CN103961552B - A kind of external-applied ointment and preparation method for the treatment of decubital ulcer - Google Patents
A kind of external-applied ointment and preparation method for the treatment of decubital ulcer Download PDFInfo
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Abstract
A kind of external-applied ointment and preparation method for the treatment of decubital ulcer, it is characterized in that: its Chinese medicine proportioning raw materials is: Radix Et Rhizoma Rhei 15g, dried Alumen 30g, Gypsum Fibrosum Preparatum 30g, Sanguis Draxonis 10g, Radix Notoginseng powder 6g, Nidus Vespae 30g, Corium elephatis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Pheretima 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Caulis Spatholobi 15g, Os Draconis (calcined) 20g, Flos Caryophylli 20g, Moschus 2g, Ramulus Cinnamomi 15g, Indigo Naturalis 20g, Aloe 30g, Folium Artemisiae Argyi 10g, Poria 15g, Cortex Moutan 15g, Pollen Pini 10g, Radix Astragali 15g, be equipped with the Oleum Sesami of conventional amount used, Membrana Follicularis ovi 5g, injection heparin 2500u.All medical herbs are except Membrana Follicularis ovi above, pulverize, and add Oleum Sesami and reconcile into paste, and put into aluminum box with holes, upper pot steams 30 minutes, add powdery Membrana Follicularis ovi 5g after cooling, stand-by after being in harmonious proportion.Heparin 2500u mediation evenly rear external is added during use.Use the present invention to treat patients with bedsore 91 example, 46 examples of fully recovering, effective 22 examples, effective 18 examples, invalid 4 examples, total effective rate is 94.50%, occurs without complication such as local skin allergy.
Description
Technical field
The present invention relates to a kind of external-applied ointment and preparation method for the treatment of decubital ulcer.
Background technology
Decubital ulcer (pressure ulcer) is due to the long-term pressurized of local organization, and continuous ischemia, anoxia, malnutrition and cause a kind of disease of tissue fester's necrosis occur.Be more common in the long-term bedridden patients such as paraplegia, chronic debilitating illness, large-area burns and degree of depth stupor.Decubital ulcer is one of common clinically complication, and according to incompletely statistics, the incidence rate of inpatient is 5.1% ~ 32.1%.Often there is wound surface protracted course of disease clinically, expand and deepen, infect and increase the weight of, make skin graft or flap and be difficult to heal by district, the even situation such as flap necrobiosis, and easily cause infection, once deterioration can bring great misery to patient, even there is septicemia and cause death.
Summary of the invention
The object of this invention is to provide a kind of external-applied ointment and preparation method for the treatment of decubital ulcer.
For achieving the above object, the technical solution used in the present invention is:
A kind of external-applied ointment for the treatment of decubital ulcer, it is characterized in that: its Chinese medicine proportioning raw materials is: Radix Et Rhizoma Rhei 15g, dried Alumen 30g, Gypsum Fibrosum Preparatum 30g, Sanguis Draxonis 10g, Radix Notoginseng powder 6g, Nidus Vespae 30g, Corium elephatis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Pheretima 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Caulis Spatholobi 15g, Os Draconis (calcined) 20g, Flos Caryophylli 20g, Moschus 2g, Ramulus Cinnamomi 15g, Indigo Naturalis 20g, Aloe 30g, Folium Artemisiae Argyi 10g, Poria 15g, Cortex Moutan 15g, Pollen Pini 10g, Radix Astragali 15g, be equipped with the Oleum Sesami of conventional amount used, Membrana Follicularis ovi 5g, injection heparin 2500u.
Prepare a method for the external-applied ointment of described treatment decubital ulcer, it is characterized in that: above all medical herbs, except Membrana Follicularis ovi, are pulverized, and add Oleum Sesami and reconcile into paste, put into aluminum box with holes, upper pot steams 30 minutes, adds powdery Membrana Follicularis ovi 5g after cooling, stand-by after being in harmonious proportion.Heparin 2500u mediation evenly rear external is added during use.
