CN103961690B - A kind of external-applied ointment and preparation method for the treatment of decubital ulcer - Google Patents
A kind of external-applied ointment and preparation method for the treatment of decubital ulcer Download PDFInfo
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- CN103961690B CN103961690B CN201410221196.7A CN201410221196A CN103961690B CN 103961690 B CN103961690 B CN 103961690B CN 201410221196 A CN201410221196 A CN 201410221196A CN 103961690 B CN103961690 B CN 103961690B
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Abstract
A kind of external-applied ointment and preparation method for the treatment of decubital ulcer, be made by following medicine material: Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g, be equipped with injection liquid of gentamicin 80,000 U, insuline pro injection 8U.Medicine material is pulverized, and adds clear water and reconciles into paste, and put into aluminum box with holes, upper pot steams 30 minutes, cooling.Used time adds injection liquid of gentamicin 80,000 U, insulin 8U, is in harmonious proportion evenly and uses.The present invention's application Chinese medicinal ointment associating dressing change in surgical department treatment patient 68 example, treatment group recovery from illness 30 example, effective 21 examples, effective 14 examples, invalid 3 examples, total effective rate is 95.59%, without complication appearance such as local skin are irritated.
Description
Technical field
The present invention relates to a kind of external-applied ointment and preparation method for the treatment of decubital ulcer.
Background technology
Decubital ulcer is due to local soft tissue continuous compression, and hemodynamic change causes histiocyte hypoxic-ischemic, Nutrition and Metabolism obstacle and degeneration necrosis occurs.The old age of paralysis, malnutrition or long-term bed easily occurs per capita.Paralytic due to paralysis position stiff, skin loses sensibility, and does not have the pain signal after normal skin pressurized to stimulate, be formation decubital ulcer main cause, autonomic nervous dysfunction causes ischemia to be also one of reason in addition
Decubital ulcer is one of common clinically complication, and according to incompletely statistics, the incidence rate of inpatient is 5.1% ~ 32.1%.Malpractice, often there is wound surface protracted course of disease clinically, expand and deepen, infect and increase the weight of, make skin graft or flap and be difficult to heal by district, even the situation such as flap necrobiosis, and easily cause infection, once deterioration can bring great misery to patient, even there is septicemia and cause death.
Summary of the invention
The object of this invention is to provide a kind of external-applied ointment and preparation method for the treatment of decubital ulcer.
For achieving the above object, the technical solution used in the present invention is:
A kind of external-applied ointment for the treatment of decubital ulcer, it is characterized in that: be made by following medicine material: Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g, be equipped with injection liquid of gentamicin 80,000 U, insuline pro injection 8U.
Prepare a preparation method for the external-applied ointment for the treatment of decubital ulcer, it is characterized in that: described medicine material is pulverized, add clear water and reconcile into paste, put into aluminum box with holes, upper pot steams 30 minutes, cooling.Used time, add injection liquid of gentamicin 80,000 U, insulin 8U, be in harmonious proportion evenly and use.
The present invention's application Chinese medicinal ointment associating dressing change in surgical department treatment patient 68 example, treatment group recovery from illness 30 example, effective 21 examples, effective 14 examples, invalid 3 examples, total effective rate is 95.59%, without complication appearance such as local skin are irritated.Compare with not using the matched group of Chinese medicinal ointment, difference has significant (P<0.01).Illustrate that this Chinese medicinal ointment obviously can promote the healing of decubital ulcer, clinical efficacy is remarkable.Gypsum Fibrosum Preparatum removing dampness in Chinese medicinal ointment prescription, granulation promoting, sore, hemostasis is decubital ulcer key medicine.Calamina dampness, receives warm sore.Spina Gleditsiae searches wind, draws out pus by applying a plaster to the affected part, detumescence, evacuation of pus, and " Amplification on Materia Medica addendum " is pointed out " to be controlled carbuncle routed, can cause the place that bursts." ointment be the one that is mixed of powder and solid oils evenly, fine and smooth, semisolid external preparation; deeply effect is comparatively strong, can protect skin, prevent extraneous physics, chemical factor to the stimulation of skin; skin of can moistening, protection wound surface and hinder the evaporation of moisture of skin.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment
The present invention treats the external-applied ointment medicine material of decubital ulcer:
Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g, be equipped with injection liquid of gentamicin 80,000 U, insuline pro injection 8U.
