CN101959849A - 作为抗菌剂的新型半合成糖肽 - Google Patents

作为抗菌剂的新型半合成糖肽 Download PDF

Info

Publication number
CN101959849A
CN101959849A CN2008801275540A CN200880127554A CN101959849A CN 101959849 A CN101959849 A CN 101959849A CN 2008801275540 A CN2008801275540 A CN 2008801275540A CN 200880127554 A CN200880127554 A CN 200880127554A CN 101959849 A CN101959849 A CN 101959849A
Authority
CN
China
Prior art keywords
alkyl
substituted
compound
alkoxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801275540A
Other languages
English (en)
Chinese (zh)
Inventor
丹尼尔·楚
叶涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Lead Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Therapeutics Inc filed Critical Lead Therapeutics Inc
Publication of CN101959849A publication Critical patent/CN101959849A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2008801275540A 2007-12-26 2008-12-05 作为抗菌剂的新型半合成糖肽 Pending CN101959849A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1678307P 2007-12-26 2007-12-26
US61/016,783 2007-12-26
PCT/US2008/085716 WO2009085562A1 (en) 2007-12-26 2008-12-05 Novel semi-synthetic glycopeptides as antibacterial agents

Publications (1)

Publication Number Publication Date
CN101959849A true CN101959849A (zh) 2011-01-26

Family

ID=40344127

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801275540A Pending CN101959849A (zh) 2007-12-26 2008-12-05 作为抗菌剂的新型半合成糖肽

Country Status (12)

Country Link
US (1) US20120129763A1 (https=)
EP (1) EP2238102A4 (https=)
JP (1) JP2011507959A (https=)
KR (1) KR20100109936A (https=)
CN (1) CN101959849A (https=)
AR (1) AR071552A1 (https=)
AU (1) AU2008343502A1 (https=)
CA (1) CA2710602A1 (https=)
GB (1) GB2457549B (https=)
IL (1) IL206622A0 (https=)
TW (1) TW200940083A (https=)
WO (1) WO2009085562A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349343A (zh) * 2016-03-24 2017-01-25 中国医学科学院医药生物技术研究所 去甲万古霉素衍生物及其制备纯化方法
WO2018010476A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN110996984A (zh) * 2017-05-22 2020-04-10 英斯麦德公司 脂糖肽可裂解衍生物及其用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
WO2011140009A1 (en) * 2010-05-04 2011-11-10 Biomarin Pharmaceutical Inc. Methods of using semi-synthetic glycopeptides as antibacterial agents
CN103897040B (zh) * 2012-12-27 2018-05-22 浙江医药股份有限公司新昌制药厂 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途
CN108948157B (zh) * 2018-07-31 2021-08-03 丽珠集团新北江制药股份有限公司 一种制备特拉万星的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662674B2 (ja) * 1985-01-11 1994-08-17 三共株式会社 抗生物質クロロポリスポリンｂまたはｃ
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
DE69908819T2 (de) * 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
US6699836B2 (en) * 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
JP4381531B2 (ja) * 1999-12-08 2009-12-09 塩野義製薬株式会社 グリコペプチド誘導体
MXPA02006029A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
US6770621B2 (en) * 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
WO2005007162A1 (en) * 2003-07-10 2005-01-27 Vertex Pharmaceuticals Incorporated Compounds augmenting the activity of antibacterial agents
ATE381957T1 (de) * 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
CN1883706A (zh) * 2006-05-22 2006-12-27 济南康泉医药科技有限公司 一种局部应用的抗生素缓释剂
US8236926B2 (en) * 2006-09-06 2012-08-07 Wisconsin Alumni Research Foundation Rapid glycopeptide optimization via neoglycosylation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349343A (zh) * 2016-03-24 2017-01-25 中国医学科学院医药生物技术研究所 去甲万古霉素衍生物及其制备纯化方法
WO2017161909A1 (zh) * 2016-03-24 2017-09-28 中国医学科学院医药生物技术研究所 去甲万古霉素衍生物及其制备纯化方法
WO2018010476A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN107619432A (zh) * 2016-07-15 2018-01-23 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN107619432B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN110996984A (zh) * 2017-05-22 2020-04-10 英斯麦德公司 脂糖肽可裂解衍生物及其用途
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途

Also Published As

Publication number Publication date
KR20100109936A (ko) 2010-10-11
CA2710602A1 (en) 2009-07-09
JP2011507959A (ja) 2011-03-10
IL206622A0 (en) 2010-12-30
GB2457549A (en) 2009-08-26
US20120129763A1 (en) 2012-05-24
AR071552A1 (es) 2010-06-30
WO2009085562A1 (en) 2009-07-09
EP2238102A4 (en) 2011-03-09
GB2457549B (en) 2010-04-07
GB0823463D0 (en) 2009-01-28
EP2238102A1 (en) 2010-10-13
TW200940083A (en) 2009-10-01
AU2008343502A1 (en) 2009-07-09

Similar Documents

Publication Publication Date Title
CN101959849A (zh) 作为抗菌剂的新型半合成糖肽
CN105308065A (zh) 多粘菌素衍生物及其在与不同抗生素的组合疗法中的用途
KR20110119699A (ko) 데옥시악타가르딘 유도체
US20080214444A1 (en) Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
JP2012509866A (ja) 抗菌活性を強化したランチビオティック型カルボキシアミド誘導体
WO2011140009A1 (en) Methods of using semi-synthetic glycopeptides as antibacterial agents
US7632918B2 (en) Semi-synthetic glycopeptides with antibiotic activity
US20090131304A1 (en) Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity
CN102307903A (zh) 作为抗菌剂的新型半合成糖肽
US20100216699A1 (en) Semi-synthetic glycopeptides having antibacterial activity
WO2008140973A1 (en) Semi-synthetic glycopeptides with antibacterial activity
CN101107000A (zh) 3,6-双环大环内酯物
US20120252741A1 (en) Novel semi-synthetic glycopeptides as antibacterial agents
WO2001081373A2 (en) Glycopeptide antibacterial compounds and methods of using same
EP2531519A1 (en) Lantibiotic salts

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: BIOMARIN PHARMACEUTICAL INC.

Free format text: FORMER OWNER: LIDE TREATMENT COMPANY

Effective date: 20110518

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20110518

Address after: American California

Applicant after: Biomarin Pharmaceutical Inc.

Address before: American California

Applicant before: Lead Therapeutics Inc.

EE01 Entry into force of recordation of patent licensing contract

Assignee: Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd.

Assignor: Biomarin Pharmaceutical Inc.

Contract record no.: 2012990000415

Denomination of invention: Novel semi-synthetic glycopeptides as antibacterial agents

License type: Exclusive License

Open date: 20110126

Record date: 20120613

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110126