CN101889074A - 采用电子显微镜对核酸聚合物测序 - Google Patents

采用电子显微镜对核酸聚合物测序 Download PDF

Info

Publication number
CN101889074A
CN101889074A CN2008801193343A CN200880119334A CN101889074A CN 101889074 A CN101889074 A CN 101889074A CN 2008801193343 A CN2008801193343 A CN 2008801193343A CN 200880119334 A CN200880119334 A CN 200880119334A CN 101889074 A CN101889074 A CN 101889074A
Authority
CN
China
Prior art keywords
nucleic acid
base
dna
substrate
chains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801193343A
Other languages
English (en)
Chinese (zh)
Inventor
威廉·安德雷格
迈克尔·安德雷格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Halcyon Molecular Inc
Original Assignee
Halcyon Molecular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halcyon Molecular Inc filed Critical Halcyon Molecular Inc
Publication of CN101889074A publication Critical patent/CN101889074A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2008801193343A 2007-10-04 2008-10-06 采用电子显微镜对核酸聚合物测序 Pending CN101889074A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99742707P 2007-10-04 2007-10-04
US60/997,427 2007-10-04
US13296008P 2008-06-23 2008-06-23
US61/132,960 2008-06-23
PCT/US2008/078986 WO2009046445A1 (en) 2007-10-04 2008-10-06 Sequencing nucleic acid polymers with electron microscopy

Publications (1)

Publication Number Publication Date
CN101889074A true CN101889074A (zh) 2010-11-17

Family

ID=40526732

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801193343A Pending CN101889074A (zh) 2007-10-04 2008-10-06 采用电子显微镜对核酸聚合物测序

Country Status (12)

Country Link
US (8) US20100331195A1 (enExample)
EP (1) EP2203547A4 (enExample)
JP (1) JP2010539991A (enExample)
KR (1) KR20100089060A (enExample)
CN (1) CN101889074A (enExample)
AU (1) AU2008308457A1 (enExample)
CA (1) CA2701726A1 (enExample)
EA (1) EA201000427A1 (enExample)
IL (1) IL204866A0 (enExample)
MX (1) MX2010003724A (enExample)
WO (1) WO2009046445A1 (enExample)
ZA (1) ZA201002881B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103945930A (zh) * 2011-10-25 2014-07-23 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN104630346A (zh) * 2015-01-05 2015-05-20 东南大学 基于高分辨透射电子显微学的单分子dna测序方法
CN107084998A (zh) * 2016-02-16 2017-08-22 通用电气公司 用于增材制造工件的射线照相和ct检查的方法

