CA2690772A1 - Novel peptide amphiphiles having improved solubility and methods of using same - Google Patents
Novel peptide amphiphiles having improved solubility and methods of using same Download PDFInfo
- Publication number
- CA2690772A1 CA2690772A1 CA2690772A CA2690772A CA2690772A1 CA 2690772 A1 CA2690772 A1 CA 2690772A1 CA 2690772 A CA2690772 A CA 2690772A CA 2690772 A CA2690772 A CA 2690772A CA 2690772 A1 CA2690772 A1 CA 2690772A1
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- Canada
- Prior art keywords
- peptide
- ala
- val
- seq
- peptide amphiphile
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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Applications Claiming Priority (5)
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| US91228907P | 2007-04-17 | 2007-04-17 | |
| US60/912,289 | 2007-04-17 | ||
| US12/104,407 US8076295B2 (en) | 2007-04-17 | 2008-04-16 | Peptide amphiphiles having improved solubility and methods of using same |
| US12/104,407 | 2008-04-16 | ||
| PCT/US2008/060559 WO2008131052A2 (en) | 2007-04-17 | 2008-04-17 | Novel peptide amphiphiles having improved solubility and methods of using same |
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| CA2690772A1 true CA2690772A1 (en) | 2008-10-30 |
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| CA2690772A Abandoned CA2690772A1 (en) | 2007-04-17 | 2008-04-17 | Novel peptide amphiphiles having improved solubility and methods of using same |
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| EP (1) | EP2146734A4 (enExample) |
| JP (1) | JP2010524958A (enExample) |
| KR (1) | KR20100021567A (enExample) |
| CN (1) | CN101848722A (enExample) |
| AU (1) | AU2008242940A1 (enExample) |
| CA (1) | CA2690772A1 (enExample) |
| WO (1) | WO2008131052A2 (enExample) |
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| AU2003215280A1 (en) * | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| US7554021B2 (en) * | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| ES2380340T3 (es) * | 2003-12-05 | 2012-05-10 | Northwestern University | Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento |
| US20060247165A1 (en) * | 2005-01-21 | 2006-11-02 | Stupp Samuel I | Methods and compositions for encapsulation of cells |
| US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
| EP2419116A1 (en) * | 2009-04-13 | 2012-02-22 | North Western University | Novel peptide-based scaffolds for cartilage regeneration and methods for their use |
| US9067084B2 (en) * | 2010-03-31 | 2015-06-30 | Agency For Science, Technology And Research | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| NZ627528A (en) * | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| KR101501436B1 (ko) * | 2013-02-14 | 2015-03-18 | 주식회사 나이벡 | 생리활성 펩타이드가 자기회합된 젤 형태의 지지체 및 그 제조방법 |
| WO2017066545A1 (en) | 2015-10-14 | 2017-04-20 | Northwestern University | Nanofiber paste for growth factor delivery and bone regeneration |
| CN105694030B (zh) * | 2016-04-05 | 2018-01-26 | 中国科学院化学研究所 | 一种寡聚氨基酸与海藻酸钠复合的杂化抗菌水凝胶 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| SG11201903382SA (en) | 2016-10-21 | 2019-05-30 | Univ Northwestern | Anti-microbial supramolecular structures |
| US11745165B2 (en) | 2017-08-18 | 2023-09-05 | The Johns Hopkins University | Supramolecular filamentous assemblies for protein purification |
| CN108070021B (zh) * | 2017-12-27 | 2021-06-15 | 中南民族大学 | 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法 |
| JP7560884B2 (ja) * | 2019-01-24 | 2024-10-03 | ノースウエスタン ユニバーシティ | 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する |
| WO2020162835A1 (en) * | 2019-02-08 | 2020-08-13 | Agency For Science, Technology And Research | A self-assembling short amphiphilic peptide and related methods and uses |
| US12214076B2 (en) | 2019-02-18 | 2025-02-04 | Northwestern University | Drug delivery vehicles for atherosclerosis nanomedicine |
| KR20220039725A (ko) * | 2019-07-02 | 2022-03-29 | 트러스티즈 오브 터프츠 칼리지 | 작용제의 세포 및 조직으로의 전달을 위한 신규 펩티드, 조성물 및 방법 |
| US11998589B2 (en) | 2020-07-13 | 2024-06-04 | Northwestern University | PEGylated peptide amphiphile nanofibers and methods of use |
| US12247063B2 (en) | 2020-07-13 | 2025-03-11 | Northwestern University | Cell surface modification by coating with peptide amphiphiles (PAs) |
| US12116461B2 (en) | 2020-08-21 | 2024-10-15 | Northwestern University | Host-guest interactions for pa superstructure formation |
| WO2023019141A1 (en) * | 2021-08-09 | 2023-02-16 | Gel4Med, Inc. | Self-assembling amphiphilic peptide hydrogels for treatment of nerve injury |
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-
2008
- 2008-04-16 US US12/104,407 patent/US8076295B2/en not_active Expired - Fee Related
- 2008-04-17 AU AU2008242940A patent/AU2008242940A1/en not_active Abandoned
- 2008-04-17 CN CN200880020680A patent/CN101848722A/zh active Pending
- 2008-04-17 KR KR1020097023819A patent/KR20100021567A/ko not_active Withdrawn
- 2008-04-17 WO PCT/US2008/060559 patent/WO2008131052A2/en not_active Ceased
- 2008-04-17 EP EP08746046A patent/EP2146734A4/en not_active Withdrawn
- 2008-04-17 JP JP2010504238A patent/JP2010524958A/ja active Pending
- 2008-04-17 CA CA2690772A patent/CA2690772A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100021567A (ko) | 2010-02-25 |
| EP2146734A2 (en) | 2010-01-27 |
| JP2010524958A (ja) | 2010-07-22 |
| EP2146734A4 (en) | 2010-12-15 |
| CN101848722A (zh) | 2010-09-29 |
| US8076295B2 (en) | 2011-12-13 |
| AU2008242940A1 (en) | 2008-10-30 |
| US20090042804A1 (en) | 2009-02-12 |
| WO2008131052A2 (en) | 2008-10-30 |
| WO2008131052A9 (en) | 2010-02-25 |
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