CN101765596A - 用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂 - Google Patents
用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂 Download PDFInfo
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- CN101765596A CN101765596A CN200880015925A CN200880015925A CN101765596A CN 101765596 A CN101765596 A CN 101765596A CN 200880015925 A CN200880015925 A CN 200880015925A CN 200880015925 A CN200880015925 A CN 200880015925A CN 101765596 A CN101765596 A CN 101765596A
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- China
- Prior art keywords
- methyl
- benzyl
- isophthalic acid
- pyrazole
- methyl isophthalic
- Prior art date
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Abstract
Description
实施例号 | IUPAC名称 |
1 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
2 | 3-{4-[(4-氯苄基)氧基]苯基}-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
3 | 3-(4-溴苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
4 | 3-(4-叔丁基苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
5 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4’-(三氟甲氧基)联苯-4-基]-1,2,4-噁二唑 |
6 | 3-甲基-1-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}苯基)哌啶 |
7 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲基)苯基]-1,2,4-噁二唑 |
8 | 3-(4-溴苯基)-5-{5-甲基-1-[1-(4-甲基苯基)乙基]-1H-吡唑-3-基}-1,2,4-噁二唑 |
9 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-苯基-1,2,4-噁二唑 |
10 | 3-(4-氟苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
11 | 3-(4-环己基苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
12 | 1-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-苯基)哌啶 |
13 | 3-(4-碘苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
14 | 4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}吡啶 |
15 | 3-(3-溴-4-氟苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
16 | 3-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}吡啶 |
17 | 5-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-2-(三氟甲基)吡啶 |
18 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(2,2,2-三氟乙氧基)苯基]-1,2,4-噁二唑 |
19 | 3-[4-(环戊氧基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
20 | 3-(4-异丙氧基苯基)-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
21 | 4-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-苯基)吗啉 |
22 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-(4-吡咯烷-1-基苯基)-1,2,4-噁二唑 |
23 | N,N-二乙基-4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}苯胺 |
24 | 1-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-苯基)吡咯烷-2-酮 |
25 | 3-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}苯基)-1,3-噁唑烷-2-酮 |
26 | 4-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-苯基)吗啉-3-酮 |
实施例号 | IUPAC名称 |
27 | 2-甲氧基-N-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}苯基)乙酰胺 |
28 | 1-(4-{5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基}-苯基)哌啶-2-酮 |
29 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-5-苯基-1,3-苯并噁唑 |
30 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-苯氧基-1,3-苯并噁唑 |
31 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-苯并噁唑 |
32 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-5-(1-甲基-1-苯基乙基)-1,3-苯并噁唑 |
33 | 5-苄基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-苯并噁唑 |
34 | 5-(3-氟苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-苯并噁唑 |
35 | 5-(2-氟苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-苯并噁唑 |
36 | 5-(3-氯苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-苯并噁唑 |
37 | 6-溴-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
38 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
39 | 6-甲基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
40 | 4-甲基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
实施例号 | IUPAC名称 |
