KR20100109936A - 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드 - Google Patents

항박테리아제로서의 신규한 반(半)-합성 글리코펩티드 Download PDF

Info

Publication number
KR20100109936A
KR20100109936A KR1020107016605A KR20107016605A KR20100109936A KR 20100109936 A KR20100109936 A KR 20100109936A KR 1020107016605 A KR1020107016605 A KR 1020107016605A KR 20107016605 A KR20107016605 A KR 20107016605A KR 20100109936 A KR20100109936 A KR 20100109936A
Authority
KR
South Korea
Prior art keywords
alkyl
substituted
compound
alkoxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107016605A
Other languages
English (en)
Korean (ko)
Inventor
다니엘 츄
타오 예
Original Assignee
리드 테라퓨틱스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리드 테라퓨틱스, 인크. filed Critical 리드 테라퓨틱스, 인크.
Publication of KR20100109936A publication Critical patent/KR20100109936A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020107016605A 2007-12-26 2008-12-05 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드 Withdrawn KR20100109936A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1678307P 2007-12-26 2007-12-26
US61/016,783 2007-12-26

Publications (1)

Publication Number Publication Date
KR20100109936A true KR20100109936A (ko) 2010-10-11

Family

ID=40344127

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107016605A Withdrawn KR20100109936A (ko) 2007-12-26 2008-12-05 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드

Country Status (12)

Country Link
US (1) US20120129763A1 (https=)
EP (1) EP2238102A4 (https=)
JP (1) JP2011507959A (https=)
KR (1) KR20100109936A (https=)
CN (1) CN101959849A (https=)
AR (1) AR071552A1 (https=)
AU (1) AU2008343502A1 (https=)
CA (1) CA2710602A1 (https=)
GB (1) GB2457549B (https=)
IL (1) IL206622A0 (https=)
TW (1) TW200940083A (https=)
WO (1) WO2009085562A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
WO2011140009A1 (en) * 2010-05-04 2011-11-10 Biomarin Pharmaceutical Inc. Methods of using semi-synthetic glycopeptides as antibacterial agents
CN103897040B (zh) * 2012-12-27 2018-05-22 浙江医药股份有限公司新昌制药厂 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途
CN105585617A (zh) * 2016-03-24 2016-05-18 中国医学科学院医药生物技术研究所 去甲万古霉素衍生物及其制备纯化方法
CN107619433B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
GB2577420B (en) * 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108948157B (zh) * 2018-07-31 2021-08-03 丽珠集团新北江制药股份有限公司 一种制备特拉万星的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662674B2 (ja) * 1985-01-11 1994-08-17 三共株式会社 抗生物質クロロポリスポリンｂまたはｃ
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
DE69908819T2 (de) * 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
US6699836B2 (en) * 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
JP4381531B2 (ja) * 1999-12-08 2009-12-09 塩野義製薬株式会社 グリコペプチド誘導体
MXPA02006029A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
US6770621B2 (en) * 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
WO2005007162A1 (en) * 2003-07-10 2005-01-27 Vertex Pharmaceuticals Incorporated Compounds augmenting the activity of antibacterial agents
ATE381957T1 (de) * 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
CN1883706A (zh) * 2006-05-22 2006-12-27 济南康泉医药科技有限公司 一种局部应用的抗生素缓释剂
US8236926B2 (en) * 2006-09-06 2012-08-07 Wisconsin Alumni Research Foundation Rapid glycopeptide optimization via neoglycosylation

Also Published As

Publication number Publication date
CN101959849A (zh) 2011-01-26
CA2710602A1 (en) 2009-07-09
JP2011507959A (ja) 2011-03-10
IL206622A0 (en) 2010-12-30
GB2457549A (en) 2009-08-26
US20120129763A1 (en) 2012-05-24
AR071552A1 (es) 2010-06-30
WO2009085562A1 (en) 2009-07-09
EP2238102A4 (en) 2011-03-09
GB2457549B (en) 2010-04-07
GB0823463D0 (en) 2009-01-28
EP2238102A1 (en) 2010-10-13
TW200940083A (en) 2009-10-01
AU2008343502A1 (en) 2009-07-09

Similar Documents

Publication Publication Date Title
KR20100109936A (ko) 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드
TWI665218B (zh) 多黏菌素化合物、包含其之醫藥組成物及其用途
RU2506272C2 (ru) Лантибиотические карбоксиамидные производные с усиленной антибактериальной активностью
US20080214444A1 (en) Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2011140009A1 (en) Methods of using semi-synthetic glycopeptides as antibacterial agents
US20090131304A1 (en) Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity
US7632918B2 (en) Semi-synthetic glycopeptides with antibiotic activity
EP3450450B1 (en) Vancomycin derivative, preparation method, pharmaceutical composition and use thereof
US20100216699A1 (en) Semi-synthetic glycopeptides having antibacterial activity
US20110015119A1 (en) Novel semi-synthetic glycopeptides as antibacterial agents
GB2449156A (en) Semi-synthetic glycopeptides with antibacterial activity
US20120252741A1 (en) Novel semi-synthetic glycopeptides as antibacterial agents

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100723

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110311

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid