CN101848996B - △9延伸酶及其在制备多不饱和脂肪酸中的用途 - Google Patents
△9延伸酶及其在制备多不饱和脂肪酸中的用途 Download PDFInfo
- Publication number
- CN101848996B CN101848996B CN2008800203954A CN200880020395A CN101848996B CN 101848996 B CN101848996 B CN 101848996B CN 2008800203954 A CN2008800203954 A CN 2008800203954A CN 200880020395 A CN200880020395 A CN 200880020395A CN 101848996 B CN101848996 B CN 101848996B
- Authority
- CN
- China
- Prior art keywords
- seq
- acid
- host cell
- elongase
- microbial host
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91192507P | 2007-04-16 | 2007-04-16 | |
| US60/911,925 | 2007-04-16 | ||
| PCT/US2008/060396 WO2008128241A1 (en) | 2007-04-16 | 2008-04-16 | Delta 9 elongases and their use in making polyunsaturated fatty acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101848996A CN101848996A (zh) | 2010-09-29 |
| CN101848996B true CN101848996B (zh) | 2013-05-29 |
Family
ID=39619289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800203954A Expired - Fee Related CN101848996B (zh) | 2007-04-16 | 2008-04-16 | △9延伸酶及其在制备多不饱和脂肪酸中的用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7794701B2 (https=) |
| EP (2) | EP2134837B1 (https=) |
| JP (1) | JP5501954B2 (https=) |
| CN (1) | CN101848996B (https=) |
| AU (2) | AU2008240029B2 (https=) |
| BR (1) | BRPI0807291A2 (https=) |
| CA (2) | CA2679485A1 (https=) |
| DK (1) | DK2137304T3 (https=) |
| WO (2) | WO2008128241A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| CN101578363A (zh) | 2006-08-29 | 2009-11-11 | 联邦科学技术研究组织 | 脂肪酸的合成 |
| US7794701B2 (en) * | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| WO2008146745A1 (ja) * | 2007-05-25 | 2008-12-04 | Suntory Holdings Limited | 新規なリゾホスファチジン酸アシル基転移酵素遺伝子 |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| NO2358882T3 (https=) | 2008-11-18 | 2017-12-23 | ||
| CN102257126B (zh) * | 2008-12-18 | 2014-07-09 | 纳幕尔杜邦公司 | 减少发酵过程中的丙二酸副产物 |
| EP2442666B1 (en) | 2009-06-16 | 2015-04-08 | E. I. du Pont de Nemours and Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| US8188335B2 (en) * | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| ES2750241T3 (es) | 2009-11-03 | 2020-03-25 | Dsm Ip Assets Bv | Aceite vegetal que comprende un ácido graso poliinsaturado que tiene al menos 20 átomos de carbono |
| DK2496092T3 (en) | 2009-11-03 | 2018-07-16 | Dsm Ip Assets Bv | COMPOSITION WITH CELLS AND A POLYUM Saturated FAT ACID WITH AT LEAST 20 CARBON ATOMS (LC-PUFA) |
| WO2011133610A1 (en) | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| EP2609203B1 (en) | 2010-08-26 | 2018-06-20 | E. I. du Pont de Nemours and Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| AU2011293167B2 (en) * | 2010-08-26 | 2016-12-08 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| CA2808002A1 (en) | 2010-08-26 | 2012-03-01 | E. I. Du Pont De Nemours And Company | Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| JP2014503216A (ja) | 2010-12-30 | 2014-02-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | スクロース利用のための、ヤロウィア・リポリティカ(Yarrowialipolytica)におけるサッカロミセス・セレビシア(Saccharomycescerevisiae)SUC2遺伝子の使用 |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| PL2861059T3 (pl) | 2012-06-15 | 2017-10-31 | Commw Scient Ind Res Org | Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych |
| EP2935591B1 (en) | 2012-12-21 | 2017-07-05 | E. I. du Pont de Nemours and Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| CA2923296A1 (en) | 2013-10-25 | 2015-04-30 | Pioneer Hi-Bred International, Inc. | Stem canker tolerant soybeans and methods of use |
