CN101889074A - 采用电子显微镜对核酸聚合物测序 - Google Patents

采用电子显微镜对核酸聚合物测序 Download PDF

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Publication number
CN101889074A
CN101889074A CN2008801193343A CN200880119334A CN101889074A CN 101889074 A CN101889074 A CN 101889074A CN 2008801193343 A CN2008801193343 A CN 2008801193343A CN 200880119334 A CN200880119334 A CN 200880119334A CN 101889074 A CN101889074 A CN 101889074A
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nucleic acid
base
dna
substrate
chains
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Chinese (zh)
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威廉·安德雷格
迈克尔·安德雷格
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Halcyon Molecular Inc
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Halcyon Molecular Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2008801193343A 2007-10-04 2008-10-06 采用电子显微镜对核酸聚合物测序 Pending CN101889074A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99742707P 2007-10-04 2007-10-04
US60/997,427 2007-10-04
US13296008P 2008-06-23 2008-06-23
US61/132,960 2008-06-23
PCT/US2008/078986 WO2009046445A1 (en) 2007-10-04 2008-10-06 Sequencing nucleic acid polymers with electron microscopy

Publications (1)

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CN101889074A true CN101889074A (zh) 2010-11-17

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CN2008801193343A Pending CN101889074A (zh) 2007-10-04 2008-10-06 采用电子显微镜对核酸聚合物测序

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US (8) US20100331195A1 (enExample)
EP (1) EP2203547A4 (enExample)
JP (1) JP2010539991A (enExample)
KR (1) KR20100089060A (enExample)
CN (1) CN101889074A (enExample)
AU (1) AU2008308457A1 (enExample)
CA (1) CA2701726A1 (enExample)
EA (1) EA201000427A1 (enExample)
IL (1) IL204866A0 (enExample)
MX (1) MX2010003724A (enExample)
WO (1) WO2009046445A1 (enExample)
ZA (1) ZA201002881B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103945930A (zh) * 2011-10-25 2014-07-23 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN104630346A (zh) * 2015-01-05 2015-05-20 东南大学 基于高分辨透射电子显微学的单分子dna测序方法
CN107084998A (zh) * 2016-02-16 2017-08-22 通用电气公司 用于增材制造工件的射线照相和ct检查的方法

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021841B1 (en) * 2007-07-11 2011-09-20 Kenneth David Schatz Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
AU2011207561B2 (en) 2010-01-19 2014-02-20 Verinata Health, Inc. Partition defined detection methods
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
EP2513341B1 (en) 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
AU2010343276B2 (en) 2010-01-19 2015-05-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
CN103843105A (zh) 2010-02-10 2014-06-04 摩奇有限公司(d/b/aVoxa) 暗视野像差矫正电子显微镜
EP3572528A1 (en) 2010-09-24 2019-11-27 The Board of Trustees of the Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
WO2012064850A1 (en) * 2010-11-09 2012-05-18 Michael Andregg Liquid-gas interface mediated molecule manipulation
US20140121132A1 (en) * 2011-03-11 2014-05-01 Cornell University Systems and methods for high resolution biomolecular imaging and analysis
US20150065358A1 (en) 2011-03-30 2015-03-05 Verinata Health, Inc. Method for verifying bioassay samples
PT3456844T (pt) 2011-04-12 2020-08-25 Verinata Health Inc Resolução de frações de genoma utilizando contagens de polimorfismos
CN102985561B (zh) 2011-04-14 2015-04-01 维里纳塔健康公司 用于确定并且验证常见的和罕见的染色体非整倍性的归一化染色体
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US20130029348A1 (en) * 2011-07-26 2013-01-31 Opgen, Inc. Methods of elongating nucleic acids
KR101974492B1 (ko) 2011-07-26 2019-05-02 베리나타 헬스, 인코포레이티드 샘플 중 상이한 이수성의 존재 또는 부재를 결정하는 방법
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
DK2766496T3 (en) 2011-10-11 2017-05-15 Sequenom Inc METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
JP2014176297A (ja) * 2011-11-11 2014-09-25 Nagayama Ip Holdings Llc 塩基対応標識方法、塩基配列情報取得方法及び塩基対応標識化一本鎖核酸
JP6034801B2 (ja) * 2011-11-15 2016-11-30 ナガヤマ アイピー ホールディングス エルエルシーＮａｇａｙａｍａ ＩＰ Ｈｏｌｄｉｎｇｓ， ＬＬＣ 塩基配列決定装置
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
EP4249605B1 (en) 2011-12-22 2024-08-28 President And Fellows Of Harvard College Methods for analyte detection
US8858778B2 (en) * 2012-01-19 2014-10-14 Michael James Darling Method for DNA defined etching of a graphene nanostructure
EP2805280B1 (en) 2012-01-20 2022-10-05 Sequenom, Inc. Diagnostic processes that factor experimental conditions
WO2013112999A1 (en) * 2012-01-27 2013-08-01 Cornell University Methods and arrays for controlled manipulation of dna and chromatin fragments for genetic and epigenetic analysis
HK1206055A1 (en) 2012-03-02 2015-12-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2875149B1 (en) 2012-07-20 2019-12-04 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2904534B1 (en) 2012-10-04 2021-12-15 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2014212430B2 (en) 2013-01-31 2019-06-20 Codexis, Inc. Methods, systems, and software for identifying bio-molecules with interacting components
EP2971184B1 (en) 2013-03-12 2019-04-17 President and Fellows of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
CA2906818C (en) 2013-03-15 2022-08-16 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
ES2939547T3 (es) 2013-04-03 2023-04-24 Sequenom Inc Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas
US20140336055A1 (en) 2013-05-07 2014-11-13 Sequenom, Inc. Genetic markers for macular degeneration disorder treatment
IL300163B2 (en) 2013-05-24 2024-06-01 Sequenom Inc Methods and processes for non-invasive assessment of genetic variations
EP3003392B1 (en) 2013-06-04 2019-10-23 President and Fellows of Harvard College Rna-guideded transcriptional regulation
CA2915626A1 (en) 2013-06-17 2014-12-24 Verinata Health, Inc. Method for determining copy number variations in sex chromosomes
MX2015016911A (es) 2013-06-21 2016-06-21 Sequenom Inc Metodos y procesos para evaluacion no invasiva de variaciones geneticas.
ES2693150T3 (es) 2013-09-27 2018-12-07 Codexis, Inc. Filtración automática de variantes de enzimas
IL289974B (en) 2013-10-04 2022-09-01 Sequenom Inc Methods and processes for non-invasive evaluation of genetic variations
EP3055427B1 (en) 2013-10-07 2018-09-12 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
