CN101861307B - 取代的酰胺、其制备方法及其用于治疗疾病例如癌症的用途 - Google Patents

取代的酰胺、其制备方法及其用于治疗疾病例如癌症的用途 Download PDF

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CN101861307B
CN101861307B CN2008801161200A CN200880116120A CN101861307B CN 101861307 B CN101861307 B CN 101861307B CN 2008801161200 A CN2008801161200 A CN 2008801161200A CN 200880116120 A CN200880116120 A CN 200880116120A CN 101861307 B CN101861307 B CN 101861307B
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methyl
oxo
phenyl
amino
dihydro pyrazine
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CN101861307A (zh
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P·A·布洛姆格伦
K·S·居里
S·H·李
S·A·米切尔
J·徐
A·C·施米特
Z·赵
P·E·日科因
D·G·斯塔福德
J·E·克罗普夫
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Gilead Connecticut Inc
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CGI Pharmaceuticals Inc
Gilead Connecticut Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN2008801161200A 2007-09-20 2008-09-19 取代的酰胺、其制备方法及其用于治疗疾病例如癌症的用途 Active CN101861307B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97399507P 2007-09-20 2007-09-20
US60/973,995 2007-09-20
US5077708P 2008-05-06 2008-05-06
US61/050,777 2008-05-06
PCT/US2008/077054 WO2009039397A2 (en) 2007-09-20 2008-09-19 Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer

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CN101861307A CN101861307A (zh) 2010-10-13
CN101861307B true CN101861307B (zh) 2013-05-01

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US (2) US7884108B2 (enExample)
EP (1) EP2188267B1 (enExample)
JP (1) JP5485894B2 (enExample)
KR (1) KR20100072032A (enExample)
CN (1) CN101861307B (enExample)
AR (1) AR068503A1 (enExample)
AU (1) AU2008302099B2 (enExample)
BR (1) BRPI0817130A2 (enExample)
CA (1) CA2700443A1 (enExample)
CL (1) CL2008002793A1 (enExample)
PE (1) PE20091201A1 (enExample)
RU (1) RU2470923C2 (enExample)
TW (1) TWI423966B (enExample)
WO (1) WO2009039397A2 (enExample)

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RU2010115574A (ru) 2011-10-27
US8247550B2 (en) 2012-08-21
TW200914446A (en) 2009-04-01
RU2470923C2 (ru) 2012-12-27
CA2700443A1 (en) 2009-03-26
EP2188267B1 (en) 2016-08-03
US20090082330A1 (en) 2009-03-26
AR068503A1 (es) 2009-11-18
WO2009039397A3 (en) 2009-05-22
AU2008302099B2 (en) 2013-03-28
US20110059944A1 (en) 2011-03-10
KR20100072032A (ko) 2010-06-29
TWI423966B (zh) 2014-01-21
PE20091201A1 (es) 2009-09-13
CN101861307A (zh) 2010-10-13
JP2010540452A (ja) 2010-12-24
AU2008302099A1 (en) 2009-03-26
JP5485894B2 (ja) 2014-05-07
CL2008002793A1 (es) 2009-09-04
WO2009039397A2 (en) 2009-03-26
EP2188267A2 (en) 2010-05-26
BRPI0817130A2 (pt) 2015-03-31
US7884108B2 (en) 2011-02-08

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