Use the present invention to treat external-applied ointment treatment patients with bedsore 91 example of decubital ulcer, 46 examples of fully recovering, effective 22 examples, effective 18 examples, invalid 4 examples, total effective rate is 94.50%, occurs without complication such as local skin allergy.Compare with not using the matched group of Chinese medicinal ointment, difference has statistical significance (P<0.05).This Chinese medicinal ointment obviously can promote the healing of decubital ulcer, and clinical efficacy is remarkable.Ointment is that the one that powder and solid oils are mixed is even, fine and smooth, semisolid external preparation; deeply effect is comparatively strong, can protect skin, prevent extraneous physics, chemical factor to the stimulation of skin; can to moisten skin, protection wound surface and hinder the evaporation of moisture of skin.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment
Raw material of Chinese medicine proportioning of the present invention:
Radix Et Rhizoma Rhei 15g, dried Alumen 30g, Gypsum Fibrosum Preparatum 30g, Sanguis Draxonis 10g, Radix Notoginseng powder 6g, Nidus Vespae 30g, Corium elephatis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Pheretima 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Caulis Spatholobi 15g, Os Draconis (calcined) 20g, Flos Caryophylli 20g, Moschus 2g, Ramulus Cinnamomi 15g, Indigo Naturalis 20g, Aloe 30g, Folium Artemisiae Argyi 10g, Poria 15g, Cortex Moutan 15g, Pollen Pini 10g, Radix Astragali 15g, be equipped with the Oleum Sesami of conventional amount used, Membrana Follicularis ovi 5g, injection heparin 2500u.
Preparation technology:
All medical herbs are except Membrana Follicularis ovi above, pulverize, and add Oleum Sesami and reconcile into paste, and put into aluminum box with holes, upper pot steams 30 minutes, add powdery Membrana Follicularis ovi 5g after cooling, stand-by after being in harmonious proportion.Heparin 2500u mediation evenly rear external is added during use.
Using method: after conventional debridement, with Chinese medicine lotion for external use external application affected part, a situation arises to treat observation two groups of Wound healing rates, healing time, complication after 4 weeks.
Pharmacology analysis:
Radix Et Rhizoma Rhei is bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Rush down and exert oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.
Dried Alumen is irregular crystalline solid, and matter is hard and crisp, easily smashes.Feeble QI, taste is micro-sweet and puckery." detailed outline ": " tell lower sputum drink phosphorus, dampness is detoxified, and chases after saliva, hemostasis analgesic therapy, and meat is disliked in erosion, and raw good meat is controlled carbuncle furuncle and swollen, malignant boil, epilepsy, subcutaneous ulcer disease, relieving bowels, all diseases of ability to speak eyes, brave dog snakes and scorpions hundred insect bite."
Gypsum Fibrosum Preparatum is the powder of white or loose block, and matter is soft, frangible, and odorless is lightly seasoned.Sweet in the mouth, property are pungent, puckery, cold.Attach to the lung and stomach meridians.Cure mainly removing dampness, granulation promoting, sore, hemostasis.External treatment ulcer being unable to heal, eczema pruritus, burn due to hot liquid or fire, traumatic hemorrhage
Sanguis Draxonis, " book on Chinese herbal medicine covers bamboo fish trap ": " acrid in the mouth is salty, and property gas is put down, slightly poisonous." enter the heart, liver, spleen channel.Promoting blood circulation to remove blood stasis for oral administration, analgesic therapy, external hemostasia and promoting granulation, sore.
Radix Notoginseng powder, " book on Chinese herbal medicine converges and says ": sweet and slightly bitter taste, property is put down, nontoxic.Enter liver, stomach, large intestine channel.Be known as and there is significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".
Nidus Vespae sweet in the mouth is put down, and returns stomach warp, enters Yangming Channel, liver, lung two warp.Have detoxicating and killing parasites, effect of wind-expelling pain-stopping, for sore swollen toxin.This product can be assaulted fortified position removing mass, is the product that surgery is conventional.This product light weight and property are apt to away alter, can wind-expelling pain-stopping.
