CN101889015B - 嘧啶取代的嘌呤衍生物 - Google Patents

嘧啶取代的嘌呤衍生物 Download PDF

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Publication number
CN101889015B
CN101889015B CN200880119649.8A CN200880119649A CN101889015B CN 101889015 B CN101889015 B CN 101889015B CN 200880119649 A CN200880119649 A CN 200880119649A CN 101889015 B CN101889015 B CN 101889015B
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CN
China
Prior art keywords
group
optionally substituted
compound
butyl
fragment
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Expired - Fee Related
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CN200880119649.8A
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English (en)
Chinese (zh)
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CN101889015A (zh
Inventor
H·K·M·纳加拉
M·威廉姆斯
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SBio Pte Ltd
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S bio Pte Ltd
Verastem Inc
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Priority to CN201410185174.XA priority Critical patent/CN104119336B/zh
Publication of CN101889015A publication Critical patent/CN101889015A/zh
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Publication of CN101889015B publication Critical patent/CN101889015B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN200880119649.8A 2007-10-05 2008-10-03 嘧啶取代的嘌呤衍生物 Expired - Fee Related CN101889015B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410185174.XA CN104119336B (zh) 2007-10-05 2008-10-03 嘧啶取代的嘌呤衍生物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97772007P 2007-10-05 2007-10-05
US60/977,720 2007-10-05
US7553208P 2008-06-25 2008-06-25
US61/075,532 2008-06-25
PCT/SG2008/000379 WO2009045175A1 (en) 2007-10-05 2008-10-03 Pyrimidine substituted purine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410185174.XA Division CN104119336B (zh) 2007-10-05 2008-10-03 嘧啶取代的嘌呤衍生物

Publications (2)

Publication Number Publication Date
CN101889015A CN101889015A (zh) 2010-11-17
CN101889015B true CN101889015B (zh) 2014-06-04

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CN200880119649.8A Expired - Fee Related CN101889015B (zh) 2007-10-05 2008-10-03 嘧啶取代的嘌呤衍生物
CN201410185174.XA Expired - Fee Related CN104119336B (zh) 2007-10-05 2008-10-03 嘧啶取代的嘌呤衍生物

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Country Link
US (3) US8247410B2 (enExample)
EP (1) EP2209786B1 (enExample)
JP (2) JP5479346B2 (enExample)
KR (3) KR20160116045A (enExample)
CN (2) CN101889015B (enExample)
AU (1) AU2008307798B2 (enExample)
BR (1) BRPI0817503B8 (enExample)
CA (1) CA2701581C (enExample)
DK (1) DK2209786T3 (enExample)
ES (1) ES2406129T3 (enExample)
IL (2) IL204804A (enExample)
MX (1) MX2010003668A (enExample)
MY (1) MY150993A (enExample)
RU (2) RU2518098C2 (enExample)
WO (1) WO2009045175A1 (enExample)
ZA (1) ZA201003118B (enExample)

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Patent Citations (1)

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JP2010540625A (ja) 2010-12-24
JP5479346B2 (ja) 2014-04-23
KR20150063171A (ko) 2015-06-08
IL204804A0 (en) 2010-11-30
HK1203488A1 (en) 2015-10-30
EP2209786B1 (en) 2013-02-27
US20140066620A1 (en) 2014-03-06
BRPI0817503B1 (pt) 2019-10-29
KR20160116045A (ko) 2016-10-06
RU2014110894A (ru) 2015-07-10
CA2701581C (en) 2016-12-20
ZA201003118B (en) 2011-08-31
CN104119336A (zh) 2014-10-29
RU2681081C2 (ru) 2019-03-04
RU2518098C2 (ru) 2014-06-10
CA2701581A1 (en) 2009-04-09
BRPI0817503B8 (pt) 2021-05-25
US20130079512A1 (en) 2013-03-28
JP2014139159A (ja) 2014-07-31
US8609838B2 (en) 2013-12-17
BRPI0817503A2 (pt) 2015-05-05
IL235555B (en) 2019-08-29
IL204804A (en) 2014-11-30
AU2008307798A1 (en) 2009-04-09
KR101643237B1 (ko) 2016-07-27
RU2010117737A (ru) 2011-11-10
CN101889015A (zh) 2010-11-17
KR101701109B1 (ko) 2017-02-13
MY150993A (en) 2014-03-31
KR20100075609A (ko) 2010-07-02
DK2209786T3 (da) 2013-06-03
IL235555A0 (en) 2014-12-31
EP2209786A1 (en) 2010-07-28
ES2406129T3 (es) 2013-06-05
US20100298319A1 (en) 2010-11-25
US8247410B2 (en) 2012-08-21
WO2009045175A1 (en) 2009-04-09
MX2010003668A (es) 2010-07-02
CN104119336B (zh) 2016-08-24
HK1145832A1 (en) 2011-05-06
AU2008307798B2 (en) 2013-10-03
JP5885729B2 (ja) 2016-03-15

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