CN102018703B - Azulene sulfonate-containing gynaecological special lotion - Google Patents
Azulene sulfonate-containing gynaecological special lotion Download PDFInfo
- Publication number
- CN102018703B CN102018703B CN2009100704102A CN200910070410A CN102018703B CN 102018703 B CN102018703 B CN 102018703B CN 2009100704102 A CN2009100704102 A CN 2009100704102A CN 200910070410 A CN200910070410 A CN 200910070410A CN 102018703 B CN102018703 B CN 102018703B
- Authority
- CN
- China
- Prior art keywords
- grams
- special
- lotion
- metronidazole
- sodium azulenesulfonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses azulene-sulfonate-containing gynaecological special lotion. The gynaecological special lotion is prepared from azulene sulfonate and metronidazole, wherein every 500 millimetres of lotion comprises 0.05 to 2.5 grams of azulene sulfonate, 1 to 3 grams of metronidazole and the balance of pure water, and further comprises golden cypress, radix sophorae flavescentis, common cnidium fruit and rhizoma atractylodis, wherein every 500 millimetres of lotion comprises 0.05 to 2.5 grams of azulene sulfonate, 1 to 3 grams of metronidazole, 5 to 10 grams of golden cypress, 5 to 10 grams of radix sophorae flavescentis, 10 to 25 grams of common cnidium fruit, 5 to 10 grams of rhizoma atractylodis and the balance of pure water. The azulene sulfonate-containing gynaecological special lotion is easy to prepare and convenient to use, has good effects of diminishing inflammation and relieving itching, can resist bacteria strikingly without side effects, and cannot stimulate mucousmembranes and skins. Furthermore, the lotion can relieve and eliminate various unwell symptoms of women caused by episioitis and vaginitis, and also can improve the self disease resistance of a female reproductive system.
Description
Technical field
The present invention relates to the special-purpose irrigation of a kind of gynecological; Particularly relate to and a kind ofly can alleviate and eliminate female vulva inflammation and the caused various malaise symptoms of vaginitis, can also strengthen the special-purpose irrigation of the gynecological of containing Sodium Azulenesulfonate of the disease-resistant function of self-defense of female reproductive system.
Background technology
The female genital tract inflammation is gynecological's common disease, and gynecological lotion is a kind of good Therapeutic Method.The main effective ingredient of being seen gynecological lotion has two kinds on the current domestic market, and a kind of is to be main with antibacterial, and another kind is to be main with Chinese medicine.The main feature that with the antibacterial is main gynecological lotion is that in the anaerobe of kill harmful, useful lactobacillus also together is killed, and destroys intravaginal colony balance easily.It is slower with Chinese medicine to be that main gynecological lotion then acts on, and treatment time is long, is difficult for taking effect.
According to pharmacological research, Sodium Azulenesulfonate has very strong antiinflammatory action to the mucosal tissue and the skin of human body, because it is from the natural materials extract, so side effect is seldom, and not stimulating mucosal and skin.At present, field of medicaments uses the various preparations of Sodium Azulenesulfonate to treat the various inflammation and the ulcer of digestion in a large number, does not also see to be used to treat the scorching pharmaceutical preparation of female vulva.Show that through the drug model test Sodium Azulenesulfonate and other medicines are composite can effectively alleviate and eliminate female vulva inflammation and the caused various malaise symptoms of vaginitis, can also strengthen the disease-resistant function of self-defense of female reproductive system.
Summary of the invention
Technical problem to be solved by this invention is; Provide a kind of and can alleviate and eliminate female vulva inflammation and the caused various malaise symptoms of vaginitis, can also strengthen the special-purpose irrigation of the gynecological of containing Sodium Azulenesulfonate of the disease-resistant function of self-defense of female reproductive system.
The technical scheme that the present invention adopted is: the special-purpose irrigation of a kind of gynecological of containing Sodium Azulenesulfonate, include Sodium Azulenesulfonate and metronidazole is prepared from, and wherein, contain Sodium Azulenesulfonate 0.05～2.5g in every 500ml irrigation, metronidazole 1～3g, it is in being purified water.
Also include Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii and Rhizoma Atractylodis, wherein, contain Sodium Azulenesulfonate 0.05～2.5g in every 500ml irrigation, metronidazole 1～3g, Cortex Phellodendri 5～10g, Radix Sophorae Flavescentis 5～10g, Fructus Cnidii 10～25g, Rhizoma Atractylodis 5～10g, it is in being purified water.
The special-purpose irrigation of the gynecological of containing Sodium Azulenesulfonate of the present invention is made simply, easy to use, and antiinflammatory, antipruritic effect are obvious, and tangible antibacterial action is arranged, and are free from side effects, not stimulating mucosal and skin.The caused various malaise symptoms of female vulva inflammation and vaginitis can be alleviated and eliminate, the disease-resistant function of self-defense of female reproductive system can also be strengthened.
The specific embodiment
Below in conjunction with embodiment the special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate of the present invention is made detailed description.
The special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate of the present invention includes Sodium Azulenesulfonate and metronidazole is prepared from, and wherein, contains Sodium Azulenesulfonate 0.05～2.5g in every 500ml irrigation, metronidazole 1～3g, and it is in being purified water.
The special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate of the present invention is except containing Sodium Azulenesulfonate and the metronidazole, also including Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii and Rhizoma Atractylodis; Wherein, contain Sodium Azulenesulfonate 0.05～2.5g in every 500ml irrigation, metronidazole 1～3g; Cortex Phellodendri 5～10g, Radix Sophorae Flavescentis 5～10g, Fructus Cnidii 10～25g; Rhizoma Atractylodis 5～10g, it is in being purified water.
The Sodium Azulenesulfonate that the present invention is used, its chemical name are 1.4-dimethyl-7-isopropyl-3-Sodium Azulenesulfonate, and chemical general formula is: C
15H
17NaO
3S
1/
2H
2O, structural formula is:
It is navy blue crystallization or crystalline powder, and nothing is smelt tasteless, and various inflammation, ulcer and scalds that the position took place such as digestion, respiratory system, urinary system, skin and conjunctiva are all had good curative effect.
Western medicine used in the present invention is a metronidazole.Metronidazole is the white or the crystallization or the crystalline powder of little Huang, have little smelly, bitter in the mouth and slightly salty.These article have anti-amoeba trophozoite effect, and tissue and enteric cavity entamoeba trophozoite are had killing action.The clinical treatment amebiasis is evident in efficacy, comprises asymptomatic, light disease and serious symptom ameba disease, and amebic liver abscess and the outer amebiasis of other intestinal.Anti-trichomonas vaginitis effect: can kill trichomonas vaginitis and do not influence the growth of vagina normal flora, be the at first medicine of treatment trichomonas vaginitis.The effect of anaerobe resistant: morbific anaerobe is had tangible antibacterial action.To the stronger antibacterial activity of treatment anaerobic infection, elected as the essential drugs of treatment anaerobic infection by World Health Organization (WHO) especially.
Chinese medicine used in the present invention is Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis.Their main effect is to have heat clearing and damp drying, eliminating fire and detoxication, kill infusorian, go the function of pruritus.Modern pharmacological research proves that the contained active ingredient of multi-flavor medicine has antibacterial, antipruritic, parasiticidal effect among the we.The contained bark of a cork tree alkali of Cortex Phellodendri has inhibitory action to diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium, streptococcus, staphylococcus aureus.The contained active ingredient of Radix Sophorae Flavescentis has inhibitory action to some fungus and staphylococcus aureus.Fructus Cnidii is to stronger the having of pathogen antimicrbial power: staphylococcus epidermidis, micrococcus catarrhalis, trichomonas vaginitis, leptospira; Fructus Cnidii is to medium the having of pathogen antimicrbial power: staphylococcus aureus, hog cholera bacillus, Bacillus tuberculosis; Fructus Cnidii is to more weak the having of pathogen antimicrbial power: microsporon gypseum, Sabouraudites lanosus.Rhizoma Atractylodis are to medium the having of pathogen antimicrbial power: micrococcus catarrhalis; Rhizoma Atractylodis are to more weak the having of pathogen antimicrbial power: staphylococcus aureus.
