CN101848722A - 具有改进的溶解性的新型肽两亲物及其使用方法 - Google Patents

具有改进的溶解性的新型肽两亲物及其使用方法 Download PDF

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Publication number
CN101848722A
CN101848722A CN200880020680A CN200880020680A CN101848722A CN 101848722 A CN101848722 A CN 101848722A CN 200880020680 A CN200880020680 A CN 200880020680A CN 200880020680 A CN200880020680 A CN 200880020680A CN 101848722 A CN101848722 A CN 101848722A
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peptide
ala
seq
val
growth
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J·胡威特
M·古勒
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880020680A 2007-04-17 2008-04-17 具有改进的溶解性的新型肽两亲物及其使用方法 Pending CN101848722A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91228907P 2007-04-17 2007-04-17
US60/912,289 2007-04-17
US12/104,407 US8076295B2 (en) 2007-04-17 2008-04-16 Peptide amphiphiles having improved solubility and methods of using same
US12/104,407 2008-04-16
PCT/US2008/060559 WO2008131052A2 (en) 2007-04-17 2008-04-17 Novel peptide amphiphiles having improved solubility and methods of using same

Publications (1)

Publication Number Publication Date
CN101848722A true CN101848722A (zh) 2010-09-29

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Application Number Title Priority Date Filing Date
CN200880020680A Pending CN101848722A (zh) 2007-04-17 2008-04-17 具有改进的溶解性的新型肽两亲物及其使用方法

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US (1) US8076295B2 (enExample)
EP (1) EP2146734A4 (enExample)
JP (1) JP2010524958A (enExample)
KR (1) KR20100021567A (enExample)
CN (1) CN101848722A (enExample)
AU (1) AU2008242940A1 (enExample)
CA (1) CA2690772A1 (enExample)
WO (1) WO2008131052A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105694030A (zh) * 2016-04-05 2016-06-22 中国科学院化学研究所 一种寡聚氨基酸与海藻酸钠复合的杂化抗菌水凝胶
CN108070021A (zh) * 2017-12-27 2018-05-25 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
CN112500466A (zh) * 2012-02-15 2021-03-16 艾瑞朗医疗公司 拟肽大环化合物
CN113396154A (zh) * 2019-02-08 2021-09-14 新加坡科技研究局 自组装短两亲性肽以及相关的方法和用途
CN114555625A (zh) * 2019-07-02 2022-05-27 塔夫茨学院托管部 用于将剂递送至细胞和组织中的新型肽、组合物和方法

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JP7560884B2 (ja) * 2019-01-24 2024-10-03 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する
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US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112500466A (zh) * 2012-02-15 2021-03-16 艾瑞朗医疗公司 拟肽大环化合物
CN112500466B (zh) * 2012-02-15 2022-05-03 艾瑞朗医疗公司 拟肽大环化合物
CN105694030A (zh) * 2016-04-05 2016-06-22 中国科学院化学研究所 一种寡聚氨基酸与海藻酸钠复合的杂化抗菌水凝胶
CN108070021A (zh) * 2017-12-27 2018-05-25 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
CN113396154A (zh) * 2019-02-08 2021-09-14 新加坡科技研究局 自组装短两亲性肽以及相关的方法和用途
CN114555625A (zh) * 2019-07-02 2022-05-27 塔夫茨学院托管部 用于将剂递送至细胞和组织中的新型肽、组合物和方法
CN114555625B (zh) * 2019-07-02 2025-02-25 塔夫茨学院托管部 用于将剂递送至细胞和组织中的新型肽、组合物和方法

Also Published As

Publication number Publication date
KR20100021567A (ko) 2010-02-25
EP2146734A2 (en) 2010-01-27
JP2010524958A (ja) 2010-07-22
EP2146734A4 (en) 2010-12-15
CA2690772A1 (en) 2008-10-30
US8076295B2 (en) 2011-12-13
AU2008242940A1 (en) 2008-10-30
US20090042804A1 (en) 2009-02-12
WO2008131052A2 (en) 2008-10-30
WO2008131052A9 (en) 2010-02-25

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Application publication date: 20100929