CN101985416A - 生物发酵法生产长碳链二元酸的精制工艺 - Google Patents
生物发酵法生产长碳链二元酸的精制工艺 Download PDFInfo
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- CN101985416A CN101985416A CN 201010160266 CN201010160266A CN101985416A CN 101985416 A CN101985416 A CN 101985416A CN 201010160266 CN201010160266 CN 201010160266 CN 201010160266 A CN201010160266 A CN 201010160266A CN 101985416 A CN101985416 A CN 101985416A
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- 238000007670 refining Methods 0.000 title claims abstract description 24
- 238000000855 fermentation Methods 0.000 title claims abstract description 22
- 230000004151 fermentation Effects 0.000 title claims abstract description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title abstract description 11
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract description 8
- 238000005516 engineering process Methods 0.000 title abstract description 7
- 239000002253 acid Substances 0.000 claims abstract description 41
- 238000002425 crystallisation Methods 0.000 claims abstract description 33
- 230000008025 crystallization Effects 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000000926 separation method Methods 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims abstract description 13
- 150000007520 diprotic acids Chemical class 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 23
- 239000000047 product Substances 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 239000012043 crude product Substances 0.000 claims description 8
- 238000007701 flash-distillation Methods 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 238000004042 decolorization Methods 0.000 claims description 4
- 239000004831 Hot glue Substances 0.000 abstract description 3
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- 229920006351 engineering plastic Polymers 0.000 abstract description 3
- 239000003973 paint Substances 0.000 abstract description 3
- 239000004014 plasticizer Substances 0.000 abstract description 3
- 235000013599 spices Nutrition 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 2
- 239000010687 lubricating oil Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 5
- 239000000178 monomer Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 238000012356 Product development Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- TVIDDXQYHWJXFK-UHFFFAOYSA-N dodecanedioic acid Chemical compound OC(=O)CCCCCCCCCCC(O)=O TVIDDXQYHWJXFK-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
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CN201010160266.4A CN101985416B (zh) | 2010-04-30 | 2010-04-30 | 生物发酵法生产长碳链二元酸的精制工艺 |
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CN201010160266.4A CN101985416B (zh) | 2010-04-30 | 2010-04-30 | 生物发酵法生产长碳链二元酸的精制工艺 |
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CN101985416A true CN101985416A (zh) | 2011-03-16 |
CN101985416B CN101985416B (zh) | 2016-11-09 |
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Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329211A (zh) * | 2011-09-13 | 2012-01-25 | 淮安清江石油化工有限责任公司 | C12-c13长链二元酸的精制方法 |
CN102329212A (zh) * | 2011-09-13 | 2012-01-25 | 淮安清江石油化工有限责任公司 | 长链二元酸的精制方法 |
CN104496793A (zh) * | 2014-12-26 | 2015-04-08 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的精制方法 |
CN104529741A (zh) * | 2014-12-26 | 2015-04-22 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的提纯方法 |
CN107326051A (zh) * | 2017-08-02 | 2017-11-07 | 上海凯赛生物技术研发中心有限公司 | 一种微生物发酵法生产的癸二酸及其制备方法 |
CN109516913A (zh) * | 2017-09-18 | 2019-03-26 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸水相熔融结晶工艺 |
CN109652472A (zh) * | 2019-02-26 | 2019-04-19 | 成都锦汇科技有限公司 | 一种长碳链二元酸生物发酵制备方法 |
CN110002992A (zh) * | 2019-03-24 | 2019-07-12 | 张艾琳 | 一种正长链二元酸的精制方法 |
CN110041193A (zh) * | 2019-03-24 | 2019-07-23 | 张艾琳 | 一种惰性气体保护下的正长链二元酸的精制方法 |
EP3591063A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long chain dibasic acid with low content of long chain dibasic acid impurity of shorter carbon-chain and preparation method thereof |
EP3591043A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long-chain dibasic acid with low content of fatty acid impurity and a method of producing the same |
EP3591044A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long-chain dibasic acid with low content of monobasic acid impurity and the production method thereof |
EP3591062A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof |
CN111039776A (zh) * | 2019-12-31 | 2020-04-21 | 淄博广通化工有限责任公司 | 高纯度的混合长碳链二元羧酸及其制备方法 |
CN111087298A (zh) * | 2019-12-31 | 2020-05-01 | 淄博广通化工有限责任公司 | 一种混合长碳链二元羧酸及其制备方法 |
CN117326936A (zh) * | 2023-12-01 | 2024-01-02 | 山东归源生物科技有限公司 | 一种长碳链二元酸的精制方法及其装置 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1410408A (zh) * | 2001-12-21 | 2003-04-16 | 淄博广通化工有限责任公司 | 碳11-18长链二元酸精制方法 |
CN1844404A (zh) * | 2006-02-14 | 2006-10-11 | 南通圣诺鑫生物科技有限公司 | 微生物发酵生产混合长链二元酸的方法 |
-
2010