41 | 6-氯-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
42 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3H-咪唑并[4,5-c]吡啶 |
43 | 6-叔丁基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
44 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-(三氟甲基)-1H-苯并咪唑 |
45 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-苯基-1H-苯并咪唑 |
46 | {2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑-6-基}-(苯基)甲酮 |
47 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-萘并[2,3-d]咪唑 |
48 | 6-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,7-二氢咪唑并[4,5-f]吲唑 |
49 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-哌啶-1-基-1H-苯并咪唑 |
50 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-(4-甲基哌嗪-1-基)-1H-苯并咪唑 |
51 | 6-环己基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
52 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-[1]苯并呋喃并[2,3-f]-苯并咪唑 |
53 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-吗啉-4-基-1H-苯并咪唑 |
实施例号 | IUPAC名称 |
54 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑-6-甲腈 |
55 | 2,2-二氟-6-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-5H-[1,3]二氧戊环并[4,5-f]-苯并咪唑 |
56 | 5-氯-6-氟-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
57 | 6-溴-4-甲基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
58 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-6-(三氟甲氧基)-1H-苯并咪唑 |
59 | 6-(4-氟苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
60 | 6-(2-氟苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
61 | 6-(3-氟苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
62 | 6-(2-氯苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
63 | 6-(3-氯苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
64 | 6-(4-氯苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1H-苯并咪唑 |
65 | 5-甲基-1-(4-甲基苄基)-3-{4-[4-(三氟甲氧基)苯基]-1H-咪唑-2-基}-1H-吡唑 |
66 | 3-(4,5-二苯基-1H-咪唑-2-基)-5-甲基-1-(4-甲基苄基)-1H-吡唑 |
实施例号 | IUPAC名称 |
67 | 3-(4-联苯-4-基-1H-咪唑-2-基)-5-甲基-1-(4-甲基苄基)-1H-吡唑 |
68 | 3-[4-(4-环己基苯基)-1H-咪唑-2-基]-5-甲基-1-(4-甲基苄基)-1H-吡唑 |
69 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4-苯基-4,5-二氢-1,3-噁唑 |
70 | 4-(4-叔丁基苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4,5-二氢-1,3-噁唑 |
71 | 4-异丙基-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4,5-二氢-1,3-噁唑 |
72 | 4-(4-氯苄基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4,5-二氢-1,3-噁唑 |
73 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4-[4-(三氟甲氧基)苯基]-4,5-二氢-1,3-噁唑 |
74 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4-苯基-1,3-噁唑 |
75 | 4-(4-溴苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑 |
76 | 4-(4’-氯联苯-4-基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑 |
77 | 4-(4-叔丁基苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑 |
78 | 2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-4-[4-(三氟甲氧基)苯基]-1,3-噁唑 |
79 | 1-(4-{2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑-4-基}-苯基)哌啶 |
实施例号 | IUPAC名称 |
80 | 4-(4-环己-1-烯-1-基苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑 |
81 | 4-(4-环己-1-基苯基)-2-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,3-噁唑 |
82 | 3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
83 | 3-[4-(4-甲氧基四氢-2H-吡喃-4-基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
84 | 3-(4-叔丁基苯基)-5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
85 | 4-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)四氢-2H-吡喃-4-醇 |
86 | 5-(1-苄基-5-甲基-1H-吡唑-3-基)-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
87 | 5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
88 | 5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲基)苯基]-1,2,4-噁二唑 |
89 | 3-(4-溴苯基)-5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
90 | 4-5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯甲酸甲酯 |
91 | 5-[5-乙基-4-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
92 | 5-[5-乙基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-(4-硝基苯基)-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
93 | 3-4-[(1-甲基乙基)磺酰基]苯基-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
94 | 4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯磺酰胺 |
95 | 2-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)丙-2-醇 |
96 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲基)磺酰基]苯基-1,2,4-噁二唑 |
97 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(甲基硫烷基)苯基]-1,2,4-噁二唑 |
98 | (4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)亚酰氨基焦碳酸二叔丁基酯 |
99 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(甲基磺酰基)苯基]-1,2,4-噁二唑 |
100 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(苯基磺酰基)苯基]-1,2,4-噁二唑 |
101 | (4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)氨基甲酸叔丁基酯 |
102 | 4-羟基-4-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)哌啶-1-羧酸叔丁基酯 |
103 | 3-[4-(1-氟-1-甲基乙基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
104 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-4-[(四氢-2H-吡喃-4-基氧基)甲基]苯基-1,2,4-噁二唑 |
105 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-4-[(三氟甲基)硫烷基]苯基-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
106 | 4-[(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)氧基]-哌啶-1-羧酸叔丁基酯 |
107 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(四氢-2H-吡喃-4-基甲氧基)苯基]-1,2,4-噁二唑 |
108 | 4-[(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯氧基)甲基]-哌啶-1-羧酸叔丁基酯 |
109 | N,N-二甲基-4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯氧基-磺酰胺 |
110 | (4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)甲醇 |
111 | 3-[4-(3-氟氧杂环丁烷-3-基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
112 | 3-[4-(3-甲氧基氧杂环丁烷-3-基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
113 | (4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)氨基甲酸叔丁基酯 |
114 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(苯基硫烷基)苯基]-1,2,4-噁二唑 |
115 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(四氢-2H-吡喃-4-基氧基)苯基]-1,2,4-噁二唑 |
116 | 3-[4-(2-甲氧基乙氧基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
117 | N-(2-甲氧基乙基)-4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯胺 |
118 | 3-[4-(1H-咪唑-1-基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
119 | 4-[(5-甲基-3-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑-5-基-1H-吡唑-1-基)甲基]苯酚 |
120 | 5-[1-(4-氯苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
121 | 4-[(5-甲基-3-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑-5-基-1H-吡唑-1-基)甲基]苯甲腈 |
122 | 5-[1-(4-甲氧基苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
123 | 5-[5-甲基-1-(3-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
124 | 5-[1-(3-氟-4-甲基苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
125 | 5-[1-(4-氟苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
126 | 1-(4-甲基苄基)-3-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑-5-基-1H-吡唑-5-胺 |
127 | 5-(1-4-[2-(2-甲氧基乙氧基)乙氧基]苄基-5-甲基-1H-吡唑-3-基)-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
128 | 5-[1-(4-甲基苄基)-5-(三氟甲基)-1H-吡唑-3-基)-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
129 | 5-[1-(4-氯苄基)-5-(三氟甲基)-1H-吡唑-3-基)-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
130 | 4-[3-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑-5-基-5-(三氟甲基)-1H-吡唑-1-基]甲基-苯甲腈 |
131 | 5-[1-(3-氟苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
132 | 5-[5-甲基-1-(2-甲基苄基)-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
133 | 5-[1-(2-氟苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
134 | 4-[(5-甲基-3-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑-5-基-1H-吡唑-1-基)甲基]苯甲酸甲酯 |