| NZ721036A (en) | 2013-12-18 | 2023-07-28 | Grains Res & Dev Corp | Lipid comprising long chain polyunsaturated fatty acids |
| PH12016502586B1 (en) | 2014-06-27 | 2023-07-19 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| CN106916796B (zh) * | 2015-12-28 | 2021-06-29 | 丰益(上海)生物技术研发中心有限公司 | 裂殖壶菌delta-12脂肪酸脱饱和酶相关序列及其应用 |
| CA3004914A1 (en) | 2016-02-05 | 2017-08-10 | Pioneer Hi-Bred International, Inc. | Genetic loci associated with brown stem rot resistance in soybean and methods of use |
| EP3554265A1 (en) | 2016-12-15 | 2019-10-23 | DSM IP Assets B.V. | Blend formulation comprising silicate and microbial and / or plant cells comprising a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670285A (en) | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| JP2527340B2 (ja) | 1986-12-15 | 1996-08-21 | アプライド バイオシステムズ インコーポレイテッド | ロ―ダミン染料の5−及び6−スクシニミジルカルボキシレ―ト異性体 |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| WO1992017598A1 (en) | 1991-03-29 | 1992-10-15 | The Board Of Trustees Of The University Of Illinois | Production fo transgenic soybean plants |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| US5648564A (en) | 1995-12-21 | 1997-07-15 | Kemin Industries, Inc. | Process for the formation, isolation and purification of comestible xanthophyll crystals from plants |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| NZ337459A (en) | 1997-04-11 | 2000-07-28 | Abbott Lab | Nucleic acid construct in plants and dietary supplement |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| CA2791961A1 (en) | 1998-12-07 | 2000-06-15 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| JP2004512020A (ja) | 2000-06-23 | 2004-04-22 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 組換え構築物ならびにこれを遺伝子発現を減少させる際に用いる方法 |
| DE60127967T2 (de) | 2000-07-21 | 2008-01-17 | E.I. Du Pont De Nemours And Co., Wilmington | Ein mit der synthese von delta-12 epoxy-gruppen in fettsäuren von pflanzen assoziiertes cytochrom p450 enzym |
| CA2441265A1 (en) * | 2001-03-16 | 2002-09-26 | Basf Plant Science Gmbh | Sugar and lipid metabolism regulators in plants |
| GB0107510D0 (en) * | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US6797303B2 (en) | 2001-09-04 | 2004-09-28 | Lycored Natural Products Industries Ltd. | Carotenoid extraction process |
| CA2510462A1 (en) * | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for producing polyunsaturated fatty acids in a transgenic plant or microorganism comprising an introduced delta-9-elongase and a delta-8-desaturase |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| US7129089B2 (en) | 2003-02-12 | 2006-10-31 | E. I. Du Pont De Nemours And Company | Annexin and P34 promoters and use in expression of transgenic genes in plants |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| ES2713548T3 (es) | 2003-08-01 | 2019-05-22 | Basf Plant Science Gmbh | Procedimiento para la producción de ácidos grasos poliinsaturados en organismos transgénicos |
| AU2004290051A1 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| WO2005049805A2 (en) | 2003-11-14 | 2005-06-02 | E.I. Dupont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
| CA2559360A1 (en) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Method for producing c18, c20 and c22 polyunsaturated fatty acids in transgenic plants |
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7550651B2 (en) * | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| DK1951866T3 (da) | 2005-11-23 | 2014-10-27 | Du Pont | Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer |
| US7465793B2 (en) * | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US8389808B2 (en) | 2007-02-12 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| ES2559312T3 (es) * | 2007-04-03 | 2016-02-11 | E. I. Du Pont De Nemours And Company | Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados |
| US7790156B2 (en) * | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US7794701B2 (en) | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US20090117253A1 (en) * | 2007-10-03 | 2009-05-07 | E. I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms |
| CA2719361A1 (en) * | 2008-04-03 | 2009-10-08 | E.I. Du Pont De Nemours And Company | Multizymes |
| JP5768056B2 (ja) | 2009-10-30 | 2015-08-26 | リコール メディカル インコーポレイテッドReCor Medical, Inc. | 経皮的超音波腎神経除去による高血圧症を治療するための方法及び装置 |
| SG11201608230PA (en) | 2014-03-31 | 2016-10-28 | Agency Science Tech & Res | Image processing devices and image processing methods |
-
2008
- 2008-04-15 US US12/102,879 patent/US7794701B2/en not_active Expired - Fee Related
- 2008-04-15 US US12/102,979 patent/US8119860B2/en active Active
- 2008-04-16 JP JP2010504199A patent/JP5501954B2/ja not_active Expired - Fee Related
- 2008-04-16 BR BRPI0807291-4A2A patent/BRPI0807291A2/pt not_active Application Discontinuation
- 2008-04-16 CA CA002679485A patent/CA2679485A1/en not_active Abandoned
- 2008-04-16 AU AU2008240029A patent/AU2008240029B2/en not_active Ceased
- 2008-04-16 EP EP08745901.2A patent/EP2134837B1/en not_active Not-in-force
- 2008-04-16 WO PCT/US2008/060396 patent/WO2008128241A1/en not_active Ceased
- 2008-04-16 WO PCT/US2008/060393 patent/WO2008128240A1/en not_active Ceased
- 2008-04-16 DK DK08745904.6T patent/DK2137304T3/da active
- 2008-04-16 CN CN2008800203954A patent/CN101848996B/zh not_active Expired - Fee Related
- 2008-04-16 AU AU2008240028A patent/AU2008240028B2/en active Active
- 2008-04-16 CA CA002682962A patent/CA2682962A1/en not_active Abandoned
- 2008-04-16 US US12/530,481 patent/US20100162435A1/en not_active Abandoned
- 2008-04-16 EP EP08745904.6A patent/EP2137304B1/en not_active Not-in-force
-
2010
- 2010-06-29 US US12/825,523 patent/US8298797B2/en not_active Expired - Fee Related
-
2012
- 2012-01-11 US US13/347,938 patent/US8377673B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Sheveleva Elena V.Identification and comparative analysisi of the chloroplast alpha-subunit gene of DNA-dependent RNA polymerase from seven Euglena species.《Nucleic acids research》.2002,第30卷(第5期),1247-1254. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080254195A1 (en) | 2008-10-16 |
| WO2008128240A1 (en) | 2008-10-23 |
| US8119860B2 (en) | 2012-02-21 |
| WO2008128241A1 (en) | 2008-10-23 |
| US8298797B2 (en) | 2012-10-30 |
| AU2008240028B2 (en) | 2014-03-06 |
| US20080254522A1 (en) | 2008-10-16 |
| CA2679485A1 (en) | 2008-10-23 |
| EP2137304B1 (en) | 2013-08-14 |
| US20120100595A1 (en) | 2012-04-26 |
| AU2008240028A1 (en) | 2008-10-23 |
| US8377673B2 (en) | 2013-02-19 |
| EP2134837A1 (en) | 2009-12-23 |
| CA2682962A1 (en) | 2008-10-23 |
| AU2008240029B2 (en) | 2013-05-02 |
| DK2137304T3 (da) | 2013-11-11 |
| JP2010524468A (ja) | 2010-07-22 |
| CN101848996A (zh) | 2010-09-29 |
| JP5501954B2 (ja) | 2014-05-28 |
| US20100162435A1 (en) | 2010-06-24 |
| AU2008240029A1 (en) | 2008-10-23 |
| US7794701B2 (en) | 2010-09-14 |
| US20100267098A1 (en) | 2010-10-21 |
| EP2134837B1 (en) | 2014-01-01 |
| EP2137304A1 (en) | 2009-12-30 |
| BRPI0807291A2 (pt) | 2014-04-29 |
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