JP2010524958A - 改善された溶解度を有する両親媒性ペプチドおよびその使用方法 - Google Patents

改善された溶解度を有する両親媒性ペプチドおよびその使用方法 Download PDF

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JP2010524958A
JP2010524958A JP2010504238A JP2010504238A JP2010524958A JP 2010524958 A JP2010524958 A JP 2010524958A JP 2010504238 A JP2010504238 A JP 2010504238A JP 2010504238 A JP2010504238 A JP 2010504238A JP 2010524958 A JP2010524958 A JP 2010524958A
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peptide
amphiphilic
amphiphilic peptide
growth
composition
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JP2010524958A5 (enExample
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ジェイムズ エフ． フルバット
ムスタファ オー． ギュレー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010504238A 2007-04-17 2008-04-17 改善された溶解度を有する両親媒性ペプチドおよびその使用方法 Pending JP2010524958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91228907P 2007-04-17 2007-04-17
US12/104,407 US8076295B2 (en) 2007-04-17 2008-04-16 Peptide amphiphiles having improved solubility and methods of using same
PCT/US2008/060559 WO2008131052A2 (en) 2007-04-17 2008-04-17 Novel peptide amphiphiles having improved solubility and methods of using same

Publications (2)

Publication Number Publication Date
JP2010524958A true JP2010524958A (ja) 2010-07-22
JP2010524958A5 JP2010524958A5 (enExample) 2011-05-19

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JP2010504238A Pending JP2010524958A (ja) 2007-04-17 2008-04-17 改善された溶解度を有する両親媒性ペプチドおよびその使用方法

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Country Link
US (1) US8076295B2 (enExample)
EP (1) EP2146734A4 (enExample)
JP (1) JP2010524958A (enExample)
KR (1) KR20100021567A (enExample)
CN (1) CN101848722A (enExample)
AU (1) AU2008242940A1 (enExample)
CA (1) CA2690772A1 (enExample)
WO (1) WO2008131052A2 (enExample)

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JP2022523299A (ja) * 2019-01-24 2022-04-22 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する

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AU2010236584A1 (en) * 2009-04-13 2011-11-10 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
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US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
RU2642299C2 (ru) * 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
KR101501436B1 (ko) * 2013-02-14 2015-03-18 주식회사 나이벡 생리활성 펩타이드가 자기회합된 젤 형태의 지지체 및 그 제조방법
US11517648B2 (en) 2015-10-14 2022-12-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
CN105694030B (zh) * 2016-04-05 2018-01-26 中国科学院化学研究所 一种寡聚氨基酸与海藻酸钠复合的杂化抗菌水凝胶
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
WO2019036631A1 (en) 2017-08-18 2019-02-21 The Johns Hopkins University SUPRAMOLECULAR FILAMENT ASSEMBLIES FOR THE PURIFICATION OF PROTEINS
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
WO2020162835A1 (en) * 2019-02-08 2020-08-13 Agency For Science, Technology And Research A self-assembling short amphiphilic peptide and related methods and uses
US12214076B2 (en) 2019-02-18 2025-02-04 Northwestern University Drug delivery vehicles for atherosclerosis nanomedicine
CN114555625B (zh) * 2019-07-02 2025-02-25 塔夫茨学院托管部 用于将剂递送至细胞和组织中的新型肽、组合物和方法
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
US12570709B2 (en) 2021-07-29 2026-03-10 Northwestern University Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (TGF-ß1) mimetic epitope
CA3229054A1 (en) * 2021-08-09 2023-02-16 Gel4Med, Inc. Self-assembling amphiphilic peptide hydrogels for treatment of nerve injury

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JP2022523299A (ja) * 2019-01-24 2022-04-22 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する
JP7560884B2 (ja) 2019-01-24 2024-10-03 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する
JP2024138368A (ja) * 2019-01-24 2024-10-08 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する

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WO2008131052A9 (en) 2010-02-25
AU2008242940A1 (en) 2008-10-30
CA2690772A1 (en) 2008-10-30
CN101848722A (zh) 2010-09-29
US20090042804A1 (en) 2009-02-12
US8076295B2 (en) 2011-12-13
KR20100021567A (ko) 2010-02-25
EP2146734A4 (en) 2010-12-15
WO2008131052A2 (en) 2008-10-30
EP2146734A2 (en) 2010-01-27

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