CN101981003B - 酰胺化合物、组合物及其应用 - Google Patents
酰胺化合物、组合物及其应用 Download PDFInfo
- Publication number
- CN101981003B CN101981003B CN200980111248.2A CN200980111248A CN101981003B CN 101981003 B CN101981003 B CN 101981003B CN 200980111248 A CN200980111248 A CN 200980111248A CN 101981003 B CN101981003 B CN 101981003B
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- Prior art keywords
- methyl
- biphenyl
- carboxylic acid
- amide
- pyridin
- Prior art date
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Classifications
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US6759008P | 2008-02-29 | 2008-02-29 | |
| US61/067,590 | 2008-02-29 | ||
| US12453108P | 2008-04-17 | 2008-04-17 | |
| US61/124,531 | 2008-04-17 | ||
| US11629008P | 2008-11-19 | 2008-11-19 | |
| US61/116,290 | 2008-11-19 | ||
| US15590509P | 2009-02-26 | 2009-02-26 | |
| US61/155,905 | 2009-02-26 | ||
| PCT/US2009/001249 WO2009110985A2 (en) | 2008-02-29 | 2009-02-27 | Amide compounds, compositions and uses thereof |
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| CN201410266032.6A Division CN104058999A (zh) | 2008-02-29 | 2009-02-27 | 酰胺化合物、组合物及其应用 |
| CN201410266996.0A Division CN104016907B (zh) | 2008-02-29 | 2009-02-27 | 酰胺化合物、组合物及其应用 |
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| CN101981003A CN101981003A (zh) | 2011-02-23 |
| CN101981003B true CN101981003B (zh) | 2014-07-02 |
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| US (2) | US8946439B2 (https=) |
| EP (1) | EP2262766B1 (https=) |
| JP (2) | JP5539235B2 (https=) |
| CN (2) | CN101981003B (https=) |
| CA (1) | CA2715835C (https=) |
| ES (1) | ES2557281T3 (https=) |
| MX (1) | MX2010009561A (https=) |
| WO (1) | WO2009110985A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2703909A1 (en) * | 2007-10-31 | 2009-05-07 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| MX2010009561A (es) * | 2008-02-29 | 2010-09-24 | Renovis Inc | Compuestos amida, composiciones y usos de los mismos. |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| EP2435407B1 (en) * | 2009-05-29 | 2019-12-25 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
| US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| EP3130583B1 (en) | 2012-04-05 | 2024-01-03 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2014135508A1 (de) * | 2013-03-06 | 2014-09-12 | Lanxess Deutschland Gmbh | Verfahren zur herstellung von halogen-n,n-dimethylbenzylaminen |
| EP2774911A1 (de) * | 2013-03-06 | 2014-09-10 | LANXESS Deutschland GmbH | Verfahren zur Herstellung von Halogen-N,N-dimethylbenzylaminen |
| WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| EP2970136A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| CA2903264A1 (en) | 2013-03-14 | 2014-11-06 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| US9045455B2 (en) | 2013-03-14 | 2015-06-02 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| PL2970132T3 (pl) | 2013-03-14 | 2021-04-06 | Epizyme, Inc. | Inhibitory metylotransferazy argininy i ich zastosowania |
| US9765035B2 (en) | 2013-03-14 | 2017-09-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9023883B2 (en) | 2013-03-14 | 2015-05-05 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| EP3363434A1 (en) | 2013-03-14 | 2018-08-22 | Epizyme Inc | Arginine methyltransferase inhibitors and uses thereof |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
| CA2903813C (en) | 2013-03-15 | 2023-08-29 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| EP2970266B1 (en) | 2013-03-15 | 2018-01-31 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| ES2754473T3 (es) | 2013-09-26 | 2020-04-17 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas, y método de uso de los mismos |
| US9884853B2 (en) | 2013-09-26 | 2018-02-06 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2015078374A1 (en) * | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| EP2905282A1 (en) | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
| WO2015170218A1 (en) | 2014-05-07 | 2015-11-12 | Pfizer Inc. | Tropomyosin-related kinase inhibitors |
| WO2016044641A2 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Carm1 inhibitors and uses thereof |
| WO2016044585A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| HUE058009T2 (hu) * | 2014-12-09 | 2022-06-28 | Bayer Ag | 1,3-Tiazol-2-il szubsztituált benzamid-származékok |
