid (γ-linolenic acid, C18: 3 (6,9,12)), eleostearic acid (C18: 3 (9,11,13)), 5,8,11 -Triene unsaturated fatty acids such as icosatrienoic acid (C20: 3 (5,8,11)); arachidonic acid (C20: 4 (5,8,11,14), stearidonic acid (C18: 4 (6,9, 12,15)) tetraene unsaturated fatty acids; eicosapentaenoic acid (C20: 5 (5,8,11,14,17)), Unsaturated pentaene fatty acids such as eagle acid (C22: 5 (7,10,13,16,19)); docosahexaenoic acid (DHA, C22: 6 (4,7,10,13,16,19)) These fatty acids are commercially available.

  Of these, unsaturated fatty acids having 16 to 20 carbon atoms are preferable, unsaturated fatty acids having 18 to 20 carbon atoms are more preferable, and unsaturated fatty acids having 18 carbon atoms are even more preferable in view of high AGE decomposition activity. As for the degree of unsaturation, a diene unsaturated fatty acid or a triene unsaturated fatty acid is preferable in terms of high AGE decomposition activity. In particular, a diene or triene unsaturated fatty acid having 18 carbon atoms is preferred.

In the present invention, pharmaceutically acceptable derivatives of unsaturated fatty acids can also be used. Derivatives include salts, glycerides, esters, and amides.
Examples of pharmaceutically acceptable salts of unsaturated fatty acids include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts and the like.
The pharmaceutically acceptable glyceride of the unsaturated fatty acid may be any of monoglyceride, diglyceride and triglyceride. The monoglyceride may be any of 1-acyl glyceride, 2-acyl glyceride and 3-acyl glyceride. The diglyceride may be any of 1,2-acyl glyceride, 1,3-acyl glyceride and 2,3-acyl glyceride.

When the glyceride of the unsaturated fatty acid is diglyceride or triglyceride, at least one of the constituent fatty acids may be an unsaturated fatty acid, and the ratio of the unsaturated fatty acid in the fatty acid constituting the glyceride is preferably 30% by weight or more. 50 wt% is more preferable, and 65 wt% or more is even more preferable. Moreover, when it is a diglyceride or a triglyceride, the unsaturated fatty acid may be the same or different.
Examples of pharmaceutically acceptable esters of unsaturated fatty acids include esters with aliphatic alcohols having 1 to 20 carbon atoms.
Examples of pharmaceutically acceptable amides of unsaturated fatty acids include ammonia, alkylamine (alkyl group having 1 to 4 carbon atoms), dialkylamine (alkyl group having 1 to 4 carbon atoms), trialkylamine (alkyl group). May be an amide of an unsaturated fatty acid with an alkanolamine (carbon number of the alkyl group is 1 to 4).
An unsaturated fatty acid and its derivative can be used individually by 1 type or in combination of 2 or more types.

Vegetable oils As vegetable oils, vegetable oils containing at least one selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof, specifically evening primrose oil, cario carbaziriense fruit oil, meadow foam oil , Shea fat, avocado oil, olive oil, persic oil, cucumber nut oil, grape seed oil, safflower oil, almond oil, corn oil, pistachio seed oil, sunflower oil, hazelnut oil, macadamia nut oil, rosehip oil, soybean oil, sesame oil , Wheat germ oil, rapeseed oil, cottonseed oil, rice bran oil and the like. Among them, evening primrose oil, cario carbagiriense fruit oil, meadow foam oil, and shea fat are preferable, evening primrose oil and cario carbagiriense fruit oil are more preferable, and evening primrose oil is even more preferable. Evening primrose oil is a fatty oil obtained from the seeds of evening primrose (Akabanae evening primrose) or a plant belonging to the same genus, and Cariocarbrasiliense fruit oil is a fatty oil obtained from the pulp of Cariocarbrasiliense.

These vegetable oils can be produced by known methods. For example, the crude oil can be obtained by mechanically squeezing seeds and the like to squeeze out the oil, further extracting the remaining oil with a solvent such as hexane, and then completely removing the solvent by distillation. The crude oil is then obtained by adding water to the crude oil to separate the gum and removing it with a centrifuge. Phosphoric acid is added to this crude oil to remove the remaining gum, sodium hydroxide is added to remove free fatty acids, water is washed, and then activated clay is added and stirred to adsorb pigments such as chlorophyll. Filtered to remove white clay, then cooled to remove the solid oil and wax that precipitates and remove odorous components by steam distillation under high temperature and vacuum to obtain a refined vegetable oil. It is done.
In the present invention, any of crude oil, crude oil, and refined oil can be used as an active ingredient for preventing, suppressing, or improving the deterioration of skin due to accumulation of AGEs and AGEs.
Moreover, refined evening primrose oil can be purchased from, for example, Oriza Oil Chemical Co., Ltd., Nisshin Oillio Group, etc., and refined Cario carbagiriense fruit oil can be purchased from, for example, Croda Japan.
A vegetable oil having a ratio of unsaturated fatty acids having 18 carbon atoms of 90% by weight or more based on the total fatty acids can also be used as an active ingredient of the AGEs degradation inhibitor. Examples of such vegetable oil include evening primrose oil.
A vegetable oil can be used individually by 1 type or in combination of 2 or more types.

Cosmetic composition The AGEs decomposing agent of the present invention, and the prevention, suppression, or amelioration of skin deterioration due to accumulation of AGEs, together with the above-described active ingredients, together with known bases or carriers that are acceptable as cosmetic ingredients It can mix and it can be set as a cosmetic composition. When each agent of this invention contains 2 or more types of active ingredients, it is good also as a formulation which prepares each component as a separate composition, and combined those compositions.
The form of the cosmetic composition is not particularly limited. For example, lotion, milky lotion, cream, cosmetic liquid, sunscreen cosmetics, basic cosmetics such as packs, hand creams, body lotions, body creams; Cosmetics for cleaning such as makeup remover, body shampoo, shampoo, rinse; makeup cosmetics such as foundation, makeup base, lip balm, lipstick, cheek color; bathing agent and the like.
The content of the active ingredient in the cosmetic composition may be, for example, about 0.00001 to 70% by weight, preferably about 0.0001 to 50% by weight, and more preferably about 0.001 to 30% by weight. If it is the said range, sufficient AGEs decomposition | disassembly effect by the normal usage-amount of cosmetics, and the prevention, suppression, or improvement effect of the deterioration of the whole skin by accumulation | storage of AGEs will be acquired.

  Bases or carriers include paraffin, liquid paraffin, squalane, white wax, gelled hydrocarbon (such as plastic base), ozokerite, ceresin, petrolatum, hard fat, microcrystalline wax, α-olefin oligomer, light liquid paraffin, etc. Hydrocarbons; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; such as glyceryl tri-2-ethylhexanoate (trioctanoin), tri (caprylic acid / capric acid) glyceryl Tri-fatty acid glycerides; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol; methyl polysiloxanes, highly polymerized methyl polysiloxanes, dimethylsiloxane methyl (polyoxyethylene) siloxane methyl Polyoxypropylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene-methylpolysiloxane copolymer, poly ( Oxyethylene / oxypropylene) / methylpolysiloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methyl Polysiloxane, cross-linked methylphenyl polysiloxane, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, cross-linked alkyl-modified silicone, decamethylcyclopenta Silicone such as siloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane network polymer, polyoxyethylene-methylpolysiloxane copolymer, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethylpolysiloxane Oils; glycol acetates such as ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2-propene-1,1-diol diacetate Tart; Triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanediol diisobut Glycol esters such as acrylates; such as ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate Glycol acrylates; glycol dinitrates such as ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and propylene glycol dinitrate; 2,2 '-[1,4-phenylenedioxy] diethanol; ethylcellulose, hydroxy Cellulose derivatives such as propylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; Diethylene; Butylene glycol adipic acid polyester; Esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrite tetra-2-ethylhexanoate; dextrin, malto Polysaccharides such as dextrin; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether ,Propylene glycol Examples thereof include glycol ethers such as monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether and dipropylene glycol monopropyl ether; aqueous bases such as water.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), tri fatty acid glycerides (especially glyceryl tri-2-ethylhexanoate, tri (caprylic acid / capric acid) glyceryl), higher alcohols ( In particular, cetanol, stearyl alcohol, behenyl alcohol), silicone oil (especially methylpolysiloxane, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, Methyl siloxane network polymer, polyoxyethylene / methyl polysiloxane copolymer, methyl hydrogen polysiloxane, triethoxysilylethyl polydimethylsiloxyethylhexyl dimethicone, dimethicone Polypolysiloxane), esters (especially isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol monoethyl ether), water are preferred. .
A base or a carrier can be used alone or in combination of two or more.

In addition, the cosmetic composition is a known additive that is added to the cosmetic, for example, a surfactant, a thickener, a preservative, a pH adjuster, a chelating agent, a stable agent, as long as the effects of the present invention are not impaired. An agent, a stimulus reducing agent, a preservative, a colorant, a dispersant, a fragrance, a pearl luster imparting agent, and the like can be added. An additive can be used individually by 1 type or in combination of 2 or more types.
Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters; glyceryl fatty acids such as glyceryl monostearate and glyceryl monostearate; polyglyceryl fatty acids such as polyglyceryl monostearate, polyglyceryl monoisostearate and polyglyceryl diisostearate; propylene glycol monostearate Propylene glycol fatty acid esters such as: polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor Cured castor oil derivatives such as oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80; polylauric acid monolaurate (20) sorbitan (polysorbate 20), Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; Polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; stearylamine, oleyl Amines such as tromethamine, polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and the like silicone-based surfactants such as PEG-9 polydimethylsiloxyethyl dimethicone.

  Among them, glycerin fatty acids (particularly glyceryl monostearate), polyglycerin fatty acids (particularly polyglyceryl monostearate), hardened castor oil derivatives (particularly polyoxyethylene hardened castor oil 50 (HCO-50), polyoxyethylene) Hydrogenated castor oil 60 (HCO-60)), polyoxyethylene sorbitan fatty acid esters (particularly polyoxyethylene (20) sorbitan isostearate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60)), polyoxyalkylene Alkyl ether (especially polyoxyethylene cetyl ether), silicone surfactant (especially polyoxyethylene methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethyl) Lucyloxyethyl dimethicone) is preferred.

  Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, dextran, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium alginate, propylene glycol alginate, polyvinyl Alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxy vinyl polymer, alkyl methacrylate copolymer, sodium polyacrylate, polyethylene glycol, bentonite, dextrin fatty acid ester, pectin, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer The Chill distearyl ammonium hectorite, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, polyethylene glycol distearate, triisostearate, ethylene glycol, triisostearate, polyoxyethylene (20) and the like methyl glucoside. Among them, xanthan gum, alkyl methacrylate methacrylate copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, carboxyvinyl polymer, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, dimethyl distearyl ammonium hectorite (Acryloyl dimethyl taurate ammonium / vinyl pyrrolidone) copolymer, polyethylene glycol distearate, ethylene glycol triisostearate, polyoxyethylene (20) methyl glucoside triisostearate.

  Preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid Examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol. Of these, methyl paraoxybenzoate, propyl paraoxybenzoate, and phenoxyethanol are preferable.

  Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, Oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic base (sodium bicarbonate, sodium carbonate, hydroxylation) Potassium, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.) and organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Among these, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide, and sodium hydroxide are preferable.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metalin An acid etc. are mentioned. Of these, sodium edetate is preferable.
Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.
Examples of the irritation reducing agent include licorice extract and sodium alginate.

Examples of the colorant include inorganic pigments and natural pigments.
Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate. Of these, ethylene glycol distearate is preferable.
In addition, the cosmetic composition can improve, suppress, and reduce the deterioration of the entire skin caused by accumulation of AGEs in the skin (for example, change in skin color such as yellowish blur, reduction in firmness and transparency), Alternatively, known anti-glycation components that can be added to cosmetics can be blended for the purpose of further enhancing the effects of the present invention, such as prevention and slowing down the progress (speed) of the deterioration of the entire skin. Known anti-glycation components can be used singly or in combination of two or more.
Known anti-glycation components include, for example, Amler fruits, fruit juices or extracts thereof (JP 2006-028090, JP 2006-62989, etc.); L-arginine, L-lysine, hydrolyzed casein (above, JP 2001-039816); Hydrolyzable tannin (JP 9-40519); Carnosine, α-lipoic acid ("Latest skin diagnostic manual for beauty", Fragrance Journal, August 15, 2006) Issue): Western rose flower / ovary, hybrid rose flower / ovary / gaku / leaf / stem, age, grape leaf, oyster leaf, apple leaf, marigold flower, magnolia leaf extract Open 2006-273811); button genus plant extract, seaweed genus plant extract, genus genus plant extract, sunflower plant extract, aloe genus plant extract, amadocho genus plant extract, flax genus plant extract, Rose plant extract , Linden plant extract, kangwei plant extract, genus plant extract, kanto plant extract, burdock plant extract, mint plant extract, elder plant extract (above, JP 2003-212749 A) No.); Extract of Odaka Ryokan (Japanese Patent Laid-Open No. 2006-62987); Extracts of grapes, green willow, mugwort, mocca, litchi, roman chamomile (above, JP-A-2003-212770); Dermatosus, die Extracts of cormorant, tea tree, cinnamon tree, cinne berry senna, tencha, toccoli strawberry, tormentilla, rose, button, salamander, yachabushi, bayberry, eucalyptus tree, logwood, bitumen (above, JP 2002-241299); Extracts of aloe, apricot, hippopotamus, cypress, trash, sanchinin ginseng, taukogi, narco lily, chickweed, scallop, bukuro, yuzu (above, JP 2002-241293); karkade, hibiscus, chazenshi, tonin, maronier, keishi , Trash, sicon, senna, toshishi, beakkyu extract (above, JP-A-11-106336); jujube fruit nucleus (acid sour), MACJONG fruit, pumpkin seeds, eucommia leaves, salacia root, ooh Extract of Umegasao leaves (above, JP 2007-254345); Snow lotus flower, devils crow, Ezoukogi, Rosea, Ercampure extract (above, JP 2007-254344); Papaya extract (JP 2006-298812); Simonil extract (JP 2006-219447) Extract of genus genus (Japanese Patent Laid-Open No. 2006-117700); agrimony, ashwagandha, anise, amachazuru, sweet candy, ginkgo, fennel, witch hazel, turmeric, echinacea, elephant, elder, elba mate, plantain Olive, oregano, orange, persimmon, persimmon, chamomile, guarana, cocoon grass, chrysanthemum, gymnema, cat's claw, catnip, killaway, goldfish, guava, cucumber, zakuza, cumixtin, black soybeans, hoe, cinnamon, tsutsumeishi, bitter gourd, Cola nut, gokahi, tsutsukora, coriander, comfrey, saximaso Cormorant, safflower, salacia oblonga, hawthorn, sanitary carrot, perilla, juyaku, juniper berry, ginger, cedar, horsetail, stevia, spearmint, sage, savory, hawthorn, sanctuary, thyme, tahibo, dandelion, chervil , Chanoki, chabodia, clove, daisy, dill, eucommia, nutmeg, nanban, nettle, hibiscus, birch mother moth, white flower serpentine grass, cabbage, basil, lotus, half-branch, heath, peach, hyssop, wrinkle, Fever-Fu, Fukugi, Wisteria, Plantago Thyrium, Blueberry, Blue Mallow, Penny Royal, Safflower, Peppermint, Hop, Poligi, Pound Apple, Marshmallow, Marjoram, Marigold, Malene, Marlowe Small, Marouble , Mifuragi, Milk Thistle, Megurinoki, Medu Sweet, Mokka, Yaeyama Aoki, Yakurakugi, Yarrow Flower, Eucalyptus, Yakuinin, Mugwort, Raspberry, Lavender, Linden, Rooibos, Lemongrass, Lemon Thyme, Lemon Verbena, Lemon Balm, Rosehip, Rose Pink Butts , Rosemary, Rose Red, Laurel, Rafu, Wild Strawberry extract (above, JP-A-2004-250445); Extract of Akamegashiwa, Oyster, Mulberry, Hypericum perforatum, Azalea, Yakuyo garage, Yaba Santa, Rosehip (above) , JP 2004-189663); extract of cherry, red scenic heaven, blueberry, bearberry, white peach, chickweed, tiger weevil, henna, larrea (above, JP 2001-316221); Extracts of king spider, goldfish, bay bay, sorghum, peony, swordfish, baimo, potato mulberry (above, JP-A-8-259431); carrot leaf extract (JP-A-2004-51580); Extract of hawthorn, chanoki, cinnamon, dokudami, tormentilla, rose, grape, maronier, roman chamomile (above, JP 2005-35911); aminoguanidine or its salt (latest medicine, 49-2, p78-83) 1994); black soybean seed coat, mate tea leaves (green), linden flowers, radish leaves, black rice seeds, willow bark and shoots, Ibright above ground, black cohosh root, Agni fruit, artichoke leaves, lychee seeds, cutlet bark, auto Above-ground wheat, passion flower leaves, chadebugure leaves, buckwheat leaves, maria thistle fruit, tomorrow Leaf, devil's claw root, ipe bark, agaricus mycelium, paffia root, acai fruit, mozuku whole plant and processed product of Japanese cypress stem and leaf (above, JP 2008-088102); neem extract; aristine; glucosamine, etc. It is done. Among them, ingredients derived from plants such as Amler, lychee, rose, maroonier, Maria thistle, Neem (especially Amler extract, lychee seed extract, rose petal extract, Maronier extract, Maria Thistle extract, Neem extract); hydrolysis Sexual tannins (particularly derived from chestnut astringent skin); L-arginine or a salt thereof; lysine or a salt thereof; carnosine; α-lipoic acid; aminoguanidine or a salt thereof;

The amount of the known anti-glycation component used is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, more preferably about 0.001 to 5% by weight, based on the total cosmetic composition. is there. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Furthermore, the cosmetic composition has an antioxidant component, an anti-aging component, an anti-inflammatory component, a whitening component, a keratin softening component, a cell activation component, vitamins, a blood circulation promoting component, as long as the effects of the present invention are not hindered. Other medicinal ingredients that can be added to cosmetics, such as moisturizing ingredients, ingredients that prevent and / or repair DNA damage, UV-absorbing ingredients, UV-scattering ingredients, cleaning ingredients, antibacterial ingredients, and astringent ingredients it can. Other medicinal ingredients can be used alone or in combination of two or more.

