CN101698028A - Fat-reducing and weight-losing composite and preparation method thereof - Google Patents
Fat-reducing and weight-losing composite and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a functional composite which is prepared by plant raw materials and a preparation method thereof, in particular to a fat-reducing and weight-losing composite and preparation method thereof. The composite comprises the following raw materials: medlar, glossy privet fruit, cassia seed, haw, rehmannia and astragalus. The composite can be prepared into any one of normal oral formulations, remarkably treats and prevents fatness, has the total effective rate to the fatness more than 98%, has no rebound, and is suitable for fat persons and fashionable persons who want to keep fit.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for metabolic disease, particularly a kind of natural activity composition and method of making the same of lowering blood-fat and reducing weight of obesity.
Background technology
In recent years, along with the raising of people's living standard, also in rapid expansion, human body was too obese obese people, had not only influenced people's quality of life, also was the healthy seed of burying many diseases.
Medical research proves, obesity be meant the body fat overheap and (or) distribute unusually, weight increase is the coefficient result of h and E factor.The obesity of human body is how greasy because of surfeit, and quantity of motion is few relevant with endocrine dysfunction.Obesity can cause numerous chronic diseases, as: blood fat height, blood viscosity height, cholesterol height, fatty liver, heart disease, hypertension, cerebral thrombosis and arteriosclerosis, diabetes, gout, sleep apnea syndrome, osteoporosis etc., have a strong impact on the human life quality, the fat serious public health problem that influences people ' s health that become.Oneself is listed as chronic disease with obesity and cardiovascular diseases, diabetes, hypertension, cancer etc. World Health Organization (WHO).
Frequent too much absorption high lipid food, a large amount of oils and fatss are absorbed by gastrointestinal, and the transhipment by internal organs such as spleens turns usefulness into, the surface of a large amount of lipidosiss and internal organs subcutaneous at human body.If people in such cases more not reasonably motion consume fat, promote the body fat burning, to making body fat accumulate more and more, cause fat.In addition owing to have a large amount of high heat fat in the body, human body needs to replenish a large amount of moisture again, to safeguard the equilibrated demand of internal organs, is absorbed by the muscle of human body and intravital fat yet work as portion of water, people's the body weight of accumulating over a long period just can increase gradually, and obesity becomes.Some obese people especially is more common in the women in addition, though light food is eaten in happiness at ordinary times, but health is still fat, studies show that mostly this type of crowd is because organ function gets muddled, collaborative work that can not be good, metabolism and digestive function performance are unusual, make nutrient substance in the food can not be normally picked-up by spleen, absorb and be transported to each internal organs, and the conversion of a large amount of nutritional labeling by intestinal be by muscle and fat absorption, make the human body unusual plentiful obesity that becomes through blood.Another factor that causes body fat is exactly often to eat some to contain the animal flesh of hormone feed nursing or expedite the emergence of long plant agricultural byproducts relevant.
The ancient Chinese medicine theory is thought: the overweight people is the card of the real deficiency in origin of mark.The surface body sturdy and actual be positive QI-insufficiency.In addition because of being in easy circumstances, well seated quiet, QI and blood is popular, and slowly digestive function of spleen and stomach weakens, and essence of water and grain loses and turns to cream fat and water in defeated cloth and wet and amass in skin, causes fat.The simple obesity pathological factor is that phlegm-damp is retarded by silt, and it is that its basic pathology changes that phlegm-damp, cream fat amass in body.Fat generation and phlegm-damp congestion are closely related.Damp-phlegm is stranded in the resistance burnt, stops up in skin and then sees obesity.Eating and drinking without temperance is gone into more than going out, and causes fat." element is asked strange sick opinion " said: " husband's five tastes inlet is hidden in stomach, and spleen is the Xingqi vital essence for it, and body fluid is at spleen, so make us sweet taste in the mouth also.This fertile institute is sent out also.It is sweet and refreshing and how fertile that this person must count food ...Gold dollar four everybody one of Li Dongyuan propose also that " people that stares at of taste can eat and be fat.But surfeit is the impairment of the spleen also, retention of water-damp in the body, and strongly fragrant and heat-transformation, damp and hot overflowing in skin, performance is fat.The seven emotions variation exceeds the Human Physiology range of accommodation, must influence daily life, causes the transformation and transportation of the spleen and stomach obstacle, spends high equal can causeing fat a little less than function is crossed.
For to anti-obesity, the mankind have taked various modes, general manyly set about from keeping a diet, health-related food is also arranged, also have, the research cause of disease from theory of Chinese medical science, make Chinese medicine preparation by scientific and reasonable composition of prescription, reach the purpose for the treatment of both the principal and secondary aspects of a disease, to realize the effect of lowering blood-fat and reducing weight.
Adopt the method for Chinese herbal medicine lowering blood-fat and reducing weight to have following 6 kinds:
One and diabetes involving middle-JIAO fat method
Because the food person of causeing fat of a large amount of edible sweet fertilizer, oils and fats is sticky prior to stomach, and often the gastral cavity abdomen is glutted, belching and acid regurgitation, and taste is foul, greasy fur on tongue.The utilization Fructus Crataegi, Fructus Hordei Germinatus, medicines such as Semen Raphani are aid digestion with stomach function regulating, the greasy food of fortune carburetion.
Two, blood circulation promoting competent silt method
The people of obesity, hyperliposis in the blood causes arteriosclerosis, the particularly heart easily, and how cerebrovascular disease produces thus, and the medicine of blood circulation promoting and blood stasis dispelling is to coronary artery dilator, blood flow increasing, blood fat reducing, and prevent that speckle from forming and promote it to disappear to take off effect is all arranged.Fat common have congestion to block, women's amenorrhea, or see that body of the tongue has livid purple stasis of blood person, adopt activating blood and removing stasis Method, lowering blood-fat and reducing weight.