| WO2017112576A1 (en) * | 2015-12-21 | 2017-06-29 | Dow Global Technologies Llc | Methods for external base-free suzuki couplings |
| CN106349153B (zh) * | 2016-08-25 | 2019-03-05 | 西安天一生物技术股份有限公司 | 2-甲基-5-乙烯基吡啶合成方法 |
| RU2679892C1 (ru) * | 2017-11-01 | 2019-02-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) | 4-метилфениламид n-бензоил-5-бром антраниловой кислоты, проявляющий противовоспалительную активность |
| WO2019219674A1 (en) * | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| CA3100096A1 (en) * | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| US10844044B2 (en) | 2018-06-14 | 2020-11-24 | Vanderbilt University | WDR5 inhibitors and modulators |
| US10807959B2 (en) * | 2018-08-16 | 2020-10-20 | Vanderbilt University | WDR5-MLL1 inhibitors and modulators |
| US12186307B2 (en) | 2019-02-13 | 2025-01-07 | Yale University | Methods of treating epilepsy |
| CN114222741B (zh) | 2019-05-31 | 2025-12-30 | 奇斯药制品公司 | 作为p2x3抑制剂的吡啶并嘧啶类衍生物 |
| BR112021022099A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| JP2022116370A (ja) * | 2019-06-13 | 2022-08-10 | アグロカネショウ株式会社 | 新規な1-ベンジルアミン誘導体及びこれを有効成分とする農園芸用薬剤 |
| EP3757103A1 (en) * | 2019-06-27 | 2020-12-30 | Bayer AG | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases |
| CN115397813A (zh) * | 2020-04-16 | 2022-11-25 | 豪夫迈·罗氏有限公司 | 联苯衍生物 |
| AU2021282039A1 (en) * | 2020-05-25 | 2022-12-01 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Arylformamide compound and preparation method and medical use thereof |
| AU2021388923A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| JP2023550830A (ja) | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | P2x3阻害剤としての(アザ)キノリン4-アミン誘導体 |
| KR20230113289A (ko) | 2020-11-27 | 2023-07-28 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 프탈라진 유도체 |
| CN121399115A (zh) * | 2023-05-30 | 2026-01-23 | 三进制药株式会社 | 新的苯甲酰胺衍生物化合物及包含其的药物组合物 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2731469A (en) * | 1953-10-23 | 1956-01-17 | Searle & Co | N-dialkylaminoalkyl derivatives of diarylisonicotinamides |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| CA1316920C (en) | 1987-06-12 | 1993-04-27 | Terry N. Myers | Hindered amine light stabilizers containing aromatic carboxy groups and derivatives |
| JPS6413083A (en) | 1987-07-07 | 1989-01-17 | Akishiro Nakamura | Streptonigrin derivative and medicinal composition |
| US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
| GB9600063D0 (en) | 1996-01-03 | 1996-03-06 | Fujisawa Pharmaceutical Co | Guaridine derivatives |
| US6037324A (en) | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| ATE306481T1 (de) | 1999-05-12 | 2005-10-15 | Ortho Mcneil Pharm Inc | Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| AU2001294557A1 (en) * | 2000-09-11 | 2002-03-26 | Merck And Co., Inc. | Thrombin inhibitors |
| WO2002070469A2 (en) | 2001-03-05 | 2002-09-12 | Icos Corporation | Selective pde3b inhibitors and use of the same in therapy |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| ES2249589T3 (es) * | 2001-05-18 | 2006-04-01 | Abbott Laboratories | Trisustituido-n-((1s)-1,2,3,4-tetrahidro-1-naftalenil)benzamidas que inhiben receptores que contienen antagonistas p2x3 y p2x2/3. |
| WO2008011131A2 (en) | 2006-07-21 | 2008-01-24 | Takeda Pharmaceutical Company Limited | Amide compounds |
| AR037460A1 (es) | 2001-11-30 | 2004-11-10 | Smithkline Beecham Plc | Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion |
| EP1503997A1 (en) | 2002-05-14 | 2005-02-09 | Axys Pharmaceuticals, Inc. | Cysteine protease inhibitors |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| WO2004052921A1 (en) | 2002-12-05 | 2004-06-24 | Axys Pharmaceuticals, Inc. | Cyanomethyl derivatives as cysteine protease inhibitors |
| WO2004056774A2 (en) | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| AU2004277981B2 (en) * | 2003-10-03 | 2009-10-01 | Merck & Co., Inc. | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease |
| CA2548849A1 (en) | 2003-12-19 | 2005-07-21 | Merck & Co., Inc. | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2005073193A1 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| AU2005245376A1 (en) * | 2004-05-13 | 2005-12-01 | Merck & Co., Inc. | Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| MX2007013595A (es) | 2005-05-04 | 2008-01-24 | Renovis Inc | Compuestos heterociclicos fusionados y composiciones y usos de estos. |