Preparation technology:
All medicines are pulverized above, add clear water and reconcile into paste, and put into aluminum box with holes, upper pot steams 30 minutes, cooling.Add injection liquid of gentamicin 80,000 U, insulin 8U during use, be in harmonious proportion evenly and use.
Therapeutic Method: route dressing change+outer painting Chinese medicinal ointment of the present invention.
With the cotton ball soaked in alcohol sterilization skin ulcer week skin of 75%, sterilize from inside to outside twice.If pus is too many, try only from inside to outside with normal saline cotton balls, immobilization with adhesive tape with Chinese medicinal ointment even spread of the present invention, then coated with antiseptic gauze, is used in skin ulcer face.Change dressings every day 1 time.
Pharmacology analysis:
Calamina master, containing zinc carbonate (ZnCO3), cures mainly: the antipruritic sore of removing dampness.Do not hold back for decubital ulcer, pus is dripping, eczema, skin pruritus.External can suppress local aureus growth.Can wound extract be partially absorbed, have convergence, protective effect.
Lasiosphaera Seu Calvatia is pungent, flat, nontoxic.Main as local hemostatic, carbuncle furuncle, chilblain." surgery good recipe ": Lasiosphaera Seu Calvatia crocus, rice vinegar dresses the record controlling carbuncle.
Nidus Vespae sweet in the mouth is put down, and returns stomach warp, enters Yangming Channel, liver, lung two warp.Have detoxicating and killing parasites, effect of wind-expelling pain-stopping, for sore swollen toxin.This product can be assaulted fortified position removing mass, is the product that surgery is conventional.This product light weight and property are apt to away alter, can wind-expelling pain-stopping.
Herba Houttuyniae acrid in the mouth, cold.Energy heat-clearing and toxic substances removing, detumescence treat skin ulcer, promoting urination to remove dampness, with controlling sore swollen toxin, retention of heat in the spleen and stomach etc.Modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.
Herba Andrographis bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.External can treat furuncle toxic swelling, trauma infection contamination etc.
Endoconcha Sepiae is the inner shell of sepiella maindroni de Rochebrune or golden cuttlefish, salty in the mouth, puckery, and slightly warm in nature, returns liver, kidney channel.Effect astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, antacid sore.
Auricularia sweet in the mouth is put down, and has removing heat from blood, anastalsis, cures mainly spitting of blood dysentery, metrorrhagia, bleeding hemorrhoids, constipation band blood etc.
Margarita powder, " Chinese medicine voluminous dictionary " indicates: Margarita has effects such as arresting convulsion, removing toxic substances and promoting granulation of calming the nerves, and modern study also shows that Margarita powder is improving the effect all in body immunity, supplement calcium etc. with uniqueness.Compendium of Material Medica is recorded, and Margarita has separates effect that pox treats poison, treats all kinds of skin injurys, traumatic pain exactly, such as carbuncle, skin infection etc.
Corium elephatis, " book on Chinese herbal medicine is newly organized ": " sweet in the mouth, gas is put down, nontoxic." enter bladder meridian." join Endoconcha Sepiae: sore of invigorating blood circulation; Join Olibanum: promoting blood circulation and stopping pain, detumescence blood circulation promoting and blood stasis dispelling.Cure mainly granulation promoting, sore.Do not close up for a long time for skin infection.