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021841B1 (en) * 2007-07-11 2011-09-20 Kenneth David Schatz Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
ES2704701T3 (es) 2010-01-19 2019-03-19 Verinata Health Inc Nuevo protocolo de preparación de bibliotecas de secuenciación
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US8700341B2 (en) 2010-01-19 2014-04-15 Verinata Health, Inc. Partition defined detection methods
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
AU2011207544A1 (en) 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
WO2011100434A2 (en) 2010-02-10 2011-08-18 Chistopher Su-Yan Own Aberration-correcting dark-field electron microscopy
AU2011305445B2 (en) 2010-09-24 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
WO2012064850A1 (en) * 2010-11-09 2012-05-18 Michael Andregg Liquid-gas interface mediated molecule manipulation
WO2012125547A2 (en) * 2011-03-11 2012-09-20 Cornell University Systems and methods for high resolution biomolecular imaging and analysis
AU2012236200B2 (en) 2011-03-30 2015-05-14 Verinata Health, Inc. Method for verifying bioassay samples
ES2572912T3 (es) 2011-04-12 2016-06-03 Verinata Health, Inc Resolución de fracciones de genoma mediante recuento de polimorfismos
CN102985561B (zh) 2011-04-14 2015-04-01 维里纳塔健康公司 用于确定并且验证常见的和罕见的染色体非整倍性的归一化染色体
WO2014014498A1 (en) 2012-07-20 2014-01-23 Verinata Health, Inc. Detecting and classifying copy number variation in a fetal genome
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US20130029348A1 (en) * 2011-07-26 2013-01-31 Opgen, Inc. Methods of elongating nucleic acids
GB2485635B (en) 2011-07-26 2012-11-28 Verinata Health Inc Method for determining the presence or absence of different aneuploidies in a sample
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2764458B1 (en) 2011-10-06 2021-04-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
EP3243908B1 (en) 2011-10-11 2019-01-02 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2766498B1 (en) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequencing by structure assembly
JP2014176297A (ja) * 2011-11-11 2014-09-25 Nagayama Ip Holdings Llc 塩基対応標識方法、塩基配列情報取得方法及び塩基対応標識化一本鎖核酸
WO2013073610A1 (ja) * 2011-11-15 2013-05-23 ナガヤマ アイピー ホールディングス エルエルシー 塩基配列決定装置
EP2794928B1 (en) 2011-12-22 2019-02-20 President and Fellows of Harvard College Compositions and methods for analyte detection
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
US8858778B2 (en) * 2012-01-19 2014-10-14 Michael James Darling Method for DNA defined etching of a graphene nanostructure
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
US9856513B2 (en) * 2012-01-27 2018-01-02 Cornell University Methods and arrays for controlled manipulation of DNA and chromatin fragments for genetic and epigenetic analysis
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA3120521A1 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
RU2695146C2 (ru) 2013-01-31 2019-07-22 Кодексис, Инк. Способы, системы и программное обеспечение для идентификации биомолекул со взаимодействующими компонентами
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
WO2014145078A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140336055A1 (en) 2013-05-07 2014-11-13 Sequenom, Inc. Genetic markers for macular degeneration disorder treatment
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3603679B1 (en) 2013-06-04 2022-08-10 President and Fellows of Harvard College Rna-guided transcriptional regulation
CN105722994B (zh) 2013-06-17 2020-12-18 维里纳塔健康公司 用于确定性染色体中的拷贝数变异的方法
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
DK3049973T3 (en) 2013-09-27 2018-10-22 Codexis Inc AUTOMATED SCREENING OF ENZYM VARIENTS
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム， インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
JP6534191B2 (ja) 2013-10-21 2019-06-26 ベリナタ ヘルス インコーポレイテッド コピー数変動を決定することにおける検出の感度を向上させるための方法
CN111118121B (zh) 2013-12-05 2024-07-19 生捷科技控股公司 图案化阵列的制备
CN105940024B (zh) 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
CN107002117B (zh) 2013-12-05 2021-12-10 生捷科技控股公司 核酸测序方法
JP6666852B2 (ja) 2014-01-16 2020-03-18 イルミナ インコーポレイテッド 前立腺がん再発の予後に関する遺伝子発現パネル
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
WO2015184404A1 (en) 2014-05-30 2015-12-03 Verinata Health, Inc. Detecting fetal sub-chromosomal aneuploidies and copy number variations
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
AU2015289414B2 (en) 2014-07-18 2021-07-08 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US20160032281A1 (en) * 2014-07-31 2016-02-04 Fei Company Functionalized grids for locating and imaging biological specimens and methods of using the same
CN106795567B (zh) 2014-10-09 2021-07-30 豪夫迈·罗氏有限公司 在表皮生长因子受体激酶结构域中的突变
US11789906B2 (en) 2014-11-19 2023-10-17 Arc Bio, Llc Systems and methods for genomic manipulations and analysis
DK3230469T3 (da) 2014-12-12 2019-07-15 Verinata Health Inc Anvendelse af cellefri DNA-fragmentstørrelse til bestemmelse af kopiantalsvariationer
