MX2007010478A - Glicopeptidos semisinteticos con actividad antibiotica. - Google Patents

Glicopeptidos semisinteticos con actividad antibiotica.

Info

Publication number
MX2007010478A
MX2007010478A MX2007010478A MX2007010478A MX2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A
Authority
MX
Mexico
Prior art keywords
scaffolds
certain
amino
compounds
semi
Prior art date
Application number
MX2007010478A
Other languages
English (en)
Inventor
Daniel Chu
Maria Preobrazhenskaya
Svetlana Printsevskaya
Eugenia Olsufyeva
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of MX2007010478A publication Critical patent/MX2007010478A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los glicopeptidos semisinteticos, que tienen actividad antibacteriana, se basan en modificaciones de la eremomicina, A82846B, vancomicina, teicoplanina y estructuras A-40,926, en particular, la acilacion de las partes de azucar en estas estructuras con ciertos grupos de acilo: y/o la conversion de una parte de acido sobre el anillo macrociclico en estas estructuras en ciertas amidas sustituidas; o que tienen una combinacion de una modificacion de alquilacion del sustituyente de amino en la parte de azucar sustituida con amino, en estas estructuras con ciertos grupos de alquilo o la modificacion de acilacion del sustituyente de amino en la parte de azucar sustituida con amino en esta estructura con ciertos grupos de alquilo, y la conversion de la parte de acido en el anillo macrociclico de las estructuras en ciertas amidas sustituidas. Igualmente se proporcionan metodos para la sintesis de los compuestos, composiciones farmaceuticas que contienen los compuestos, y metodos de uso de los compuestos para el tratamiento y/o profilaxis de enfermedades, especialmente infecciones bacteriales.
MX2007010478A 2005-02-28 2006-02-27 Glicopeptidos semisinteticos con actividad antibiotica. MX2007010478A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65729705P 2005-02-28 2005-02-28
PCT/US2006/007049 WO2006093947A2 (en) 2005-02-28 2006-02-27 Semi-synthetic glycopeptides with antibiotic activity

Publications (1)

Publication Number Publication Date
MX2007010478A true MX2007010478A (es) 2008-02-07

Family

ID=36941732

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010478A MX2007010478A (es) 2005-02-28 2006-02-27 Glicopeptidos semisinteticos con actividad antibiotica.

Country Status (10)

Country Link
US (1) US7632918B2 (es)
EP (1) EP1861115A4 (es)
JP (2) JP2008531702A (es)
KR (1) KR20080004455A (es)
CN (1) CN101222933A (es)
AU (1) AU2006218665A1 (es)
BR (1) BRPI0607702A2 (es)
CA (1) CA2600453A1 (es)
MX (1) MX2007010478A (es)
WO (1) WO2006093947A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
CN101959849A (zh) * 2007-12-26 2011-01-26 利德治疗公司 作为抗菌剂的新型半合成糖肽
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
CA2972276A1 (en) 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
MX2017013792A (es) * 2015-09-16 2018-07-06 Xuanzhu Pharma Co Ltd INHIBIDORES DE íŸ-LACTAMASA Y USOS DE LOS MISMOS.
CN107619433B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
GB2577419B (en) 2017-05-22 2022-08-17 Insmed Inc Lipo-glycopeptide cleavable derivatives and uses thereof
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应
CN110938114B (zh) * 2018-09-21 2023-04-28 中国科学院上海药物研究所 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途
EP3883590A4 (en) * 2018-11-21 2022-09-21 Insmed Incorporated GLYCOPEPTIDE DERIVATIVE COMPOUNDS AND USES THEREOF

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3011278B1 (de) 1980-03-24 1981-04-02 Rohde & Schwarz GmbH & Co KG, 8000 München Funkpeiler
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
GB8522574D0 (en) 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8701872D0 (en) 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
CA1339808C (en) 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5500410A (en) 1989-03-29 1996-03-19 Gruppo Lepetit S.P.A. Substituted alkylamide derivatives of teicoplanin
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
MY128335A (en) 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5488131A (en) 1994-03-23 1996-01-30 California Institute Of Technology Synthesis of compounds with predetermined chirality
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
PT1140993E (pt) * 1998-12-23 2003-10-31 Theravance Inc Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
CA2370782A1 (en) 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
US6498238B1 (en) 1999-05-19 2002-12-24 Princeton University Glycopeptide antibacterial compounds, compositions containing same and methods of using same
AU3818001A (en) 2000-02-11 2001-08-20 Lilly Co Eli Selective n-acylation of a82846 glycopeptide analogs
US20030008812A1 (en) 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
US7348309B2 (en) 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
JP2006503015A (ja) 2002-08-30 2006-01-26 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント グリコペプチド抗生物質誘導体
AU2003287605A1 (en) 2002-11-12 2004-06-03 Enzon Pharmaceuticals, Inc. Polymeric prodrugs of vancomycin
JP2006528704A (ja) * 2003-05-27 2006-12-21 セラヴァンス インコーポレーテッド グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用
US7368422B2 (en) 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity

Also Published As

Publication number Publication date
US20060276623A1 (en) 2006-12-07
WO2006093947A3 (en) 2007-05-31
EP1861115A4 (en) 2011-03-16
JP2009102446A (ja) 2009-05-14
WO2006093947A2 (en) 2006-09-08
KR20080004455A (ko) 2008-01-09
US7632918B2 (en) 2009-12-15
CA2600453A1 (en) 2006-09-08
AU2006218665A1 (en) 2006-09-08
BRPI0607702A2 (pt) 2009-11-03
JP2008531702A (ja) 2008-08-14
CN101222933A (zh) 2008-07-16
EP1861115A2 (en) 2007-12-05

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