CN101889981A - 包含含有药物成分的亲脂胺的稳定脂质体组合物 - Google Patents

包含含有药物成分的亲脂胺的稳定脂质体组合物 Download PDF

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Publication number
CN101889981A
CN101889981A CN2010101414947A CN201010141494A CN101889981A CN 101889981 A CN101889981 A CN 101889981A CN 2010101414947 A CN2010101414947 A CN 2010101414947A CN 201010141494 A CN201010141494 A CN 201010141494A CN 101889981 A CN101889981 A CN 101889981A
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CN
China
Prior art keywords
liposome
compositions
acid
composition
stable
Prior art date
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Pending
Application number
CN2010101414947A
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English (en)
Chinese (zh)
Inventor
黛安娜·海伦·普柳拉
布拉戈亚·里斯泰夫斯基
詹姆斯·查尔斯·博伊兰
李红
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead YM ULC
Original Assignee
Delex Therapeutics Inc
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Filing date
Publication date
Application filed by Delex Therapeutics Inc filed Critical Delex Therapeutics Inc
Publication of CN101889981A publication Critical patent/CN101889981A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010101414947A 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物 Pending CN101889981A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52331603P 2003-11-20 2003-11-20
US60/523,316 2003-11-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2004800343913A Division CN1893926B (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Publications (1)

Publication Number Publication Date
CN101889981A true CN101889981A (zh) 2010-11-24

Family

ID=34619598

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010101414947A Pending CN101889981A (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物
CN2004800343913A Expired - Fee Related CN1893926B (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2004800343913A Expired - Fee Related CN1893926B (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Country Status (13)

Country Link
US (1) US20070269502A1 (https=)
EP (1) EP1689364A4 (https=)
JP (1) JP2007511545A (https=)
KR (1) KR20060123341A (https=)
CN (2) CN101889981A (https=)
AU (1) AU2004290476A1 (https=)
BR (1) BRPI0416650A (https=)
CA (1) CA2588012A1 (https=)
MX (1) MXPA06005688A (https=)
NO (1) NO20062877L (https=)
RU (1) RU2369384C2 (https=)
WO (1) WO2005048986A1 (https=)
ZA (1) ZA200604808B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111432801A (zh) * 2017-12-21 2020-07-17 台湾微脂体股份有限公司 缓释型曲普坦组合物及通过皮下或类似途径使用其的方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4599849B2 (ja) * 2004-02-18 2010-12-15 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
US8772359B2 (en) * 2006-11-08 2014-07-08 Cp Kelco U.S., Inc. Surfactant thickened systems comprising microfibrous cellulose and methods of making same
US9045716B2 (en) 2006-11-08 2015-06-02 Cp Kelco U.S., Inc. Surfactant thickened systems comprising microfibrous cellulose and methods of making same
WO2009107753A1 (ja) * 2008-02-29 2009-09-03 財団法人 名古屋産業科学研究所 後眼部到達用リポソーム及び後眼部疾患用医薬組成物
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
WO2010077165A1 (en) * 2008-12-31 2010-07-08 Obschestvo S Ogranichennoi Otvetstvennostju Scientific Company Flamena Phospholipid emulsion containing dihydroquercetin, and method of producing thereof
EP2585046A4 (en) * 2010-06-23 2013-11-06 Brightside Innovations Inc LECITHINTRÄGERVESIKEL AND METHOD FOR THE PRODUCTION THEREOF
EP2771341A4 (en) * 2011-10-28 2015-09-23 Univ Texas NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
RU2014133467A (ru) 2012-02-17 2016-04-10 Селшн Корпорейшн Термочувствительные составы в виде наночастиц и способ их получения
WO2014017233A1 (ja) * 2012-07-27 2014-01-30 住友重機械工業株式会社 微生物用活性調節剤及び微生物の活性を調節する方法
RU2529179C1 (ru) * 2013-04-23 2014-09-27 Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" Стабилизатор липосомальных суспензий и способ его получения
AU2016256979B2 (en) 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
WO2017142834A1 (en) * 2016-02-15 2017-08-24 Kemin Industries, Inc. Water soluble lipophilic materials
WO2020259670A1 (zh) 2019-06-28 2020-12-30 江苏恒瑞医药股份有限公司 一种缓释脂质组合物及其制备方法
WO2021041374A1 (en) * 2019-08-28 2021-03-04 Cai Gu Huang Liposome formulation of fluticasone furoate and method of preparation
RU2712079C1 (ru) * 2019-09-05 2020-01-24 Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) Липосомальное лекарственное средство для лечения местных радиационных поражений кожи
CN113197848B (zh) * 2021-05-24 2023-06-09 成都欣捷高新技术开发股份有限公司 一种重酒石酸间羟胺药物组合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152379A3 (de) * 1984-02-15 1986-10-29 Ciba-Geigy Ag Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
WO1990003808A1 (en) * 1988-10-07 1990-04-19 The Liposome Company, Inc. Heat treating liposomes
EP0472639A4 (en) * 1989-05-15 1992-07-01 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
JP3383704B2 (ja) * 1993-04-02 2003-03-04 わかもと製薬株式会社 安定なリポソーム水分散液
US5451408A (en) * 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
GB9605915D0 (en) * 1996-03-21 1996-05-22 Univ Bruxelles Liposome encapsulated amphiphilic drug compositions
GB9708066D0 (en) * 1997-04-22 1997-06-11 Woolcombers Group Plc Compositions and their use
JP2005530704A (ja) * 2002-03-05 2005-10-13 トランセイブ， インク． 細胞内感染を予防及び治療するための吸入システム

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111432801A (zh) * 2017-12-21 2020-07-17 台湾微脂体股份有限公司 缓释型曲普坦组合物及通过皮下或类似途径使用其的方法

Also Published As

Publication number Publication date
WO2005048986A1 (en) 2005-06-02
ZA200604808B (en) 2007-11-28
KR20060123341A (ko) 2006-12-01
AU2004290476A1 (en) 2005-06-02
JP2007511545A (ja) 2007-05-10
BRPI0416650A (pt) 2007-01-16
CN1893926A (zh) 2007-01-10
MXPA06005688A (es) 2006-12-14
EP1689364A4 (en) 2008-10-29
EP1689364A1 (en) 2006-08-16
RU2369384C2 (ru) 2009-10-10
NO20062877L (no) 2006-08-21
CN1893926B (zh) 2010-09-08
RU2006121554A (ru) 2007-12-27
CA2588012A1 (en) 2005-06-02
US20070269502A1 (en) 2007-11-22

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Open date: 20101124