AU2008232954A1 - Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome - Google Patents
Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome Download PDFInfo
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- AU2008232954A1 AU2008232954A1 AU2008232954A AU2008232954A AU2008232954A1 AU 2008232954 A1 AU2008232954 A1 AU 2008232954A1 AU 2008232954 A AU2008232954 A AU 2008232954A AU 2008232954 A AU2008232954 A AU 2008232954A AU 2008232954 A1 AU2008232954 A1 AU 2008232954A1
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- phenyl
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- hydroxypyrrolidin
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- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
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| PCT/US2008/056317 WO2008121496A1 (en) | 2007-03-30 | 2008-03-07 | Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome |
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| RU (1) | RU2441655C2 (enExample) |
| SI (1) | SI2136801T1 (enExample) |
| WO (1) | WO2008121496A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20120798T1 (hr) * | 2007-03-30 | 2012-11-30 | Tioga Pharmaceuticals, Inc. | Kappa-opijatni agonisti za lijeäśenje dijareja-predominantnog i naizmjeniäśnog sindroma iritabilnog crijeva |
| WO2012012410A2 (en) * | 2010-07-19 | 2012-01-26 | Dr. Reddy's Laboratories Ltd. | Kappa opioid receptor agonists |
| US8637538B1 (en) | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
| US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| CA2893427C (en) | 2012-12-24 | 2023-01-10 | Neurogastrx, Inc. | Methods for treating gi tract disorders |
| US9844554B2 (en) | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
| JP6410641B2 (ja) | 2015-03-04 | 2018-10-24 | ローム株式会社 | ワイヤレス送電装置、異物検出方法、充電器 |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
| CA3047325A1 (en) | 2016-12-21 | 2018-06-28 | Tioga Pharmaceuticals Inc. | Solid pharmaceutical formulations of asimadoline |
| WO2019122361A1 (en) | 2017-12-22 | 2019-06-27 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis |
| MX2021000908A (es) | 2018-07-23 | 2021-06-08 | Trevi Therapeutics Inc | Tratamiento de la tos cronica, la dificultad respiratoria y la disnea. |
| EP4087569A4 (en) | 2020-01-10 | 2024-01-24 | Trevi Therapeutics, Inc. | METHODS OF ADMINISTRATION OF NALBUPHINE |
| CN115335072A (zh) * | 2020-03-18 | 2022-11-11 | 卡拉治疗学股份有限公司 | κ阿片受体激动剂的寡糖配制品 |
| US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
| EP3932390A1 (en) | 2020-07-02 | 2022-01-05 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical gel formulation containing asimadoline |
| WO2022085736A1 (ja) * | 2020-10-20 | 2022-04-28 | 協和化学工業株式会社 | 診療支援装置、診療支援方法及び診療支援プログラム |
| WO2022155332A1 (en) * | 2021-01-13 | 2022-07-21 | Blue Therapeutics, Inc. | Methods of treating irritable bowel syndrome |
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| FR2421891A1 (fr) | 1977-10-17 | 1979-11-02 | Fabre Sa Pierre | Obtention industrielle d'amides de la pyrrolidine ethyl amine |
| US4663343A (en) | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
| US4889860A (en) | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4760069A (en) | 1985-09-23 | 1988-07-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
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| DE3916663A1 (de) | 1989-05-23 | 1990-11-29 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
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| US5300687A (en) | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
| DE4215213A1 (de) | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
| DE4425071C2 (de) | 1994-07-15 | 1996-08-29 | Degussa | Verfahren zur Herstellung optisch aktiver Pyrrolidine mit hoher Enantiomerenreinheit |
| DE19523502A1 (de) | 1995-06-28 | 1997-01-02 | Merck Patent Gmbh | Kappa-Opiatagonisten für entzündliche Darmerkrankungen |
| DE19531464A1 (de) | 1995-08-26 | 1997-02-27 | Merck Patent Gmbh | N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid |
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| PT1033364E (pt) | 1999-03-01 | 2005-07-29 | Pfizer Prod Inc | Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide |
| GB0015562D0 (en) | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
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| DE10116978A1 (de) | 2001-04-05 | 2002-10-10 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase |
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| CN100411618C (zh) * | 2002-05-17 | 2008-08-20 | 迪欧加药品公司 | 有效的选择性阿片受体调制剂化合物的用途 |
| MXPA05002983A (es) * | 2002-09-18 | 2005-06-22 | Univ Missouri | Analogos de opiato selectivos del receptor opioide d. |
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| JP2006522817A (ja) | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
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| PL1644021T3 (pl) * | 2003-06-13 | 2013-01-31 | Ironwood Pharmaceuticals Inc | Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych |
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| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| HRP20120798T1 (hr) * | 2007-03-30 | 2012-11-30 | Tioga Pharmaceuticals, Inc. | Kappa-opijatni agonisti za lijeäśenje dijareja-predominantnog i naizmjeniäśnog sindroma iritabilnog crijeva |
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2008
- 2008-03-07 HR HRP20120798AT patent/HRP20120798T1/hr unknown
- 2008-03-07 WO PCT/US2008/056317 patent/WO2008121496A1/en not_active Ceased
- 2008-03-07 EP EP12182095A patent/EP2561870A1/en not_active Withdrawn
- 2008-03-07 EP EP13161453.9A patent/EP2636407A3/en not_active Withdrawn
- 2008-03-07 PL PL08731748T patent/PL2136801T3/pl unknown
- 2008-03-07 CN CN2012101134057A patent/CN102641265A/zh active Pending
- 2008-03-07 US US12/044,906 patent/US7960429B2/en not_active Expired - Fee Related
- 2008-03-07 RU RU2009140042/15A patent/RU2441655C2/ru not_active IP Right Cessation
- 2008-03-07 SI SI200830830T patent/SI2136801T1/sl unknown
- 2008-03-07 KR KR1020127010007A patent/KR101263225B1/ko not_active Expired - Fee Related
- 2008-03-07 EP EP08731748A patent/EP2136801B1/en not_active Not-in-force
- 2008-03-07 AU AU2008232954A patent/AU2008232954A1/en not_active Abandoned
- 2008-03-07 ES ES08731748T patent/ES2393815T3/es active Active
- 2008-03-07 CA CA002682608A patent/CA2682608A1/en not_active Abandoned
- 2008-03-07 BR BRPI0809651-1A2A patent/BRPI0809651A2/pt not_active IP Right Cessation
- 2008-03-07 JP JP2010501048A patent/JP5416085B2/ja not_active Expired - Fee Related
- 2008-03-07 KR KR1020097022558A patent/KR101208326B1/ko not_active Expired - Fee Related
- 2008-03-07 DK DK08731748.3T patent/DK2136801T3/da active
- 2008-03-07 MX MX2009010409A patent/MX2009010409A/es not_active Application Discontinuation
- 2008-03-07 CN CN2008800173249A patent/CN101677997B/zh not_active Expired - Fee Related
- 2008-03-07 PT PT87317483T patent/PT2136801E/pt unknown
-
2009
- 2009-09-29 IL IL201226A patent/IL201226A0/en unknown
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2010
- 2010-11-05 US US12/940,979 patent/US8877800B2/en not_active Expired - Fee Related
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2012
- 2012-11-06 CY CY20121101057T patent/CY1113317T1/el unknown
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2013
- 2013-05-13 JP JP2013101705A patent/JP2013173790A/ja active Pending
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| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |