JP5658238B2 - グリチルレチン酸エステル誘導体の合成方法及びデオキシグリチルレチン酸エステル化合物 - Google Patents
グリチルレチン酸エステル誘導体の合成方法及びデオキシグリチルレチン酸エステル化合物 Download PDFInfo
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- JP5658238B2 JP5658238B2 JP2012513459A JP2012513459A JP5658238B2 JP 5658238 B2 JP5658238 B2 JP 5658238B2 JP 2012513459 A JP2012513459 A JP 2012513459A JP 2012513459 A JP2012513459 A JP 2012513459A JP 5658238 B2 JP5658238 B2 JP 5658238B2
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- deoxy
- compound
- acid
- glycyrrhetinic
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910027345A CN101899081B (zh) | 2009-05-31 | 2009-05-31 | 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 |
| CN200910027345.5 | 2009-05-31 | ||
| PCT/CN2010/073339 WO2010139253A1 (zh) | 2009-05-31 | 2010-05-28 | 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 |
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| JP2012528801A JP2012528801A (ja) | 2012-11-15 |
| JP2012528801A5 JP2012528801A5 (enExample) | 2013-07-11 |
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| JP (1) | JP5658238B2 (enExample) |
| CN (1) | CN101899081B (enExample) |
| AU (1) | AU2010256187B2 (enExample) |
| RU (1) | RU2522455C2 (enExample) |
| WO (1) | WO2010139253A1 (enExample) |
| ZA (1) | ZA201109483B (enExample) |
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| CN103772477B (zh) * | 2014-01-24 | 2015-07-08 | 华东师范大学 | 甘草次酸衍生物及其制备方法和应用 |
| CN105713064B (zh) * | 2014-12-05 | 2017-10-27 | 中国科学院大连化学物理研究所 | 五环三萜类化合物及其作为人肠羧酸酯酶抑制剂的应用 |
| CN107325149B (zh) * | 2017-06-27 | 2018-04-03 | 亿利耐雀生物科技有限公司 | 一种甘草烯酸衍生物及其制备方法与用途 |
| CN112176018B (zh) * | 2020-08-28 | 2022-09-13 | 河北仁心药业有限公司 | 基于炙甘草制备甘草次酸及其衍生物的方法和用途 |
| CN113632796A (zh) * | 2021-07-29 | 2021-11-12 | 安徽黑包公有害生物防控有限公司 | 一种高效混合悬浮型除草剂 |
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|---|---|---|---|---|
| JPS588044A (ja) * | 1981-07-06 | 1983-01-18 | Maruzen Seiyaku Kk | １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬 |
| JPS59172420A (ja) | 1983-03-22 | 1984-09-29 | Sanwa Kagaku Kenkyusho:Kk | 肝疾患治療剤 |
| JPS63135351A (ja) * | 1986-11-28 | 1988-06-07 | Sanwa Kagaku Kenkyusho Co Ltd | グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤 |
| GB0105772D0 (en) * | 2001-03-08 | 2001-04-25 | Sterix Ltd | Use |
| CN100488979C (zh) * | 2005-10-14 | 2009-05-20 | 天津药物研究院 | 甘草次酸-30-酰胺类衍生物及其用途 |
| CN101062937B (zh) * | 2006-04-29 | 2011-04-20 | 江苏正大天晴药业股份有限公司 | 18α-甘草酸衍生物及其制剂 |
| CN101190936A (zh) * | 2006-12-01 | 2008-06-04 | 黄振华 | 具有抗病毒活性的化合物 |
| RU2401273C1 (ru) * | 2009-03-30 | 2010-10-10 | Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (статус государственного учреждения) | Противоопухолевое средство тритерпеновой природы, полученное путем модификации глицирретовой кислоты |
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2009
- 2009-05-31 CN CN200910027345A patent/CN101899081B/zh active Active
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- 2010-05-28 AU AU2010256187A patent/AU2010256187B2/en not_active Ceased
- 2010-05-28 WO PCT/CN2010/073339 patent/WO2010139253A1/zh not_active Ceased
- 2010-05-28 US US13/375,332 patent/US20120172438A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US20120172438A1 (en) | 2012-07-05 |
| RU2522455C2 (ru) | 2014-07-10 |
| CN101899081A (zh) | 2010-12-01 |
| RU2011148301A (ru) | 2013-07-20 |
| AU2010256187B2 (en) | 2015-07-16 |
| AU2010256187A1 (en) | 2011-12-22 |
| ZA201109483B (en) | 2012-09-26 |
| CN101899081B (zh) | 2012-09-05 |
| JP2012528801A (ja) | 2012-11-15 |
| WO2010139253A1 (zh) | 2010-12-09 |
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