Corium elephatis, " book on Chinese herbal medicine is newly organized ": " sweet in the mouth, gas is put down, nontoxic." enter bladder meridian.Cure mainly granulation promoting, sore.Do not close up for a long time for skin infection.
Radix Arnebiae (Radix Lithospermi) bitter in the mouth, cold in nature, cure mainly and invigorate blood circulation, heat clearing away, removing toxic substances, burn, eczema, erysipelas, carbuncle and ulcer.Modern study proves that Radix Arnebiae (Radix Lithospermi) has inhibitory action to staphylococcus aureus, pyogenic baeceria, escherichia coli.And epithelial growth and treatment burn can be accelerated.Topical application can promote wound healing.
Pheretima acrid in the mouth, temperature.Main Function is dispelling, collateral-activating, arresting convulsion, eliminating stagnation, controls paralysis due to windstroke, severe and migratory arthralgia pain, wind-phlegm infantile convulsion, scrofula, malignant boil etc.
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, puckery, cold nature, returns lung, liver, stomach warp.Cure mainly astringing to arrest bleeding, detumescence and promoting granulation, sore swollen toxin, chapped skin.
Caulis Spatholobi bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel.There is relaxing muscles and tendons to promote blood circulation, effect of the waist gonalgia, rheumatic arthralgia, numb limbs and tense tendons, the normal and compatibility such as the Radix Astragali, Radix Salviae Miltiorrhizae.
Os Draconis (calcined) sweet in the mouth adstringency, flat, there is hemostasis astringing intestine to stop diarrhea, effect of promoting tissue regeneration and ulcer healing.
Flos Caryophylli, " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel.Cure mainly trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
Moschus is warm in nature, nontoxic, bitter in the mouth, enters the heart, spleen, Liver Channel.Have and have one's ideas straightened out, ward off dirty, dredging collateral, scattered silt function.Cure mainly attacked by pestiferous factors unhappiness, trusted subordinate's sudden pain, traumatic injury, swollen ulcer drug.
Ramulus Cinnamomi nature and flavor acrid, sweet, warm, enter lung, the heart, urinary bladder channel, are to cure mainly the conventional drugs for dispelling internal cold of interior cold, have effect of complement sun, promoting blood circulation, warming the spleen and stomach.
Indigo Naturalis nature and flavor are salty-cold, have heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Cure mainly: epidemic febrile disease intenseness of heat, skin ulcer swells, erysipelas." Kaibao Bencao " is recorded: all poison of drug of principal solution, the poison such as deposited herpes simplex of rubbing, evil are swollen, incised wound, hematochezia, Serpentis dog.
Aloe, containing compositions such as phenols, aloin, organic acid, has killing action to some antibacterial, fungus, virus.There is ulcer, promote wound healing, stimulating cellular growth and anastalsis.
Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, nontoxic, return spleen, liver, kidney channel.Pharmacological research shows that Folium Artemisiae Argyi is a kind of medicine of broad-spectrum antibacterial antiviral, and it has suppression and lethal effect to a lot of virus and antibacterial, has warming the meridian for stopping bleeding, effect of dispersing cold for relieving pain
Poria sweet in the mouth, light, property is put down, GUIXIN, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.The lymphocytic cytotoxic effect of T can be strengthened, and therefore activate the immune surveillance system of body to tumor.
Cortex Moutan cures mainly clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, and carbuncle sore tumefacting virus falls and flutters the pain of injury." herbal classic ": " main cold and heat, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer."
Pollen Pini comprises the nutrient substance such as multiple proteins, aminoacid, nucleic acid, monosaccharide, polysaccharide.Warm in nature, sweet in the mouth, has benefiting QI and nourishing blood, a QI invigorating of dispeling the wind, removing dampness, the effects such as hemostasis.Controlling all skin ulcers wets rotten, wound hemorrhage.
Radix Astragali sweet in the mouth, slightly warm in nature, returns lung, spleen, liver, kidney channel.Skin infection is not closed up for a long time, has the effect of promoting tissue regeneration and wound healing.Cave in for skin infection not diabrosis for a long time, have and promote diabrosis and limitation effect.
Oleum Sesami, Chinese medicine is thought: nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Record according in Compendium of Material Medica: " have moisturize, detoxify, pain relieving, detumescence merit.”
Membrana Follicularis ovi, the traditional Chinese medical science calls the inner membrance of Ovum crusta Gallus domesticus " Membrana Follicularis ovi ".This product is the fibrous connective tissue of height collagenzation, be made up of the fibrous tissue parallel with surface of densification, stick bed sore surface, thin and soft because of it, occupancy is strong, and antigenicity is weak, a kind of good natural biological dressing, the maintenance film providing one deck new for wound surface and barrier, make wound surface temporary closure, the chance reducing moisture evaporation and pollute and infect.
Heparin is a kind of anticoagulant, is the glycosaminoglycan be alternately formed by connecting by two kinds of polysaccharide, has the effects such as anticoagulant, infection, promotion revascularization, is conducive to tissue repair and re-epithelialization.Energy alleviating pain, anticoagulant, inflammation-inhibiting reaction, promotion revascularization, recover local blood confession, raising immunity of organisms.Topical application heparin is a kind of effective means for the treatment of decubital ulcer.
Pharmacodynamics statistical analysis:
The clinical efficacy of Chinese medicine lotion for external use treatment decubital ulcer of the present invention.
Method: 182 routine patients with bedsore are pressed the simple randomization method of dividision into groups, is divided into treatment group 91 example, matched group 91 example.After the conventional debridement for the treatment of group, with Chinese medicine lotion for external use external application affected part of the present invention, matched group gives conventional debridement and changes dressings.A situation arises to treat observation two groups of Wound healing rates, healing time, complication after 4 weeks.
Result: treatment group recovery from illness 46 example, effective 22 example, effective 18 example, invalid 5 example, total effective rate is 94.50%, without local skin allergy etc. complication; Matched group recovery from illness 20 example, effective 18 examples, effective 22 examples, invalid 31 examples, total effective rate is 65.93%.Two groups of comparing differences have significant (P<0.05).Conclusion: Chinese medicine lotion for external use of the present invention (certainly intending name: decubital ulcer more) can obviously promote that bedsore wound heals, and evident in efficacy, have no adverse reaction, clinic is applied.
By 182 routine decubital ulcer patients clinical treatments, adopt the Chinese medicine lotion for external use of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting to treat in 91 routine patient's topical therapeutics, compare clinical efficacy with matched group remarkable, facilitate the healing of decubital ulcer.Now be reported as follows:
1. clinical data
1.1 object of study: 182 routine patients with bedsore.Meet in primary disease, Western medicine diagnose standard.After patient's informed consent, tested voluntarily and sign Informed Consent Form.
1.1.1 by the routine patient of sex 182, press the simple randomization method of dividision into groups with the ratio of 1:1, be divided into treatment group and matched group.Details sees the following form 1
Table 1
Two groups of patients divide into groups in sex, and through statistical procedures, no significant difference (P>0.05), has comparability.
1.1.2 age-based, the course of disease, decubital ulcer area, 182 routine patients press the simple randomization method of dividision into groups with the ratio of 1:1, are divided into treatment group and matched group.Details sees the following form 2:
Table 2
Two groups of patients are at age, the course of disease, initial wound surface area through statistical procedures, and no significant difference (P>0.05), has comparability.
1.1.3 by protopathy, the ratio of 182 routine patient 1:1 presses the simple randomization method of dividision into groups, is divided into treatment group and matched group.Details sees the following form 3:
Table 3
Two groups of patients are through statistical procedures in protopathy, and no significant difference (P>0.05), has comparability.