135 | 5-5-甲基-1-[4-(三氟甲基)苄基]-1H-吡唑-3-基-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
136 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-{4-[(三氟甲基)亚硫酰基]苯基)-1,2,4-噁二唑 |
137 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(甲基亚硫酰基)苯基]-1,2,4-噁二唑 |
138 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(苯基亚硫酰基)苯基]-1,2,4-噁二唑 |
139 | 1-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)甲胺 |
140 | 5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-3-[4-(1H-吡咯-1-基-甲基)苯基]-1,2,4-噁二唑 |
141 | 3-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)咪唑烷-4-酮 |
142 | 5-[1-(4-氯苄基)-5-甲基-1H-吡唑-3-基]-3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑 |
143 | N-(4-[5-甲基-3-(3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑-5-基)-1H-吡唑-1-基]-甲基苯基)乙酰胺 |
144 | 4-[5-甲基-3-(3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑-5-基)-1H-吡唑-1-基]甲基-苯甲腈 |
实施例号 | IUPAC名称 |
145 | 5-[1-(4-甲氧基苄基)-5-甲基-1H-吡唑-3-基]-3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑 |
146 | 5-1-[2-(二氟甲氧基)苄基]-5-甲基-1H-吡唑-3-基-3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑 |
147 | 3-[5-甲基-3-(3-4-[(三氟甲基)磺酰基]苯基-1,2,4-噁二唑-5-基)-1H-吡唑-1-基]甲基苯甲酸甲酯 |
148 | 5-[1-(4-氯苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(2-氟丙-2-基)苯基]-1,2,4-噁二唑 |
149 | N-4-[(3-3-[4-(2-氟丙-2-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]苯基乙酰胺 |
150 | 4-[(3-3-[4-(2-氟丙-2-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]-苯甲腈 |
151 | 3-[4-(2-氟丙-2-基)苯基]-5-[1-(4-甲氧基苄基)-5-甲基-1H-吡唑-3-基]-1,2,4-噁二唑 |
152 | 5-1-[2-(二氟甲氧基)苄基]-5-甲基-1H-吡唑-3-基-3-[4-(2-氟丙-2-基)苯基]-1,2,4-噁二唑 |
153 | 3-[(3-3-[4-(2-氟丙-2-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]-苯甲酸甲酯 |
154 | 3-[(3-3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]苯甲酸甲酯 |
155 | 4-[(3-3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]苯甲腈 |
156 | 3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-5-[1-(4-甲氧基苄基)-5-甲基-1H-吡唑-3-基]-1,2,4-噁二唑 |
157 | 5-[1-(4-氯苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-1,2,4-噁二唑 |
实施例号 | IUPAC名称 |
158 | 3-[(5-甲基-3-3-[4-(三氟甲氧基)-苯基]-1,2,4-噁二唑-5-基-1H-吡唑-1-基)甲基]苯甲酸甲酯 |
159 | 5-[1-(4-氯苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(3-甲氧基氧杂环丁烷-3-基)苯基]-1,2,4-噁二唑 |
160 | 5-1-[2-(二氟甲氧基)苄基]-5-甲基-1H-吡唑-3-基-3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-1,2,4-噁二唑 |
161 | 5-1-[2-(二氟甲氧基)苄基]-5-甲基-1H-吡唑-3-基-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
162 | N-4-[(3-3-[4-(4-氟四氢-2H-吡喃-4-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]苯基乙酰胺 |
163 | N-4-[(3-3-[4-(3-甲氧基氧杂环丁烷-3-基)苯基]-1,2,4-噁二唑-5-基-5-甲基-1H-吡唑-1-基)甲基]苯基乙酰胺 |
164 | 5-[1-(4-碘苄基)-5-甲基-1H-吡唑-3-基]-3-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
165 | 3-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-5-[4-(三氟甲氧基)苯基]-1,2,4-噁二唑 |
166 | 1-甲基-3-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苯基)咪唑烷-4-酮 |
167 | 1-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)哌啶 |
168 | 4-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)吗啉 |
169 | 3-[4-(氮杂环丁烷-1-基甲基)苯基]-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑 |
170 | N-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)-N-(丙-2-基)-丙-2-胺 |
实施例号 | IUPAC名称 |
171 | N-甲基-N-(4-5-[5-甲基-1-(4-甲基苄基)-1H-吡唑-3-基]-1,2,4-噁二唑-3-基苄基)丙-2-胺 |
实施例编号 | IC50[μmol/L] |
1 | 0.03 |
4 | 0.005 |
18 | 0.03 |
24 | 0.08 |
59 | 0.005 |
64 | 0.003 |
67 | 0.008 |
68 | 0.006 |
77 | 0.02 |
81 | 0.05 |
103 | 0.01 |
105 | 0.03 |
120 | 0.02 |
121 | 0.03 |
140 | 0.04 |
Claims (55)
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ES2525217T3 (es) * | 2005-06-27 | 2014-12-19 | Exelixis Patent Company Llc | Moduladores de LXR basados en imidazol |
WO2007034279A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | C3a antagonists and pharmaceutical compositions thereof |
US20130172311A1 (en) * | 2010-05-08 | 2013-07-04 | Bayer Intellectual Property Gmbh | Substituted heterocyclyl benzyl pyrazoles, and use thereof |
-
2008
- 2008-05-08 AU AU2008253311A patent/AU2008253311A1/en not_active Abandoned
- 2008-05-08 EP EP20080758408 patent/EP2148877A2/en not_active Withdrawn
- 2008-05-08 MX MX2009012000A patent/MX2009012000A/es not_active Application Discontinuation
- 2008-05-08 JP JP2010508718A patent/JP5702138B2/ja not_active Expired - Fee Related
- 2008-05-08 KR KR1020097023930A patent/KR20100016617A/ko not_active Application Discontinuation
- 2008-05-08 CN CN200880015925.6A patent/CN101765596B/zh not_active Expired - Fee Related
- 2008-05-08 US US12/600,640 patent/US8796253B2/en not_active Expired - Fee Related
- 2008-05-08 BR BRPI0812361-6A2A patent/BRPI0812361A2/pt not_active IP Right Cessation
- 2008-05-08 RU RU2009146851/04A patent/RU2009146851A/ru not_active Application Discontinuation
- 2008-05-08 CA CA002687306A patent/CA2687306A1/en not_active Abandoned
- 2008-05-08 WO PCT/EP2008/003681 patent/WO2008141731A2/en active Application Filing
- 2008-05-09 UY UY31080A patent/UY31080A1/es not_active Application Discontinuation
- 2008-05-09 CL CL2008001372A patent/CL2008001372A1/es unknown
- 2008-05-12 PE PE2008000823A patent/PE20090297A1/es not_active Application Discontinuation
- 2008-05-12 PA PA20088780201A patent/PA8780201A1/es unknown
- 2008-05-16 TW TW097117928A patent/TW200909428A/zh unknown
- 2008-05-16 AR ARP080102099A patent/AR066617A1/es not_active Application Discontinuation
-
2009
- 2009-10-15 IL IL201537A patent/IL201537A0/en unknown
- 2009-11-13 ZA ZA2009/07999A patent/ZA200907999B/en unknown
Cited By (11)
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CN104736535A (zh) * | 2012-08-24 | 2015-06-24 | 德州大学系统董事会 | 用于治疗疾病的hif活性的杂环调节剂 |
CN104736535B (zh) * | 2012-08-24 | 2017-12-19 | 德州大学系统董事会 | 用于治疗疾病的hif活性的杂环调节剂 |
CN104968667A (zh) * | 2013-02-05 | 2015-10-07 | 山东轩竹医药科技有限公司 | 四并环激酶抑制剂 |
CN104968667B (zh) * | 2013-02-05 | 2017-06-20 | 山东轩竹医药科技有限公司 | 四并环激酶抑制剂 |
CN106366078A (zh) * | 2015-07-24 | 2017-02-01 | 浙江大学 | 吲唑-噁二唑类衍生物、含其的药物组合物及其在抗肿瘤中的应用 |
CN108164520A (zh) * | 2018-01-15 | 2018-06-15 | 东南大学 | 缺氧抑制剂与抗肿瘤药物的偶联化合物及其制备和应用 |
CN108164520B (zh) * | 2018-01-15 | 2021-03-19 | 东南大学 | 缺氧抑制剂与抗肿瘤药物的偶联化合物及其制备和应用 |
CN112110908A (zh) * | 2020-09-25 | 2020-12-22 | 山东大学 | 一种1,3-二取代吲唑类化合物及其制备方法和应用 |
CN112426422A (zh) * | 2020-12-02 | 2021-03-02 | 安徽医科大学 | 吡啶甲酰胺衍生物AMSP-30m在制备防治类风湿关节炎药物中的应用 |
WO2024067708A1 (zh) * | 2022-09-30 | 2024-04-04 | 苏州阿尔脉生物科技有限公司 | 草酸胺类衍生物、包含其的药物组合物及其医药用途 |
WO2024067566A1 (zh) * | 2022-09-30 | 2024-04-04 | 苏州阿尔脉生物科技有限公司 | 饱和环类衍生物、包含其的药物组合物及其医药用途 |
Also Published As
Publication number | Publication date |
---|---|
EP2148877A2 (en) | 2010-02-03 |
AR066617A1 (es) | 2009-09-02 |
UY31080A1 (es) | 2009-01-05 |
MX2009012000A (es) | 2009-11-19 |
WO2008141731A3 (en) | 2009-03-26 |
PE20090297A1 (es) | 2009-03-27 |
ZA200907999B (en) | 2011-06-29 |
US20100249085A1 (en) | 2010-09-30 |
CA2687306A1 (en) | 2008-11-27 |
PA8780201A1 (es) | 2009-02-09 |
RU2009146851A (ru) | 2011-06-27 |
BRPI0812361A2 (pt) | 2015-02-03 |
CL2008001372A1 (es) | 2008-12-05 |
US8796253B2 (en) | 2014-08-05 |
WO2008141731A2 (en) | 2008-11-27 |
KR20100016617A (ko) | 2010-02-12 |
JP2010527378A (ja) | 2010-08-12 |
IL201537A0 (en) | 2010-05-31 |
CN101765596B (zh) | 2015-04-29 |
JP5702138B2 (ja) | 2015-04-15 |
AU2008253311A1 (en) | 2008-11-27 |
TW200909428A (en) | 2009-03-01 |
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