AU2008302099B2 - Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer - Google Patents

Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer Download PDF

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Publication number
AU2008302099B2
AU2008302099B2 AU2008302099A AU2008302099A AU2008302099B2 AU 2008302099 B2 AU2008302099 B2 AU 2008302099B2 AU 2008302099 A AU2008302099 A AU 2008302099A AU 2008302099 A AU2008302099 A AU 2008302099A AU 2008302099 B2 AU2008302099 B2 AU 2008302099B2
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AU
Australia
Prior art keywords
methyl
oxo
phenyl
amino
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008302099A
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English (en)
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AU2008302099A1 (en
Inventor
Peter A. Blomgren
Kevin S. Currie
Jeffrey E. Kroft
Seung H. Lee
Scott A. Mitchell
Aaron C. Schmitt
Douglas G. Stafford
Jianjun Xu
Zhongdong Zhao
Pavel E. Zhichkin
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Gilead Connecticut Inc
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Gilead Connecticut Inc
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Application filed by Gilead Connecticut Inc filed Critical Gilead Connecticut Inc
Publication of AU2008302099A1 publication Critical patent/AU2008302099A1/en
Assigned to GILEAD CONNECTICUT, INC. reassignment GILEAD CONNECTICUT, INC. Request for Assignment Assignors: CGI PHARMACEUTICALS, INC.
Application granted granted Critical
Publication of AU2008302099B2 publication Critical patent/AU2008302099B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2008302099A 2007-09-20 2008-09-19 Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer Ceased AU2008302099B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97399507P 2007-09-20 2007-09-20
US60/973,995 2007-09-20
US5077708P 2008-05-06 2008-05-06
US61/050,777 2008-05-06
PCT/US2008/077054 WO2009039397A2 (en) 2007-09-20 2008-09-19 Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer

Publications (2)

Publication Number Publication Date
AU2008302099A1 AU2008302099A1 (en) 2009-03-26
AU2008302099B2 true AU2008302099B2 (en) 2013-03-28

Family

ID=40377565

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008302099A Ceased AU2008302099B2 (en) 2007-09-20 2008-09-19 Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer

Country Status (14)

Country Link
US (2) US7884108B2 (enExample)
EP (1) EP2188267B1 (enExample)
JP (1) JP5485894B2 (enExample)
KR (1) KR20100072032A (enExample)
CN (1) CN101861307B (enExample)
AR (1) AR068503A1 (enExample)
AU (1) AU2008302099B2 (enExample)
BR (1) BRPI0817130A2 (enExample)
CA (1) CA2700443A1 (enExample)
CL (1) CL2008002793A1 (enExample)
PE (1) PE20091201A1 (enExample)
RU (1) RU2470923C2 (enExample)
TW (1) TWI423966B (enExample)
WO (1) WO2009039397A2 (enExample)

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Also Published As

Publication number Publication date
RU2010115574A (ru) 2011-10-27
US8247550B2 (en) 2012-08-21
CN101861307B (zh) 2013-05-01
TW200914446A (en) 2009-04-01
RU2470923C2 (ru) 2012-12-27
CA2700443A1 (en) 2009-03-26
EP2188267B1 (en) 2016-08-03
US20090082330A1 (en) 2009-03-26
AR068503A1 (es) 2009-11-18
WO2009039397A3 (en) 2009-05-22
US20110059944A1 (en) 2011-03-10
KR20100072032A (ko) 2010-06-29
TWI423966B (zh) 2014-01-21
PE20091201A1 (es) 2009-09-13
CN101861307A (zh) 2010-10-13
JP2010540452A (ja) 2010-12-24
AU2008302099A1 (en) 2009-03-26
JP5485894B2 (ja) 2014-05-07
CL2008002793A1 (es) 2009-09-04
WO2009039397A2 (en) 2009-03-26
EP2188267A2 (en) 2010-05-26
BRPI0817130A2 (pt) 2015-03-31
US7884108B2 (en) 2011-02-08

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