CN101910157B - 吲哚化合物和治疗内脏痛的方法 - Google Patents
吲哚化合物和治疗内脏痛的方法 Download PDFInfo
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- CN101910157B CN101910157B CN200880124852.4A CN200880124852A CN101910157B CN 101910157 B CN101910157 B CN 101910157B CN 200880124852 A CN200880124852 A CN 200880124852A CN 101910157 B CN101910157 B CN 101910157B
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- alkyl
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- indol
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- 0 *c1c(*)[n](*)c2c(*)c(*)c(*)c(*I)c12 Chemical compound *c1c(*)[n](*)c2c(*)c(*)c(*)c(*I)c12 0.000 description 8
- NWUGWNUIRGACCZ-UHFFFAOYSA-N CN(CC1)CC1c1c[nH]c(cc2)c1cc2NC(c1ccc[s]1)=N Chemical compound CN(CC1)CC1c1c[nH]c(cc2)c1cc2NC(c1ccc[s]1)=N NWUGWNUIRGACCZ-UHFFFAOYSA-N 0.000 description 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98875707P | 2007-11-16 | 2007-11-16 | |
| US60/988,757 | 2007-11-16 | ||
| US13393008P | 2008-07-03 | 2008-07-03 | |
| US61/133,930 | 2008-07-03 | ||
| PCT/CA2008/002047 WO2009062319A1 (en) | 2007-11-16 | 2008-11-17 | Indole compounds and methods for treating visceral pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101910157A CN101910157A (zh) | 2010-12-08 |
| CN101910157B true CN101910157B (zh) | 2014-05-07 |
Family
ID=40638299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880124852.4A Expired - Fee Related CN101910157B (zh) | 2007-11-16 | 2008-11-17 | 吲哚化合物和治疗内脏痛的方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8673909B2 (enExample) |
| EP (1) | EP2220075A4 (enExample) |
| JP (2) | JP2011503120A (enExample) |
| KR (1) | KR20100103799A (enExample) |
| CN (1) | CN101910157B (enExample) |
| AU (1) | AU2008323526A1 (enExample) |
| BR (1) | BRPI0820632A2 (enExample) |
| CA (1) | CA2705835A1 (enExample) |
| EA (1) | EA201000808A1 (enExample) |
| MX (1) | MX356032B (enExample) |
| NZ (1) | NZ586082A (enExample) |
| SG (1) | SG185991A1 (enExample) |
| WO (1) | WO2009062319A1 (enExample) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007063418A2 (en) | 2005-04-13 | 2007-06-07 | Neuraxon, Inc. | Substituted indole compounds having nos inhibitory activity |
| JP5350219B2 (ja) * | 2006-04-13 | 2013-11-27 | ニューラクソン,インコーポレーテッド | Nos阻害活性を有する1,5および3,6−置換インドール化合物 |
| EP2219449A4 (en) * | 2007-11-16 | 2010-10-27 | Univ Arizona State | METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| CN102854263B (zh) * | 2012-08-31 | 2014-04-16 | 石家庄中硕药业集团有限公司 | 一种同时测定布洛芬注射液中布洛芬及精氨酸含量的方法 |
| CN103006642B (zh) * | 2013-01-04 | 2014-10-22 | 中国药科大学 | 一类炔亚甲基吲哚-2-酮类衍生物的用途 |
| WO2014139388A1 (en) * | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015011189A1 (en) * | 2013-07-23 | 2015-01-29 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
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| WO2009062319A1 (en) | 2009-05-22 |
| NZ586082A (en) | 2013-03-28 |
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| EA201000808A1 (ru) | 2011-04-29 |
| US8673909B2 (en) | 2014-03-18 |
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| CA2705835A1 (en) | 2009-05-22 |
| JP2015157826A (ja) | 2015-09-03 |
| AU2008323526A1 (en) | 2009-05-22 |
| SG185991A1 (en) | 2012-12-28 |
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