1.1.4 by the site of pathological change of decubital ulcer, 182 routine patients press the simple randomization method of dividision into groups with the ratio of 1:1, are divided into treatment group and matched group.Details sees the following form 4:
Table 4
Two groups of patients are through statistical procedures in site of pathological change, and no significant difference (P>0.05), has comparability.
1.2 diagnostic criterias: 1. Western medicine diagnose standard and by stages: variously weigh the skin decubital ulcer caused wounded, through conventional therapy more than 1 month non-healing person of wound surface.Decubital ulcer is by stages: I phase: pressurized position is rubescent; II phase: pressurized position is rubescent, swelling, scleroma, sometimes visible blisters formed, be deep to festering of skin corium; III phase: cutaneous necrosis, expose fatty tissue; IV phase: adipose tissue necrosis, expose muscular tissue; V phase: muscular tissue is downright bad, exposes periosteum, produce osteomyelitis and suppurative arthritis.
The assessment of wound should by observe wound surface performance and wound surface antibacterial culturing judge whether be infected wound wound by stages: a mummification necrosis phase: wound surface shows as the alternate slough of HUANGBAI(sic) or black crust; The b inflammatory reaction phase: wound surface has a large amount of inflammatory exudate; C granulation trophophase: wound surface is cerise; D epithelium Formation period: wound surface pinkiness, wound shoals; 2. tcm diagnosis standard: local is from the beginning of pain after often first itching, and color is red, rotten to the corn, transfers decubital ulcer to rapidly.Decubital ulcer differs in size, in greyish white or kermesinus, and surface or with yellow pus tongue, pus is dirty smelly unpleasant.Sick decubital ulcer edge is thickening raised for a long time, surrounding color of the leather darkness, unrestrained swollen or with eczema, easy recurrent exerbation after closing up.
1.3 observation index: 1. Wound healing rate: wound healing degree=(original wound surface area-do not heal wound surface area)/original wound surface area × 100%; 2. complication rate: local skin is irritated, suppress allergic symptoms such as breathing heavily.
2. Therapeutic Method
After the debridement for the treatment of group conventional surgical, immobilization with adhesive tape with Chinese medicine lotion for external use even spread of the present invention, then coated with antiseptic gauze, is used in skin ulcer face.Change dressings every day 1 time.Matched group, after conventional surgical debridement, then coated with antiseptic gauze, uses immobilization with adhesive tape.Change dressings every day 1 time.Nursing accomplishes that duty is stood up, diligently clean, diligent massage, diligently to arrange, diligently to change, duty hands over to the next shift
3. the standard of curative effect evaluation
Formulate with reference to " People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect ".Clinical recovery: wound surface heals completely; Effective: wound surface obviously reduces, >=75%, clinical symptom disappearance; Effective: wound surface reduces, <75% or >=25%, clinical symptoms is improved; Invalid: wound surface reduces, <25%, even expands, and clinical symptoms is not improved.
4. therapeutic outcome
4.1 decubital ulcer healing rate statistical tables:
Two groups of patients compare, and treatment group effective percentage is 94.50%, apparently higher than matched group 65.93%.Difference has significant (P<0.05).
4.2 decubital ulcer healing time statistical tables:
Two groups of patients compare, and treatment group healing time is starkly lower than matched group.Difference has significant (P<0.05).
4.3 complication: the allergic symptoms such as the irritated pruritus of local skin do not appear in treatment group, also do not find uncomfortable in chest, suppress the complication such as symptom such as allergy such as breathing heavily.
5. statistical analysis:
SPSS13.0forWindows Chinese edition is adopted to carry out chi-square criterion to observed result. decubital ulcer healing rate and healing time have statistical significance (χ 2=6.160, P < 0.05).
6. discuss
" medical science source and course " is thought: " method of surgery, the heaviest external treatment." " infections section outline " point out: ", for sick, send out outside seeing, external treatment medicine is particularly important for skin infection.All gently shallow cards, specially rely on external treatment, admittedly can receive merit; And dangerous large infections, You Bilai external treatment is proper, is use alternately, of this surgeon." decubital ulcer mostly occurs in sacrococcygeal region, hip and rotor portions.Location tables is shallow, and local application can make the through sick institute of the efficacy of a drug more can play a role, therefore local application becomes main Therapeutic Method, and removing the necrotic tissue and promoting granulation method can promote decubital ulcer slough to come off and granulation tissue growth.