CN114350752B (zh) 2015-07-17 2025-02-25 布鲁克空间生物学公司 在横切面组织的用户定义区域中的基因表达的同时定量
JP6946292B2 (ja) 2015-08-06 2021-10-06 エイアールシー バイオ リミテッド ライアビリティ カンパニー ゲノム分析のためのシステムおよび方法
WO2017049180A1 (en) 2015-09-18 2017-03-23 Agena Bioscience, Inc. Methods and compositions for the quantitation of mitochondrial nucleic acid
CN108474022A (zh) 2015-11-03 2018-08-31 哈佛学院董事及会员团体 用于包含三维核酸的基质容积成像的设备和方法
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
AU2017257624B2 (en) 2016-04-25 2023-05-25 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
EP4582805A3 (en) 2016-08-31 2025-10-08 President And Fellows Of Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
AU2017361521B2 (en) 2016-11-21 2020-08-27 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
CA3207879C (en) 2017-01-24 2026-06-16 Sequenom, Inc. Methods and processes for assessment of genetic variations
JP7024490B2 (ja) * 2017-02-27 2022-02-24 住友金属鉱山株式会社 汚染堆積物の定量方法および試料分析方法
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
CA3019250A1 (en) 2017-04-14 2019-10-13 President And Fellows Of Harvard College Methods for generation of cell-derived microfilament network
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
WO2018236911A1 (en) 2017-06-20 2018-12-27 Illumina, Inc. Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
US11990208B2 (en) 2017-06-20 2024-05-21 Illumina, Inc. Methods for accurate computational decomposition of DNA mixtures from contributors of unknown genotypes
EP3622522A1 (en) 2017-12-01 2020-03-18 Illumina, Inc. Methods and systems for determining somatic mutation clonality
KR102893736B1 (ko) 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
CN112770776B (zh) 2018-07-30 2025-08-19 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
WO2021155063A1 (en) 2020-01-29 2021-08-05 Readcoor, Llc Compositions and methods for analyte detection
CN111324096B (zh) * 2020-03-03 2021-04-23 郑州旭飞光电科技有限公司 一种基板玻璃加工、包装信息可追溯系统及方法
CN111537529A (zh) * 2020-04-09 2020-08-14 中国科学院微电子研究所 一种用于附着穿透式电子显微镜样品的硅网及其制备方法
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2022164968A1 (en) 2021-01-29 2022-08-04 Day Zero Diagnostics, Inc. Methods for enriching microorganisms from low abundance clinical samples for dna sequencing
WO2024249175A1 (en) 2023-05-26 2024-12-05 Illumina, Inc. Methods for discriminating between fetal and maternal events in non-invasive prenatal test samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
US20020086317A1 (en) * 2000-11-17 2002-07-04 Jeol Ltd. Method of determining base sequence of DNA or RNA and DNA sequencer
WO2004097032A2 (en) * 2003-04-28 2004-11-11 Nagayama Ip Holdings Llc Method for nucleic acid sequencing
US20040243023A1 (en) * 2003-05-30 2004-12-02 Grigoryants Sergey S Transbronchial needle aspiration device
US20060286573A1 (en) * 2005-03-25 2006-12-21 Canon Kabushiki Kaisha Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689295A (en) * 1983-01-20 1987-08-25 Integrated Genetics, Inc. Test for Salmonella
US6221581B1 (en) * 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US6150089A (en) * 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5106729A (en) * 1989-07-24 1992-04-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Method for visualizing the base sequence of nucleic acid polymers
US5789161A (en) * 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
JPH05244997A (ja) * 1992-03-04 1993-09-24 Hitachi Ltd Ｄｎａまたはｒｎａの塩基配列決定法
US5871912A (en) * 1992-04-30 1999-02-16 Institut Pasteur Nucleic acid probes, sequences and methods for detecting mycobacterium tuberculosis resistant to isoniazid
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
CA2155186A1 (en) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
GB9401200D0 (en) * 1994-01-21 1994-03-16 Medical Res Council Sequencing of nucleic acids
US20020168642A1 (en) * 1994-06-06 2002-11-14 Andrzej Drukier Sequencing duplex DNA by mass spectroscopy
JPH10506280A (ja) * 1994-09-23 1998-06-23 ディー． フィンケルスタイン，シドニー 形態的遺伝子型識別法
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU730633B2 (en) * 1996-05-29 2001-03-08 Phillip Belgrader Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
CA2205081A1 (en) * 1997-06-04 1998-12-04 Graham Dellaire A method to map and isolate regions of chromosomes that interact or associate functionally within or between chromosomes in vivo
US5903085A (en) * 1997-06-18 1999-05-11 Phase Metrics, Inc. Piezoelectric nanopositioner
DE19900511C2 (de) * 1999-01-08 2001-03-15 Deutsches Krebsforsch Molekularbiologische Marker für die analytische Elektronenmikroskopie
WO2000075868A2 (en) * 1999-06-07 2000-12-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in three-dimensional structural determination
DE19937512B4 (de) * 1999-08-09 2006-08-24 Alexander Cherkasky Verfahren und Gerät zur schnellen Genom-Sequenzierung durch Linearisierung oder Auseinanderziehen der DNA
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
CA2405412A1 (en) * 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US7211414B2 (en) * 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