Gypsum Fibrosum Preparatum is white powder or loose block.Sweet in the mouth, property is pungent, puckery, cold, attaches to the lung and stomach meridians.Cure mainly removing dampness, granulation promoting, sore, hemostasis.External treatment decubital ulcer is not held back, burn due to hot liquid or fire.More than external curing all surgery diseases, have the effect of heat clearing away, convergence, granulation promoting.
Blood amber sweet in the mouth, property is put down, GUIXIN, liver, small intestinal, bladder, lung, spleen channel.Cure mainly tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, relieving stranguria by diuresis, carbuncle sore tumefacting virus.
Olibanum acrid in the mouth, hardship, warm in nature.Regulating qi and activating blood, analgesic therapy, chases after poison, controls carbuncle pyogenic infections from tumour or sore, traumatic injury.External be powder with deposited skin infection, can detoxify, detumescence, granulation promoting, to relieve the pain, though the product for opening, unlikely wasting QI-blood, sincere good medicine is also.
Myrrha bitter in the mouth, pungent, warm in nature, nontoxic.Myrrha compatibility Flos Carthami Myrrha promoting blood circulation and stopping pain, Flos Carthami activating blood and removing stasis stimulates the menstrual flow.Papillary, have invigorate blood circulation, silt of dispelling, stimulate the menstrual flow, effect of pain relieving, by the stasis pain of the traumatic injury caused by what treatment blood stasis.
Radix Notoginseng has another name called Radix Notoginseng, and ancient times is also known as clear ginseng, Herba Wedeliae Wallichii.Warm in nature, acrid in the mouth, is known as and has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".
Cortex Eucommiae sweet in the mouth, micro-pungent, warm in nature.The modern study Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, diuresis heat clearing away, broad-spectrum antiseptic, improves leukocyte pharmacological action.
Flos Carthami acrid in the mouth, warm in nature, enter the heart, Liver Channel.Cure mainly promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, blood stasis is had a pain, and traumatic injury, skin infection swell and ache curative effect.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen.
Catechu has the functions such as heat clearing away, hemostasis, sore, granulation promoting, analgesic therapy.All inhibitory action is had to staphylococcus aureus, diphtheria corynebacterium, Bacillus proteus, Bacillus typhi.
The clinical efficacy of Chinese medicinal ointment treatment decubital ulcer of the present invention:
Method: 136 routine patients with bedsore are pressed the simple randomization method of dividision into groups, is divided into treatment group 68 example, matched group 68 example.With Chinese medicinal ointment external application affected part of the present invention after treatment group debridement, matched group gives conventional debridement and changes dressings.Treat and to observe 2 after 4 weeks and form face healing, healing time and complication a situation arises.
Result: treatment group recovery from illness 30 example, effective 21 examples, effective 14 examples, invalid 3 examples, total effective rate is 95.59%, without complication appearance such as local skin are irritated.Matched group recovery from illness 10 example, effective 18 examples, effective 24 examples, invalid 16 examples, total effective rate is 65.79%.Two groups of comparing differences have significant (P<0.01).
Conclusion: Chinese medicinal ointment of the present invention can obviously promote that bedsore wound heals, evident in efficacy, and have no adverse reaction, clinic is applied.
Through to 136 routine decubital ulcer patients, adopt the Chinese medicinal ointment of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting to treat in 68 routine patient's topical therapeutics, clinical efficacy is remarkable, is now reported as follows:
1. clinical data
1.1 object of study: 136 routine patients with bedsore.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard
Variously weigh the skin decubital ulcer caused wounded, through conventional therapy more than 1 month non-healing person of wound surface.Decubital ulcer is by stages: I phase: pressurized position is rubescent; II phase: pressurized position is rubescent, swelling, scleroma, sometimes visible blisters formed, be deep to festering of skin corium; III phase: cutaneous necrosis, expose fatty tissue; IV phase: adipose tissue necrosis, expose muscular tissue; V phase: muscular tissue is downright bad, exposes periosteum, produce osteomyelitis and suppurative arthritis.