  Antioxidant components include components derived from plants (eg, grapes, ginseng, comfrey, etc.); proanthocyanidins, tocopherols and derivatives thereof, ascorbic acid and derivatives thereof, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, erythorbine Examples thereof include acids and salts thereof, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, and hypotaurine. Among them, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, tocopherol and its derivatives (particularly δ-tocopherol, α-tocopherol), ascorbic acid and its derivatives (particularly ascorbic acid, ascorbic acid) Sodium phosphate ester, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin and ergothioneine are preferred.

The amount used in the case of using an antioxidant component is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, and more preferably about 0.001 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Antiaging components include hydrolyzed soy protein, retinoids (retinol and derivatives thereof, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L- Examples include serine and mevalonolactone. Of these, hydrolyzed soy protein, retinol, retinol acetate, and retinol palmitate are preferred.
When the anti-aging component is used, the amount used is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition.

Anti-inflammatory components include components derived from plants (eg Comfrey); allantoin, calamine, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin , Salicylic acid or a derivative thereof. Of these, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate are preferable.
The amount used in the case of using the anti-inflammatory component is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.

Examples of whitening ingredients include arbutin; hydroquinone; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; ascorbic acid or a derivative thereof; vitamin E or a derivative thereof; pantothenic acid or a derivative thereof; Plant components (for example, plant extracts and essential oils) having Among these, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetracordylhexyldecanoate) and tranexamic acid are preferable.
When the whitening component is used, the amount used is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used when using a plant component having a whitening effect as the whitening component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to the total amount of the cosmetic composition, in terms of an extract such as an extract or an essential oil It is 15% by weight, more preferably about 0.001 to 10% by weight.

Examples of the keratin soft component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid and the like. Of these, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferred.
When the keratin softening component is used, the amount used is, for example, 0.0001 to 50% by weight, preferably about 0.001 to 50% by weight, and more preferably about 0.05 to 25% by weight, based on the entire cosmetic composition.

Cell activation components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; vitamins such as retinol and its derivatives, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids Α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoins, and photosensitizer 301. Among them, bilberry leaf extract, retinol, retinol acetate, and retinol palmitate are preferable.
The amount used in the case of using the cell activating component is preferably about 0.0001 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.
Vitamins include retinol, retinol acetate, retinol palmitate, etc., retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl retinoate Vitamins such as β-tocopheryl retinoate; provitamins A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, echinone; δ-tocopherol, α- Vitamin Es such as tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin Vitamin B2 such as denine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate; nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinamide; stearic acid Ascorbyl, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbic acid Vitamin Cs such as glucoside; Vitamin Ds such as methyl hesperidin, ergocalciferol, cholecalciferol; Vitamin Ks such as dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, Vitamin B1 such as thiamine triphosphate, thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride , Vitamin B6 such as pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin Folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-panthetin, coenzyme A, pantothenyl ethyl ether; biotin and biocytin In addition, vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol and the like can be mentioned.

Among them, vitamin A such as retinol, retinol acetate, retinol palmitate, etc .; vitamin C such as ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate) Vitamin E such as δ-tocopherol and tocopherol nicotinate; nicotinic acid such as nicotinamide is preferred.
The amount of vitamins to be used can be appropriately selected in consideration of the feeling of use and effects on the skin. % By weight, more preferably about 0.5 to 20% by weight.

Examples of the blood circulation promoting component include plants (e.g. ginseng, ashitaba, arnica, ginkgo, fennel, enmelio, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, sorghum, nematode, Assembly, thyme, clove, chimney, spruce, spruce, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokuinin, rosemary, rosehip, chimpi, touki, spruce, peach, apricot, walnut , A component derived from corn); tocopherol nicotinate, glucosyl hesperidin, hesperidin. Among these, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, and hesperidin are preferable.
The amount of the blood circulation promoting component is, for example, about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight, and more preferably about 0.001 to 4% by weight, based on the entire cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.

As moisturizing ingredients, ingredients derived from plants (eg, Tigaya); amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, theanine and derivatives thereof; collagen, gelatin, elastin Such proteins and peptides, hydrolysates thereof; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, dipropylene glycol, diglycerin; sugar alcohols such as sorbitol; lecithin, hydrogenated lecithin Phospholipids such as: hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, heparin, chondroitin mucopolysaccharides; lactic acid, sodium pyrrolidone carboxylate NMF-derived components such as urea and urea; polyglutamic acid; a polymer having a phospholipid polar group such as MPC polymer (for example, LIPIDURE (registered trademark)); polyoxypropylene methylglucoside; trimethylglycine (betaine); hydroxyethyl Urea; acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer; sorbitol and the like. Among them, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethyl glycine (betaine), hydroxyethyl urea Acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate and sorbitol are preferred.
When the moisturizing component is used, the amount used is, for example, 0.001 to 10% by weight, preferably about 0.01 to 5% by weight, and more preferably about 0.1 to 5% by weight, based on the entire cosmetic composition. The amount used in the case of using a plant component is, for example, about 0.00001 to 20% by weight, preferably about 0.0001 to 15% by weight, and more preferably based on the total amount of the cosmetic composition in terms of extracts such as extracts and essential oils. About 0.001 to 10% by weight.

The component having the action of preventing and / or repairing DNA damage includes components derived from animals (eg, Artemia); components derived from plants (eg, cat's claw); DNA, DNA salts, RNA, RNA salts, etc. Examples include nucleic acid components. Of these, artemia extract and DNA-Na are preferred.
The amount of the component having an effect of preventing and / or repairing DNA damage is, for example, about 0.001 to 3% by weight, preferably about 0.01 to 1% by weight, based on the whole cosmetic composition. When animal components are used, the amount used is about 0.00001 to 0.1% by weight, preferably about 0.0001 to 0.01% by weight, based on the total amount of the cosmetic composition, in terms of extracts such as extracts.

  Examples of ultraviolet ray absorbing components include 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) ) Anilino] -1,3,5-triazine, dimethoxybenzylideneoxoimidazolidinepropionate 2-ethylhexyl, 2,4-bis-[{4- (2-ethylhexyloxy) -2-hydroxy} -phenyl] -6 (4-methoxyphenyl) -1,3,5-triazine and the like. Among them, 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino]- 1,3,5-triazine is preferred.

The amount used in the case of using the ultraviolet absorbing component is, for example, about 0.01 to 20% by weight, preferably about 0.1 to 15% by weight, based on the whole cosmetic composition.
Ultraviolet scattering components include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silicic acid, and those inorganic compounds Coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, or compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, silicon oil and fatty acid aluminum salts, etc. And the like processed with. Among these, inorganic compounds such as zinc oxide, titanium oxide and iron oxide, and those inorganic compounds coated with inorganic powder such as aluminum hydroxide, hydrous silicic acid, mica and talc, and silicon oil are preferable.
The amount used in the case of using the ultraviolet scattering component is, for example, about 0.001 to 35% by weight, preferably about 0.1 to 25% by weight, based on the whole cosmetic composition.

  As washing components, polyoxyalkylene alkyl (or alkenyl) ether sulfate, alkyl (or alkenyl) sulfate, higher fatty acid salt, ether carboxylate, amide ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid Anionic surfactants such as salts, polyoxyalkylene fatty acid amide ether sulfates, acylated isethionates, acylated taurates; amine oxides, glycerin fatty acid esters, sorbitan fatty acid esters, alkyl saccharides, polyoxyalkylene alkyl ethers, fatty acid alkanolamides , Nonionic surfactants such as polyoxyalkylene hydrogenated castor oil; mono- or di-long alkyl quaternary ammonium having a linear or branched long-chain alkyl group, to which alkylene oxide may be added Cationic surfactants such as ium salts; carboxymethyl betaine, sulfobetaine, imidazolinium betaine, amphoteric surfactants such as amide betaine.

  Of these, anionic surfactants, nonionic surfactants, and amphoteric surfactants are preferred. Anionic surfactants include higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid) are preferred. Among the nonionic surfactants, fatty acid alkanolamides (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide) and amine oxides (especially coconut oil alkyldimethylamine oxide, lauryldimethylamine oxide) are preferable. Amphoteric surfactants include imidazolinium betaines (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium. ) Is preferred.

The blending amount of the cleaning component is about 0.01 to 80% by weight, preferably about 0.1 to 60% by weight, based on the whole cosmetic composition.
Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101 Photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride and the like. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride Are preferred, and benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol are more preferred.

When the antibacterial component is used, the amount used is preferably about 0.0003 to 10% by weight, more preferably about 0.01 to 5% by weight, based on the whole cosmetic composition.
Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Among these, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferable.
When the astringent component is used, the amount used is, for example, about 0.0003 to 10% by weight, preferably about 0.01 to 5% by weight, more preferably about 0.01 to 5% by weight, based on the entire cosmetic composition.

  The cosmetic composition of the present invention can be prepared by mixing and stirring each component according to a conventional method. For example, an ingredient insoluble in a cosmetic base and an oil component can be mixed and stirred in advance, and then an aqueous component can be blended and mixed and stirred again. A stirrer such as a homomixer may be used to facilitate the dispersion of components insoluble in the base.

Preferred combinations of components Examples of preferred combinations of the active ingredient of the present invention and other active ingredients include the following combinations.
When it contains a known anti-glycation component, Amlar extract, lychee seed extract, rose petal extract, maronier extract, maria thistle extract, neem extract, hydrolyzable tannin, L-arginine or salt thereof, lysine or salt thereof, Carnosine, α-lipoic acid, aminoguanidine or a salt thereof, aristine, or glucosamine;
When antioxidant components are included, grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, proanthocyanidins, δ-tocopherol, α-tocopherol, ascorbic acid, sodium ascorbate phosphate, ascorbate phosphate ester Magnesium, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), hesperidin, glucosyl hesperidin, or ergothioneine;
When it contains an anti-aging ingredient, hydrolyzed soy protein, retinol, retinol acetate, or retinol palmitate,

When containing an anti-inflammatory component, Comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, or stearyl glycyrrhetinate
When containing a whitening component, arbutin, hydroquinone, kojic acid, ascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), or tranexamic acid,
When containing a keratin soft component, lactic acid, sodium lactate, glycolic acid, salicylic acid, or phytic acid,
When containing a cell activation component, bilberry leaf extract, retinol, retinol acetate, or retinol palmitate,
When vitamins are included, vitamins A (retinol, retinol acetate, retinol palmitate), vitamins C (ascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetra 2) -Ascorbyl hexyldecanoate)), vitamin Es (δ-tocopherol, tocopherol nicotinate), nicotinic acids (nicotinamide),

When containing a blood circulation promoting component, ginseng extract, tocopherol nicotinate, glucosyl hesperidin, or hesperidin,
When moisturizing ingredients are included, chigaya root extract, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, polyethylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methylglucoside, trimethylglycine (betaine) ), Hydroxyethyl urea, acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate, or sorbitol,
When it contains a component having an action of preventing and / or repairing DNA damage, Artemia extract or DNA-Na,

When an ultraviolet absorbing component or an ultraviolet scattering component is included, paramethoxycinnamic acid 2-ethylhexyl, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, or 2,4,6-tris [4 -(2-Ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, zinc oxide, titanium oxide, iron oxide, inorganic powders of these inorganic compounds (aluminum hydroxide, hydrous silicic acid, mica, or talc) Or coated with silicone oil,
When it contains a cleaning component, higher fatty acid salts (particularly salts of higher fatty acids such as palmitic acid, lauric acid, myristic acid, stearic acid), N-acyl amino acid salts (particularly sodium N-lauroyl aspartate, potassium hydroxide) / N-coconut oil fatty acid potassium acylglutamate, coconut oil fatty acid acylglycine sodium, myristoyl glutamic acid), fatty acid alkanolamide (especially coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide), amine oxide (especially coconut oil alkyldimethyl) Amine oxide, lauryl dimethylamine oxide), imidazolinium betaine (especially 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-coconut oil fatty acid acyl-N-carboxymethoxyethyl) Ru-N-carboxymethylethylenediamine disodium),
When it contains an antibacterial component, benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, or isopropylmethylphenol,
In the case of containing an astringent component, examples include alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, or a combination with tannic acid.

  Among these, known anti-glycation components, antioxidant components, anti-aging components, anti-inflammatory components, keratin softening components, cell activation components, vitamins, blood circulation promoting components, moisturizing components, prevention and / or repair of DNA damage It is preferable to combine a component having an action, an ultraviolet absorption or scattering component, and a cleaning component. Among them, it is more preferable to combine a known anti-glycation component, anti-aging component, antioxidant component, and a component having an action of preventing and / or repairing DNA damage, and known anti-glycation component, anti-aging component, and antioxidant. Even more preferred is a combination of components.

Food Composition The AGEs decomposing agent of the present invention and the agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs can be used as food compositions.
This food composition can be suitably used as a health food or a nutritional supplement (including balanced nutritional foods, supplements, etc.). It is also suitable for health functional foods (including foods for specified health use (including disease risk reduction labeling, standard-standard foods), foods for condition specific health use, and foods with functional nutrition).
The dosage form is not particularly limited, but since the active ingredient is an oily component, examples of the dosage form include soft capsules and emulsions, and soft capsules are preferred. If necessary, the above-described active ingredients may be added to other oils and fats, stabilizers, emulsifiers, dispersants, suspending agents, fragrances, thickeners, sweeteners, colorants, fragrances, preservatives, antioxidants, What is necessary is just to mix with food additives, such as an organic acid, and to formulate.

Formulation may be performed according to a conventional method. The soft capsule is obtained by using, for example, a soft capsule manufacturing machine, a mixture obtained by mixing an unsaturated fatty acid that is an active ingredient of the agent of the present invention, a derivative thereof, and / or a vegetable oil, and other components as necessary. It is obtained by wrapping with a material and press-molding. The emulsion is prepared by, for example, mixing an unsaturated fatty acid that is an active ingredient of the agent of the present invention, a derivative thereof, and / or vegetable oil, an emulsifier, and other components as necessary, and this mixture and purified water. Can be obtained by mixing and stirring.
Other oils and fats include natural vegetable oils such as peanut oil, cocoa butter, rice germ oil, perilla oil, linseed oil, etc., hardened oils thereof, and glycerides of fatty acids (including medium chain fatty acids) (glycerides, diglycerides, triglycerides, etc.) , Beeswax and the like. Of these, beeswax is preferred.

Examples of emulsifiers, dispersants, suspending agents, and stabilizers include polyhydric alcohols such as polyethylene glycol, propylene glycol, glycerin, and sorbitol; glycerin fatty acid esters; carboxymethylcellulose sodium. Of these, glycerin, glycerin fatty acid ester, and sodium carboxymethylcellulose are preferable.
Examples of thickeners include locust bean gum, guar gum, xanthan gum, tamarind gum, pectin, and carrageenan. Of these, xanthan gum is preferable.
Examples of the sweetener include sucrose, fructose, maltose, erythritol, trehalose, maltitol, licorice extract, stevia processed sweetener, aspartame, acesulfame potassium, sorbitol, xylitol and the like.

Examples of the preservative include benzoic acid or a salt thereof, sorbic acid or a salt thereof, butyl paraoxybenzoate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, and the like.
Antioxidants include ascorbic acid, sodium ascorbate, ascorbic acid stearate, sodium ascorbate stearate, ascorbyl palmitate, bisulfite, sodium hyposulfite, sulfur dioxide, disodium EDTA calcium, erythorbic acid, Examples include sodium erythorbate and tocopherol. Of these, ascorbic acid, ascorbyl palmitate, and tocopherol are preferable.

Examples of the organic acid include citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid, maleic acid and the like.
A food additive can be used alone or in combination of two or more.
Other active ingredients can be added to the formulation.
As other active ingredients, food compositions improve the overall deterioration of the skin due to the accumulation of AGEs in the skin (for example, changes in skin tone such as yellowing, reduction in firmness and transparency) For the purpose of further enhancing the effects of the present invention, such as suppression and / or prevention and slowing down the progress (speed) of the deterioration of the entire skin, known anti-glycation components that can be added to cosmetics can be blended. . Known anti-glycation components can be used singly or in combination of two or more.

