TN2010000136A1 - Composition comprising sphingosine 1 phosphate (s1p) receptor modulators - Google Patents
Composition comprising sphingosine 1 phosphate (s1p) receptor modulatorsInfo
- Publication number
- TN2010000136A1 TN2010000136A1 TNP2010000136A TN2010000136A TN2010000136A1 TN 2010000136 A1 TN2010000136 A1 TN 2010000136A1 TN P2010000136 A TNP2010000136 A TN P2010000136A TN 2010000136 A TN2010000136 A TN 2010000136A TN 2010000136 A1 TN2010000136 A1 TN 2010000136A1
- Authority
- TN
- Tunisia
- Prior art keywords
- sphingosine
- phosphate
- receptor modulators
- composition
- amino
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97948207P | 2007-10-12 | 2007-10-12 | |
PCT/US2008/079264 WO2009048993A2 (fr) | 2007-10-12 | 2008-10-09 | Compositions comprenant des modulateurs du récepteur de sphingosine 1-phosphate (s1p) |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000136A1 true TN2010000136A1 (en) | 2011-09-26 |
Family
ID=40032615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2010000136A TN2010000136A1 (en) | 2007-10-12 | 2010-03-26 | Composition comprising sphingosine 1 phosphate (s1p) receptor modulators |
Country Status (33)
Country | Link |
---|---|
US (6) | US8673918B2 (fr) |
EP (7) | EP3733161A1 (fr) |
JP (2) | JP6034000B2 (fr) |
KR (3) | KR20170021904A (fr) |
CN (1) | CN101820916A (fr) |
AR (1) | AR068986A1 (fr) |
AU (1) | AU2008310846C1 (fr) |
BR (1) | BRPI0818161B8 (fr) |
CA (2) | CA2925175A1 (fr) |
CL (1) | CL2008003003A1 (fr) |
CO (1) | CO6270342A2 (fr) |
DK (1) | DK2952177T3 (fr) |
EC (1) | ECSP10010169A (fr) |
ES (2) | ES2545361T3 (fr) |
HK (1) | HK1213768A1 (fr) |
HR (1) | HRP20150838T1 (fr) |
HU (2) | HUE027696T2 (fr) |
IL (3) | IL204514B (fr) |
JO (2) | JOP20080436B1 (fr) |
MA (1) | MA31799B1 (fr) |
MX (1) | MX337152B (fr) |
MY (1) | MY159358A (fr) |
NZ (1) | NZ600355A (fr) |
PE (2) | PE20090799A1 (fr) |
PL (2) | PL2952177T3 (fr) |
PT (2) | PT2952177T (fr) |
RU (1) | RU2010118457A (fr) |
SG (2) | SG187458A1 (fr) |
SI (2) | SI2952177T1 (fr) |
TN (1) | TN2010000136A1 (fr) |
TW (1) | TW200927142A (fr) |
WO (1) | WO2009048993A2 (fr) |
ZA (1) | ZA201001819B (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8785484B2 (en) | 2008-03-17 | 2014-07-22 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective S1P1 receptor agonist |
US20110144082A1 (en) | 2008-08-18 | 2011-06-16 | David Leppert | Compounds for the treatment of peripheral neuropathies |
AR074826A1 (es) * | 2008-12-22 | 2011-02-16 | Novartis Ag | Regimen de dosificacion para un agonista de los receptores de s1p |
CN102264363A (zh) | 2008-12-22 | 2011-11-30 | 诺瓦提斯公司 | S1p受体激动剂的给药方案 |
US20130102682A1 (en) * | 2010-04-22 | 2013-04-25 | Ratiopharm Gmbh | Fingolimod in the form of a solid solution |
EA201291097A1 (ru) * | 2010-04-22 | 2013-04-30 | Рациофарм Гмбх | Финголимод в форме гранулированного расплава |
CN101973898B (zh) * | 2010-09-09 | 2013-06-19 | 南京明生医药技术有限公司 | 2-对辛基苯乙基-2-氨基丙二醇衍生物及其应用 |
PL2661261T3 (pl) * | 2011-01-07 | 2020-01-31 | Novartis Ag | Formulacje immunosupresyjne |
WO2012095853A1 (fr) | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Formulations à libération modifiée comprenant des modulateurs des récepteurs sip |
ES2388273B1 (es) * | 2011-03-16 | 2013-10-01 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de inhibidores de receptores de s1p para el tratamiento de la estenosis aórtica calcificada |
AR085749A1 (es) * | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
WO2013019872A1 (fr) | 2011-08-01 | 2013-02-07 | Teva Pharmaceutical Industries Ltd. | Procédé de préparation de compositions pharmaceutiques comprenant du fingolimod |
