CN101899081B - 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 - Google Patents

甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 Download PDF

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Publication number
CN101899081B
CN101899081B CN200910027345A CN200910027345A CN101899081B CN 101899081 B CN101899081 B CN 101899081B CN 200910027345 A CN200910027345 A CN 200910027345A CN 200910027345 A CN200910027345 A CN 200910027345A CN 101899081 B CN101899081 B CN 101899081B
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China
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compound
glycyrrhetinic acid
acid ester
preparation
branched
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CN200910027345A
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Chinese (zh)
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CN101899081A (zh
Inventor
张爱明
张喜全
夏春光
徐宏江
王衡奇
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd
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Priority to CN200910027345A priority Critical patent/CN101899081B/zh
Application filed by Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd filed Critical Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd
Priority to AU2010256187A priority patent/AU2010256187B2/en
Priority to RU2011148301/04A priority patent/RU2522455C2/ru
Priority to US13/375,332 priority patent/US20120172438A1/en
Priority to JP2012513459A priority patent/JP5658238B2/ja
Priority to PCT/CN2010/073339 priority patent/WO2010139253A1/zh
Publication of CN101899081A publication Critical patent/CN101899081A/zh
Priority to ZA2011/09483A priority patent/ZA201109483B/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200910027345A 2009-05-31 2009-05-31 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 Active CN101899081B (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN200910027345A CN101899081B (zh) 2009-05-31 2009-05-31 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物
RU2011148301/04A RU2522455C2 (ru) 2009-05-31 2010-05-28 Способ синтеза производного эфира и глицирретиновой кислоты и соединение сложного эфира дезоксиглицирретиновой кислоты
US13/375,332 US20120172438A1 (en) 2009-05-31 2010-05-28 Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compound
JP2012513459A JP5658238B2 (ja) 2009-05-31 2010-05-28 グリチルレチン酸エステル誘導体の合成方法及びデオキシグリチルレチン酸エステル化合物
AU2010256187A AU2010256187B2 (en) 2009-05-31 2010-05-28 Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compound
PCT/CN2010/073339 WO2010139253A1 (zh) 2009-05-31 2010-05-28 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物
ZA2011/09483A ZA201109483B (en) 2009-05-31 2011-12-22 Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200910027345A CN101899081B (zh) 2009-05-31 2009-05-31 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物

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CN2012101026584A Division CN102718830A (zh) 2009-05-31 2009-05-31 甘草次酸酯类衍生物合成方法

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CN101899081B true CN101899081B (zh) 2012-09-05

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US (1) US20120172438A1 (enExample)
JP (1) JP5658238B2 (enExample)
CN (1) CN101899081B (enExample)
AU (1) AU2010256187B2 (enExample)
RU (1) RU2522455C2 (enExample)
WO (1) WO2010139253A1 (enExample)
ZA (1) ZA201109483B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103772477B (zh) * 2014-01-24 2015-07-08 华东师范大学 甘草次酸衍生物及其制备方法和应用
CN105713064B (zh) * 2014-12-05 2017-10-27 中国科学院大连化学物理研究所 五环三萜类化合物及其作为人肠羧酸酯酶抑制剂的应用
CN107325149B (zh) * 2017-06-27 2018-04-03 亿利耐雀生物科技有限公司 一种甘草烯酸衍生物及其制备方法与用途
CN112176018B (zh) * 2020-08-28 2022-09-13 河北仁心药业有限公司 基于炙甘草制备甘草次酸及其衍生物的方法和用途
CN113632796A (zh) * 2021-07-29 2021-11-12 安徽黑包公有害生物防控有限公司 一种高效混合悬浮型除草剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172420A (ja) 1983-03-22 1984-09-29 Sanwa Kagaku Kenkyusho:Kk 肝疾患治療剤
CN101062937A (zh) * 2006-04-29 2007-10-31 江苏正大天晴药业股份有限公司 18α－甘草酸衍生物及其制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588044A (ja) * 1981-07-06 1983-01-18 Maruzen Seiyaku Kk １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬
JPS63135351A (ja) * 1986-11-28 1988-06-07 Sanwa Kagaku Kenkyusho Co Ltd グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤
GB0105772D0 (en) * 2001-03-08 2001-04-25 Sterix Ltd Use
CN100488979C (zh) * 2005-10-14 2009-05-20 天津药物研究院 甘草次酸-30-酰胺类衍生物及其用途
CN101190936A (zh) * 2006-12-01 2008-06-04 黄振华 具有抗病毒活性的化合物
RU2401273C1 (ru) * 2009-03-30 2010-10-10 Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (статус государственного учреждения) Противоопухолевое средство тритерпеновой природы, полученное путем модификации глицирретовой кислоты

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172420A (ja) 1983-03-22 1984-09-29 Sanwa Kagaku Kenkyusho:Kk 肝疾患治療剤
CN101062937A (zh) * 2006-04-29 2007-10-31 江苏正大天晴药业股份有限公司 18α－甘草酸衍生物及其制剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
TERASAWA, T.等.Glycyrrhetinic acid derivatives as potent inhibitors of Na+-, K+-ATPase. Synthesis and structure-activity relationships.《Eur. J. Med. Chem.》.1992,第27卷(第4期),345-351页,参见第346页右栏第3段,第350页化合物13a和27a. *
刘文丛等.水热法合成甘草次酸甲酯的研究.《东北师大学报(自然科学版)》.2007,第39卷(第4期),154-156页. *
彭子模.甘草次酸及其衍生物的研究现状和展望.《中医药学报》.1998,(第1期),32-35页,参见2.6节. *

Also Published As

Publication number Publication date
CN101899081A (zh) 2010-12-01
WO2010139253A1 (zh) 2010-12-09
RU2011148301A (ru) 2013-07-20
JP5658238B2 (ja) 2015-01-21
US20120172438A1 (en) 2012-07-05
AU2010256187A1 (en) 2011-12-22
RU2522455C2 (ru) 2014-07-10
JP2012528801A (ja) 2012-11-15
AU2010256187B2 (en) 2015-07-16
ZA201109483B (en) 2012-09-26

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Owner name: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

Free format text: FORMER NAME: JIANGSU ZHENGDA TIANQING PHARMACEUTICAL CO., LTD.

CP01 Change in the name or title of a patent holder

Address after: 222006 Sinpo City, Lianyungang Province, North Road, No. 8, No.

Patentee after: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd.

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Patentee before: JIANGSU CHIATAI TIANQING PHARMACEUTICAL Co.,Ltd.

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Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province

Patentee after: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd.

Country or region after: China

Address before: 222006 No. 8 Julong North Road, Sinpo District, Jiangsu, Lianyungang

Patentee before: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd.

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