KR101643237B1 - 피리미딘 치환된 퓨린 유도체 - Google Patents

피리미딘 치환된 퓨린 유도체 Download PDF

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Publication number
KR101643237B1
KR101643237B1 KR1020107009977A KR20107009977A KR101643237B1 KR 101643237 B1 KR101643237 B1 KR 101643237B1 KR 1020107009977 A KR1020107009977 A KR 1020107009977A KR 20107009977 A KR20107009977 A KR 20107009977A KR 101643237 B1 KR101643237 B1 KR 101643237B1
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KR20100075609A (ko
Inventor
해리쉬 쿠마 마이소르 나가라지
메르디스 윌리암즈
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베라스템, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020107009977A 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체 Expired - Fee Related KR101643237B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97772007P 2007-10-05 2007-10-05
US60/977,720 2007-10-05
US7553208P 2008-06-25 2008-06-25
US61/075,532 2008-06-25

Related Child Applications (1)

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KR1020157013280A Division KR101701109B1 (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체

Publications (2)

Publication Number Publication Date
KR20100075609A KR20100075609A (ko) 2010-07-02
KR101643237B1 true KR101643237B1 (ko) 2016-07-27

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KR1020107009977A Expired - Fee Related KR101643237B1 (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체
KR1020167026687A Withdrawn KR20160116045A (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체
KR1020157013280A Expired - Fee Related KR101701109B1 (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체

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KR1020167026687A Withdrawn KR20160116045A (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체
KR1020157013280A Expired - Fee Related KR101701109B1 (ko) 2007-10-05 2008-10-03 피리미딘 치환된 퓨린 유도체

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Country Link
US (3) US8247410B2 (enExample)
EP (1) EP2209786B1 (enExample)
JP (2) JP5479346B2 (enExample)
KR (3) KR101643237B1 (enExample)
CN (2) CN101889015B (enExample)
AU (1) AU2008307798B2 (enExample)
BR (1) BRPI0817503B8 (enExample)
CA (1) CA2701581C (enExample)
DK (1) DK2209786T3 (enExample)
ES (1) ES2406129T3 (enExample)
IL (2) IL204804A (enExample)
MX (1) MX2010003668A (enExample)
MY (1) MY150993A (enExample)
RU (2) RU2681081C2 (enExample)
WO (1) WO2009045175A1 (enExample)
ZA (1) ZA201003118B (enExample)

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Patent Citations (1)

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US8247410B2 (en) 2012-08-21
HK1145832A1 (en) 2011-05-06
EP2209786B1 (en) 2013-02-27
US8609838B2 (en) 2013-12-17
RU2518098C2 (ru) 2014-06-10
KR20150063171A (ko) 2015-06-08
BRPI0817503B1 (pt) 2019-10-29
RU2681081C2 (ru) 2019-03-04
ZA201003118B (en) 2011-08-31
KR20160116045A (ko) 2016-10-06
CN104119336A (zh) 2014-10-29
MY150993A (en) 2014-03-31
BRPI0817503A2 (pt) 2015-05-05
JP2010540625A (ja) 2010-12-24
WO2009045175A1 (en) 2009-04-09
CN101889015A (zh) 2010-11-17
RU2014110894A (ru) 2015-07-10
CA2701581C (en) 2016-12-20
HK1203488A1 (en) 2015-10-30
RU2010117737A (ru) 2011-11-10
US20100298319A1 (en) 2010-11-25
KR20100075609A (ko) 2010-07-02
MX2010003668A (es) 2010-07-02
CN101889015B (zh) 2014-06-04
ES2406129T3 (es) 2013-06-05
US20130079512A1 (en) 2013-03-28
AU2008307798A1 (en) 2009-04-09
JP5885729B2 (ja) 2016-03-15
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IL235555B (en) 2019-08-29
DK2209786T3 (da) 2013-06-03
JP5479346B2 (ja) 2014-04-23
IL235555A0 (en) 2014-12-31
JP2014139159A (ja) 2014-07-31
BRPI0817503B8 (pt) 2021-05-25
IL204804A0 (en) 2010-11-30
EP2209786A1 (en) 2010-07-28
IL204804A (en) 2014-11-30
US20140066620A1 (en) 2014-03-06
AU2008307798B2 (en) 2013-10-03
CA2701581A1 (en) 2009-04-09
KR101701109B1 (ko) 2017-02-13

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