CN101677997B - 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 - Google Patents

用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 Download PDF

Info

Publication number
CN101677997B
CN101677997B CN2008800173249A CN200880017324A CN101677997B CN 101677997 B CN101677997 B CN 101677997B CN 2008800173249 A CN2008800173249 A CN 2008800173249A CN 200880017324 A CN200880017324 A CN 200880017324A CN 101677997 B CN101677997 B CN 101677997B
Authority
CN
China
Prior art keywords
ibs
ethyl
treatment
phenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800173249A
Other languages
English (en)
Chinese (zh)
Other versions
CN101677997A (zh
Inventor
艾伦·曼格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tioga Pharmaceuticals Inc
Original Assignee
Tioga Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tioga Pharmaceuticals Inc filed Critical Tioga Pharmaceuticals Inc
Publication of CN101677997A publication Critical patent/CN101677997A/zh
Application granted granted Critical
Publication of CN101677997B publication Critical patent/CN101677997B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
CN2008800173249A 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 Expired - Fee Related CN101677997B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92084107P 2007-03-30 2007-03-30
US60/920,841 2007-03-30
PCT/US2008/056317 WO2008121496A1 (en) 2007-03-30 2008-03-07 Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2012101134057A Division CN102641265A (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Publications (2)

Publication Number Publication Date
CN101677997A CN101677997A (zh) 2010-03-24
CN101677997B true CN101677997B (zh) 2012-05-09

Family

ID=39795494

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2012101134057A Pending CN102641265A (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
CN2008800173249A Expired - Fee Related CN101677997B (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2012101134057A Pending CN102641265A (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Country Status (19)

Country Link
US (2) US7960429B2 (enExample)
EP (3) EP2561870A1 (enExample)
JP (2) JP5416085B2 (enExample)
KR (2) KR101263225B1 (enExample)
CN (2) CN102641265A (enExample)
AU (1) AU2008232954A1 (enExample)
BR (1) BRPI0809651A2 (enExample)
CA (1) CA2682608A1 (enExample)
CY (1) CY1113317T1 (enExample)
DK (1) DK2136801T3 (enExample)
ES (1) ES2393815T3 (enExample)
HR (1) HRP20120798T1 (enExample)
IL (1) IL201226A0 (enExample)
MX (1) MX2009010409A (enExample)
PL (1) PL2136801T3 (enExample)
PT (1) PT2136801E (enExample)
RU (1) RU2441655C2 (enExample)
SI (1) SI2136801T1 (enExample)
WO (1) WO2008121496A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641265A (zh) * 2007-03-30 2012-08-22 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012410A2 (en) * 2010-07-19 2012-01-26 Dr. Reddy's Laboratories Ltd. Kappa opioid receptor agonists
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
CA2893427C (en) 2012-12-24 2023-01-10 Neurogastrx, Inc. Methods for treating gi tract disorders
US9844554B2 (en) 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
JP6410641B2 (ja) 2015-03-04 2018-10-24 ローム株式会社 ワイヤレス送電装置、異物検出方法、充電器
WO2018035046A1 (en) 2016-08-15 2018-02-22 President And Fellows Of Harvard College Treating infections using idsd from proteus mirabilis
CA3047325A1 (en) 2016-12-21 2018-06-28 Tioga Pharmaceuticals Inc. Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
MX2021000908A (es) 2018-07-23 2021-06-08 Trevi Therapeutics Inc Tratamiento de la tos cronica, la dificultad respiratoria y la disnea.
EP4087569A4 (en) 2020-01-10 2024-01-24 Trevi Therapeutics, Inc. METHODS OF ADMINISTRATION OF NALBUPHINE
CN115335072A (zh) * 2020-03-18 2022-11-11 卡拉治疗学股份有限公司 κ阿片受体激动剂的寡糖配制品
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline
WO2022085736A1 (ja) * 2020-10-20 2022-04-28 協和化学工業株式会社 診療支援装置、診療支援方法及び診療支援プログラム
WO2022155332A1 (en) * 2021-01-13 2022-07-21 Blue Therapeutics, Inc. Methods of treating irritable bowel syndrome