External-applied ointment treatment patients with bedsore 91 example of application for the treatment of decubital ulcer of the present invention, 46 examples of fully recovering, effective 22 examples, effective 18 examples, invalid 4 examples, total effective rate is 94.50%, occurs without complication such as local skin allergy.Compare with not using the matched group of Chinese medicinal ointment, difference has statistical significance (P<0.05).This Chinese medicinal ointment obviously can promote the healing of decubital ulcer, and clinical efficacy is remarkable.Ointment is that the one that powder and solid oils are mixed is even, fine and smooth, semisolid external preparation; deeply effect is comparatively strong, can protect skin, prevent extraneous physics, chemical factor to the stimulation of skin; can to moisten skin, protection wound surface and hinder the evaporation of moisture of skin.
The traditional Chinese medical science is thought, and " decubital ulcer is that to hinder also be skin ulcer, and hinder then qi depression to blood stasis, the stasis of blood is then obstructed, stagnation of QI and blood may bring about pain; The stagnation of QI then temperature is long-pending, the long-pending then rotten pus and blood of temperature ... " by as above method, Chinese medicine is added taste and make various preparation, with blood circulation promoting and blood stasis dispelling, granulation promoting pain relieving and curing the wound; With clearing away heat and cooling blood, putrefaction-removing granulation-promoting and control skin ulcer; Consolidate the principle treatment decubital ulcers such as granulation promoting, have significant curative effect clinically.This clinical research shows, Chinese medicine lotion for external use of the present invention has obvious anti-inflammation detumescence, removing the necrotic tissue and promoting granulation, the healing of promotion bedsore wound, and clinical efficacy is remarkable, and without obvious adverse reaction, clinic is applied.
Embodiment recited above is only be described the preferred embodiment of the present invention; not design of the present invention and protection domain are limited; under the prerequisite not departing from design concept of the present invention; the various modification that in this area, common engineers and technicians make technical scheme of the present invention and improvement, all should fall into protection scope of the present invention.
Claims (2)
1. treat the external-applied ointment of decubital ulcer for one kind, it is characterized in that: its Chinese medicine proportioning raw materials is: Radix Et Rhizoma Rhei 15g, dried Alumen 30g, Gypsum Fibrosum Preparatum 30g, Sanguis Draxonis 10g, Radix Notoginseng powder 6g, Nidus Vespae 30g, Corium elephatis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Pheretima 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Caulis Spatholobi 15g, Os Draconis (calcined) 20g, Flos Caryophylli 20g, Moschus 2g, Ramulus Cinnamomi 15g, Indigo Naturalis 20g, Aloe 30g, Folium Artemisiae Argyi 10g, Poria 15g, Cortex Moutan 15g, Pollen Pini 10g, Radix Astragali 15g, be equipped with the Oleum Sesami of conventional amount used, Membrana Follicularis ovi 5g, injection heparin 2500u.
2. prepare a method for the external-applied ointment for the treatment of decubital ulcer described in claim 1, it is characterized in that: above all medical herbs, except Membrana Follicularis ovi, are pulverized, add Oleum Sesami and reconcile into paste, put into aluminum box with holes, upper pot steams 30 minutes, powdery Membrana Follicularis ovi 5g is added after cooling, stand-by after being in harmonious proportion; Heparin 2500u mediation evenly rear external is added during use.
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| CN105456940A (en) * | 2015-12-30 | 2016-04-06 | 项阳 | External ointment for treating bedsores |
| CN106421396A (en) * | 2016-11-21 | 2017-02-22 | 冯祥柱 | Traditional Chinese medicine ointment with efficacy of tissue regeneration promotion and preparation method of traditional Chinese medicine ointment with efficacy of tissue regeneration promotion |
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