JP2011507959A - 抗菌薬としての新規半合成糖ペプチド - Google Patents

抗菌薬としての新規半合成糖ペプチド Download PDF

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Publication number
JP2011507959A
JP2011507959A JP2010540728A JP2010540728A JP2011507959A JP 2011507959 A JP2011507959 A JP 2011507959A JP 2010540728 A JP2010540728 A JP 2010540728A JP 2010540728 A JP2010540728 A JP 2010540728A JP 2011507959 A JP2011507959 A JP 2011507959A
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alkyl
substituted
alkoxy
compound
group
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Japanese (ja)
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JP2011507959A5 (https=
Inventor
チュ ダニエル
イエ タオ
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レアド トヘラペウトイクス，インコーポレーテッド
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Publication of JP2011507959A publication Critical patent/JP2011507959A/ja
Publication of JP2011507959A5 publication Critical patent/JP2011507959A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010540728A 2007-12-26 2008-12-05 抗菌薬としての新規半合成糖ペプチド Pending JP2011507959A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1678307P 2007-12-26 2007-12-26
PCT/US2008/085716 WO2009085562A1 (en) 2007-12-26 2008-12-05 Novel semi-synthetic glycopeptides as antibacterial agents

Publications (2)

Publication Number Publication Date
JP2011507959A true JP2011507959A (ja) 2011-03-10
JP2011507959A5 JP2011507959A5 (https=) 2013-01-24

Family

ID=40344127

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010540728A Pending JP2011507959A (ja) 2007-12-26 2008-12-05 抗菌薬としての新規半合成糖ペプチド

Country Status (12)

Country Link
US (1) US20120129763A1 (https=)
EP (1) EP2238102A4 (https=)
JP (1) JP2011507959A (https=)
KR (1) KR20100109936A (https=)
CN (1) CN101959849A (https=)
AR (1) AR071552A1 (https=)
AU (1) AU2008343502A1 (https=)
CA (1) CA2710602A1 (https=)
GB (1) GB2457549B (https=)
IL (1) IL206622A0 (https=)
TW (1) TW200940083A (https=)
WO (1) WO2009085562A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012510999A (ja) * 2008-12-05 2012-05-17 ビオマリン プハルマセウトイカル インコーポレイテッド 抗菌薬としての新規の半合成糖ペプチド

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
WO2011140009A1 (en) * 2010-05-04 2011-11-10 Biomarin Pharmaceutical Inc. Methods of using semi-synthetic glycopeptides as antibacterial agents
CN103897040B (zh) * 2012-12-27 2018-05-22 浙江医药股份有限公司新昌制药厂 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途
CN105585617A (zh) * 2016-03-24 2016-05-18 中国医学科学院医药生物技术研究所 去甲万古霉素衍生物及其制备纯化方法
CN107619433B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
GB2577420B (en) * 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108948157B (zh) * 2018-07-31 2021-08-03 丽珠集团新北江制药股份有限公司 一种制备特拉万星的方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001163898A (ja) * 1999-12-08 2001-06-19 Shionogi & Co Ltd グリコペプチド誘導体
WO2001081372A2 (en) * 2000-04-25 2001-11-01 The Trustees Of Princeton University Vancomycin analogs
JP2002533472A (ja) * 1998-12-23 2002-10-08 セラヴァンス インコーポレーテッド グリコペプチド誘導体およびそれを含有する薬学的組成物
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
JP2005505542A (ja) * 2001-08-24 2005-02-24 セラヴァンス インコーポレーテッド グリコペプチドホスホネート誘導体を精製する方法
WO2005018743A1 (en) * 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
US7074760B2 (en) * 2000-05-02 2006-07-11 Theravance, Inc. Polyacid glycopeptide derivatives
WO2006093933A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2006094082A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2006093947A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic glycopeptides with antibiotic activity
US7208471B2 (en) * 2000-06-22 2007-04-24 Theravance, Inc. Glycopeptide phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662674B2 (ja) * 1985-01-11 1994-08-17 三共株式会社 抗生物質クロロポリスポリンｂまたはｃ
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
MXPA02006029A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
WO2005007162A1 (en) * 2003-07-10 2005-01-27 Vertex Pharmaceuticals Incorporated Compounds augmenting the activity of antibacterial agents
CN1883706A (zh) * 2006-05-22 2006-12-27 济南康泉医药科技有限公司 一种局部应用的抗生素缓释剂
US8236926B2 (en) * 2006-09-06 2012-08-07 Wisconsin Alumni Research Foundation Rapid glycopeptide optimization via neoglycosylation

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533472A (ja) * 1998-12-23 2002-10-08 セラヴァンス インコーポレーテッド グリコペプチド誘導体およびそれを含有する薬学的組成物
JP2001163898A (ja) * 1999-12-08 2001-06-19 Shionogi & Co Ltd グリコペプチド誘導体
WO2001081372A2 (en) * 2000-04-25 2001-11-01 The Trustees Of Princeton University Vancomycin analogs
US7074760B2 (en) * 2000-05-02 2006-07-11 Theravance, Inc. Polyacid glycopeptide derivatives
US7208471B2 (en) * 2000-06-22 2007-04-24 Theravance, Inc. Glycopeptide phosphonate derivatives
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
JP2005505542A (ja) * 2001-08-24 2005-02-24 セラヴァンス インコーポレーテッド グリコペプチドホスホネート誘導体を精製する方法
WO2005018743A1 (en) * 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
WO2006093933A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2006094082A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
WO2006093947A2 (en) * 2005-02-28 2006-09-08 Novartis Vaccines And Diagnostics Inc. Semi-synthetic glycopeptides with antibiotic activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013048564; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　ａｎｔｉｂｉｏｔｉｃｓ．　１９９９，　Ｖｏｌ．５２，　Ｎｏ．３，　ｐ．３１９-３２４ *
JPN6013048566; Ｂｉｏｏｒｇａｎｉｃ　＆　ｍｅｄｉｃｉｎａｌ　ｃｈｅｍｉｓｔｒｙ　ｌｅｔｔｅｒｓ．　２００２，　Ｖｏｌ．１２，　Ｎｏ．９，　ｐ．１３１９-１３２２ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012510999A (ja) * 2008-12-05 2012-05-17 ビオマリン プハルマセウトイカル インコーポレイテッド 抗菌薬としての新規の半合成糖ペプチド

Also Published As

Publication number Publication date
KR20100109936A (ko) 2010-10-11
CN101959849A (zh) 2011-01-26
CA2710602A1 (en) 2009-07-09
IL206622A0 (en) 2010-12-30
GB2457549A (en) 2009-08-26
US20120129763A1 (en) 2012-05-24
AR071552A1 (es) 2010-06-30
WO2009085562A1 (en) 2009-07-09
EP2238102A4 (en) 2011-03-09
GB2457549B (en) 2010-04-07
GB0823463D0 (en) 2009-01-28
EP2238102A1 (en) 2010-10-13
TW200940083A (en) 2009-10-01
AU2008343502A1 (en) 2009-07-09

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