  Known anti-glycation components include, for example, Amler fruits, fruit juices or extracts thereof (JP 2006-028090, JP 2006-62989, etc.); L-arginine, L-lysine, hydrolyzed casein (above, JP 2001-039816); Hydrolyzable tannin (JP 9-40519); Carnosine, α-lipoic acid (above, “Latest skin diagnostic manual for beauty”, Fragrance Journal, August 15, 2006 Issued): Western rose flower / ovary, hybrid rose flower / ovary / gaku / leaf / stem, age, grape leaf, oyster leaf, apple leaf, marigold flower, magnolia leaf extract Open 2006-273811); button genus plant extract, seaweed genus plant extract, genus genus plant extract, sunflower plant extract, aloe genus plant extract, amadokoroko genus plant extract, flax genus plant extract, Rose plant extract , Linden plant extract, kangwei plant extract, genus plant extract, kanto plant extract, burdock plant extract, mint plant extract, elder plant extract (above, JP 2003-212749 A) No.); an extract of Odaka Ryo (Japanese Patent Laid-Open No. 2006-62987); Asunaro, Asenyaku, Itadori, Ichiyakusou, Apricots, Keikanka, Hakukayumatou, Birch, Hawthorn, Achillea millefolium, Tarayo, Dokudami, Torumenchira, Bakumondo, Hiba, Extracts of grapes, green willow, mugwort, mocca, litchi, roman chamomile (above, JP-A-2003-212770); American witch hazel, apricots, Ichiyakusou, Owaurushi, Ouren, Greater Salve, Gambier, Gennoshiko, Kouhone, Pomegranate, Peonies, Natsuyukisou, die Extract of cormorant, chanoki, cinnamon, cinneberry senna, tencha, toccoli strawberry, tormentilla, rose, button, salamander, yachabushi, bayberry, eucalyptus, logwood, walmok (above, JP 2002-241299); Extracts of aloe, apricot, hippopotamus, cypress, trash, sanchinin carrot, sardine carrot, narco lily, chickweed, scallop, bukuro, yuzu (above, JP-A-2002-241293); calcade, hibiscus, shazenshi, tonin, maronier, keishi , Trash, sicon, senna, toshishi, beakkyu extract (above, JP 11-106336); jujube fruit kernel (acid jinjin), MACJONG fruit, pumpkin seeds, eucommia leaves, salacia root, ooh Extract of leaf of Umegasao (above, JP 2007-254345); Achacha, Enishida Snow lotus flower, devils crow, Ezoukogi, Rosea, Ercampure extract (above, JP 2007-254344); Papaya extract (JP 2006-298812); Simonil extract (JP 2006-219447) An extract of a genus genus (Japanese Patent Laid-Open No. 2006-117700); agrimony, ashwagandha, anise, amachazal, sweet candy, ginkgo, fennel, witch hazel, turmeric, echinacea, elephant, elder, elba mate, plantain Olive, oregano, orange, persimmon, persimmon, chamomile, guarana, cocoon grass, chrysanthemum, gymnema, cat's claw, catnip, killaway, goldfish, guava, cucumber, zakuza, cumixtin, black soybeans, wrinkles, cinnamon, tsutsumeishi, bitter gourd, Cola nut, gokahi, tsutsukora, coriander, comfrey, saximaso Cormorant, safflower, salacia oblonga, hawthorn, sanitary carrot, perilla, juyaku, juniper berry, ginger, cedar, horsetail, stevia, spearmint, sage, savory, hawthorn, sanctuary, thyme, tahibo, dandelion, chervil , Chanoki, chabodia, clove, daisy, dill, eucommia, nutmeg, nanban, nettle, hibiscus, white birch, white flower snake tongue grass, cabbage, basil, lotus, half-branch, heath, peach, hyssop, wisteria Fever-Fu, Fukugi, Wisteria, Plantago Thyrium, Blueberry, Blue Mallow, Penny Royal, Safflower, Peppermint, Hop, Poligi, Pound Apple, Marshmallow, Marjoram, Marigold, Mullin, Marlow Mall, Marlow Bull , Mifuragi, Milk Thistle, Megurinoki, Medu Sweet, Mokka, Yaeyama Aoki, Yakurakugi, Yarrow Flower, Eucalyptus, Yakuinin, Mugwort, Raspberry, Lavender, Linden, Rooibos, Lemongrass, Lemon Thyme, Lemon Verbena, Lemon Balm, Rosehip, Rose Pink Butts , Rosemary, Rose Red, Laurel, Rafu, Wild Strawberry extract (above, JP-A-2004-250445); Extract of Akamegashiwa, Oyster, Mulberry, Hypericum perforatum, Azalea, Yakuyo garage, Yaba Santa, Rosehip (above) , JP 2004-189663); extract of cherry, red scenic heaven, blueberry, bearberry, white peach, chickweed, tiger weevil, henna, and larea (above, JP 2001-316221); Extracts of king spider, goldfish, bay bay, sorghum, peony, swordfish, baimo, potato mulberry (above, JP-A-8-259431); carrot leaf extract (JP-A-2004-51580); Extract of hawthorn, chanoki, cinnamon, dokudami, tormentilla, rose, grape, maronnier, roman chamomile (above, JP 2005-35911); aminoguanidine or its salt (latest medicine, 49-2, p78-83) 1994); black soybean seed coat, mate tea leaves (green), linden flowers, radish leaves, black rice seeds, willow bark and shoots, Ibright aboveground, black cohosh root, agni fruit, artichoke leaves, litchi seeds, cutlet bark, auto Above-ground wheat, passion flower leaves, chadebugure leaves, buckwheat leaves, maria thistle fruit, tomorrow Leaf, devil's claw root, ipe bark, agaricus mycelium, paffia root, acai fruit, mozuku whole plant and processed product of cypress stem and leaf (above, JP 2008-088102); neem extract; aristine; glucosamine, etc. It is done. Among them, ingredients derived from plants such as Amler, lychee, rose, maroonier, Maria thistle, Neem (especially Amler extract, lychee seed extract, rose petal extract, Maronier extract, Maria Thistle extract, Neem extract); hydrolysis Sexual tannins (particularly derived from chestnut astringent skin); L-arginine or a salt thereof; lysine or a salt thereof; carnosine; α-lipoic acid; aminoguanidine or a salt thereof;

  As active ingredients other than known anti-glycation ingredients, antioxidant ingredients, anti-aging ingredients, anti-inflammatory ingredients, whitening ingredients, cell activation ingredients, vitamins, blood circulation promoting ingredients, moisturizing ingredients, prevention of DNA damage and / or Ingredients having a restoring action, etc., specifically, vitamins such as vitamin A, vitamin B, vitamin C, vitamin E, vitamin D, vitamin K; threonine, methionine, phenylalanine, Amino acids such as tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine; taurine, collagen, glucosamine, acetyl Glucosamine, hyaluronic acid, Isoflavones, polyphenols (eg, polyphenols derived from plants such as chestnut astringent skin, grape seeds), biotin, whey peptide, soybean peptide, royal jelly, γ-oryzanol, orotic acid, rutin, hesperidin, carnitine, carnitine chloride, collagen peptide , Elastin peptide, ceramide, lycopene, astaxanthin, lactic acid bacteria extract (eg, LFK), glutathione, rutin, plant (eg, cat's claw, grape, ginger, lotus, grape, melon, hematococcus algae), ubiquinone Derivatives (for example, coenzyme Q10), spider's nest powder and the like.

  Here, examples of vitamin A include retinal, retinol, retinoic acid, carotene, dehydroretinal, lycopene and the like, and examples of vitamin B include bistyamine, thiamine disulfide, thiamine dicetyl sulfate, benfotiamine, pro Sultiamine, fursultiamine, bisbenchamine, chicotiamine, octothiamine, allythiamine, thiamine propyl disulfide, thiamine tetrahydrofurfuryl disulfide, dicetiamine, bisibutiamine, thiamine monophosphate disulfide, thiamine pyrophosphate, chicotiamine, thiamineethyl disulfide, thiamine Propyl disulfide, riboflavin, flavin adenine dinucleotide, pyridoxine, pyridoxal, hydroxocobalamin, shear Examples include cobalamin, methylcobalamin, deoxyadenocobalamin, folic acid, tetrahydrofolic acid, dihydrofolic acid, nicotinic acid, nicotinic acid amide, nicotinic alcohol, pantothenic acid, panthenol, biotin, choline, inositol, etc. Examples include ascorbic acid, sodium ascorbate, ascorbic acid stearate, sodium ascorbate stearate, ascorbyl palmitate, erythorbic acid and the like, and vitamins D include ergocalciferol, cholecalciferol, hydroxycholecalciferol , Dihydroxycholecalciferol, dihydrotaxosterol, etc. can be exemplified, and examples of vitamin E include tocopherol and its derivatives .

  Among other active ingredients, polyphenols (for example, polyphenols derived from plants such as chestnut astringent skin, grape seeds), soybean peptide, hyaluronic acid, collagen peptide, elastin peptide, ceramide, lycopene, coenzyme Q10, astaxanthin, melon extract Lactic acid bacteria extract (for example, LFK), glutathione, rutin, cat's claw extract, red grape leaf extract, hematococcus algae extract, ginger extract, lotus germ extract, ascorbic acid, tocopherol are preferred.

Other active ingredients can be used singly or in combination of two or more.
If the components of the capsule preparation are described in detail, the material of the capsule film is not particularly limited, and examples thereof include pork skin gelatin, pork bone gelatin, fish gelatin, natural hydrophilic polymer, cow skin gelatin, and the like. Can be used. Of these, pork skin gelatin, pork bone gelatin, pullulan and the like are preferable. These capsule films can be produced by a known and conventional method.
The capsule film may contain not only raw materials derived from the above-mentioned specific animals and plants, but also fats and oils, polyhydric alcohols, surfactants, antioxidants, colorants, fragrances and the like. Examples of fats and oils include soybean oil, safflower oil, olive oil, germ oil, rapeseed oil, sunflower oil, peanut oil, cottonseed oil, rice bran oil, cocoa butter, and other natural oils and hardened oils thereof, fatty acids (including medium chain fatty acids) ) Glycerides (glycerides, diglycerides, triglycerides, etc.). Examples of the polyhydric alcohol include polyethylene glycol, propylene glycol, glycerin, sorbitol and the like. Examples of the surfactant include nonionic surfactants such as sorbitan fatty acid ester and polyglycerin fatty acid ester. Examples of the colorant include carotenoid pigments, anthocyanin pigments, cacao pigments, anthranone pigments, caramel pigments, safflower yellow, titanium dioxide and the like. Among these, addition of oils and fats, polyhydric alcohols, surfactants, and / or natural pigments to the capsule film is preferable because the capsule formulation can be further stabilized.

Preferred combinations of components Examples of preferred combinations of the active ingredient of the present invention and other components include the following combinations.
If it contains other oils and fats,
When it contains an emulsifier, dispersant, suspending agent, or stabilizer, glycerin, glycerin fatty acid ester, or sodium carboxymethylcellulose;
When containing a thickener, xanthan gum,
When containing a sweetener, sucrose, fructose, maltose, erythritol, trehalose, maltitol, licorice extract, stevia processed sweetener, aspartame, acesulfame potassium, sorbitol, or xylitol,
When containing a preservative, benzoic acid or a salt thereof, sorbic acid or a salt thereof, butyl paraoxybenzoate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, or ethyl paraoxybenzoate,
When containing an antioxidant, ascorbic acid, ascorbyl palmitate, or tocopherol,

When containing an organic acid, citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid, or maleic acid,
When it contains a known anti-glycation component, Amlar extract, lychee seed extract, rose petal extract, maronier extract, maria thistle extract, neem extract, hydrolyzable tannin, L-arginine or salt thereof, lysine or salt thereof, Carnosine, α-lipoic acid, aminoguanidine or a salt thereof, aristine, glucosamine,
When other active ingredients are included, polyphenol derived from chestnut astringent skin or grape seeds, soybean peptide, hyaluronic acid, collagen peptide, elastin peptide, ceramide, lycopene, coenzyme Q10, astaxanthin, melon extract, lactic acid bacteria extract (for example, , LFK), glutathione, rutin, cat's claw extract, red grape leaf extract, hematococcus algae extract, ginger extract, lotus germ extract, ascorbic acid, or a combination with tocopherol.

Among these, other fats and oils, emulsifiers, dispersants, suspending agents or stabilizers, thickeners, known anti-glycation components, other active components (antioxidant components, anti-aging components, anti-inflammatory components, whitening components) It is preferable to combine a cell activation component, vitamins, a blood circulation promoting component, a moisturizing component, a component having an action of preventing and / or repairing DNA damage, and the like.
As a combination of active ingredients, it is preferable to combine known anti-glycation ingredients, anti-aging ingredients, antioxidant ingredients, whitening ingredients, and ingredients having an action of preventing and / or repairing DNA damage.
When the food composition is formulated as a supplement as described above, the content of the active ingredient is preferably about 10 to 60% by weight, and about 20 to 50% by weight with respect to the whole food composition. % Is more preferred, and about 30-40% by weight is even more preferred. If it is within the above range, the amount of food composition that can be taken comfortably includes an active ingredient sufficient to obtain a sufficient AGEs decomposition effect, and thus, prevention, suppression, or improvement of skin deterioration due to accumulation of AGEs. Will be.

<General food composition>
Moreover, this food composition can be prepared by adding the above-described active ingredient to a general food. Examples of foods include milk, milk drinks, lactic acid bacteria drinks, soft drinks with fruit juice, carbonated drinks, vegetable juice drinks, tea drinks, fruit juice drinks, ion drinks, sports drinks, functional drinks, vitamin supplement drinks, and nutrition supplement balance drinks , Beverages such as jelly beverages, alcoholic beverages, soups; puddings such as custard pudding, milk pudding, pudding with fruit juice, gel-like confectionery such as jelly, dressing, cream, chewing gum, bubble gum Gum (plate gum, sugar-coated grain gum, etc.), chocolate (solid chocolate, coated chocolate, chocolate with flavor such as strawberry chocolate, blueberry chocolate, melon chocolate, etc.), soft candy (caramel, nougat, gummy candy) , Including marshmallows) Mels, biscuits (hard biscuits, soft biscuits, soft cookies, crackers, half biscuits, etc.), cakes and other confectionery; ice cream, ice milk, lacto ice, sherbet, ice confectionery and other frozen confectionery; breads; noodles; Pet food etc. are mentioned.
The content of the active ingredient in the case where the food composition is obtained by adding an active ingredient to a general food is not particularly limited.

How to Use The cosmetic composition may be applied in the usual manner of use and the number of uses.
The food composition may be taken so that the daily intake of the active ingredient is, for example, about 50 to 4000 mg, preferably about 50 to 500 mg, more preferably about 50 to 180 mg.
The subject of use of the agent for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs and AGEs of the present invention is not particularly limited, but the cosmetic composition is caused by the elderly, generation of AGEs, and accumulation Suitable subjects include humans in whom the overall skin has declined, humans in whom the entire skin has a tendency to decline due to the generation and accumulation of AGEs. In addition, for food compositions, there are other elderly people, humans with a decline in the whole skin due to the generation and accumulation of AGEs, humans with a tendency to decline in the whole skin due to the generation and accumulation of AGEs. , Diabetics (especially those causing complications such as cataracts, arteriosclerosis, renal dysfunction, retinopathy, neuropathy), arteriosclerosis patients, malignant tumor patients, bone disease patients, Alzheimer's disease patients, Parkinson's disease Patients and the like are suitable targets. In addition, in any case of the cosmetic composition and the food composition, healthy people can also be targeted, thereby preventing or declining the deterioration of the entire skin due to the generation and accumulation of AGEs due to aging and the like. Can slow down.
From the viewpoint of more effectively demonstrating the effects of the present invention, the cosmetic composition is applied to the skin to give the active ingredient to the skin from the outside, and by ingesting the food composition, the skin is taken by the oral route. It is preferable to give an active ingredient to. That is, it is particularly suitable to use the cosmetic composition of the present invention and the food composition of the present invention in combination.

In addition, the present invention includes the following aspects.
(i) A method for decomposing AGEs, or a method for preventing, suppressing, or improving skin deterioration due to accumulation of AGEs, wherein an effective amount of the active ingredient described above is administered to a human or non-human mammal.
(ii) The above-described active ingredient for preventing, suppressing, or improving skin deterioration due to degradation of AGEs or accumulation of AGEs.
(iii) Use of the above-described active ingredient as an active ingredient for the production of a food additive for preventing, suppressing, or improving skin deterioration due to AGEs degradation or accumulation of AGEs.
(iv) Use of the active ingredient described above for the manufacture of an agent for preventing, suppressing, or improving the deterioration of the skin due to the accumulation of AGEs or AGEs.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples.
Example 1 (Measurement of AGEs resolution)
(1) Test sample (vegetable oil / fatty acid)
Evening primrose oil was purchased from Oriza Yuka and Nisshin Oilio Group. Cario Calbrasiliense fruit oil was purchased from Croda Japan. γ-linolenic acid and α-linolenic acid were purchased from Cayman Chemical Co. Linoleic acid and oleic acid were purchased from Wako Pure Chemical Industries. Docosahexaenoic acid (DHA) was purchased from ChromaDex, Inc. Evening primrose extract was purchased from Oriza Yuka.

(2) Measurement method
It is known that AGEs are decomposed by cleaving CC bonds between ketones having an α-diketone structure present in AGEs. By referring to the method described in JP-A-2007-161662, by measuring the ability to cleave the CC bond between ketones of 1-phenyl-1,2-propanedion (hereinafter referred to as PPD) having an α-diketone structure, AGEs resolution was measured.
1 ml of an ethanol solution in which PPD was dissolved and 1 ml of PBS in which a vegetable oil or fatty acid sample was dissolved so as to have a concentration shown in Table 2 below were mixed to prepare a reaction solution so that the final concentration was 22 mM PPD. . This reaction solution was reacted at 37 ° C. for 15 hours. After the reaction, the amount of benzoic acid which is a decomposition product of PPD in the reaction solution was quantified by HPLC.

The analysis conditions of HPLC are as follows.
Detector: UV absorptiometer (measurement wavelength: 260nm)
Column: Inertsil ODS-3 (4.6 x 250 mm)
Column temperature: Constant temperature flow around 30 ° C: 1.20 mL / min
Mobile phase: Mobile phase A Trifluoroacetic acid (1 → 1000) solution diluted with water Mobile phase B Trifluoroacetic acid (1 → 1000) solution diluted with acetonitrile mixture The gradient program is shown in Table 1 below.

(3) Results
The PPD cleavage rate (AGEs decomposition rate) was the ratio (percentage) of the amount of benzoic acid produced after the actual reaction with the test material to the total amount of benzoic acid theoretically produced from PPD. The results are shown in Table 2 below.

  As is apparent from Table 2, unsaturated fatty acids having 18 and 20 carbon atoms and evening primrose oil showed very strong AGE resolution. Moreover, AGEs resolution | decomposability was so high that the unsaturated fatty acid of carbon number 18 contained many double bonds. On the other hand, AGEs-degrading activity of evening primrose extract obtained by extracting evening primrose seeds with hydrous ethanol was very weak.

Example 2 (Examination of the effect on skin color)
The evening primrose oil used was purchased from Nisshin Oillio Group.
Test sites were marked by marking 2 cm x 2 cm sections on the forearm of adults in their 20s and 40s (4 people per group). Evening primrose oil was applied to four test sites twice a day (morning and evening) at 0.05 ml / division. The forearm area where nothing was applied in each subject was used as a control. The skin color (b * value) was measured using a spectrocolorimeter (manufactured by Minolta, CM-2002) before the start of application and 28 days after the application. The b * value is an index of chromaticity, and the larger the value, the stronger the yellowness, and the smaller the value, the stronger the blueness.

  The amount of change in the b * value after 28 days of application of the test sample is shown in Table 3 below and FIG. The numerical values in Table 3 and FIG. 1 are average values of changes in b * values derived from four measured values (total 16 measured values) of four subjects.

表３、及び図１から、月見草油の塗布により、b*値が大きく減少し、肌の黄色みが低減したことが分かる。

From Table 3 and FIG. 1, it can be seen that application of evening primrose oil greatly reduced the b * value and reduced the yellowness of the skin.