RU2014120411A (ru) * | 2011-10-21 | 2015-11-27 | Новартис Аг | Схема приема модулятора или агониста рецептора s1p |
WO2013091704A1 (fr) | 2011-12-22 | 2013-06-27 | Synthon Bv | Composition pharmaceutique comprenant le fingolimod |
RU2482842C1 (ru) * | 2012-04-26 | 2013-05-27 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения |
RU2506949C1 (ru) * | 2012-06-13 | 2014-02-20 | Открытое акционерное общество "Новосибхимфарм" | Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний |
RU2496486C1 (ru) * | 2012-07-11 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение |
JP2014129238A (ja) * | 2012-12-28 | 2014-07-10 | Lion Corp | エトドラク含有固形製剤 |
WO2014141298A2 (fr) * | 2013-03-11 | 2014-09-18 | Astron Research Limited | Composition pharmaceutique stable de fingolimod |
EP2996681B1 (fr) * | 2013-05-13 | 2019-12-18 | Synthon B.V. | Composition pharmaceutique contenant du fingolimod |
MX2016001422A (es) * | 2013-07-29 | 2016-10-05 | Aizant Drug Res Solutions Pvt Ltd | Composicion farmaceutica de fingolimod. |
US20150141520A1 (en) * | 2013-11-18 | 2015-05-21 | Chandrasekhar Kandi | Stabilized pharmaceutical compositions of fingolimod and process for preparation thereof |
EP3626713B1 (fr) | 2014-02-13 | 2021-09-29 | Incyte Corporation | Cyclopropylamines pour leur utilissation en tant qu'inhibiteurs de lsd1 |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
CN106488915B (zh) | 2014-02-13 | 2020-10-02 | 因赛特公司 | 作为lsd1抑制剂的环丙胺 |
EP3392244A1 (fr) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
SI3129006T1 (sl) * | 2014-04-10 | 2021-08-31 | Novartis Ag | Formulacija imunosupresivov |
US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
WO2016007727A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
US20170231928A1 (en) * | 2014-08-22 | 2017-08-17 | Sunshine Lake Pharma Co., Ltd. | Solid composition of fingolimod and preparation thereof |
WO2016042493A1 (fr) | 2014-09-19 | 2016-03-24 | Aizant Drug Research Pvt. Ltd | Compositions pharmaceutiques de fingolimod |
EP3247362A4 (fr) * | 2014-11-17 | 2018-10-10 | Context Biopharma Inc. | Compositions à libération prolongée d'onapristone et méthodes associées |
CA2974375A1 (fr) * | 2015-01-20 | 2016-07-28 | Handa Pharmaceuticals, Llc | Forme galenique solide stable de fingolimod |
US9925138B2 (en) | 2015-01-20 | 2018-03-27 | Handa Pharmaceuticals, Llc | Stable solid fingolimod dosage forms |
AU2016243939B2 (en) | 2015-04-03 | 2020-09-03 | Incyte Holdings Corporation | Heterocyclic compounds as LSD1 inhibitors |
MX2017013896A (es) * | 2015-04-28 | 2018-03-15 | Astellas Pharma Inc | Composicion farmaceutica para administracion oral. |
EA035534B1 (ru) | 2015-08-12 | 2020-06-30 | Инсайт Корпорейшн | Соли ингибитора lsd1 |
RU2639424C2 (ru) * | 2015-09-15 | 2017-12-21 | Закрытое Акционерное Общество "Биокад" | Твердая пероральная фармацевтическая композиция S1P-агониста или его фармацевтически приемлемой соли, способы ее получения и способы лечения и снижения частоты клинических обострений рассеянного склероза |
US20180280322A1 (en) * | 2015-10-02 | 2018-10-04 | Mylan Inc. | Stable formulations of fingolimod |
SG11201809299QA (en) * | 2016-04-22 | 2018-11-29 | Incyte Corp | Formulations of an lsd1 inhibitor |
US11629124B2 (en) | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
EP3419607B1 (fr) | 2017-03-29 | 2019-11-20 | Deva Holding Anonim Sirketi | Formulations stables de fingolimod |
CA3105187A1 (fr) | 2018-06-28 | 2020-01-02 | Arx, Llc | Procede de distribution pour produire des constructions de film de dose unitaire soluble |
WO2020047198A1 (fr) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Sels d'un inhibiteur de lsd1 et leurs procédés de préparation |
CN117202893A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE172711T1 (de) * | 1992-10-21 | 1998-11-15 | Yoshitomi Pharmaceutical | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
DE69524962D1 (de) | 1994-08-22 | 2002-02-14 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
US5616621A (en) * | 1995-01-30 | 1997-04-01 | American Home Products Corporation | Taste masking liquids |
EP0812588B1 (fr) | 1995-12-28 | 2004-10-13 | Mitsubishi Pharma Corporation | Composition pharmaceutique destineé à l'administration topique comprenant de la 2-amino-2-(2-(4-octylphényl)ethyl)propane-1,3-diol pour le traitement des maladies causées par un trouble immunitaire |
AU735406B2 (en) | 1997-02-27 | 2001-07-05 | Novartis Ag | Pharmaceutical composition |
SI1002792T1 (en) | 1997-04-04 | 2004-12-31 | Mitsubishi Pharma Corporation | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
JP4627356B2 (ja) | 1999-06-30 | 2011-02-09 | 松森 昭 | ウイルス性心筋炎の予防または治療薬剤 |
WO2002006268A1 (fr) | 2000-07-13 | 2002-01-24 | Sankyo Company, Limited | Derives d'alcool amino |
AU2001285331B2 (en) | 2000-08-31 | 2006-04-06 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
WO2003029184A1 (fr) | 2001-09-27 | 2003-04-10 | Kyorin Pharmaceutical Co., Ltd. | Derive d'ether de diaryle, son sel d'addition et son immunosuppresseur |
JP4217620B2 (ja) | 2001-09-27 | 2009-02-04 | 杏林製薬株式会社 | ジアリールスルフィド誘導体とその付加塩及び免疫抑制剤 |
EP1470137B1 (fr) | 2002-01-18 | 2009-09-02 | Merck & Co., Inc. | Agonistes du recepteur edg |
WO2003062248A2 (fr) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | N-(benzyl)aminoalkyl carboxylates, phosphinates, phosphonates et tetrazoles en tant qu'agonistes de recepteur edg |
KR101003877B1 (ko) | 2002-09-19 | 2010-12-30 | 교린 세이야꾸 가부시키 가이샤 | 아미노알코올 유도체와 그 부가염 및 면역 억제제 |
CN100344638C (zh) | 2003-02-18 | 2007-10-24 | 杏林制药株式会社 | 氨基膦酸衍生物、其加成盐以及s1p受体调节剂 |
MXPA05010860A (es) * | 2003-04-08 | 2006-05-25 | Novartis Ag | Composiciones solidas farmaceuticas que comprenden un agonista de receptor sip y y un alcohol de azucar. |
TW200503783A (en) | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
FR2854549B1 (fr) | 2003-05-06 | 2005-06-24 | Actis Ets | Tete pour l'equipement d'un bras de robot destine a realiser une operation d'ebavurage ou de cardage |
PE20050158A1 (es) | 2003-05-19 | 2005-05-12 | Irm Llc | Compuestos inmunosupresores y composiciones |
MY150088A (en) * | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
CN100431534C (zh) | 2003-06-24 | 2008-11-12 | 康涅狄格大学 | 血管内皮鞘氨醇-1-磷酸受体拮抗剂在制备药物中的应用 |
PL1660449T3 (pl) | 2003-08-28 | 2010-05-31 | Novartis Ag | Pochodne aminopropanolu |
CA2539033C (fr) | 2003-09-12 | 2013-03-05 | Neuronova Ab | Traitement d'une maladie ou d'une lesion du systeme nerveux au moyen de fty720 |
UA74941C2 (en) | 2004-04-26 | 2006-02-15 | Fos Internat S A | A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same |
WO2005113330A1 (fr) | 2004-05-05 | 2005-12-01 | Adler, Richard, S. | Systemes et techniques de protection d'un bateau contre des attaques en surface ou sous l'eau |
GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
US8633161B2 (en) | 2005-03-24 | 2014-01-21 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of leukemia |
CN1891212B (zh) | 2005-07-07 | 2010-10-13 | 马启明 | 一种口服制剂及其制备方法 |
GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
KR101884047B1 (ko) * | 2006-09-26 | 2018-07-31 | 노파르티스 아게 | S1p 조정제를 포함하는 제약 조성물 |
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