JPH05286845A - Cosmetic for preventing skin ageing - Google Patents

Abstract

PURPOSE:To obtain a cosmetic which is chemically stable, and has effects of inhibiting skin ageing and improving skin roughening by admixing EPA or DHA and/or fat and/or oil containing the same. CONSTITUTION:The objective cosmetic comprises (A) eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) or fat and/or oil containing them and (B) at least one or more selected from Japanese green gentian extract, camphor, nicotinic acid, or its derivatives, garlic essence, cepharanthine and Guinea pepper extract.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition, and more particularly to a cosmetic composition for preventing skin aging, which has excellent effects of preventing skin aging, improving skin roughness and the like.

[0002]

2. Description of the Prior Art Medicinal ingredients that have been conventionally used to improve skin roughness and prevent skin aging include allantoin, aloe extract, ginseng extract, placenta extract, bovine blood deproteinate and fermented metabolites. Are known. However, cosmetics containing these medicinal components cannot obtain sufficient effects, and development of cosmetics having more excellent action has been desired.

On the other hand, anti-inflammatory action and anti-allergic action ("Oil Chemistry", 37, p9, (1988), "Oil Chemistry", 40,
As a compound having p203, (1991)) or the like, an oil and fat containing eicosapentaenoic acid (hereinafter abbreviated as “EPA”) and docosahexaenoic acid (hereinafter abbreviated as “DHA”) has been attracting attention. It has long been known that EPA and DHA are contained in fish oil in a large amount and have pharmacological effects such as thrombus prevention activity and arteriosclerosis prevention activity. Further, in recent years, it has been found that local administration has a vasomotor and vasodilatory effect (Japanese Patent Application Laid-Open No. HEI 2
-48528).

[0004]

DISCLOSURE OF THE INVENTION The present inventors have found that EPA
Attention was paid to the above-mentioned action of DHA and DHA, and an attempt was made to mix them with a cosmetic, particularly a cosmetic for the purpose of preventing skin aging. However, it cannot be said that the effect of preventing skin aging and the effect of improving skin roughness when EPA, DHA or oils and fats containing them are blended alone are sufficient, and due to the influence of other bases etc. The reality is that the effects cannot be fully exerted.

Further, for the purpose of obtaining a higher effect, EPA
And / or DHA or fats and oils containing this has a limited effect when mixed at a high concentration, and conversely,
There is also a problem that due to the generation of unique colors and odors possessed by these compounds themselves, there is a limitation in terms of product amount and formulation.

[0006]

In view of the above-mentioned circumstances, the inventors of the present invention have conducted diligent research so as to sufficiently bring out the action of EPA and / or DHA or fats and oils containing the same. As a result, they have found that, by combining these with a specific component, an excellent effect of preventing skin aging and an effect of improving rough skin can be stably and synergistically achieved, and the present invention has been completed.

That is, the present invention relates to EPA and / or D
Provided is a cosmetic composition for preventing skin aging, which comprises HA or oils or fats containing the same, and one or more components selected from senburi extract, camphor, nicotinic acid or its derivative, garlic extract, cepharanthin and capsicum tincture. To do.

As described above, EPA and / or DHA are unsaturated fatty acids contained in a large amount in fish oils such as sardine oil, saury oil, herring oil, mackerel oil and cod oil. For example, sardine oil contains about 16% EPA, about 8.4% DHA, and saury oil contains about 4.9% EPA and about 1 DHA.
0.5%, mackerel oil about EPA 8.1%, DHA about 1
0.6%, cod oil EPA about 13.3%, DHA about 1
3.7% each is included.

The EPA and / or DHA or fats and oils containing the same used in the present invention may be obtained by separating and purifying fish oil by a conventional method, but EPA obtained by simply extracting fish oil. Oils and fats containing DHA and / or DHA may be used. The method for extracting fish oil is not particularly limited, and a known method such as a critical gas extraction method, a molecular distillation method, a liquid chromatography method, or the like can be adopted as a method for extracting fats and oils.

The fats and oils containing EPA and / or DHA may be blended as they are with the cosmetic of the present invention, or may be refined by steam distillation, activated carbon treatment, acid clay treatment or the like.

The content of EPA and / or DHA in the cosmetic composition of the present invention is 0.0001 to 10% by weight (hereinafter simply referred to as "%"), and more preferably 0.01 to 10.
5%. When using a low-purity oil or fat of EPA and / or DHA, the content of EPA and / or DHA may be within the above range.