Three, the chest stuffiness relieving Circulation Resolving Phlegm
TCM Document has the argument of " fertile people's excessive phlegm ", and this expectorant is meant that obviously the expectorant of obesity is turbid, just hyperliposis.The people of clinical findings obesity, moving then breathe hard, very then dizzy, vomiting uncomfortable in chest, feel sick, tongue fur is satiny.Somebody's phlegm-fire is heavy, and irascible temperament is easy to fly into a rage, angry, so that hypertension, feeling of fullness in the head cranial tinnitus and pain, sleep disorder, yellowish fur, dry stool knot.The multiple heart, cerebrovascular disease.Adopt the chest stuffiness relieving to reduce phlegm, regulate the flow of vital energy and in medicine can blood fat reducing reduce phlegm, the medicine of the chest stuffiness relieving Circulation Resolving Phlegm mainly contains Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae etc.
Four, depressed liver-energy dispersing and function of gallbladder promoting method
Bile can digest fat.Suffer from the people of hepatitis, cholecystitis, liver and bile stone, bile secretion deficiency, depressed liver-energy dispersing and function of gallbladder promoting method are indispensable to liver-gallbladder disease, Patients with Fatty Liver especially, and this method commonly used is respond well.Semen Cassiae energy liver heat removing and eyesight improving, the normal drink of making tea at ordinary times, the removing fire from the liver blood fat reducing function is arranged.
Five, diuresis eliminating dampness by diuresis method
Chinese medicine is thought: Wen Shengsheng expectorant, and the wet metabolism of water is not normal easily to be mixed mutually with blood, clear QI being mixed up with turbid QI, blood fat raises.Adopting diuresis eliminating dampness by diuresis method lowering blood-fat and reducing weight is a kind of the most frequently used method.Rhizoma Alismatis, Poria, Stigma Maydis etc. have the effect of diuresis eliminating dampness by diuresis, all can make lipid lowerers and use.
Six, relieving constipation by purgation method
The people of obesity, body constitution is strong solid mostly, and is evil turbid to drain the fat dirt with the relieving constipation by purgation method.Common drug is a Radix Et Rhizoma Rhei, is the main medication of relieving constipation by purgation simply, and the merit of lowering blood-fat and reducing weight is speed very.All the other also have Rhizoma Polygoni Cuspidati, Radix Polygoni Multiflori etc. all can be used for this method to carry out lowering blood-fat and reducing weight.
The various diet teas of being sold in the city serve as main the composition with the relieving constipation by purgation medicine just in the prescription.After the obese people takes, can cause acutely and rush down suddenly that body weight alleviates immediately.
At present a large amount of appetrol, diet food and methods of weight-reducing also is born in succession.The slimming medicine Western medicine mainly comprises two big classes: non-central appetrol and central appetrol.Main medicine has orlistat, fenfluramine, sibutramine etc., and main adverse reaction has flatulence, headache, xerostomia, insomnia, heart rate quickening etc., and some is forbidden in heart disease and patients with cerebrovascular disease.Bring very big inconvenience to clinical application, some medicine is withdrawn from the market because of its untoward reaction.
Increasing people adopts Chinese medicine blood fat reducing, fat-reducing, body slimming, it is mainly based on appetite-suppressing and cathartic, also brought more misery to the patient, as: take medicine back loose stool and diarrhea, anorexia, dizzy weak, alopecia, insomnia, sweating due to debility, digestive functional disturbance, menoxenia etc., serious organ injury phenomenon not only fails to reach the weight reducing purpose, the opposite misery that has but therefore increased numerous disease, in addition, bounce-back easily after the drug withdrawal, weight increase.
At present, kind and method that the Chinese herbal medicine that adopts is lost weight are numerous, for example publication number is that the Chinese invention patent of CN101019946 discloses a kind of medicine for the treatment of simple obesity, and it mainly is to have Fructus Crataegi, Folium Nelumbinis, Semen Cassiae, Herba Lobeliae Chinensis to be prepared from according to a certain weight ratio; Notification number is that the Chinese invention patent of CN100376266C discloses a kind of compositions with fat-reducing and lipid-reducing function, and said composition is made up of following raw materials by weight percent: Fructus Phyllanthi powder 40-70%, Folium Camelliae sinensis powder 25-60%, Radix Notoginseng extract powder 4-10% have the effect of blood lipid regulation, loosening bowel to relieve constipation and fat-reducing; Publication number is that the Chinese invention patent of CN1947770 discloses a kind of functional composition that is combined by plant material, especially has the compositions of weight losing function.Compositions with weight losing function of the present invention is made up of following raw materials by weight percent: Fructus Phyllanthi powder 20-80%, konjaku powder 20-80%.The present invention has the effect of fat-reducing, blood lipid regulation and loosening bowel to relieve constipation; Publication number is that the Chinese invention patent of CN101007145 discloses a kind of fitness ointment compositions and manufacture method of being made by Folium Artemisiae Argyi leaf, Flos Chrysanthemi Indici, Ganoderma, Stigma Croci, Herba Saussureae Involueratae, Bulbus Lilii, Fructus Forsythiae, Flos Lonicerae, Cordyceps, Folium Artemisiae Argyi root, Fructus Gardeniae, Radix Puerariae, Flos Chrysanthemi, Folium Nelumbinis, Caulis Hederae Sinensis, Rhizoma Alismatis, Herba Lophatheri, Ilicis Purpureae, Semen Vitis viniferae, Exocarpium Benincasae, Fructus Crataegi thereof; Publication number is that the Chinese invention patent of CN101015603 discloses a kind of pharmaceutical composition with fat-reducing and bowel relaxing functions and preparation method thereof and method of quality control.Said composition is a primary raw material with Semen Cassiae, Radix et Rhizoma Rhei (processed), Thallus Laminariae (Thallus Eckloniae), Fructus Chebulae, earlier the part Radix et Rhizoma Rhei (processed) is ground into fine powder, again with all the other crude drug alcohol reflux, concentrate, drying, the dry extract powder, and make clinical acceptable preparation behind the Radix et Rhizoma Rhei (processed) fine powder mix homogeneously.The quality control index of said composition is a general anthraquinone, stipulates that every 100g unit formulation contains general anthraquinone more than or equal to 300mg.