US10741269B2 (en) 2013-10-21 2020-08-11 Verinata Health, Inc. Method for improving the sensitivity of detection in determining copy number variations
US10597715B2 (en) 2013-12-05 2020-03-24 Centrillion Technology Holdings Methods for sequencing nucleic acids
EP3628747B1 (en) 2013-12-05 2022-10-05 Centrillion Technology Holdings Corporation Fabrication of patterned arrays
CN105940024B (zh) 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
CN105917008B (zh) 2014-01-16 2020-11-27 启迪公司 用于前列腺癌复发的预后的基因表达面板
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
US10318704B2 (en) 2014-05-30 2019-06-11 Verinata Health, Inc. Detecting fetal sub-chromosomal aneuploidies
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP3940703A1 (en) 2014-07-18 2022-01-19 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic conditions using cellular dna and cell free dna
EP3760739B1 (en) 2014-07-30 2025-09-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20160032281A1 (en) * 2014-07-31 2016-02-04 Fei Company Functionalized grids for locating and imaging biological specimens and methods of using the same
ES2688840T3 (es) 2014-10-09 2018-11-07 F. Hoffmann-La Roche Ag Mutaciones en el dominio cinasa del receptor del factor de crecimiento epidérmico
US11789906B2 (en) 2014-11-19 2023-10-17 Arc Bio, Llc Systems and methods for genomic manipulations and analysis
WO2016094853A1 (en) 2014-12-12 2016-06-16 Verinata Health, Inc. Using cell-free dna fragment size to determine copy number variations
EP3332034B1 (en) 2015-08-06 2024-09-25 Arc Bio, LLC Systems and methods for genomic analysis
WO2017049180A1 (en) 2015-09-18 2017-03-23 Agena Bioscience, Inc. Methods and compositions for the quantitation of mitochondrial nucleic acid
JP6882282B2 (ja) 2015-11-03 2021-06-02 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元核酸含有マトリックスの立体撮像のための方法と装置
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
EP3449016B1 (en) 2016-04-25 2025-07-23 President and Fellows of Harvard College Hybridization chain reaction methods for in situ molecular detection
CA3030890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
JP7239465B2 (ja) 2016-08-31 2023-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光ｉｎ ｓｉｔｕ配列決定による検出のための核酸配列ライブラリの作製法
WO2018045186A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
JP7237003B2 (ja) 2017-01-24 2023-03-10 セクエノム， インコーポレイテッド 遺伝子片の評価のための方法およびプロセス
JP7024490B2 (ja) * 2017-02-27 2022-02-24 住友金属鉱山株式会社 汚染堆積物の定量方法および試料分析方法
US12421550B2 (en) 2017-03-17 2025-09-23 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
KR20190140906A (ko) 2017-04-14 2019-12-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포-유래 마이크로필라멘트 네트워크의 생성 방법
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
SG11201911538YA (en) 2017-06-20 2020-01-30 Illumina Inc Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
KR102543270B1 (ko) 2017-06-20 2023-06-13 일루미나, 인코포레이티드 미지의 유전자형의 기여자로부터의 dna 혼합물의 정확한 컴퓨팅 분해를 위한 방법
US12367978B2 (en) 2017-12-01 2025-07-22 Illumina, Inc. Methods and systems for determining somatic mutation clonality
KR102893736B1 (ko) 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
EP3836967A4 (en) 2018-07-30 2022-06-15 ReadCoor, LLC METHODS AND SYSTEMS FOR SAMPLE PROCESSING OR ANALYSIS
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
CN111324096B (zh) * 2020-03-03 2021-04-23 郑州旭飞光电科技有限公司 一种基板玻璃加工、包装信息可追溯系统及方法
CN111537529A (zh) * 2020-04-09 2020-08-14 中国科学院微电子研究所 一种用于附着穿透式电子显微镜样品的硅网及其制备方法
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2022164968A1 (en) 2021-01-29 2022-08-04 Day Zero Diagnostics, Inc. Methods for enriching microorganisms from low abundance clinical samples for dna sequencing
WO2024249175A1 (en) 2023-05-26 2024-12-05 Illumina, Inc. Methods for discriminating between fetal and maternal events in non-invasive prenatal test samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
US20020086317A1 (en) * 2000-11-17 2002-07-04 Jeol Ltd. Method of determining base sequence of DNA or RNA and DNA sequencer
WO2004097032A2 (en) * 2003-04-28 2004-11-11 Nagayama Ip Holdings Llc Method for nucleic acid sequencing