The content of EPA and / or DHA is 0.
If it is less than 0001%, a sufficient effect may not be obtained, and even if it exceeds 10%, no further increase in the effect is observed. Instead, depending on the coloring, the generation of odor, and the dosage form. Problems such as precipitation may occur on the product side.

On the other hand, in the present invention, other essential components such as assembly extract, camphor, nicotinic acid or a derivative thereof, garlic extract, cepharanthin and capsicum tincture (hereinafter collectively referred to as "second component").
Are all components that have been conventionally blended in cosmetics.

Among these second components, citrus extract, camphor, garlic extract, cepharanthin and capsicum tincture are substances obtained by extraction from natural products.

[0015] That is, the assembly extract is an extract obtained by extracting whole plants of the assembly [Swertia japonica Makino (Gentianaceae)] at the flowering stage with ethanol, purified water, or a mixture thereof, and camphor is a camphor tree [Cinnamomum]. camphora Linne (Lauraceae)].

The garlic extract is garlic (Alli
um scordoplasm L. or Allium sativum L.) bulbs purified water, absolute ethanol, propylene glycol,
It is an extract obtained by extraction with 1,3-butylene glycol or a mixture thereof.

[0017] Further, cepharanthin is a plant belonging to the family Cistancheaceae, Stephaura cepharantha Haya.
It is obtained by extracting from the root of ta). Furthermore,
Capsicum annuum Li
nne (Solanaceae)] or a variant thereof is a tincture obtained by leaching with ethanol. In any case, there is no particular restriction on the extraction method and the purification treatment method.

On the other hand, nicotinic acid and its derivatives are a kind of vitamin B, and may be those obtained by extraction from beef liver, rice bran or the like, or those obtained by synthesis. In addition to nicotinic acid, nicotinic acid amide, nicotine Acid D
Illustrative are nicotinic acid derivatives such as L-α-tocopherol and methyl nicotinate.

The content of these second components in the cosmetic of the present invention is generally 0.0001 to 5%, preferably 0.001.
~ 3%. If the content of these components is less than 0.0001%, sufficient effects may not be obtained,
In addition, the effect becomes almost constant even if it exceeds 5%,
No increase is seen.

The cosmetic for preventing skin aging of the present invention comprises, in accordance with a conventional method, EPA and / or DHA as essential components or oils and fats containing the same, and a second component as another essential component. It can be prepared by blending with various types of bases known as ingredients.

The form of the cosmetic is not particularly limited, and may be cosmetics such as emulsion, cream, lotion, pack, dispersion, and cleaning agent. The base of the cosmetic is Bases depending on the form of these cosmetics, for example,
Purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, various cosmetic ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances and the like can be used.

[0022]

EXAMPLES Next, the present invention will be described in more detail by way of examples, which should not be construed as limiting the invention thereto.

Examples 1 to 4 Cream: A cream having the composition shown in Table 1 below was produced, and the effect of improving rough skin was examined. The results are also shown in Table 1. In addition,
The cream production method and evaluation method are as follows.

(Production Method) A. Components (8) and (10) to (14) are mixed by heating and kept at 70 ° C. B. Ingredients (1)-(7) and (9) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix, and uniformly emulsify. D. After cooling the above C, (15) was added and uniformly mixed to obtain a cream.

(Evaluation method) 135 healthy men were used as a panel, and 15 people per group, the creams of Examples 1 to 4 or Comparative Examples 1 to 5 on one half of the face, and the cream of Comparative Example 6 on the other half. , Once a day for 2 weeks. Two weeks later, a facial skin replica was collected and evaluated according to the criteria shown below. The value obtained by subtracting the score of the replica of the cream-applied portion of Comparative Example 6 from the obtained score of the replica of the cream-applied portion of Examples 1 to 4 and Comparative Examples 1 to 5 was taken as the degree of skin roughening improvement. In addition, the score before the start of the test is 1 on the panel
Or I chose 2 men.

Skin condition score: [Score] [Situation] 1 Skin crevices on the skin are not clear, and exfoliation of keratin is observed. 2 The skin groove on the skin is slightly blurred or unidirectional. 3 Skin groove is observed, but it is shallow or slightly unidirectional. 4 Skin crevices are observed or are slightly mesh-like. 5 Skin crevices are clearly visible or have a clean mesh.

(Result)

[Table 1]

From the above results, it is clear that the cosmetic of the present invention containing DHA and the second component exhibits a remarkable effect of improving rough skin, as compared with the case where DHA or the second component is added alone. ..