Summary of the invention
Primary and foremost purpose of the present invention is to provide a kind of compositions with lowering blood-fat and reducing weight function at the problems referred to above.This fat-reducing and weight-losing composite at because of surfeit greasy, overnutrition and organ function disorder, the cause of disease of body obesity due to the reasons such as endocrine disturbance, the employing plurality of Chinese cooperatively interacts, the mutual Synergistic of its active component reduces fat effectively and accumulates in that the people is intravital, and the present composition is to the curative effect height of prevention and quality obesity, without any side effects, and fat-reducing back body weight does not rebound.
For realizing purpose of the present invention, one aspect of the present invention provides a kind of compositions with lowering blood-fat and reducing weight function, comprises following raw material: Fructus Lycii, Fructus Ligustri Lucidi, Semen Cassiae, Fructus Crataegi, Radix Rehmanniae, the Radix Astragali.
Wherein, described weight portion proportioning with composition material of lowering blood-fat and reducing weight function is:
Fructus Lycii 10-35, Fructus Ligustri Lucidi 10-25, Semen Cassiae 15-35, Fructus Crataegi 10-40, Radix Rehmanniae 10-40, Radix Astragali 15-45;
Particularly, the weight portion proportioning of described raw material is: Fructus Lycii 20-30, Fructus Ligustri Lucidi 15-20, Semen Cassiae 15-30, Fructus Crataegi 15-30, Radix Rehmanniae 20-35, Radix Astragali 20-30;
Especially, the weight portion proportioning of described raw material is: Fructus Lycii 20, Fructus Ligustri Lucidi 20, Semen Cassiae 20, Fructus Crataegi 20, Radix Rehmanniae 30, the Radix Astragali 30.
Wherein, Radix Rehmanniae described in the present invention is a Radix Rehmanniae.
Fat-reducing and weight-losing composite of the present invention is based on Chinese medicine the pathogenetic of obesity is fully realized, achievement in conjunction with modern pharmacy and pharmaceutical research, select Fructus Lycii, Fructus Ligustri Lucidi, Semen Cassiae, Fructus Crataegi, Radix Rehmanniae, the Radix Astragali to carry out scientific composition and be prepared from, Chinese crude drug with pure natural is a raw material, have no side effect, it is by benefiting qi and nourishing blood, and nourishing the liver and kidney, invigorating the stomach and promoting digestion, carburetion grease removal, liver heat removing and eyesight improving, loosening bowel to relieve constipation reach the purpose of treatment and prevention of obesity.
Wherein, Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum, and property is flat, and sweet in the mouth is returned liver, kidney channel.Have nourishing the liver and kidney, the function of replenishing vital essence to improve eyesight is mainly used in the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear, seminal emission, night sweat, the blood deficiency yellowish complexion, neurasthenia, hepatitis, carbuncle, chilblain is scalded, decubital ulcer, chronic atrophic gastritis, stomach and duodenal bulbar ulcer.
Contain carotene, thiamine, riboflavin, nicotinic acid, ascorbic acid, betanin, atropine, hyoscyamine, physalin etc. in the fruit of Fructus Lycii; Contain aminoacid in the seed of Fructus Lycii: aspartic acid, proline, alanine, leucine, phenylalanine, serine, glycine, glutamic acid, cysteine, lysine, arginine, isoleucine, threonine, histidine, tyrosine, tryptophan, methionine etc.
Modern pharmacological research shows that Fructus Lycii has lipotropic effect, and the infusion of Fructus Lycii (irritating stomach for 20%, 8 milliliter/day) to the mice of being poisoned by carbon tetrachloride, has the effect that fat deposits, promotes hepatocyte new life that suppresses in hepatocyte.The lipotropic effect of water extract also shows, prevents the liver dysfunction that carbon tetrachloride causes.Fructus Lycii mainly is because wherein contained betanin causes that betanin plays the methyl supplying in vivo to lipid metabolism or lipotropic effect.Lycium barbarum polysaccharide has the effect of significant immunostimulant and regulating action, blood sugar lowering, blood fat to mice nonspecific immunity and specific immunity, can slow down aging and antifatigue effect.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plant Fructus Ligustri Lucidi, and is cool in nature, and bitter in the mouth, sweet is returned liver, kidney channel.Fructus Ligustri Lucidi has nourishing the liver and kidney, the function of black hair makes eye bright, be mainly used in vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision, the treatment hepatic and renal YIN deficiency, interior-heat, Light-headedness, tinnitus dim eyesight, soreness of the waist and knees, beard and hair are early from, glaucoma, habitual constipation, chronic bronchitis, cerebral edema, renal failure, angina pectoris, ascites, coronary heart disease etc.The chemical constituent that Fructus Ligustri Lucidi contains has: nuzhenide, oleuropein, oleanolic acid, acetyloleanolic acid, ursolic acid, acetic acid ursolic acid, 4-hydroxyl-B-phenethyl-B-D-glycoside, betulinol, Quercetin, eigustroside, new nuzhenide, eigustroside acid, cleupin acid etc.
Fructus Ligustri Lucidi has the function of blood fat reducing and arteriosclerosis: Fructus Ligustri Lucidi powder is admixed feed in the foodstuff, can reduce serum ornitrol and content of triglyceride to experimental hyperlipidemia rabbit, and aorta lipid speckle and the formation of crown atherosclerotic plaque are subdued; Chemical constituent oleanolic acid 30mg/kg in the Fructus Ligustri Lucidi admixes beverage feed rat, and 0.4% oleanolic acid suspension 0.5ml irritates stomach to rabbit, and hyperlipidemia rat, rabbit are all had effect for reducing blood fat; Oleanolic acid 30,60mg/kg are added on 8 weeks of feed Japanese quail in the feedstuff, obviously reduce the total cholesterol of serum, lipid peroxide, the total cholesterol content of arterial wall, reduce atherosclerotic incidence rate; Fructus Ligustri Lucidi also has the effect of blood sugar lowering, anti-liver injury and human body immunity improving function; Promote cardiovascular system effects such as body hemopoietic, heart tonifying, expansion coronary vasodilator, expansion peripheral blood vessel; Diuresis, cough-relieving, cathartic, effect such as antibiotic grade.
Semen Cassiae is called Horse hoof Semen Cassiae, blunt leaf Semen Cassiae, false Semen phaseoli radiati, Semen Cassiae again, is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae, cold nature, and sweet in the mouth, hardship, salty are returned liver, large intestine channel.Semen Cassiae has clearing away heat to improve acuity of vision, and the effect of loosening bowel to relieve constipation is used for the treatment of the puckery pain of conjunctival congestion, the many tears of photophobia, and it is dizzy to have a headache, poor vision, diseases such as constipation.
Semen Cassiae contains chrysophanol, emodin, aloe-emodin, chrysophanic acid, emodin monoglucoside, emodin anthrone, physcione, obtusin, aurantio-obtusin, rubrofusarin, Semen Cassiae pine, toralactone etc.Pharmacological research shows that Semen Cassiae has blood pressure lowering, blood fat reducing, cholesterol reducing, protects the liver, the effect of loosening bowel to relieve constipation and promotion gastric secretion: the infusion of Semen Cassiae, pure immersion all have hypotensive effect to anesthetized dog, cat, rabbit etc., and hypotensive effect is obvious, and the persistent period is longer; The high fat beverage that contains Semen Cassiae is fed mice, and serum high-density LP-cholesterol (HDL-C) content and improve HDL-C/TC ratio of obviously raising promptly obviously improves the distribution situation of body inner cholesterol, and it is atherosis to help prevention of arterial; Semen Cassiae looses the effect that reduces experimental hyperlipidemia rat plasma T-CHOL and triacylglycerol (triglyceride), can also reduce the effect of triacylglycerol and anticoagulant in the liver.There is data to prove that anthraquinone analog compound has effect for reducing blood fat in the Semen Cassiae.Composition is identical with the model of action of Sennoside A in mice under the rushing down of Semen Cassiae, promptly under intestinal bacterium effect, generates the material of intestinal tube effect is played a role.One of material under the rushing down that Semen Cassiae contains is the chrysophanol dianthrone glycoside that is equivalent to Sennoside A.The fluid extract of Semen Cassiae also can promote the secretion of gastric juice.
Fructus Crataegi another name red fruit, TANGLIZI are the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi, slightly warm in nature; Sour in the mouth, sweet; Return spleen, stomach, Liver Channel.Fructus Crataegi has promoting digestion and invigorating the stomach, and the effect of circulation of qi promoting dissipating blood stasis is used for meat stagnation, gastral cavilty distension, dysentery stomachache, gastric acid, dysentery, hemorrhoidal hamorrhage, hernia, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.
Fructus Crataegi mainly contains epicatechin, Quercetin, hyperin, chlorogenic acid, Crataegolic acid, citric acid, citric acid mono-methyl, citric acid dimethyl ester, trimethyl citrate, ursolic acid, amygdalin, flavan polymers, digestive enzyme and trace element, copper, zinc, ferrum etc.According to pharmacological research, that Fructus Crataegi has is anticancer, antibiotic, strengthen myocardial contraction, blood pressure lowering, blood fat reducing, cholesterol reducing, diuresis, arteriosclerosis, contained lipase can promote steatolysis and strengthen the digestion and metabolism function.The lipase that Fructus Crataegi contains can promote lipid metabolism, and can increase the secretion of peptic digestion enzyme, and facilitating digestion has certain regulating action to gastrointestinal function; Crataegus pin natifida var. Major extract and pure extractum are oral to make lecithin ratio raising in the atherosclerosis rabbits blood, and cholesterol and the lipid deposition on organ reduces.The Fructus Crataegi water decoction has inhibitory action to the cholesterol synthase vigor, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase vigor of its hepatocyte microsome and mucous membrane of small intestine is descended.The Fructus Crataegi aqueous extract can show reduction serum total cholesterol content, and its effect is significantly higher than pantethine, and can obviously increase HDL-C in the serum, HDL2-C, HDL3-C concentration; The Fructus Crataegi aqueous extract has the oxygen-derived free radicals of removing, suppresses the mouse liver lipid peroxidation, lowers through the inductive hyaluronic acid depolymerisation of oxygen-derived free radicals.
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant, and is cool in nature, and sweet in the mouth, hardship are gone into the heart, liver, kidney channel.Have clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting is mainly used in calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, and the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
The chemical constituent of Radix Rehmanniae mainly contains iridoid and glycoside thereof, sugar, aminoacid, organic acid, sterol, flavone and vitamin etc.Wherein, sterols mainly contains cupreol, stigmasterol, micro-campesterol; Flavone mainly contains luteolin, mountain balsam flavin; Iridoid and glycoside thereof mainly comprise catalpol, dihydro catalpol, acetylcatalpol, Herba Leonuri glycoside, aucubin, single sweet special power glycoside, sweet special power glycoside, sterol glycoside, iridoid A, B, C, D, cohosh glycoside, compound saccharic, cerebroside, chlorination iridoid glycoside, Rehmannioside A, B, C, the bitter glycoside of Radix Rehmanniae etc.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali, and warm in nature, sweet in the mouth is returned lung, spleen channel, has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the function of expelling pus and promoting granulation, it is weak to be mainly used in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes etc.
The chemical constituent of the Radix Astragali is flavone and flavonoid glycoside: as calycosin, 2 ', and 4 ' dihydroxy-5,6-dimethoxy isoflavone, 3-hydroxyl-9,10-dimethoxy Lignum pterocarpi indici alkane, astragaloside I, V, III; Also contain the folic acid of a large amount of astragalus polysaccharidess and cupreol, linoleic acid, linolenic acid, choline, betanin, aminoacid, sucrose, glucuronic acid and trace etc.