US20040243023A1 (en) * 2003-05-30 2004-12-02 Grigoryants Sergey S Transbronchial needle aspiration device
US20060286573A1 (en) * 2005-03-25 2006-12-21 Canon Kabushiki Kaisha Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689295A (en) * 1983-01-20 1987-08-25 Integrated Genetics, Inc. Test for Salmonella
US6221581B1 (en) * 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US6150089A (en) * 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5106729A (en) * 1989-07-24 1992-04-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Method for visualizing the base sequence of nucleic acid polymers
US5789161A (en) * 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
JPH05244997A (ja) * 1992-03-04 1993-09-24 Hitachi Ltd Ｄｎａまたはｒｎａの塩基配列決定法
US5871912A (en) * 1992-04-30 1999-02-16 Institut Pasteur Nucleic acid probes, sequences and methods for detecting mycobacterium tuberculosis resistant to isoniazid
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
JPH08506664A (ja) * 1993-02-01 1996-07-16 セック，リミテッド Ｄｎａ配列決定の方法および装置
GB9401200D0 (en) * 1994-01-21 1994-03-16 Medical Res Council Sequencing of nucleic acids
US20020168642A1 (en) 1994-06-06 2002-11-14 Andrzej Drukier Sequencing duplex DNA by mass spectroscopy
WO1996009410A1 (en) * 1994-09-23 1996-03-28 Finkelstein Sydney D Topographic genotyping
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU730633B2 (en) * 1996-05-29 2001-03-08 Phillip Belgrader Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
CA2205081A1 (en) * 1997-06-04 1998-12-04 Graham Dellaire A method to map and isolate regions of chromosomes that interact or associate functionally within or between chromosomes in vivo
US5903085A (en) * 1997-06-18 1999-05-11 Phase Metrics, Inc. Piezoelectric nanopositioner
DE19900511C2 (de) * 1999-01-08 2001-03-15 Deutsches Krebsforsch Molekularbiologische Marker für die analytische Elektronenmikroskopie
WO2000075868A2 (en) * 1999-06-07 2000-12-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in three-dimensional structural determination
DE19937512B4 (de) * 1999-08-09 2006-08-24 Alexander Cherkasky Verfahren und Gerät zur schnellen Genom-Sequenzierung durch Linearisierung oder Auseinanderziehen der DNA
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP5508654B2 (ja) * 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
EP1354064A2 (en) * 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
KR100803186B1 (ko) * 2000-12-15 2008-02-14 디 아리조나 보드 오브 리전츠 나노입자 함유 전구체를 사용한 금속의 패턴형성 방법
WO2002075306A1 (en) * 2001-03-16 2002-09-26 Large Scale Biology Corporation Episomal non-transforming nucleic acid elements in functional genomic and antigenic applications
EP2801624B1 (en) * 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
FR2823223B1 (fr) * 2001-04-04 2004-03-12 Centre Nat Rech Scient Structure bicouche supportee de presentation d'un acide nucleique associe a une proteine
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB2378245A (en) * 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US7101667B2 (en) * 2001-09-07 2006-09-05 Massachusetts Institute Of Technology Lanthanide binding tags
FR2829580B1 (fr) * 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
US20040086885A1 (en) * 2002-02-22 2004-05-06 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
JP4120240B2 (ja) * 2002-03-06 2008-07-16 株式会社島津製作所 生体由来異物検査法
US20060003437A1 (en) * 2002-06-26 2006-01-05 Fujitsu Limited Target detecting device and target capturer, device and method for molecular adsorption or desorption, and device and method for protein detection
US20050009055A1 (en) * 2002-07-12 2005-01-13 Affymetrix, Inc. System and method for examination of microarrays using scanning electron microscope
US20040081985A1 (en) * 2002-07-12 2004-04-29 Affymetrix, Inc. Systems and method for examination of microarrays using scanning electron microscope
EP1556506A1 (en) * 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
EP1424671A1 (en) * 2002-11-29 2004-06-02 Alrec Sign & Display B.V. Illuminated sign
JP2004212355A (ja) * 2003-01-09 2004-07-29 Hitachi Ltd バイオ電子顕微鏡及び試料の観察方法