Example 2 (Examination of the effect on skin elasticity)
In the same manner as in Example 1, the test sample was applied to the subject's forearm. After application for 28 days, using a skin viscoelasticity measuring device (Cutometer SEM575, manufactured by Integral), the applied part of the skin is aspirated for 2 seconds at a pressure of 300 mbar and then opened for 2 seconds to measure changes in skin height. Thus, the elasticity of the skin was evaluated.
The ratio (Ua / Uf) of the height recovery due to opening (Ua) to the skin height (Uf) at the time of maximum suction was used as an index indicating the elasticity of the skin. In addition, the ratio (Ur / Ue) of the height recovery (Ur) 0.1 seconds after release to the skin height (Ue) after 0.1 seconds of suction, the ease of return of the skin condition by suction and release It was used as an indicator. The meaning of Uf, Ua, Ue, Ur is illustrated in FIG.
The average value of each group 28 days after application is shown in FIG. As apparent from FIG. 3, both the elasticity of the skin (Ua / Uf) and the ease of return of the skin condition (Ur / Ue) were improved as compared with the control.

Example 4 (Examination of influence on moisture content of skin)
In the same manner as in Example 2, evening primrose oil was applied to the subject's forearm. Before the start of application and after 14 days of application, the moisture content of the skin at the application part was measured using an impedance meter (IBS, Skicon-200).
The results are shown in FIG. It can be seen that the amount of moisture in the skin increased (moisturized) by the application of evening primrose oil.

Formulation example
(1) Cosmetic composition The unit of the numerical value in the formulation examples of the cosmetic composition below is "% by weight".
Formulation Example 1 Transparent lotion evening primrose oil 0.001
Meadow foam oil 0.1
Amler extract 0.01
Lysine 1
Hydrolyzed soy protein 0.5
Proanthocyanidins 0.0005
MPC polymer 0.01
Glycerin 4
1,3-butylene glycol 6
Polyoxyethylene hydrogenated castor oil 0.5
Preservatives (methyl paraoxybenzoate, propyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 2 Transparent lotion γ-linolenic acid 0.01
Grape seed extract 0.001
α-Tocopherol 0.1
Ascorbic acid 0.5
Comfrey leaf extract 0.001
Dipropylene glycol 15
Polyoxyethylene sorbitan isostearate (20EO) 0.5
Hydroxyethyl cellulose 0.01
Preservatives (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount Perfume Appropriate amount
Water balance
Total 100

Formulation Example 3 Emulsification lotion Cariocarbrasiliense fruit oil 0.1
Arginine 0.5
Carnosine 0.01
Retinol acetate 0.01
Grape seed extract 0.01
Polyoxypropylene methyl glucoside 1
Hyaluronic acid 0.05
1,3-butylene glycol 13
Polyoxyethylene hydrogenated castor oil 0.5
Tri (caprylic / capric) glyceryl 0.2
Glyceryl tri-2-ethylhexanoate 0.2
Xanthan gum 0.1
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 4 Emulsification Lotion Meadow Foam Oil 0.3
γ-linolenic acid 0.05
Arginine 0.7
Arginine hydrochloride 0.3
Hydrolyzed soy protein 0.2
Grape seed extract 0.1
Magnesium ascorbate phosphate 0.01
MPC polymer 0.1
Dipropylene glycol 8
Glycerin 1
1,3-butylene glycol 0.5
Polyoxyethylene hydrogenated castor oil 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 0.5
Acrylic acid / alkyl methacrylate copolymer 0.25
Hydroxyethyl cellulose 0.01
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 5 an emulsion lotion <br/> evening primrose oil 0.05
Linoleic acid 0.01
Lychee seed extract 0.001
Rose petal extract 0.001
Hydrolyzed soy protein 0.001
d-δ-tocopherol 0.01
Proanthocyanidins 0.001
Sodium ascorbate phosphate 0.1
1,3-butylene glycol 7
Diglycerin 3
Polyoxyethylene sorbitan isostearate (20EO) 0.5
Glyceryl tri-2-ethylhexanoate 1
Hydroxyethyl cellulose 0.05
Carboxyvinyl polymer 0.1
Chelating agent Appropriate amount of preservatives (propyl paraoxybenzoate, phenoxyethanol) Appropriate amount
Water balance
Total 100

Formulation Example 6 Latex evening primrose oil 0.4
Lychee seed extract 0.2
Carnosine 0.1
Hydrolyzed soy protein 0.5
d-δ-tocopherol 0.01
Nicotinamide 1.5
Hydrolyzed collagen 0.05
Comfrey leaf extract 0.1
Bilberry leaf extract 0.0001
Dipropylene glycol 3
1,3-butylene glycol 10
POE sorbitan monostearate (polysorbate 60) 0.8
Tetra-2-ethylhexanoic acid pentaerythrit 5
Glyceryl tri-2-ethylhexanoate 2
Squalane 1
Methyl trimethicone 0.1
Decamethylcyclopentasiloxane 0.2
Behenyl alcohol 0.4
Acrylic acid / alkyl methacrylate copolymer 0.1
Xanthan gum 0.1
(Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer
0.8
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance
Total 100

Formulation Example 7 Latex Cariocarbrasiliense fruit oil 0.05
Meadow Foam Oil 0.8
Lychee seed extract 0.2
Lysine 0.5
Hydrolyzed soy protein 1
d-δ-tocopherol 0.1
α-Tocopherol 0.9
Chigaya Root Extract 0.5
Polyoxypropylene methyl glucoside 0.1
Allantoin 0.005
Lactic acid 0.5
Dipropylene glycol 1
Glycerin 4
1,3-butylene glycol 10
Glyceryl monostearate 0.2
Polyoxyethylene cetyl ether 0.8
Tetra-2-ethylhexanoic acid pentaerythrit 3
Methyl polysiloxane 0.5
Ethyltrisiloxane 3
Acrylic acid / alkyl methacrylate copolymer 0.75
Carboxyvinyl polymer 0.001
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 8 Cream Evening Primrose Oil 1
Shea fat 0.3
Retinol palmitate 0.5
d-δ-tocopherol 0.005
α-Tocopherol 0.005
Nicotinamide 0.5
Hydrolyzed collagen 0.01
Hydrolyzed elastin 0.01
Hydrogenated soybean phospholipid 0.3
Hyaluronic acid 0.1
Glycerin 2
1,3-butylene glycol 5
Polyoxyethylene hydrogenated castor oil 3
Tri (caprylic / capric) glyceryl 2
Tetra-2-ethylhexanoic acid pentaerythrit 3
Squalane 7
Cetanol 1
Stearyl alcohol 0.5
Acrylic acid / alkyl methacrylate copolymer 0.3
Chelating agent
Water balance
Total 100

Formulation Example 9 Cream Shea Fat 5
γ-linolenic acid 0.5
Linoleic acid 0.3
Rose petal extract 0.5
Hydrolyzed soy protein 0.8
Grape seed extract 0.1
Tocopherol nicotinate 0.3
Polyoxypropylene methyl glucoside 3
Panax ginseng extract 0.1
Bilberry leaf extract 0.1
Dipropylene glycol 1.5
Glycerin 2
1,3-butylene glycol 3.5
Polyethylene glycol 0.01
Polyoxyethylene hydrogenated castor oil 2
Glyceryl monostearate 1
Tri (caprylic / capric) glyceryl 5
Squalane 2
Liquid paraffin 1
Methyl polysiloxane 0.1
Cyclomethicone 0.1
Cetanol 2
Carboxyvinyl polymer 0.4
Chelating agent
Water balance
Total 100

Formulation Example 10 Cream Meadow Foam Oil 0.2
Shea fat 1.5
Amler extract 0.01
Arginine 0.01
Retinol 0.1
α-Tocopherol 0.5
Ascorbyl tetraisopalmitate 0.5
Artemia extract 0.001
DNA-Na 0.05
2-Ethylhexyl paramethoxycinnamate 8
Diethylaminohydroxybenzoyl hexyl benzoate 2
Silicone-coated zinc oxide 0.1
Silicone-coated titanium oxide 10
1,3-butylene glycol 8
Polyethylene glycol 0.03
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 3
PEG-9 polydimethylsiloxyethyl dimethicone 1.5
Tri (caprylic / capric) glyceryl 4
Methyltrimethicone 35
Methylsiloxane network polymer 3
Cross-linked methylpolysiloxane 0.5
Acrylic acid / alkyl methacrylate copolymer 0.2
Carboxyvinyl polymer 0.05
Dimethyl distearyl ammonium hectorite 1.5
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 11 Cream Evening Primrose Oil 3
Lychee seed extract 0.1
α-Lipoic acid 0.01
Hydrolyzed soy protein 0.1
Grape Seed Extract 0.005
Chigaya Root Extract 0.001
Artemia extract 0.5
2-Ethylhexyl paramethoxycinnamate 10
Diethylaminohydroxybenzoyl hexyl benzoate 5
2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] 1,3,5-triazine 3
Silicone coated zinc oxide 5
Silicone-coated titanium oxide 1
Inorganic compound-coated zinc oxide 0.05
Glycerin 5
1,3-butylene glycol 2
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 1
PEG-9 polydimethylsiloxyethyl dimethicone 1
Glyceryl tri-2-ethylhexanoate 1.5
Methyl polysiloxane 3
Decamethylcyclopentasiloxane 30
Methylsiloxane network polymer 5
Alkyl acrylate copolymer methyl polysiloxane ester 0.1
Acrylic acid / alkyl methacrylate copolymer 0.05
Mica 2
Chelating agent Appropriate amount of preservatives (propyl paraoxybenzoate, phenoxyethanol) Appropriate amount
Water balance
Total 100