Provide specific embodiment below
Embodiment 1
Get: Sodium Azulenesulfonate 0.1g
Metronidazole 2g
Cortex Phellodendri 10g
Radix Sophorae Flavescentis 8g
Fructus Cnidii 20g
Rhizoma Atractylodis 9g
Purified water 450.9g
Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether.
Several kinds of above-mentioned Chinese medicines: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
Embodiment 2
Get: Sodium Azulenesulfonate 0.09g
Metronidazole 3g
Cortex Phellodendri 8g
Radix Sophorae Flavescentis 8g
Fructus Cnidii 15g
Rhizoma Atractylodis 8g
Purified water 457.91g
Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether.
Several kinds of above-mentioned Chinese medicines: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
Embodiment 3
Get: Sodium Azulenesulfonate 2.0g
Metronidazole 1.5g
Cortex Phellodendri 12g
Radix Sophorae Flavescentis 12g
Fructus Cnidii 25g
Rhizoma Atractylodis 12g
Purified water 435.5g
Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether.
Several kinds of above-mentioned Chinese medicines: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
Provide the instance of clinical experiment below:
Select for use case to diagnose patient's 100 examples that gynecological inflammation and pruritus are arranged, do not have other disease through identification.The case inclusion criteria is between 20 one full year of life one full year of life to 50, does not use other antibiotic female patient in the week.
Observation of curative effect: be divided into each 50 people of experimental group and matched group, experimental group contains Sodium Azulenesulfonate, and matched group does not contain Sodium Azulenesulfonate, and treating the course of treatment is 7 days, and every day twice, its result sees the following form.
From table, can find out, the effective percentage 98% of test group, matched group efficient 86%, group difference is remarkable.Therefore, can think that the lotion that contains Sodium Azulenesulfonate is significant to the therapeutic effect of gynecological inflammation and pruritus.
Claims (3)
1. the special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate is characterized in that, is to get: Sodium Azulenesulfonate 0.1g; Metronidazole 2g, Cortex Phellodendri 10g, Radix Sophorae Flavescentis 8g; Fructus Cnidii 20g, Rhizoma Atractylodis 9g, purified water 450.9g; Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether, the Chinese medicine in above-mentioned: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
2. the special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate is characterized in that, is to get: Sodium Azulenesulfonate 0.09g; Metronidazole 3g, Cortex Phellodendri 8g, Radix Sophorae Flavescentis 8g; Fructus Cnidii 15g, Rhizoma Atractylodis 8g, purified water 457.91g; Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether, the Chinese medicine in above-mentioned: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
3. the special-purpose irrigation of gynecological that contains Sodium Azulenesulfonate is characterized in that, is to get: Sodium Azulenesulfonate 2.0g; Metronidazole 1.5g, Cortex Phellodendri 12g, Radix Sophorae Flavescentis 12g; Fructus Cnidii 25g, Rhizoma Atractylodis 12g, purified water 435.5g; Process the special-purpose irrigation 500ml of the gynecological of containing Sodium Azulenesulfonate altogether, the Chinese medicine in above-mentioned: it is composite with other medicines again that Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis are made leachate earlier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100704102A CN102018703B (en) | 2009-09-11 | 2009-09-11 | Azulene sulfonate-containing gynaecological special lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100704102A CN102018703B (en) | 2009-09-11 | 2009-09-11 | Azulene sulfonate-containing gynaecological special lotion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102018703A CN102018703A (en) | 2011-04-20 |
| CN102018703B true CN102018703B (en) | 2012-07-25 |
Family
ID=43860755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100704102A Active CN102018703B (en) | 2009-09-11 | 2009-09-11 | Azulene sulfonate-containing gynaecological special lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102018703B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111632073A (en) * | 2019-03-01 | 2020-09-08 | 王飞 | Antibacterial and anti-inflammatory female privates probiotic composition and preparation thereof |
| CN111631991A (en) * | 2019-03-01 | 2020-09-08 | 王飞 | Private nursing lotion |
