AR071552A1 - Glicopeptidos semisinteticos como agentes antibacterianos - Google Patents
Glicopeptidos semisinteticos como agentes antibacterianosInfo
- Publication number
- AR071552A1 AR071552A1 ARP080105718A ARP080105718A AR071552A1 AR 071552 A1 AR071552 A1 AR 071552A1 AR P080105718 A ARP080105718 A AR P080105718A AR P080105718 A ARP080105718 A AR P080105718A AR 071552 A1 AR071552 A1 AR 071552A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- amino acid
- amino
- monosaccharide
- compounds
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 102000002068 Glycopeptides Human genes 0.000 abstract 4
- 108010015899 Glycopeptides Proteins 0.000 abstract 4
- 229940024606 amino acid Drugs 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000002772 monosaccharides Chemical class 0.000 abstract 3
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002336 glycosamine derivatives Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003140 primary amides Chemical class 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1678307P | 2007-12-26 | 2007-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071552A1 true AR071552A1 (es) | 2010-06-30 |
Family
ID=40344127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105718A AR071552A1 (es) | 2007-12-26 | 2008-12-23 | Glicopeptidos semisinteticos como agentes antibacterianos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120129763A1 (https=) |
| EP (1) | EP2238102A4 (https=) |
| JP (1) | JP2011507959A (https=) |
| KR (1) | KR20100109936A (https=) |
| CN (1) | CN101959849A (https=) |
| AR (1) | AR071552A1 (https=) |
| AU (1) | AU2008343502A1 (https=) |
| CA (1) | CA2710602A1 (https=) |
| GB (1) | GB2457549B (https=) |
| IL (1) | IL206622A0 (https=) |
| TW (1) | TW200940083A (https=) |
| WO (1) | WO2009085562A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100105607A1 (en) * | 2008-10-24 | 2010-04-29 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
| WO2011140009A1 (en) * | 2010-05-04 | 2011-11-10 | Biomarin Pharmaceutical Inc. | Methods of using semi-synthetic glycopeptides as antibacterial agents |
| CN103897040B (zh) * | 2012-12-27 | 2018-05-22 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途 |
| CN105585617A (zh) * | 2016-03-24 | 2016-05-18 | 中国医学科学院医药生物技术研究所 | 去甲万古霉素衍生物及其制备纯化方法 |
| CN107619433B (zh) * | 2016-07-15 | 2023-03-17 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
| GB2577420B (en) * | 2017-05-22 | 2022-07-06 | Insmed Inc | Glycopeptide derivative compounds and uses thereof |
| CN109422800A (zh) * | 2017-08-22 | 2019-03-05 | 复旦大学 | 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途 |
| CN108948157B (zh) * | 2018-07-31 | 2021-08-03 | 丽珠集团新北江制药股份有限公司 | 一种制备特拉万星的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0662674B2 (ja) * | 1985-01-11 | 1994-08-17 | 三共株式会社 | 抗生物質クロロポリスポリンｂまたはｃ |
| US4643987A (en) * | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| DE69908819T2 (de) * | 1998-12-23 | 2004-05-06 | Theravance, Inc., South San Francisco | Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten |
| US6699836B2 (en) * | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| JP4381531B2 (ja) * | 1999-12-08 | 2009-12-09 | 塩野義製薬株式会社 | グリコペプチド誘導体 |
| MXPA02006029A (es) * | 1999-12-15 | 2004-08-23 | Cubist Pharm Inc | Lipopeptidos novedosos como agentes antibacterianos. |
| US6770621B2 (en) * | 2000-05-02 | 2004-08-03 | Theravance, Inc. | Polyacid glycopeptide derivatives |
| UA75083C2 (uk) * | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
| US20030008812A1 (en) * | 2001-02-02 | 2003-01-09 | Christensen Burton G. | Glycopeptide derivatives |
| TWI233932B (en) * | 2001-08-24 | 2005-06-11 | Theravance Inc | Process for purifying glycopeptide phosphonate derivatives |
| US7521418B2 (en) * | 2003-05-27 | 2009-04-21 | Theravance, Inc. | Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent |
| WO2005007162A1 (en) * | 2003-07-10 | 2005-01-27 | Vertex Pharmaceuticals Incorporated | Compounds augmenting the activity of antibacterial agents |
| ATE381957T1 (de) * | 2003-07-22 | 2008-01-15 | Theravance Inc | Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel |
| US20070185015A1 (en) * | 2005-02-28 | 2007-08-09 | Chiron Corporation and North China Pharmaceutical Corporation | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US7632918B2 (en) * | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| US7368422B2 (en) * | 2005-02-28 | 2008-05-06 | Novartis Vaccines And Diagnostics Inc. | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| CN1883706A (zh) * | 2006-05-22 | 2006-12-27 | 济南康泉医药科技有限公司 | 一种局部应用的抗生素缓释剂 |
| US8236926B2 (en) * | 2006-09-06 | 2012-08-07 | Wisconsin Alumni Research Foundation | Rapid glycopeptide optimization via neoglycosylation |
-
2008
- 2008-12-05 CN CN2008801275540A patent/CN101959849A/zh active Pending
- 2008-12-05 EP EP08868184A patent/EP2238102A4/en not_active Withdrawn
- 2008-12-05 CA CA2710602A patent/CA2710602A1/en not_active Abandoned
- 2008-12-05 WO PCT/US2008/085716 patent/WO2009085562A1/en not_active Ceased
- 2008-12-05 KR KR1020107016605A patent/KR20100109936A/ko not_active Withdrawn
- 2008-12-05 AU AU2008343502A patent/AU2008343502A1/en not_active Abandoned
- 2008-12-05 JP JP2010540728A patent/JP2011507959A/ja active Pending
- 2008-12-18 TW TW097149455A patent/TW200940083A/zh unknown
- 2008-12-23 GB GB0823463A patent/GB2457549B/en not_active Expired - Fee Related
- 2008-12-23 AR ARP080105718A patent/AR071552A1/es not_active Application Discontinuation
-
2010
- 2010-06-24 IL IL206622A patent/IL206622A0/en unknown
-
2012
- 2012-01-25 US US13/358,374 patent/US20120129763A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100109936A (ko) | 2010-10-11 |
| CN101959849A (zh) | 2011-01-26 |
| CA2710602A1 (en) | 2009-07-09 |
| JP2011507959A (ja) | 2011-03-10 |
| IL206622A0 (en) | 2010-12-30 |
| GB2457549A (en) | 2009-08-26 |
| US20120129763A1 (en) | 2012-05-24 |
| WO2009085562A1 (en) | 2009-07-09 |
| EP2238102A4 (en) | 2011-03-09 |
| GB2457549B (en) | 2010-04-07 |
| GB0823463D0 (en) | 2009-01-28 |
| EP2238102A1 (en) | 2010-10-13 |
| TW200940083A (en) | 2009-10-01 |
| AU2008343502A1 (en) | 2009-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |