ZA201109483B - Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compound - Google Patents
Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compoundInfo
- Publication number
- ZA201109483B ZA201109483B ZA2011/09483A ZA201109483A ZA201109483B ZA 201109483 B ZA201109483 B ZA 201109483B ZA 2011/09483 A ZA2011/09483 A ZA 2011/09483A ZA 201109483 A ZA201109483 A ZA 201109483A ZA 201109483 B ZA201109483 B ZA 201109483B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid ester
- synthesis method
- deoxoglycyrrhetinic
- derivative synthesis
- ester compound
- Prior art date
Links
- -1 Glycyrrhetinic acid ester Chemical class 0.000 title 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N Glycyrrhetinic acid Natural products C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229960003720 enoxolone Drugs 0.000 title 1
- 238000001308 synthesis method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910027345A CN101899081B (zh) | 2009-05-31 | 2009-05-31 | 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 |
| PCT/CN2010/073339 WO2010139253A1 (zh) | 2009-05-31 | 2010-05-28 | 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201109483B true ZA201109483B (en) | 2012-09-26 |
Family
ID=43225035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/09483A ZA201109483B (en) | 2009-05-31 | 2011-12-22 | Glycyrrhetinic acid ester derivative synthesis method and deoxoglycyrrhetinic acid ester compound |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120172438A1 (enExample) |
| JP (1) | JP5658238B2 (enExample) |
| CN (1) | CN101899081B (enExample) |
| AU (1) | AU2010256187B2 (enExample) |
| RU (1) | RU2522455C2 (enExample) |
| WO (1) | WO2010139253A1 (enExample) |
| ZA (1) | ZA201109483B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103772477B (zh) * | 2014-01-24 | 2015-07-08 | 华东师范大学 | 甘草次酸衍生物及其制备方法和应用 |
| CN105713064B (zh) * | 2014-12-05 | 2017-10-27 | 中国科学院大连化学物理研究所 | 五环三萜类化合物及其作为人肠羧酸酯酶抑制剂的应用 |
| CN107325149B (zh) * | 2017-06-27 | 2018-04-03 | 亿利耐雀生物科技有限公司 | 一种甘草烯酸衍生物及其制备方法与用途 |
| CN112176018B (zh) * | 2020-08-28 | 2022-09-13 | 河北仁心药业有限公司 | 基于炙甘草制备甘草次酸及其衍生物的方法和用途 |
| CN113632796A (zh) * | 2021-07-29 | 2021-11-12 | 安徽黑包公有害生物防控有限公司 | 一种高效混合悬浮型除草剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS588044A (ja) * | 1981-07-06 | 1983-01-18 | Maruzen Seiyaku Kk | １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬 |
| JPS59172420A (ja) | 1983-03-22 | 1984-09-29 | Sanwa Kagaku Kenkyusho:Kk | 肝疾患治療剤 |
| JPS63135351A (ja) * | 1986-11-28 | 1988-06-07 | Sanwa Kagaku Kenkyusho Co Ltd | グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤 |
| GB0105772D0 (en) * | 2001-03-08 | 2001-04-25 | Sterix Ltd | Use |
| CN100488979C (zh) * | 2005-10-14 | 2009-05-20 | 天津药物研究院 | 甘草次酸-30-酰胺类衍生物及其用途 |
| CN101062937B (zh) * | 2006-04-29 | 2011-04-20 | 江苏正大天晴药业股份有限公司 | 18α-甘草酸衍生物及其制剂 |
| CN101190936A (zh) * | 2006-12-01 | 2008-06-04 | 黄振华 | 具有抗病毒活性的化合物 |
| RU2401273C1 (ru) * | 2009-03-30 | 2010-10-10 | Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (статус государственного учреждения) | Противоопухолевое средство тритерпеновой природы, полученное путем модификации глицирретовой кислоты |
-
2009
- 2009-05-31 CN CN200910027345A patent/CN101899081B/zh active Active
-
2010
- 2010-05-28 AU AU2010256187A patent/AU2010256187B2/en not_active Ceased
- 2010-05-28 WO PCT/CN2010/073339 patent/WO2010139253A1/zh not_active Ceased
- 2010-05-28 RU RU2011148301/04A patent/RU2522455C2/ru not_active IP Right Cessation
- 2010-05-28 US US13/375,332 patent/US20120172438A1/en not_active Abandoned
- 2010-05-28 JP JP2012513459A patent/JP5658238B2/ja not_active Expired - Fee Related
-
2011
- 2011-12-22 ZA ZA2011/09483A patent/ZA201109483B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011148301A (ru) | 2013-07-20 |
| RU2522455C2 (ru) | 2014-07-10 |
| AU2010256187B2 (en) | 2015-07-16 |
| WO2010139253A1 (zh) | 2010-12-09 |
| AU2010256187A1 (en) | 2011-12-22 |
| US20120172438A1 (en) | 2012-07-05 |
| CN101899081B (zh) | 2012-09-05 |
| JP2012528801A (ja) | 2012-11-15 |
| JP5658238B2 (ja) | 2015-01-21 |
| CN101899081A (zh) | 2010-12-01 |
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