- 2010-04-30 CN CN201010160266.4A patent/CN101985416B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1410408A (zh) * | 2001-12-21 | 2003-04-16 | 淄博广通化工有限责任公司 | 碳11-18长链二元酸精制方法 |
CN1844404A (zh) * | 2006-02-14 | 2006-10-11 | 南通圣诺鑫生物科技有限公司 | 微生物发酵生产混合长链二元酸的方法 |
Non-Patent Citations (1)
Title |
---|
《合成纤维工业》 20090410 李占朝 十二碳二元酸的重结晶精制工艺 31-34 1-6 第32卷, 第2期 * |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329211A (zh) * | 2011-09-13 | 2012-01-25 | 淮安清江石油化工有限责任公司 | C12-c13长链二元酸的精制方法 |
CN102329212A (zh) * | 2011-09-13 | 2012-01-25 | 淮安清江石油化工有限责任公司 | 长链二元酸的精制方法 |
CN102329212B (zh) * | 2011-09-13 | 2014-02-12 | 中国石油化工股份有限公司 | 长链二元酸的精制方法 |
CN102329211B (zh) * | 2011-09-13 | 2014-04-09 | 中国石油化工股份有限公司 | C12-c13长链二元酸的精制方法 |
CN104496793A (zh) * | 2014-12-26 | 2015-04-08 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的精制方法 |
CN104529741A (zh) * | 2014-12-26 | 2015-04-22 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的提纯方法 |
CN104529741B (zh) * | 2014-12-26 | 2016-03-30 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的提纯方法 |
CN104496793B (zh) * | 2014-12-26 | 2016-05-18 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的精制方法 |
US11802298B2 (en) | 2017-08-02 | 2023-10-31 | Cathay Biotech Inc. | Decanedioic acid produced by microbial fermentation process and preparation method thereof |
CN107326051A (zh) * | 2017-08-02 | 2017-11-07 | 上海凯赛生物技术研发中心有限公司 | 一种微生物发酵法生产的癸二酸及其制备方法 |
US10851394B2 (en) | 2017-08-02 | 2020-12-01 | Cathay Biotech Inc. | Decanedioic acid produced by microbial fermentation process and preparation method thereof |
CN107326051B (zh) * | 2017-08-02 | 2021-06-08 | 上海凯赛生物技术股份有限公司 | 一种微生物发酵法生产的癸二酸及其制备方法 |
CN109516913A (zh) * | 2017-09-18 | 2019-03-26 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸水相熔融结晶工艺 |
CN109516913B (zh) * | 2017-09-18 | 2022-05-10 | 上海凯赛生物技术股份有限公司 | 长链二元酸水相熔融结晶工艺 |
EP3591063A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long chain dibasic acid with low content of long chain dibasic acid impurity of shorter carbon-chain and preparation method thereof |
EP3591043A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long-chain dibasic acid with low content of fatty acid impurity and a method of producing the same |
EP3591044A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | A long-chain dibasic acid with low content of monobasic acid impurity and the production method thereof |
EP3591062A1 (en) | 2018-07-06 | 2020-01-08 | Cathay Biotech Inc. | Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof |
CN109652472A (zh) * | 2019-02-26 | 2019-04-19 | 成都锦汇科技有限公司 | 一种长碳链二元酸生物发酵制备方法 |
CN110041193A (zh) * | 2019-03-24 | 2019-07-23 | 张艾琳 | 一种惰性气体保护下的正长链二元酸的精制方法 |
CN110041193B (zh) * | 2019-03-24 | 2023-01-06 | 张艾琳 | 一种惰性气体保护下的正长链二元酸的精制方法 |
CN110002992B (zh) * | 2019-03-24 | 2023-01-06 | 张艾琳 | 一种正长链二元酸的精制方法 |
CN110002992A (zh) * | 2019-03-24 | 2019-07-12 | 张艾琳 | 一种正长链二元酸的精制方法 |
CN111087298A (zh) * | 2019-12-31 | 2020-05-01 | 淄博广通化工有限责任公司 | 一种混合长碳链二元羧酸及其制备方法 |
CN111039776A (zh) * | 2019-12-31 | 2020-04-21 | 淄博广通化工有限责任公司 | 高纯度的混合长碳链二元羧酸及其制备方法 |
CN117326936A (zh) * | 2023-12-01 | 2024-01-02 | 山东归源生物科技有限公司 | 一种长碳链二元酸的精制方法及其装置 |
CN117326936B (zh) * | 2023-12-01 | 2024-02-02 | 山东归源生物科技有限公司 | 一种长碳链二元酸的精制方法及其装置 |
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Inventor after: Lei Guang Inventor after: Li Naiqiang Inventor before: Cao Wubo Inventor before: Wang Zhizhou Inventor before: Ge Minghua Inventor before: Chen Yuantong Inventor before: Fu Shenzhan |
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Effective date of registration: 20160831 Address after: 272000 South East Ring Road, 327 National Road, Jining hi tech Development Zone, Shandong, China Applicant after: Shandong Cathay Biotechnological Material Co., Ltd. Applicant after: Shanghai Cathay Biotechnology Research and Development Center Co., Ltd. Address before: 265200 Shandong Province, Laiyang City Emei Road Economic Development Zone No. 1 Applicant before: Shandong Hilead Biotechnology Co., Ltd. |
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Effective date of registration: 20160929 Address after: 201203 Shanghai City, Shanghai Free Trade Zone No. 1690 No. 5 Cailun Road, 4 floor Applicant after: Shanghai Cathay Biotechnology Research and Development Center Co., Ltd. Address before: 272000 South East Ring Road, 327 National Road, Jining hi tech Development Zone, Shandong, China Applicant before: Shandong Cathay Biotechnological Material Co., Ltd. Applicant before: Shanghai Cathay Biotechnology Research and Development Center Co., Ltd. |
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Address after: 201203 Shanghai City, Shanghai Free Trade Zone No. 1690 No. 5 Cailun Road, 4 floor Patentee after: Shanghai Kaisai Biotechnology Co., Ltd. Address before: 201203 Shanghai City, Shanghai Free Trade Zone No. 1690 No. 5 Cailun Road, 4 floor Patentee before: Shanghai Cathay Biotechnology Research and Development Center Co., Ltd. |