1.2.2 tcm diagnosis standard and TCM syndrome diagnostic criteria
" People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect ".
1.2.2.1 tcm diagnosis standard
Weigh wounded with sacrococcygeal region, bilateral hip comparatively common, local is from the beginning of pain after often first itching, and color is red, rotten to the corn, transfers decubital ulcer to rapidly.Decubital ulcer differs in size, in greyish white or kermesinus, and surface or with yellow pus tongue, pus is dirty smelly unpleasant.Sick decubital ulcer edge is thickening raised for a long time, surrounding color of the leather darkness, unrestrained swollen or with eczema, easy recurrent exerbation after closing up.
1.3 case inclusive criterias
Meet in primary disease, Western medicine diagnose standard; Lower limb bedsore wound surface area >=2.1cm2; Age >=18 years old, man, female do not limit; After informed consent, tested voluntarily and sign Informed Consent Form.
1.4 observation index
Wound healing rate: wound healing degree=(original wound surface area-do not heal wound surface area)/original wound surface area × 100%.
1.5 physical data
136 routine patients, press the simple randomization method of dividision into groups with the ratio of 1:1, are divided into treatment group and matched group.Details sees the following form:
Two groups of patients are at sex, age, the course of disease, initial wound surface area through statistical procedures, and no significant difference (P>0.05), has comparability.
2. the preparation method of Chinese medicinal ointment
Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g, all medicines are pulverized above, add clear water and reconcile into paste, implant aluminum box with holes, upper pot steams 30 minutes.Cooling.Used time adds injection liquid of gentamicin 80,000 U, insulin 8U, is in harmonious proportion evenly and uses.
3. Therapeutic Method
3.1 treatment groups: route dressing change+outer painting Chinese medicinal ointment of the present invention
With the cotton ball soaked in alcohol sterilization skin ulcer week skin of 75%, sterilize from inside to outside twice.If pus is too many, try only from inside to outside with normal saline cotton balls, immobilization with adhesive tape with Chinese medicinal ointment even spread of the present invention, then coated with antiseptic gauze, is used in skin ulcer face.Change dressings every day 1 time.
3.2 matched groups: only give conventional surgical and change dressings.
. efficacy analysis
4.1 criterions of therapeutical effect are formulated with reference to " People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect ".
4.1.1 clinical recovery: wound surface heals completely.
4.1.2 effective: wound surface obviously reduces, >=75%, clinical symptom disappearance.
4.1.3 effective: wound surface reduces, <75% or >=25%, clinical symptoms is improved.
4.1.4 invalid: wound surface reduces, <25%, even expands, and clinical symptoms is not improved.
4.2 therapeutic outcome
| Treatment group | Matched group | |
| Total number of cases | 68 examples | 68 examples |
| Recovery from illness | 30 examples | 10 examples |
| Effective | 21 examples | 18 examples |
| Effectively | 14 examples | 24 examples |
| Invalid | 3 examples | 16 examples |
| Total effective rate | 95.59% | 65.79% |
Two groups of patients compare, and difference has significant (P<0.01).Do not find the allergic symptoms such as local skin redness, pruritus in treatment group 68 example, also do not find uncomfortable in chest, suppress the symptoms such as allergy such as breathing heavily.
discuss
" medical science source and course " is thought: " method of surgery, the heaviest external treatment." " infections section outline " point out: ", for sick, send out outside seeing, external treatment medicine is particularly important for skin infection.All gently shallow cards, specially rely on external treatment, admittedly can receive merit; And dangerous large infections, You Bilai external treatment is proper, is use alternately, of this surgeon." have the prescription of 33 treatment decubital ulcers in Compendium of Material Medica, be external therapy.Decubital ulcer mostly occurs at sacrococcygeal region, and be secondly bilateral hip, location tables is shallow.Local application can make the through sick institute of the efficacy of a drug more can play a role, and entire patient's situation is often better, sometimes merit can be received by special external treatment, therefore local application becomes main Therapeutic Method, to the series of studies of " removing the necrotic tissue and promoting granulation method ", the modern times also confirm that this method really can promote decubital ulcer slough to come off and granulation tissue growth.