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1145781A (zh) * 1995-06-28 1997-03-26 默克专利股份有限公司 用于炎性肠疾病的k阿片激动剂
CN1767830A (zh) * 2003-04-08 2006-05-03 普罗热尼奇制药公司 外周阿片拮抗剂具体是甲基纳曲酮治疗肠易激综合征的用途
CN1767831A (zh) * 2003-04-08 2006-05-03 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
US7164021B2 (en) * 2002-09-18 2007-01-16 The Curators Of The University Of Missouri Opiate analogs selective for the δ-opioid receptor

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192883A (en) 1976-04-09 1980-03-11 Pierre Fabre, S.A. Amides of pyrrolidinoethylamine which can be used in lung therapy
FR2421891A1 (fr) 1977-10-17 1979-11-02 Fabre Sa Pierre Obtention industrielle d'amides de la pyrrolidine ethyl amine
US4663343A (en) 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
US4889860A (en) 1985-09-23 1989-12-26 Nova Pharmaceutical Corporation Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists
US4760069A (en) 1985-09-23 1988-07-26 Nova Pharmaceutical Corporation Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists
GB8601796D0 (en) 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
EP0330467A1 (en) 1988-02-23 1989-08-30 Glaxo Group Limited Heterocyclic compounds
DE3935371A1 (de) 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
DE4034785A1 (de) 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
US5389686A (en) 1989-02-20 1995-02-14 Jouveinal Sa Analgesic properties of fedotozine
DE3916663A1 (de) 1989-05-23 1990-11-29 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5232266A (en) 1989-07-24 1993-08-03 Mork William J Upholstered article of furniture with interchangeable seating module
AU641955B2 (en) 1989-11-24 1993-10-07 Dr. Lo Zambeletti S.P.A. N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals
GB8926560D0 (en) 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
US5300687A (en) 1991-07-18 1994-04-05 Ortho Pharmaceutical Corporation Trifluoromethylbenzylphosphonates useful in treating osteoporosis
DE4215213A1 (de) 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
DE4425071C2 (de) 1994-07-15 1996-08-29 Degussa Verfahren zur Herstellung optisch aktiver Pyrrolidine mit hoher Enantiomerenreinheit
DE19531464A1 (de) 1995-08-26 1997-02-27 Merck Patent Gmbh N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid
WO1999015210A2 (en) 1997-09-26 1999-04-01 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
US20010051181A1 (en) 1997-12-22 2001-12-13 Van Osdol William W. Novel formulations for the transdermal administration of asimadoline
DE19827633A1 (de) 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
WO2000000195A1 (en) 1998-06-30 2000-01-06 Takeda Chemical Industries, Ltd. Pharmaceutical composition for the treatment of diabetes
JP2000080047A (ja) 1998-06-30 2000-03-21 Takeda Chem Ind Ltd 医 薬
DE19849650A1 (de) * 1998-10-29 2000-05-04 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung des Irritable Bowel Syndroms (IBS)
PT1033364E (pt) 1999-03-01 2005-07-29 Pfizer Prod Inc Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide
GB0015562D0 (en) 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
US20020025948A1 (en) 2000-06-23 2002-02-28 Banks Bernard Joseph 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
US6262062B1 (en) 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
CN100411618C (zh) * 2002-05-17 2008-08-20 迪欧加药品公司 有效的选择性阿片受体调制剂化合物的用途
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
PL1644021T3 (pl) * 2003-06-13 2013-01-31 Ironwood Pharmaceuticals Inc Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych
CA2544245A1 (en) * 2003-10-30 2005-05-26 Tioga Pharmaceuticals, Inc. Use of selective opiate receptor modulators in the treatment of neuropathy
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
HRP20120798T1 (hr) * 2007-03-30 2012-11-30 Tioga Pharmaceuticals, Inc. Kappa-opijatni agonisti za lijeäśenje dijareja-predominantnog i naizmjeniäśnog sindroma iritabilnog crijeva