Formulation Example 12 Cleansing Cream <br/> evening primrose oil 0.01
Lychee seed extract 0.005
Arginine 0.1
Hydrolyzed soy protein 0.5
d-δ-tocopherol 0.01
Comfrey leaf extract 0.001
Glycyrrhizic acid 2K 0.1
Glycerin 0.01
1,3-butylene glycol 1
Diglycerin 5
Glyceryl monostearate 0.5
Polyglyceryl monostearate 2
Tri (caprylic / capric) glyceryl 10
Liquid paraffin 3
Light liquid paraffin 10
Ethyltrisiloxane 0.5
Stearyl alcohol 3
Carboxyvinyl polymer 0.5
Chelating agent
Water balance
Total 100

Formulation Example 13 Cleansing Cream γ-Linolenic Acid 1
Amler extract 0.01
Grape seed extract 0.01
Panax ginseng extract 0.1
Allantoin 0.0001
Dipropylene glycol 7
1,3-butylene glycol 0.01
Glyceryl monostearate 1
Monostearic acid POE sorbitan 2
Tetra-2-ethylhexanoic acid pentaerythlit 8
Glyceryl tri-2-ethylhexanoate 8
Squalane 1
Liquid paraffin 7
Methyl polysiloxane 2
Behenyl alcohol 1
Carboxyvinyl polymer 0.5
Chelating agent Suitable amount Preservative (Methyl paraoxybenzoate, Propyl paraoxybenzoate) Suitable amount pH adjuster Suitable amount
Water balance
Total 100

Formulation Example 14 Facial Cleansing Milk Cariocarbrasiliense fruit oil 0.1
Shea fat 0.1
Amler Extract 1
Lysine 0.01
Grape Seed Extract 0.005
MPC polymer 0.5
Acrylic acid / acrylamide / dimethyldiallylammonium chloride copolymer
3
Allantoin 0.001
1,3-butylene glycol 2
Palm oil fatty acylglycine Na 5
Hydroxylated K / N-coconut oil fatty acid acyl glutamic acid K 15
N-coconut oil fatty acid acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine 2Na 4
Coconut oil alkyldimethylamine oxide 1
Polyethylene glycol distearate 1
Triisostearic acid polyoxyethylene methyl glucoside 3
Pearl luster imparting agent 2
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

Formulation Example 15 Facial Cleansing Milk Meadow Foam Oil 0.1
γ-linolenic acid 0.3
Linoleic acid 0.2
Rose extract 0.1
Arginine 0.01
Hydrolyzed soy protein 0.01
α-Tocopherol 0.1
Polyoxypropylene methyl glucoside 3
Sorbitol 1
Hyaluronic acid 0.1
Panax ginseng extract 0.0001
Comfrey leaf extract 0.1
Dipropylene glycol 1
Lauroyl aspartate Na 10
Palm oil fatty acid monoethanolamide 7
Myristoyl glutamate Na 5
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine 3.5
Polyethylene glycol distearate 4
Pearl luster imparting agent 1
Chelating agent appropriate amount Preservative (methyl paraoxybenzoate) appropriate amount pH adjuster appropriate amount perfume appropriate amount
Water balance
Total 100

(2) Food composition The unit of the numerical value in the formulation examples of the following food composition is "part by weight".
Formulation Example 15 Soft Capsule
Capsule contents evening primrose oil 120
Hydrolyzable tannin 20
Hydrolyzed soy protein 20
Lotus germ extract 5
Ceramide 3
Hyaluronic acid 0.5
CoQ10 2
Haematococcus alga pigment extract (containing astaxanthin) 4
Vitamin C 1
Glycerin fatty acid ester 10
Beeswax 5
Capsule film gelatin 92
Pullulan 3
Glycerin 35
Coloring agent 3

Formulation Example 16 Soft Capsule
Capsule content γ-linolenic acid 110
Linoleic acid 10
Lychee seed extract 10
Arginine 5
Hydrolyzable tannin 5
Rutin 2
Vitamin C 15
Lactic acid bacteria powder 30
Glycerin fatty acid ester 2
Beeswax 8
Capsule film gelatin 100
Glycerin 30
Coloring agent 4

Formulation Example 17 Soft Capsule
Capsule contents soybean oil 120
Amler Extract 20
Vitamin C 10
Yeast extract (containing glutathione) 20
Cat's claw extract powder 2
Glycerin fatty acid ester 15
Capsule film pullulan 100
Glycerin 40
Coloring agent 2

Formulation Example 18 Soft capsule
Capsule contents sunflower oil 100
Linoleic acid 20
Amler extract 5
Hydrolyzable tannin 15
Ceramide 1
Grape Seed Extract 20
Lycopene 1
Red grape leaf extract powder 4
Rutin 1
Vitamin C 20
Vitamin E 5
Beeswax 10
Capsule film gelatin 100
Glycerin fatty acid ester 20
Glycerin 20
Coloring agent 2

Formulation Example 19 Soft capsule
Capsule contents evening primrose oil 60
Olive oil 60
Rose extract 8
Arginine 5
Lysine 10
Collagen peptide 15
Elastin peptide 2
Royal Jelly 10
Hyaluronic acid 2
Lycopene 3
Melon extract 1
Red grape leaf extract powder 1
Vitamin E 3
Glycerin fatty acid ester 8
Beeswax 12
Capsule film gelatin 100
Glycerin 40
Coloring agent 3

Formulation Example 20 Soft Capsule
Capsule contents evening primrose oil 10
Olive oil 10
Safflower oil 100
Lychee seed extract 10
Hydrolyzable tannin 10
Sialic acid 2
Ceramide 2
Grape Seed Extract 10
Melon extract 5
CoQ10 5
Rutin 2
Haematococcus alga pigment extract (containing astaxanthin) 2
Vitamin C 10
Vitamin E 1
Beeswax 20
Capsule film Pullulan 100
Glycerin fatty acid ester 5
Glycerin 15
Coloring 1

  Unsaturated fatty acids, and pharmaceutically acceptable derivatives thereof, and vegetable oils containing these have AGEs-degrading activity, so adding AGEs to the skin by adding them to cosmetic or food compositions Improve, suppress and / or prevent the deterioration of the entire skin caused by accumulation (for example, skin tone change such as yellowish dullness, reduction in elasticity and transparency), and slow down the speed of the entire skin it can. In addition, prevent or prevent various diseases caused by AGEs (cataract, arteriosclerosis, renal dysfunction, retinopathy, diabetic complications such as neuropathy, arteriosclerosis, malignant tumor, bone disease, Alzheimer's disease, Parkinson's disease, etc.) Can be improved.

Claims (11)

  Unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and at least one selected from the group consisting of pharmaceutically acceptable amides thereof Advanced glycation end products degradation agent containing as an active ingredient.   The advanced glycation end product degradation agent according to claim 1, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.   The advanced glycation end product degradation agent according to claim 2, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids.   An advanced glycation end product degradation agent comprising as an active ingredient a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof.   The advanced glycation end-product decomposing agent according to claim 4, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cariocarbra gliense fruit oil, meadowfoam oil, and shea fat.   Unsaturated fatty acids, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable glycerides thereof, pharmaceutically acceptable esters thereof, and at least one selected from the group consisting of pharmaceutically acceptable amides thereof An agent for preventing, suppressing, or improving skin deterioration caused by accumulation of advanced glycation end products, comprising as an active ingredient.   The agent for preventing, suppressing or improving skin deterioration caused by accumulation of advanced glycation end products according to claim 6, wherein the unsaturated fatty acid is an unsaturated fatty acid having 16 to 20 carbon atoms.   The unsaturated fatty acid is caused by accumulation of advanced glycation end products according to claim 7, wherein the unsaturated fatty acid is at least one unsaturated fatty acid selected from the group consisting of diene unsaturated fatty acids and triene unsaturated fatty acids. An agent for preventing, suppressing or improving skin deterioration.   Prevention of skin deterioration caused by accumulation of advanced glycation end products, comprising as an active ingredient a vegetable oil containing at least one member selected from the group consisting of unsaturated fatty acids and pharmaceutically acceptable glycerides thereof, Inhibitor or improver.   The accumulation of advanced glycation end products according to claim 9, wherein the vegetable oil is at least one vegetable oil selected from the group consisting of evening primrose oil, cario carbaziriense fruit oil, meadow foam oil, and shea fat. An agent for preventing, suppressing, or improving the deterioration of the skin caused by it.   The advanced glycation end products according to any one of claims 6 to 10, wherein the deterioration of the skin caused by accumulation of advanced glycation end products is a change in skin color or a decrease in elasticity. An agent for preventing, suppressing, or improving the deterioration of the skin caused by the accumulation of the skin.

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