Examples 5-6 Cream: A cream was prepared by the composition shown in Table 2 and by the following production method, and its skin aging-preventing action was examined by the following method.

[0030] * Kurita Water Industries Co., Ltd. ** Pepper sliced ethyl alcohol leachate *** Nicotinic acid amide (Organic Synthetic Chemicals)

(Production Method) A. Components (9) to (11) and (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (8) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix, and uniformly emulsify. D. After cooling the above C, the component (12) was added and uniformly mixed to obtain a cream.

(Evaluation method) A panel of 15 women aged 26 to 52 was applied twice daily in the morning and evening twice for 12 weeks, and an appropriate amount of the test cream was applied to the face. The effect of beautiful skin and the effect of preventing skin aging by application were evaluated according to the following criteria.

Skin beautifying effect: [Evaluation] [Content] Effectiveness The dullness of the skin became inconspicuous. Somewhat effective The dullness of the skin has become a little less noticeable. No effect No change from before use.

Skin Aging Preventive Effect: [Evaluation] [Content] Effectiveness The scalp and gloss of the skin were improved. Slightly effective Skin tone and gloss were slightly improved. No effect No change from before use.

(Results) The results are shown in Table 3.

[0036]

As is clear from the results shown in Table 3, the creams of Examples 5 and 6 are effective in preventing and improving the loss of "luster", "beam" and "dullness" of the skin, and the prevention of skin aging. The effect was recognized.

Example 7 Modified cosmetic water: <Prescription> (%) (1) Polyoxyethylene hydrogenated castor oil (60 E.O.) 1.0 (2) Ethyl alcohol 10.0 (3) Preservatives 0.0. 1 (4) Perfume proper amount (5) Sardine extract fats and oils 1.0 (6) Assemblage extract ^* 0.5 (7) Sorbitol (70% aqueous solution) 3.0 (8) Sodium pyrrolidonecarboxylate 3.0 (9) Purified water balance * Scortianine [manufactured by Ichimaru Falcos Co., Ltd.]

(Production Method) A. Components (1) to (5) are heated and mixed to dissolve. B. Components (6) to (9) are heated and mixed to dissolve. C. The above A and B were mixed to make uniform, and lotion was obtained.

Example 8 Emulsion: <Prescription> (%) (1) Polyoxyethylene sorbita 1.0 Monostearate (10E.O.) (2) Polyoxyethylene sorbit 0.5 Totetraole (60 E.O.) (3) Glycerin monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Refined avocado oil 4.0 (7) Tri-2-ethylhexanoic acid 4.0 Glycerin (8) Preservative 0.1 (9) DHA ^* 1.0 (10) Witch hazel extract 0.1 (11) Xanthan gum (2% aqueous solution) 7.0 (12) 1,3-butylene Glycol 5.0 (13) Camphor ^** 1.0 (14) Cepharanthin ^*** 1.0 (15) Purified water Remaining amount (16) Fragrance Suitable amount * Made by Serdary Research Lab. Inc. ** Camphor [Takasago Fragrance Industrial Co., Ltd.] *** Cepharanthin (Maruzen Pharmaceutical Co., Ltd.)

(Production method) A. Components (10) to (15) are mixed by heating and kept at 70 ° C. B. Components (1) to (9) are mixed by heating and kept at 70 ° C. C. Add the above B to the above A, mix, and uniformly emulsify. D. After cooling the above C, (16) was added and uniformly mixed to obtain an emulsion.

Example 9 Ointment: <Prescription> (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Oil and fat extracted from saury 2.0 (6) Garlic extract ^* 1.0 (7) Residual amount of purified water * Reisogen [Takeyama Garlic Chemical Co., Ltd.]

(Production Method) A. A part of the components (3), (4) and (7) is mixed by heating and kept at 75 ° C. B. Heat-mix components (1), (2) and (5), and
Keep at 5 ° C. C. Gradually add A above to B above. D. While cooling above C, (6) dissolved in the rest of (7) was added to obtain an ointment.

[0044]

As described in detail above, according to the present invention, EPA
And / or DHA or fats and oils containing the same is blended to obtain a cosmetic which is stable and has an excellent effect of preventing skin aging and an effect of improving rough skin.

Claims (1)

[Claims] 1. Eicosapentaenoic acid and / or docosahexaenoic acid or fats and oils containing the same, and one or more components selected from cembly extract, camphor, nicotinic acid or derivatives thereof, garlic extract, cepharanthin and capsicum tincture. A cosmetic for preventing skin aging containing and.