CN101820916A - 包含鞘氨醇1磷酸(s1p)受体调节剂的组合物 - Google Patents

包含鞘氨醇1磷酸(s1p)受体调节剂的组合物 Download PDF

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Publication number
CN101820916A
CN101820916A CN200880111160A CN200880111160A CN101820916A CN 101820916 A CN101820916 A CN 101820916A CN 200880111160 A CN200880111160 A CN 200880111160A CN 200880111160 A CN200880111160 A CN 200880111160A CN 101820916 A CN101820916 A CN 101820916A
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formula
substituted
composition
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C·吕埃格尔
M·安比尔
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Novartis AG
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Novartis AG
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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CN200880111160A 2007-10-12 2008-10-09 包含鞘氨醇1磷酸(s1p)受体调节剂的组合物 Pending CN101820916A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97948207P 2007-10-12 2007-10-12
US60/979,482 2007-10-12
PCT/US2008/079264 WO2009048993A2 (en) 2007-10-12 2008-10-09 Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators

Publications (1)

Publication Number Publication Date
CN101820916A true CN101820916A (zh) 2010-09-01

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CN200880111160A Pending CN101820916A (zh) 2007-10-12 2008-10-09 包含鞘氨醇1磷酸(s1p)受体调节剂的组合物

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US (6) US8673918B2 (https=)
EP (7) EP3120833A1 (https=)
JP (2) JP6034000B2 (https=)
KR (3) KR101710845B1 (https=)
CN (1) CN101820916A (https=)
AR (1) AR068986A1 (https=)
AU (1) AU2008310846C1 (https=)
BR (1) BRPI0818161B8 (https=)
CA (2) CA2925175A1 (https=)
CL (1) CL2008003003A1 (https=)
CO (1) CO6270342A2 (https=)
DK (1) DK2952177T3 (https=)
EC (1) ECSP10010169A (https=)
ES (2) ES2545361T3 (https=)
HR (1) HRP20150838T1 (https=)
HU (2) HUE027696T2 (https=)
IL (3) IL204514B (https=)
JO (2) JOP20080436B1 (https=)
MA (1) MA31799B1 (https=)
MX (1) MX337152B (https=)
MY (1) MY159358A (https=)
NZ (1) NZ600355A (https=)
PE (2) PE20090799A1 (https=)
PL (2) PL2952177T3 (https=)
PT (2) PT2465492E (https=)
RU (1) RU2010118457A (https=)
SG (2) SG187458A1 (https=)
SI (2) SI2465492T1 (https=)
TN (1) TN2010000136A1 (https=)
TW (1) TW200927142A (https=)
WO (1) WO2009048993A2 (https=)
ZA (1) ZA201001819B (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
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CN101973898A (zh) * 2010-09-09 2011-02-16 南京明生医药技术有限公司 2-对辛基苯乙基-2-氨基丙二醇衍生物及其应用
CN103458877A (zh) * 2011-01-07 2013-12-18 诺华股份有限公司 免疫抑制性制剂
CN103889408A (zh) * 2011-10-21 2014-06-25 诺华股份有限公司 S1p受体调节剂或激动剂的剂量方案
CN106163502A (zh) * 2014-04-10 2016-11-23 诺华股份有限公司 免疫抑制剂配方
CN109414410A (zh) * 2016-04-22 2019-03-01 因赛特公司 Lsd1抑制剂的制剂
TWI827000B (zh) * 2021-04-14 2023-12-21 南韓商Ｌｇ化學股份有限公司 直接壓錠之包含鞘胺醇-1-磷酸酯受體促效劑的醫藥組成物
TWI909035B (zh) * 2021-04-14 2025-12-21 南韓商Ｌｇ化學股份有限公司 製備包含鞘胺醇-１-磷酸酯受體促效劑之固體劑型的方法

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RS66784B9 (sr) * 2008-12-22 2025-08-29 Novartis Ag Režim doziranјa agonista s1p receptora
CN105213372A (zh) * 2008-12-22 2016-01-06 诺华股份有限公司 S1p受体激动剂的给药方案
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RU2482842C1 (ru) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
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TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
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WO2016042493A1 (en) 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
CN113559075A (zh) * 2014-11-17 2021-10-29 康泰科思特生物制药公司 奥那司酮延长释放组合物和方法
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EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
JP6680297B2 (ja) * 2015-04-28 2020-04-15 アステラス製薬株式会社 経口投与用医薬組成物
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
RU2639424C2 (ru) * 2015-09-15 2017-12-21 Закрытое Акционерное Общество "Биокад" Твердая пероральная фармацевтическая композиция S1P-агониста или его фармацевтически приемлемой соли, способы ее получения и способы лечения и снижения частоты клинических обострений рассеянного склероза
BR112018006648A2 (pt) * 2015-10-02 2018-10-23 Mylan Inc. formulações estáveis de fingolimode
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
EP3419607B1 (en) 2017-03-29 2019-11-20 Deva Holding Anonim Sirketi Stable formulations of fingolimod
US11648197B2 (en) 2018-06-28 2023-05-16 Arx, Llc Dispensing method for producing dissolvable unit dose film constructs
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