The pharmacological research of the Radix Astragali shows that the Radix Astragali can strengthen heart contraction, and the heart of depletion is had cardiotonic; Can make the expansion of tubular blood vessel and renal blood vessels, and make the expansion of whole body peripheral vessel, skin circulation is freely contained, and makes hyperpietic's blood pressure drops; The Radix Astragali also has medium diuresis, prevents the effect of nephritis and inhibition pathogenic bacteria; Have anticancer, improve immunity, promote organism metabolism, strengthening the tendons and bones, blood sugar lowering viscosity, short hemopoietic, anti-myocardial ischemia, radioprotective, defying age, protect the liver and the effect of memory reinforcing.
The present invention provides a kind of above-mentioned preparation of compositions method with lowering blood-fat and reducing weight function on the other hand, comprises the steps:
1) it is standby to take by weighing each crude drug Fructus Lycii, Fructus Ligustri Lucidi, Semen Cassiae, Fructus Crataegi, Radix Rehmanniae, the Radix Astragali;
2) the crude drug Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi are mixed, mixture is heated to decoct extract, filter and collect extracting solution;
3) extracting solution of collecting is concentrated, make the mixed concentrated liquid of the Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi;
4) medical material Fructus Crataegi, Semen Cassiae are mixed the back and pulverize, make Fructus Crataegi, Semen Cassiae mixed-powder;
5) the hawthorn and cassia seeds mixed-powder is joined stir in the mixed concentrated liquid for preparing in the step 3) and form.
Wherein, in described step 2) in, described heating extraction comprises following step in sequence:
A) mixture is added the water logging bubble, the weight of the water of adding is 6-10 with the ratio of the weight of mixture: 1, and to soak and carry out the heating extraction first time after 1-2 hour, it is 100 ℃ that heating decocts temperature, the heating extraction time is 1-3 hour;
B) extracting solution filters for the first time, collects filtrate;
C) add entry in filtering residue, carry out the heating extraction second time, wherein, the weight of the water of adding is 5-10 with the ratio of the weight of mixture: 1, and heating-up temperature is 100 ℃, the heating extraction time is 1-3 hour;
D) filter, twice filtering filtrate is merged.
Particularly, steps A) soak time described in is preferably 1-1.5 hour, and the weight of the water of adding is preferably 7-8 with the ratio of the weight of mixture: 1; The weight of the water that adds step C) is 5-7 with the ratio of the weight of mixture: 1.
Wherein, the extracting solution described in the step 3) concentrates, and is that extracting solution is carried out the evacuation concentrating under reduced pressure, and thickening temperature is 80-100 ℃, is preferably 80 ℃, and the relative pressure when concentrating is-0.05～-0.095MPa, be preferably-0.07MPa.
Particularly, the ratio with the weight of described mixed concentrated liquid and the medical material Radix Astragali, Radix Rehmanniae, Fructus Lycii and glossy privet fruit total weight in the step 3) is 0.5-1: 1, be preferably 0.5-0.8: 1.
Wherein, the granularity of mixed-powder described in the step 4) is the 100-300 order, is preferably the 150-200 order.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, adhesive etc. with the method for Chinese medicinal of routine, as pill, powder, tablet, granule, capsule, oral liquid etc.
Compositions of the present invention is with the Radix Astragali, Radix Rehmanniae, benefiting qi and nourishing blood; Fructus Lycii, Fructus Ligustri Lucidi nourishing the liver and kidney; The Fructus Crataegi invigorating the stomach and promoting digestion, the carburetion grease removal; Semen Cassiae liver heat removing and eyesight improving, loosening bowel to relieve constipation, the synergism by medicine give YIN and YANG balancing to human body liver,spleen,kidney and gastrointestinal tract, and prescription has benefit, have and rush down, and have strengthened the motion and the metabolic function of internal organs greatly.
When the fat-reducing and weight-losing composite of the present invention preparation used, oral 2-3 time of every day, each 6-12 restrained (crude drug), and the consumption that children reduce by half is taken, and the anemia of pregnant woman forbids taking, use 30 days continuously after, body weight obviously alleviates, and is of pink and healthy-looking.
The fat-reducing and weight-losing composite of the present invention's preparation has following advantage:
1, fat-reducing and weight-losing composite of the present invention is at the pathogenic factor symptomatic treatment of obesity.Fat-reducing and weight-losing composite of the present invention is prepared from by several kinds of Chinese medicinal materials, the active component of medicine wherein, and mutual synergism, the direct pin cause of disease is taked multi-facetedly at body fat deposition reason, and many target spots carry out Comprehensive Treatment, and therapeutic effect is fast, and effect is rapidly.
2, the fat-reducing and weight-losing composite of the present invention's preparation adopts the natural Chinese medicine scientific composition to form, and sets about from regulating internal organs such as human body liver,spleen,kidney and gastrointestinal tract, has prevention and the fat multi-efficiency of treatment.
3, the fat-reducing and weight-losing composite of the present invention's preparation, fat-reducing effect is remarkable, and body weight obviously reduces, and effective percentage reaches more than 98%, and body weight does not rebound after the treatment, and is without any side effects.
4, to prepare the process of fat-reducing and weight-losing composite simple in the present invention, and the constant product quality effect is obvious, and easy to use.
The specific embodiment
Below example is further set forth the degrease effect of fat-reducing and weight-losing composite of the present invention by experiment, and these tests have comprised the pharmacodynamics test and the clinical observation on the therapeutic effect test of the present composition.
Test example 1 rat fat-reducing test
1.1 the fat modelling of rat:
70 of healthy SD rats, male, be divided into modeling group and blank group at random, 60 of model group, 10 of blank groups.Blank group is with normal feedstuff feed; Model group is with high lipid food (containing normal feedstuff 90.7%, cholesterol 2%, Adeps Sus domestica 3%, casein 4%, bile 0.3%) feed.After raising for 8 weeks, according to Model Measured group rat body weight whether greater than 20% of blank group rat body weight, select 40 of obese rats after, be divided into 3 experimental grouies of the high, medium and low dosage of diet pill of embodiment 1 preparation, every group of 10 rats at random; 10 rats of hyperlipidemia model matched group.3 experimental grouies are except the feed high lipid food, according to the oral present composition pill 20g/kg of group difference, 10g/kg, 5g/kg.The hyperlipidemia model matched group continues feed high lipid food, the normal feedstuff of blank group rat feeding, carries out altogether 30 days.