The present invention's application Chinese medicinal ointment associating dressing change in surgical department treatment patient 68 example, treatment group recovery from illness 30 example, effective 21 examples, effective 14 examples, invalid 3 examples, total effective rate is 95.59%, without complication appearance such as local skin are irritated.Compare with not using the matched group of Chinese medicinal ointment, difference has significant (P<0.01).Illustrate that this Chinese medicinal ointment obviously can promote the healing of decubital ulcer, clinical efficacy is remarkable.Gypsum Fibrosum Preparatum removing dampness in Chinese medicinal ointment prescription, granulation promoting, sore, hemostasis is decubital ulcer key medicine.Calamina dampness, receives warm sore.Spina Gleditsiae searches wind, draws out pus by applying a plaster to the affected part, detumescence, evacuation of pus, and " Amplification on Materia Medica addendum " is pointed out " to be controlled carbuncle routed, can cause the place that bursts." ointment be the one that is mixed of powder and solid oils evenly, fine and smooth, semisolid external preparation; deeply effect is comparatively strong, can protect skin, prevent extraneous physics, chemical factor to the stimulation of skin; skin of can moistening, protection wound surface and hinder the evaporation of moisture of skin.
The traditional Chinese medical science is thought, and " decubital ulcer is that to hinder also be skin ulcer, and hinder then qi depression to blood stasis, the stasis of blood is then obstructed, stagnation of QI and blood may bring about pain; The stagnation of QI then temperature is long-pending, the long-pending then rotten pus and blood of temperature ... " by as above method, Chinese medicine is added taste and make various preparation, with blood circulation promoting and blood stasis dispelling, granulation promoting pain relieving and curing the wound; With clearing away heat and cooling blood, putrefaction-removing granulation-promoting and control skin ulcer; Consolidate the principle treatment decubital ulcers such as granulation promoting, have significant curative effect clinically.This clinical research shows, Chinese medicinal ointment of the present invention obviously can promote the healing of decubital ulcer, and clinical efficacy is remarkable, and the method operation is simple, without obvious adverse reaction, clinic is applied.
Embodiment recited above is only be described the preferred embodiment of the present invention; not design of the present invention and protection domain are limited; under the prerequisite not departing from design concept of the present invention; the various modification that in this area, common engineers and technicians make technical scheme of the present invention and improvement, all should fall into protection scope of the present invention.
Claims (2)
1. treat the external-applied ointment of decubital ulcer for one kind, it is characterized in that: be made by following medicine material: Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g, be equipped with injection liquid of gentamicin 80,000 U, insuline pro injection 8U.
2. prepare the preparation method of the external-applied ointment for the treatment of decubital ulcer described in claim 1 for one kind, it is characterized in that: described medicine material Calamina 30g, Lasiosphaera Seu Calvatia 20g, Nidus Vespae 50g, Herba Houttuyniae 15g, Herba Andrographis 15g, Endoconcha Sepiae 15g, Auricularia 30g, Margarita powder 20g, Corium elephatis 15g, Gypsum Fibrosum Preparatum 20g, blood amber 10g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 15g, Cortex Eucommiae 20g, Flos Carthami 20g, catechu 20g pulverizes, add clear water and reconcile into paste, put into aluminum box with holes, upper pot steams 30 minutes, cooling, used time adds injection liquid of gentamicin 80,000 U, insulin 8U, be in harmonious proportion evenly and use.
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| CN100402074C (en) * | 2006-04-19 | 2008-07-16 | 刘子会 | A Chinese medicinal ointment for promoting wound healing after anal fistula operation and preparation method thereof |
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