US20100035254A1 (en) * 2003-04-08 2010-02-11 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
CA2521329C (en) * 2003-04-21 2015-11-24 F. Hoffmann-La Roche Ag Associations of polymorphisms in the frzb gene with osteoporosis
WO2005052582A2 (en) * 2003-11-28 2005-06-09 Pamgene B.V. Methods and apparatus for cell based microarray assays
US20050147977A1 (en) * 2003-12-29 2005-07-07 Tae-Woong Koo Methods and compositions for nucleic acid detection and sequence analysis
US7381529B2 (en) * 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
EP1735811B1 (en) 2004-04-02 2015-09-09 California Institute Of Technology Method and system for ultrafast photoelectron microscope
US7618778B2 (en) 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
JP5224443B2 (ja) * 2004-07-14 2013-07-03 ゼットエス ジェネティクス，インコーポレーテッド 核酸ポリマーの分析システムおよび方法および関連構成要素
JP4563117B2 (ja) * 2004-09-03 2010-10-13 エスアイアイ・ナノテクノロジー株式会社 顕微鏡システム及び顕微鏡システムの走査法ならびに顕微鏡システムの画像合成法
US20090239215A1 (en) * 2004-12-16 2009-09-24 Brandeis University Clonable Tag for Purification and Electron Microscopy Labeling
US7875426B2 (en) * 2005-02-04 2011-01-25 University Of South Florida DNA biochip and methods of use
US20060287833A1 (en) * 2005-06-17 2006-12-21 Zohar Yakhini Method and system for sequencing nucleic acid molecules using sequencing by hybridization and comparison with decoration patterns
WO2007030014A2 (en) * 2005-09-09 2007-03-15 Keygene N.V. Homologous recombination in plants
AU2006305901A1 (en) * 2005-10-27 2007-05-03 Trustees Of Boston University Real time nucleic acid detection in vivo using protein complementation
WO2007120202A2 (en) * 2005-11-09 2007-10-25 Zs Genetics, Inc. Nano-scale ligand arrays on substrates for particle beam instruments and related methods
CN101454461A (zh) 2005-11-16 2009-06-10 Ambrx公司 包括非天然氨基酸的方法和组合物
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
WO2007089542A2 (en) * 2006-01-27 2007-08-09 Zs Genetics, Inc. Systems and methods of analyzing nucleic acid polymers by using particle beams
ES2301342B1 (es) * 2006-03-14 2009-05-01 Oryzon Genomics, S.A. "metodo de analisis de acidos nucleicos".
DE502006005397D1 (de) * 2006-03-25 2009-12-31 Univ Ruprecht Karls Heidelberg Verfahren zur mikroskopischen Ortsbestimmung eines ausgewählten, intrazellulären DNA-Abschnitts bekannter Nukleotidsequenz
JP5092462B2 (ja) * 2006-06-13 2012-12-05 株式会社デンソー 力学量センサ
US8685658B2 (en) * 2006-07-17 2014-04-01 Fox Chase Cancer Center Compositions and methods for the treatment of diseases associated with aberrant cilia assembly and regulation
CN103203256B (zh) * 2006-07-19 2015-09-23 博纳基因技术有限公司 纳米口装置阵列:它们的制备以及在大分子分析中的应用
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20080060778A1 (en) * 2006-09-08 2008-03-13 Abraham Velasco-Tellez Binder composition and method of forming foundry sand cores and molds
US20090208965A1 (en) * 2006-10-25 2009-08-20 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
WO2009015359A2 (en) * 2007-07-26 2009-01-29 Cellay, Llc Highly visible chromosome-specific probes and related methods
WO2009052214A2 (en) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
JP2009178159A (ja) * 2007-11-05 2009-08-13 Hitachi Plant Technologies Ltd 核酸配列の検出方法及び核酸配列検出基板

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
US20020086317A1 (en) * 2000-11-17 2002-07-04 Jeol Ltd. Method of determining base sequence of DNA or RNA and DNA sequencer
WO2004097032A2 (en) * 2003-04-28 2004-11-11 Nagayama Ip Holdings Llc Method for nucleic acid sequencing
US20040243023A1 (en) * 2003-05-30 2004-12-02 Grigoryants Sergey S Transbronchial needle aspiration device
US20060286573A1 (en) * 2005-03-25 2006-12-21 Canon Kabushiki Kaisha Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103945930A (zh) * 2011-10-25 2014-07-23 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN103945930B (zh) * 2011-10-25 2016-10-05 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN104630346A (zh) * 2015-01-05 2015-05-20 东南大学 基于高分辨透射电子显微学的单分子dna测序方法
CN107084998A (zh) * 2016-02-16 2017-08-22 通用电气公司 用于增材制造工件的射线照相和ct检查的方法

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