| US20100144681A1 (en) | 2005-08-11 | 2010-06-10 | Klaus Fuchs | Compounds for the treatment of alzheimer's disease |
| WO2007017510A2 (de) * | 2005-08-11 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Isophthalsäurediamide zur behandlung der alzheimer erkrankung |
| CN102659774A (zh) | 2005-08-15 | 2012-09-12 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3拮抗剂的哌啶和哌嗪衍生物 |
| CA2620129C (en) | 2005-09-01 | 2014-12-23 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2007025900A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
| JP4850914B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
| CA2619919C (en) | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| US7838676B2 (en) | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| WO2007115409A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| EP2592070B1 (en) | 2006-06-29 | 2016-08-31 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamides |
| MX2009002046A (es) | 2006-08-24 | 2009-03-06 | Astrazeneca Ab | Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos. |
| AR063258A1 (es) | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
| EP2091927B1 (en) * | 2006-11-09 | 2011-07-20 | F. Hoffmann-La Roche AG | Thiazole and oxazole-substituted arylamides |
| WO2008119773A1 (en) | 2007-03-30 | 2008-10-09 | Medivir Ab | Amide derivatives as inhibitors of aspartyl proteases |
| JP5498374B2 (ja) | 2007-04-17 | 2014-05-21 | エボテック・アーゲー | 2−シアノフェニル縮合複素環式化合物および組成物、ならびにその使用 |
| AU2008319309B2 (en) | 2007-10-31 | 2012-09-06 | Merck Sharp & Dohme Llc | P2X3 receptor antagonists for treatment of pain |
| CA2703909A1 (en) * | 2007-10-31 | 2009-05-07 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| ES2417182T3 (es) | 2007-12-17 | 2013-08-06 | F. Hoffmann-La Roche Ag | Nuevas arilamidas sustituidas con pirazol |
| CA2708791C (en) | 2007-12-17 | 2016-06-21 | F. Hoffmann-La Roche Ag | Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists |
| US7989454B2 (en) * | 2007-12-17 | 2011-08-02 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
| ES2542245T3 (es) | 2007-12-17 | 2015-08-03 | F. Hoffmann-La Roche Ag | Derivados de arilamida sustituido con triazol y su utilización como antagonistas del receptor purinérgico P2x3 y/o P2x2/3 |
| EP2234989B1 (en) | 2007-12-17 | 2014-08-13 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
| MX2010009561A (es) * | 2008-02-29 | 2010-09-24 | Renovis Inc | Compuestos amida, composiciones y usos de los mismos. |
| CA2737038A1 (en) * | 2008-09-18 | 2010-03-25 | Evotec Ag | Amide compounds, compositions and uses thereof |
| ES2534199T3 (es) | 2008-10-31 | 2015-04-20 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| EP2379518B1 (en) * | 2008-12-16 | 2014-05-07 | F. Hoffmann-La Roche AG | Thiadiazole-substituted arylamides |
| WO2010111058A1 (en) | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| AU2010229144B2 (en) | 2009-03-23 | 2012-07-12 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| US20100320456A1 (en) * | 2009-06-19 | 2010-12-23 | Epv Solar, Inc. | Method for Fabricating a Doped and/or Alloyed Semiconductor |
| EP2445889B1 (en) * | 2009-06-22 | 2016-08-10 | F.Hoffmann-La Roche Ag | Novel benzoxazolone -substituted arylamides |
| CN102574778B (zh) | 2009-06-22 | 2015-01-07 | 弗·哈夫曼-拉罗切有限公司 | 新的联苯基和苯基-吡啶酰胺类化合物 |
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- 2009-02-27 CN CN200980111248.2A patent/CN101981003B/zh not_active Expired - Fee Related
- 2009-02-27 CN CN201410266032.6A patent/CN104058999A/zh active Pending
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Also Published As
| Publication number | Publication date |
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| JP5916700B2 (ja) | 2016-05-11 |
| CN104016907A (zh) | 2014-09-03 |
| US20110065681A1 (en) | 2011-03-17 |
| JP2014065737A (ja) | 2014-04-17 |
| JP2011514894A (ja) | 2011-05-12 |
| US8946439B2 (en) | 2015-02-03 |
| CN104058999A (zh) | 2014-09-24 |
| US20150266822A1 (en) | 2015-09-24 |
| EP2262766A2 (en) | 2010-12-22 |
| CA2715835C (en) | 2017-03-21 |
| WO2009110985A2 (en) | 2009-09-11 |
| HK1149007A1 (en) | 2011-09-23 |
| JP5539235B2 (ja) | 2014-07-02 |
| CA2715835A1 (en) | 2009-09-11 |
| WO2009110985A3 (en) | 2010-02-25 |
| CN101981003A (zh) | 2011-02-23 |
| MX2010009561A (es) | 2010-09-24 |
| ES2557281T3 (es) | 2016-01-25 |
| EP2262766B1 (en) | 2015-11-11 |
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