To the sacrifice of animal of administration after 30 days, weigh, get liver, kidney then and reach the intestine and small intestine fatty tissue on every side and weigh result such as table 1 respectively:
Table 1 present composition pill is to the influence of obese rat body weight, fat/weight ratio
| Group | Initial body weight (g) | Body weight after 30 days (g) | Liver, kidney, intestine and small intestine fat weight (g) | Fat/body weight (%) |
| The blank group | ??350.36±2.15 | ??356.7±23.14 * | ??5.8±1.02 | ??1.63±0.77 * |
| The hyperlipidemia model matched group | ??349.78±25.31 | ??412.7±32.14 | ??21.9±0.94 | ??5.31±0.49 |
| The compositions high dose group | ??351.49±18.25 | ??348.78±46.57 * | ??1.5±0.97 | ??0.43±0.12 * |
| Dosage group in the compositions | ??351.56±25.41 | ??361.12±45.12 * | ??5.5±1.02 | ??1.52±0.78 * |
| The compositions low dose group | ??349.49±75.69 | ??389.52±19.7 * | ??16.0±0.53 * | ??4.11±0.46 * |
Annotate:
*Compare P＜0.01 with the hyperlipidemia model matched group.Fat/body weight=[liver, kidney and intestine and small intestine fat weight (g)/body weight (g)] * 100%
The present composition can significantly reduce the body weight of obese rat, reduces around obese rat liver and the kidney and the intestine and small intestine fat weight, and it is remarkable that reduction fat is accumulated effect in vivo, has tangible fat-reducing effect.
1.2 rat prevention of obesity modelling
Healthy from 50 of newborn SD rats, male, be divided into high fat matched group, high fat lose weight high, medium and low dosage experiments group and blank group at random, every group of 10 rats.Blank group is with normal feedstuff feed; High fat matched group is with high lipid food (containing normal feedstuff 90.7%, cholesterol 2%, Adeps Sus domestica 3%, casein 4%, bile 0.3%) feed; High fat is lost weight high, medium and low dosage experiments group except the feed high lipid food, according to the oral present composition pill 20g/kg of group difference, and 10g/kg, 5g/kg carried out 45 days altogether.
To the sacrifice of animal of administration after 45 days, weigh, get liver, kidney then and reach the intestine and small intestine fatty tissue on every side and weigh result such as table 2 respectively:
Table 2 present composition pill is to the influence of prevention rat obesity
| Group | Initial body weight (g) | Body weight after 45 days (g) | Liver, kidney, intestine and small intestine fat weight (g) | Fat/body weight (%) |
| The blank group | ??170.23±3.25 | ??350.46±23.57 * | ??6.6±0.02 | ??1.88±0.43 * |
| The hyperlipidemia model matched group | ??171.02±5.31 | ??388.27±14.23 | ??41.0±1.47 | ??10.57±0.49 |
| The compositions high dose group | ??170.79±8.25 | ??345.78±52.37 * | ??2.2±0.62 | ??0.64±0.77 * |
| Group | Initial body weight (g) | Body weight after 45 days (g) | Liver, kidney, intestine and small intestine fat weight (g) | Fat/body weight (%) |
| Dosage group in the compositions | ??169.06±3.4 | ??348.56±22.42 * | ??4.5±0.62 | ??1.29±0.17 * |
| The compositions low dose group | ??171.49±7.09 | ??360.15±20.12 * | ??9.85±1.03 * | ??2.73±0.64 * |
Annotate:
*Compare P＜0.05 with the hyperlipidemia model matched group.Fat/body weight=[liver, kidney and intestine and small intestine fat weight (g)/body weight (g)] * 100%
The present composition can effectively be controlled the body weight of rat behind the feed high lipid food, reduces around rats'liver and the kidney and the accumulation of intestine and small intestine fat, and present composition prevention of obesity effect is obvious.
Test example 2 fat-reducing and weight-losing composite toxicological tests of the present invention
(1) acute toxicity test
Fat-reducing and weight-losing composite pill of the present invention is gavaged 1000g (crude drug)/kg to kunming mice.Any toxic reaction does not appear, no animal dead in the week.
(2) long term toxicity test
Fat-reducing and weight-losing composite pill of the present invention is carried out long term toxicity test to rat, continuously heavy dose of (adult's dosage 100 times) gastric infusion, administration time long (90 days), with general performance, body weight, food ration, hematology and serum biochemistry index, routine urinalysis, bone marrow classification, organ weights, organ coefficient before and after the animals administer serves as to detect index, and be aided with the pathological examination that animal is respectively organized internal organs, the toxicity situation of overall merit medicine.The result shows that every index of rat is all normal.The result of histopathologic examination shows that rat is respectively organized the internal organs no abnormality seen.
In sum: fat-reducing and weight-losing composite toxicity of the present invention is low, and safety range is wide, and fat-reducing and weight-losing composite edible safety of the present invention is reliable.
Test example 3 fat-reducing and weight-losing composites of the present invention are to the clinical observation of obesity
(1) physical data:
Fat-reducing and weight-losing composite of the present invention (pill) is observed the understanding fat-reducing effect through 200 example ages in the Simple Obesity women of 25-55 between one full year of life altogether;
All use Body Mass Index (BMI) to weigh according to the whole world, experimenter's height and weight index (BMI)＞25 is for overweight; BMI＞30 are obesity.This Body Mass Index classification of testing routine experimenter is as shown in table 3.
Table 3 experimenter's Body Mass Index classification
Adopt and self take present composition cross-reference mode and compare.
(2) instructions of taking:
Oral 2-3 time of every day, each 6-12 gram (crude drug), intermenstrual period need not to cut out, and uses continuously 2 months.
(3) clinical test results
Experimental result is as shown in table 4.
Table 4
The result shows:
After the experimenter takes pill of the present invention continuously,, can make weight loss 4-6 jin in the week at the back three days beginning weight loss of taking medicine.Take back height and weight index and obviously reduce, produce effects (being that the BMI index recovers normally) 194 examples, total effective rate reaches 97%; Wherein the BMI index is lower than 20 114 examples that have, and what reach slender and graceful in stature accounts for 57%; The BMI index has 56 examples between 20-22, account for 28%; The BMI index has 24 examples between 22-25, account for 12%;
Without any side effects, the anaphylaxis of experimenter and other untoward reaction illustrate that fat-reducing and weight-losing composite of the present invention has no adverse effects to human body in the pill test-meal process of the present invention.
The experimenter used behind the product pill of the present invention the rebound phenomena that weight increase does not take place in 12 months the observation, and hair has more beautiful gloss.
Triglyceride obviously reduces before the treatment after taking the present composition, learns by statistics and handles difference significance (P＜0.05).The result shows that the present composition has tangible fat-reducing effect.
Further specify the preparation method of the present composition by the following examples.
The preparation of embodiment 1 present composition pill
1, takes by weighing raw material (unit: g) according to following proportioning
The Radix Astragali 30, Radix Rehmanniae 30, Fructus Lycii 20, Fructus Ligustri Lucidi 20, Fructus Crataegi 20, Semen Cassiae 20
2) the medical material Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi mix homogeneously are placed in the multi-functional extraction still of Chinese medicine, add tap water and soaked 1.5 hours, wherein, the weight of the tap water of adding is 8: 1 with the ratio of the weight of medical material mixture;
3) open multi-functional extraction still power supply and heat, be heated to 100 ℃, remain under this temperature constant temperature and mentioned 1.5 hours, filter then, obtain that extracting solution is standby for the first time;
4) add tap water in filtering residue, the weight of the tap water of adding is 6: 1 with the ratio of the weight of medical material mixture, and heating extraction, heating-up temperature are 100 ℃, and extraction time is 1.5 hours, filters to obtain extracting solution for the second time;
5) 2 extracting solution are merged to be placed in the vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure for-0.07MPa (is 0 with an atmospheric pressure promptly, the pressure of control during concentrating under reduced pressure with respect to an atmospheric pressure be-0.07MPa), be heated to 80 ℃, the weight of mixed concentrated liquid is 0.6: 1 with the ratio of the weight of medical material mixture;
6) Fructus Crataegi, Semen Cassiae are pulverized after mixing, made Fructus Crataegi-Cassia Seed, wherein the granularity of Fructus Crataegi-Cassia Seed is 150-200;
7) Fructus Crataegi-Cassia Seed is joined in the mixed concentrated liquid for preparing in the step 5), stir, dry, pulverizing back adds adjuvant, and mix homogeneously places pellet processing machine to carry out pill, and the pill that makes is dried to finished product in drying baker, promptly.
The preparation of embodiment 2 present composition pills
1, takes by weighing raw material (unit: g) according to following proportioning
The Radix Astragali 45, Radix Rehmanniae 20, Fructus Lycii 10, Fructus Ligustri Lucidi 25, Fructus Crataegi 15, Semen Cassiae 35
2) the medical material Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi mix homogeneously are placed in the multi-functional extraction still of Chinese medicine, add tap water and soaked 2 hours, wherein, the weight of the tap water of adding is 6: 1 with the ratio of the weight of medical material mixture;
3) open multi-functional extraction still power supply and heat, be heated to 100 ℃, remain under this temperature constant temperature and mentioned 3 hours, filter then, obtain that extracting solution is standby for the first time;
4) add tap water in filtering residue, the weight of the tap water of adding is 10: 1 with the ratio of the weight of medical material mixture, and heating extraction, heating-up temperature are 100 ℃, and extraction time is 1 hour, filters to obtain extracting solution for the second time;
5) 2 extracting solution are merged to be placed in the vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure for-0.05MPa (is 0 with an atmospheric pressure promptly, the pressure of control during concentrating under reduced pressure with respect to an atmospheric pressure be-0.05MPa), be heated to 100 ℃, the weight of mixed concentrated liquid is 1: 1 with the ratio of the weight of medical material mixture;
6) Fructus Crataegi, Semen Cassiae are pulverized after mixing, made Fructus Crataegi-Cassia Seed, wherein the granularity of Fructus Crataegi-Cassia Seed is 200-300;
7) Fructus Crataegi-Cassia Seed is joined in the mixed concentrated liquid for preparing in the step 5), stir, dry, pulverizing back adds adjuvant, and mix homogeneously places pellet processing machine to carry out pill, and the pill that makes is dried to finished product in drying baker, promptly.
Embodiment 3 present composition preparation tablets
1, takes by weighing raw material (unit: g) according to following proportioning
The Radix Astragali 20, Radix Rehmanniae 10, Fructus Lycii 35, Fructus Ligustri Lucidi 10, Fructus Crataegi 40, Semen Cassiae 15
2) the medical material Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi mix homogeneously are placed in the multi-functional extraction still of Chinese medicine, add tap water and soaked 1 hour, wherein, the weight of the tap water of adding is 10: 1 with the ratio of the weight of medical material mixture;
3) open multi-functional extraction still power supply and heat, be heated to 100 ℃, remain under this temperature constant temperature and mentioned 1.5 hours, filter then, obtain that extracting solution is standby for the first time;
4) add tap water in filtering residue, the weight of the tap water of adding is 5: 1 with the ratio of the weight of medical material mixture, and heating extraction, heating-up temperature are 100 ℃, and extraction time is 3 hours, filters to obtain extracting solution for the second time;
5) 2 extracting solution are merged to be placed in the vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure for-0.095MPa (is 0 with an atmospheric pressure promptly, the pressure of control during concentrating under reduced pressure with respect to an atmospheric pressure be-0.095MPa), be heated to 80 ℃, the weight of mixed concentrated liquid is 0.5: 1 with the ratio of the weight of medical material mixture;
6) Fructus Crataegi, Semen Cassiae are pulverized after mixing, made Fructus Crataegi-Cassia Seed, wherein the granularity of Fructus Crataegi-Cassia Seed is 100-150;
7) Fructus Crataegi-Cassia Seed is joined in the mixed concentrated liquid for preparing in the step 5), stir, add the adjuvant compacting in flakes, promptly.
The preparation of embodiment 4 present composition capsules
1, takes by weighing raw material (unit: g) according to following proportioning
The Radix Astragali 15, Radix Rehmanniae 40, Fructus Lycii 30, Fructus Ligustri Lucidi 15, Fructus Crataegi 30, Semen Cassiae 30
2) the medical material Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi mix homogeneously are placed in the multi-functional extraction still of Chinese medicine, add tap water and soaked 1.5 hours, wherein, the weight of the tap water of adding is 7: 1 with the ratio of the weight of medical material mixture;
3) open multi-functional extraction still power supply and heat, be heated to 100 ℃, remain under this temperature constant temperature and mentioned 1 hour, filter then, obtain that extracting solution is standby for the first time;
4) add tap water in filtering residue, the weight of the tap water of adding is 7: 1 with the ratio of the weight of medical material mixture, and heating extraction, heating-up temperature are 100 ℃, and extraction time is 1.5 hours, filters to obtain extracting solution for the second time;
5) 2 extracting solution are merged to be placed in the vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure for-0.08MPa (is 0 with an atmospheric pressure promptly, the pressure of control during concentrating under reduced pressure with respect to an atmospheric pressure be-0.08MPa), be heated to 80 ℃, the weight of mixed concentrated liquid is 0.7: 1 with the ratio of the weight of medical material mixture;
6) Fructus Crataegi, Semen Cassiae are pulverized after mixing, made Fructus Crataegi-Cassia Seed, wherein the granularity of Fructus Crataegi-Cassia Seed is 150-200;
7) Fructus Crataegi-Cassia Seed is joined in the mixed concentrated liquid for preparing in the step 5), stir, the snap fit capsule of packing into after drying, the pulverizing, promptly.
Claims (10)
1. the compositions with lowering blood-fat and reducing weight function is characterized in that comprising following raw material: Fructus Lycii, Fructus Ligustri Lucidi, Semen Cassiae, Fructus Crataegi, Radix Rehmanniae, the Radix Astragali.
2. the compositions with lowering blood-fat and reducing weight function as claimed in claim 1 is characterized in that the weight portion proportioning of described raw material is: Fructus Lycii 10-35, Fructus Ligustri Lucidi 10-25, Semen Cassiae 15-35, Fructus Crataegi 10-40, Radix Rehmanniae 10-40, Radix Astragali 15-45.
3. the compositions with lowering blood-fat and reducing weight function as claimed in claim 2 is characterized in that the weight portion proportioning of described raw material is: Fructus Lycii 20-30, Fructus Ligustri Lucidi 15-20, Semen Cassiae 15-30, Fructus Crataegi 15-30, Radix Rehmanniae 20-35, Radix Astragali 20-30.
4. the compositions with lowering blood-fat and reducing weight function as claimed in claim 3 is characterized in that the weight portion proportioning of described raw material is: Fructus Lycii 20, Fructus Ligustri Lucidi 20, Semen Cassiae 20, Fructus Crataegi 20, Radix Rehmanniae 30, the Radix Astragali 30.
5. a preparation of compositions method that has the lowering blood-fat and reducing weight function as claim 1 to 4 as described in arbitrary comprises the steps:
1) it is standby to take by weighing each crude drug Fructus Lycii, Fructus Ligustri Lucidi, Semen Cassiae, Fructus Crataegi, Radix Rehmanniae, the Radix Astragali;
2) the described crude drug Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi are mixed, mixture is carried out heating extraction, filter and collect extracting solution;
3) extracting solution of collecting is concentrated, make the mixed concentrated liquid of the Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi;
4) described crude drug Fructus Crataegi, Semen Cassiae are mixed the back and pulverize, make Fructus Crataegi, Semen Cassiae mixed powder;
5) Fructus Crataegi, Semen Cassiae mixed powder are joined to stir in the concentrated solution described in the step 3) form.
6. preparation method as claimed in claim 5 is characterized in that step 2) described in heating extraction comprise following step in sequence:
A) mixture is added the water logging bubble, the weight of the water of adding is 6-10 with the ratio of the weight of mixture: 1, and to soak and carry out the heating extraction first time after 1-2 hour, heating-up temperature is 100 ℃, the heating extraction time is 1-3 hour;
B) extracting solution filters for the first time, collects filtrate;
C) add entry in filtering residue, carry out the heating extraction second time, wherein, the weight of the water of adding is 5-10 with the ratio of the weight of mixture: 1, and heating-up temperature is 100 ℃, the heating extraction time is 1-3 hour;
D) filter, twice filtering filtrate is merged.
7. preparation method as claimed in claim 6 is characterized in that steps A) described in 1-1.5 hour heating extraction time, the weight of the water of adding is preferably 7-8 with the ratio of the weight of mixture: 1; The weight of the water that adds step C) is 5-7 with the ratio of the weight of mixture: 1.
8. as claim 5 or 6 described preparation methoies, it is characterized in that the control temperature was 80-100 ℃ when the filtrate described in the step 3) concentrated, relative pressure is-0.05～-0.095MPa.
9. as claim 5 or 6 described preparation methoies, it is characterized in that the weight of the concentrated solution described in the step 3) is 0.5-1 with the ratio of the gross weight of the crude drug Radix Astragali, Radix Rehmanniae, Fructus Lycii and Fructus Ligustri Lucidi: 1.
10. as claim 5 or 6 described preparation methoies, it is characterized in that the granularity of the hawthorn and cassia seeds mixed powder described in the step 4) is the 100-300 order.
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