| CN110368447A (en) * | 2019-08-09 | 2019-10-25 | 吉安市御美丽健康产业股份有限公司 | A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate |
| CN113230390A (en) * | 2021-01-29 | 2021-08-10 | 南京北极光生物科技有限公司 | Composition, vaginal lotion and application of vaginal lotion in gynecological mucosal injury repair |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169312A (en) * | 1996-06-28 | 1998-01-07 | 陕西咸阳达康菌必杀有限责任公司 | Junbisha vagina-cleaning effervescent agent and preparation process thereof |
| CN1312091A (en) * | 2000-07-25 | 2001-09-12 | 毕启鄂 | Vaginitis treating medicine |
| CN1927195A (en) * | 2006-08-30 | 2007-03-14 | 天津市顶硕科贸有限公司 | Film agent comprising sodium gualenate using for eyes |
-
2009
- 2009-09-11 CN CN2009100704102A patent/CN102018703B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169312A (en) * | 1996-06-28 | 1998-01-07 | 陕西咸阳达康菌必杀有限责任公司 | Junbisha vagina-cleaning effervescent agent and preparation process thereof |
| CN1312091A (en) * | 2000-07-25 | 2001-09-12 | 毕启鄂 | Vaginitis treating medicine |
| CN1927195A (en) * | 2006-08-30 | 2007-03-14 | 天津市顶硕科贸有限公司 | Film agent comprising sodium gualenate using for eyes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102018703A (en) | 2011-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101347541B (en) | Medicament for treating gynecology disease and dermatopathy and preparation thereof | |
| CN1031174C (en) | Bactericidal fabric, its producing method and use thereof | |
| CN103230493B (en) | Traditional Chinese medicine composition for treating unhealed wound | |
| CN102018703B (en) | Azulene sulfonate-containing gynaecological special lotion | |
| CN103070963A (en) | Traditional Chinese medicine preparation for treating candida albicans infection diseases | |
| CN103961552B (en) | A kind of external-applied ointment and preparation method for the treatment of decubital ulcer | |
| CN102085315B (en) | Traditional Chinese medicine composition for treating acute and chronic osteomyelitis | |
| CN103751532B (en) | A kind of Chinese medicine composition treating gynaecological imflammation and preparation method thereof | |
| CN101288754B (en) | Huyuebao preparation | |
| CN101530573B (en) | Chinese medicine for treating tumor | |
| CN106377602A (en) | Dendrobium officinale composite disinfection powder, and preparation method and application method thereof | |
| CN101391065B (en) | Compound momordica seed pepper soup for treating urgent chronic pelvic inflammatory disease | |
| CN102988844A (en) | Gynaecological gel and extraction method thereof | |
| CN103893300B (en) | A kind of Chinese medicine composition treating cow endometritis and preparation method and application | |
| CN101524498B (en) | Traditional Chinese medicine prescription for curing gynecological vaginitis | |
| CN100427118C (en) | Burn and scald medicine | |
| KR20060033070A (en) | Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it | |
| CN102078546A (en) | Gynecological medical lotion for external use | |
| CN103550510A (en) | Lotion for treating various vaginitis | |
| CN109248244A (en) | A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation | |
| CN110227109B (en) | Composition for chronic eczema of pigs and preparation method thereof | |
| CN100558376C (en) | Plain tablet of peppery second and preparation technology thereof | |
| CN103961690B (en) | A kind of external-applied ointment and preparation method for the treatment of decubital ulcer | |
| CN101590199B (en) | Chinese medicinal decoction for treating trichomonal vaginitis | |
| CN104208194A (en) | Traditional Chinese medicine composition for treating bovine endometritis, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160219 Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee after: Tianjin top pharmaceutical technology Co., Ltd. Address before: 300110 Tianjin city Xiqing District Zhangjiawo Industrial Zone Fengze Road No. 6 Patentee before: Tianjin Jing Shuo Science and Trade Co., Ltd. |
|
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 300308, Tianjin free trade test area (Airport Economic Zone), No. 80 North River Road Airport Business Park East 8 building, B205 Patentee after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee before: Tianjin top pharmaceutical technology Co., Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Special gynecological irrigating agent containing sodium azulene sulfonate Effective date of registration: 20210318 Granted publication date: 20120725 Pledgee: Business Department of Bank of Tianjin Co.,Ltd. Pledgor: Tianjin top pharmaceutical Limited by Share Ltd. Registration number: Y2021120000008 |