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1145781A (zh) * 1995-06-28 1997-03-26 默克专利股份有限公司 用于炎性肠疾病的k阿片激动剂
US7164021B2 (en) * 2002-09-18 2007-01-16 The Curators Of The University Of Missouri Opiate analogs selective for the δ-opioid receptor
CN1767830A (zh) * 2003-04-08 2006-05-03 普罗热尼奇制药公司 外周阿片拮抗剂具体是甲基纳曲酮治疗肠易激综合征的用途
CN1767831A (zh) * 2003-04-08 2006-05-03 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641265A (zh) * 2007-03-30 2012-08-22 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

Also Published As

Publication number Publication date
SI2136801T1 (sl) 2013-01-31
KR101263225B1 (ko) 2013-05-13
ES2393815T3 (es) 2012-12-28
EP2636407A3 (en) 2013-11-06
EP2136801A4 (en) 2010-05-26
MX2009010409A (es) 2010-03-29
HK1139860A1 (en) 2010-09-30
JP2010523492A (ja) 2010-07-15
CY1113317T1 (el) 2016-04-13
CN102641265A (zh) 2012-08-22
EP2136801A1 (en) 2009-12-30
US20080242720A1 (en) 2008-10-02
US7960429B2 (en) 2011-06-14
EP2136801B1 (en) 2012-08-29
PL2136801T3 (pl) 2013-01-31
RU2009140042A (ru) 2011-05-10
BRPI0809651A2 (pt) 2014-10-07
EP2561870A1 (en) 2013-02-27
US20110046174A1 (en) 2011-02-24
US8877800B2 (en) 2014-11-04
CA2682608A1 (en) 2008-10-09
KR20100016004A (ko) 2010-02-12
IL201226A0 (en) 2010-05-31
DK2136801T3 (da) 2012-12-17
PT2136801E (pt) 2012-12-06
AU2008232954A2 (en) 2011-12-01
WO2008121496A1 (en) 2008-10-09
AU2008232954A1 (en) 2008-10-09
KR101208326B1 (ko) 2012-12-05
JP2013173790A (ja) 2013-09-05
KR20120058614A (ko) 2012-06-07
JP5416085B2 (ja) 2014-02-12
HRP20120798T1 (hr) 2012-11-30
EP2636407A2 (en) 2013-09-11
CN101677997A (zh) 2010-03-24
RU2441655C2 (ru) 2012-02-10

Similar Documents

Publication Publication Date Title
CN101677997B (zh) 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
AU2003284005B2 (en) Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
US20110070319A1 (en) Bifeprunox doses for treating schizophrenia
CA2899602C (en) Pharmaceutical uses of inorganic nitrites
CN117503775A (zh) 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型
CN110958879A (zh) 玛沃谷兰在减少可卡因使用或预防复用可卡因中的用途
CA3236069A1 (en) Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating chronic rhinosinusitis
US20070185080A1 (en) Pharmaceutical Compositions
US8592466B2 (en) Methods for treating conditions caused by higher-than-normal dopaminergic activity in basal ganglia
RU2804834C2 (ru) Применение мавоглуранта при снижении употребления кокаина или при предупреждении рецидива употребления кокаина
EP4337212A1 (en) Use of complement factor d inhibitor for treatment of generalized myasthenia gravis
HK1139860B (en) Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
JP2025532301A (ja) 重症筋無力症を処置するための組成物及び方法
NZ540415A (en) Use of levocetirizine for the treatment of persistent allergic rhinitis
NZ614725B2 (en) Methods and compositions for treating depression using cyclobenzaprine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120509

Termination date: 20150307

EXPY Termination of patent right or utility model