BRPI0607702A2 - composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto - Google Patents

composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto

Info

Publication number
BRPI0607702A2
BRPI0607702A2 BRPI0607702-1A BRPI0607702A BRPI0607702A2 BR PI0607702 A2 BRPI0607702 A2 BR PI0607702A2 BR PI0607702 A BRPI0607702 A BR PI0607702A BR PI0607702 A2 BRPI0607702 A2 BR PI0607702A2
Authority
BR
Brazil
Prior art keywords
compound
conformational structures
certain
amino
compounds
Prior art date
Application number
BRPI0607702-1A
Other languages
English (en)
Inventor
Daniel Chu
Maria Preobrazhenskaya
Svetlana Printsevskaya
Eugenia Olsufyeva
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of BRPI0607702A2 publication Critical patent/BRPI0607702A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO REFERIDO COMPOSTO, E MéTODO DE PREPARAçãO DE UM COMPOSTO. Glicopeptídeos semi-sintéticos possuindo atividade antibacteriana são baseados em modificações de estruturas conformacionais de eremomicina, A82846B, vancomicina, teicoplatina, e A-40.926, em particular, acilação dos grupos açúcar nestas estruturas conformacionais com certos grupos acua; e/ou conVersão de um grupo ácido no anel macrocíclico destas estruturas conformacionais em certas amidas substituidas; ou ter uma combinação de uma modificação por alquilação do substituinte amino no grupo açúcar amino-substituído nestas estruturas conformacionais com certos grupos alquila ou modificação por acilação do substituinte amino no grupo açúcar amino-substituído nestas estruturas conformacionais com certos grupos alquila, e conversão do grupo ácido no anel macrocíclico destas estruturas conformacionais em certas amidas substituidas. Também são proporcionados métodos para a síntese dos compostos, composições farmacêuticas contendo os compostos, e métodos de uso dos compostos para o tratamento e/ou a profilaxia de doenças, especialmente de infecções bacterianas.
BRPI0607702-1A 2005-02-28 2006-02-27 composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto BRPI0607702A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65729705P 2005-02-28 2005-02-28
PCT/US2006/007049 WO2006093947A2 (en) 2005-02-28 2006-02-27 Semi-synthetic glycopeptides with antibiotic activity

Publications (1)

Publication Number Publication Date
BRPI0607702A2 true BRPI0607702A2 (pt) 2009-11-03

Family

ID=36941732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607702-1A BRPI0607702A2 (pt) 2005-02-28 2006-02-27 composto, composição farmacêutica, uso do referido composto, e método de preparação de um composto

Country Status (10)

Country Link
US (1) US7632918B2 (pt)
EP (1) EP1861115A4 (pt)
JP (2) JP2008531702A (pt)
KR (1) KR20080004455A (pt)
CN (1) CN101222933A (pt)
AU (1) AU2006218665A1 (pt)
BR (1) BRPI0607702A2 (pt)
CA (1) CA2600453A1 (pt)
MX (1) MX2007010478A (pt)
WO (1) WO2006093947A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
AU2008343502A1 (en) * 2007-12-26 2009-07-09 Biomarin Pharmaceutical Inc. Novel semi-synthetic glycopeptides as antibacterial agents
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
CA2972276A1 (en) 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
JP2018515481A (ja) * 2015-09-16 2018-06-14 シュアンチュー ファーマ カンパニー，リミティド β−ラクタマーゼ阻害剤とその利用
CN107619432B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
JP7165146B2 (ja) 2017-05-22 2022-11-02 インスメッド インコーポレイテッド グリコペプチド誘導体化合物およびそれらの使用
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应
CN110938114B (zh) * 2018-09-21 2023-04-28 中国科学院上海药物研究所 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途
US20210388028A1 (en) * 2018-11-21 2021-12-16 Insmed Incorporated Glycopeptide derivative compounds and uses thereof

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
DE3011278B1 (de) 1980-03-24 1981-04-02 Rohde & Schwarz GmbH & Co KG, 8000 München Funkpeiler
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
GB8522574D0 (en) 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8701872D0 (en) 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
CA1339808C (en) 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5500410A (en) 1989-03-29 1996-03-19 Gruppo Lepetit S.P.A. Substituted alkylamide derivatives of teicoplanin
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
AU703106B2 (en) 1994-01-28 1999-03-18 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5488131A (en) 1994-03-23 1996-01-30 California Institute Of Technology Synthesis of compounds with predetermined chirality
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
CZ301184B6 (cs) * 1998-12-23 2009-12-02 Theravance, Inc. Glykopeptidový derivát a farmaceutické prostredky, které jej obsahují
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
EP1173193A4 (en) 1999-04-02 2003-01-29 Univ Princeton DES-LEUCYL GLYCOPEPTIDE ANTIBIOTICS AND METHOD OF PREPARATION
WO2000069893A1 (en) 1999-05-19 2000-11-23 Merck & Co., Inc. Glycopeptide antibacterial compounds, compositions containing same and methods of using same
MXPA02007739A (es) 2000-02-11 2002-10-11 Lilly Co Eli N-acilacion selectiva de analogos del glicopeptido a82846.
US20030008812A1 (en) 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
US7348309B2 (en) 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
WO2004019970A2 (en) 2002-08-30 2004-03-11 K.U. Leuven Research And Development Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents
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EP1641480A1 (en) * 2003-05-27 2006-04-05 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity

Also Published As

Publication number Publication date
CA2600453A1 (en) 2006-09-08
KR20080004455A (ko) 2008-01-09
JP2008531702A (ja) 2008-08-14
AU2006218665A1 (en) 2006-09-08
MX2007010478A (es) 2008-02-07
WO2006093947A3 (en) 2007-05-31
EP1861115A2 (en) 2007-12-05
US7632918B2 (en) 2009-12-15
CN101222933A (zh) 2008-07-16
WO2006093947A2 (en) 2006-09-08
JP2009102446A (ja) 2009-05-14
US20060276623A1 (en) 2006-12-07
EP1861115A4 (en) 2011-03-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.