CA2430253C (en) * 2000-12-15 2011-04-26 The Arizona Board Of Regents Method for patterning metal using nanoparticle containing precursors
US20020182626A1 (en) * 2001-03-16 2002-12-05 Daniel Tuse Episomal non-transforming nucleic acid elements in functional genomic and antigenic applications
EP2801624B1 (en) * 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
FR2823223B1 (fr) * 2001-04-04 2004-03-12 Centre Nat Rech Scient Structure bicouche supportee de presentation d'un acide nucleique associe a une proteine
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB2378245A (en) * 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
FR2829580B1 (fr) * 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
AU2002332846A1 (en) * 2001-09-07 2003-04-07 Boston University Lanthanide binding tags
WO2003072830A1 (en) * 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
JP4120240B2 (ja) * 2002-03-06 2008-07-16 株式会社島津製作所 生体由来異物検査法
US20060003437A1 (en) * 2002-06-26 2006-01-05 Fujitsu Limited Target detecting device and target capturer, device and method for molecular adsorption or desorption, and device and method for protein detection
US20040081985A1 (en) * 2002-07-12 2004-04-29 Affymetrix, Inc. Systems and method for examination of microarrays using scanning electron microscope
US20050009055A1 (en) * 2002-07-12 2005-01-13 Affymetrix, Inc. System and method for examination of microarrays using scanning electron microscope
AU2003267583A1 (en) * 2002-09-19 2004-04-08 The Chancellor, Master And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
EP1424671A1 (en) * 2002-11-29 2004-06-02 Alrec Sign & Display B.V. Illuminated sign
JP2004212355A (ja) * 2003-01-09 2004-07-29 Hitachi Ltd バイオ電子顕微鏡及び試料の観察方法
US20100035254A1 (en) * 2003-04-08 2010-02-11 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
DE602004028924D1 (de) * 2003-04-21 2010-10-14 Roche Diagnostics Gmbh Polymorphismen des frzb gens und deren zusammenhang mit osteoporose
US20070072187A1 (en) * 2003-11-28 2007-03-29 Blok Herman J Novel methods and apparatus for cell based microarray assays
US20050147977A1 (en) * 2003-12-29 2005-07-07 Tae-Woong Koo Methods and compositions for nucleic acid detection and sequence analysis
US7381529B2 (en) * 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
US7154091B2 (en) * 2004-04-02 2006-12-26 California Institute Of Technology Method and system for ultrafast photoelectron microscope
WO2005118877A2 (en) * 2004-06-02 2005-12-15 Vicus Bioscience, Llc Producing, cataloging and classifying sequence tags
KR101229318B1 (ko) * 2004-07-14 2013-02-05 제트에스 제네틱스, 인코포레이티드 핵산 폴리머 분석 시스템과 방법 및 관련 물품
JP4563117B2 (ja) * 2004-09-03 2010-10-13 エスアイアイ・ナノテクノロジー株式会社 顕微鏡システム及び顕微鏡システムの走査法ならびに顕微鏡システムの画像合成法
WO2006118615A2 (en) * 2004-12-16 2006-11-09 Brandeis University Clonable tag for purification and electron microscopy labeling
US7875426B2 (en) * 2005-02-04 2011-01-25 University Of South Florida DNA biochip and methods of use
US20060287833A1 (en) * 2005-06-17 2006-12-21 Zohar Yakhini Method and system for sequencing nucleic acid molecules using sequencing by hybridization and comparison with decoration patterns
CN101300349A (zh) * 2005-09-09 2008-11-05 关键基因公司 植物的同源重组
US20090029370A1 (en) * 2005-10-27 2009-01-29 Trustees Of Boston University Real time nucleic acid detection in vivo using protein complementation
TW200736401A (en) * 2005-11-09 2007-10-01 Zs Genetics Inc Nano-scale ligand arrays on substrates for particle beam instruments and related methods
EP1951890A4 (en) * 2005-11-16 2009-06-24 Ambrx Inc PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
US20070190557A1 (en) * 2006-01-27 2007-08-16 Zs Genetics, Inc. Systems and methods of analyzing nucleic acid polymers and related components
ES2301342B1 (es) * 2006-03-14 2009-05-01 Oryzon Genomics, S.A. "metodo de analisis de acidos nucleicos".
DK1840223T3 (da) * 2006-03-25 2010-03-29 Univ Ruprecht Karls Heidelberg Fremgangsmåde til mikroskopisk stedbestemmelse af et udvalgt , intracellulært DNA-afsnit af kendt nukleotidsekvens
JP5092462B2 (ja) * 2006-06-13 2012-12-05 株式会社デンソー 力学量センサ
WO2008011430A2 (en) * 2006-07-17 2008-01-24 Fox Chase Cancer Center Compositions and methods for the treatment of diseases associated with aberrant cilia assembly and regulation
AU2007338862B2 (en) * 2006-07-19 2014-02-06 Bionano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20080060778A1 (en) * 2006-09-08 2008-03-13 Abraham Velasco-Tellez Binder composition and method of forming foundry sand cores and molds
US20090208965A1 (en) * 2006-10-25 2009-08-20 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
US20090215643A1 (en) * 2007-07-26 2009-08-27 Cellay, Llc Highly Visible Chromosome-Specific Probes and Related Methods
WO2009052214A2 (en) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
JP2009178159A (ja) * 2007-11-05 2009-08-13 Hitachi Plant Technologies Ltd 核酸配列の検出方法及び核酸配列検出基板

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
US20020086317A1 (en) * 2000-11-17 2002-07-04 Jeol Ltd. Method of determining base sequence of DNA or RNA and DNA sequencer
WO2004097032A2 (en) * 2003-04-28 2004-11-11 Nagayama Ip Holdings Llc Method for nucleic acid sequencing
US20040243023A1 (en) * 2003-05-30 2004-12-02 Grigoryants Sergey S Transbronchial needle aspiration device
US20060286573A1 (en) * 2005-03-25 2006-12-21 Canon Kabushiki Kaisha Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103945930A (zh) * 2011-10-25 2014-07-23 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN103945930B (zh) * 2011-10-25 2016-10-05 亚利桑那董事会，代表亚利桑那州立大学行事的亚利桑那州法人团体 可编程的阵列
CN104630346A (zh) * 2015-01-05 2015-05-20 东南大学 基于高分辨透射电子显微学的单分子dna测序方法
CN107084998A (zh) * 2016-02-16 2017-08-22 通用电气公司 用于增材制造工件的射线照相和ct检查的方法

Also Published As

Publication number Publication date
ZA201002881B (en) 2011-07-27
IL204866A0 (en) 2010-11-30
JP2010539991A (ja) 2010-12-24
US20100267154A1 (en) 2010-10-21
US20100267155A1 (en) 2010-10-21
US8153438B2 (en) 2012-04-10
US20100267157A1 (en) 2010-10-21
US20100267156A1 (en) 2010-10-21
CA2701726A1 (en) 2009-04-09
US20100268478A1 (en) 2010-10-21
AU2008308457A1 (en) 2009-04-09
US20100267152A1 (en) 2010-10-21
US20100331195A1 (en) 2010-12-30
EP2203547A4 (en) 2011-06-01
WO2009046445A1 (en) 2009-04-09
EP2203547A1 (en) 2010-07-07
KR20100089060A (ko) 2010-08-11
MX2010003724A (es) 2010-09-14
EA201000427A1 (ru) 2010-10-29
US20100267153A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
US8153438B2 (en) Sequencing nucleic acid polymers with electron microscopy
JP3670019B2 (ja) 巨大分子を平行に整列させる装置およびその使用
US20190376925A1 (en) Nucleic acid sequencing device containing graphene
JP4697852B2 (ja) 分子構造を検出および同定するための走査型プローブ顕微鏡像のモデルを用いた融合
US20050151126A1 (en) Methods of producing carbon nanotubes using peptide or nucleic acid micropatterning
EP1963500A2 (en) Compositions comprising oriented, immobilized macromolecules and methods for their preparation
WO2016134191A1 (en) Assays for single molecule detection and use thereof
US20110165665A1 (en) Apparatus and methods for detecting dna in biological samples
US20150011425A1 (en) Methods and arrays for controlled manipulation of dna and chromatin fragments for genetic and epigenetic analysis
CN1682237B (zh) 用于通过使用编码探针检测生物分子的方法和仪器
JPH05244997A (ja) Ｄｎａまたはｒｎａの塩基配列決定法
CN101189345A (zh) 珠基测序的试剂、方法和文库
HK1152071A (en) Sequencing nucleic acid polymers with electron microscopy
WO2004036591A1 (en) Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
WO2010144128A2 (en) Molecular alignment and attachment of nucleic acid molecules
WO2023055776A1 (en) Devices and methods for interrogating macromolecules
WO2026103880A1 (zh) 一种固体支持物及其用途
Becerril-Garcia DNA-templated nanomaterials
Cho Ordered DNA Fragmentation and Amplification for Sequencing Applications
Hsueh Single Molecule Science for Personalized Nanomedicine: Atomic Force Microscopy of Biopolymer-Protein Interactions
Petit Micropatterning stretched and aligned DNA for sequence-specific nanolithography
Han et al. Development of a Gene Transfer Technique Using AFM
JP2001124687A (ja) 走査型プローブ顕微鏡による二本鎖核酸の分析

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1152071

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20101117

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1152071

Country of ref document: HK