CN101652362B - 通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 - Google Patents
通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 Download PDFInfo
- Publication number
- CN101652362B CN101652362B CN2008800103886A CN200880010388A CN101652362B CN 101652362 B CN101652362 B CN 101652362B CN 2008800103886 A CN2008800103886 A CN 2008800103886A CN 200880010388 A CN200880010388 A CN 200880010388A CN 101652362 B CN101652362 B CN 101652362B
- Authority
- CN
- China
- Prior art keywords
- solvent
- formula
- phenylfluoroform
- toluene
- diene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PKIIEHIDVLBDKQ-QJAQHPNASA-M C[C@@H](CCC/C(/C)=C\CCC1=CC=C2SC(C)=NC22C1C2)C[C@@H](CC=C)C(C(C)(C)[C@H](CC([O-])=O)O)=O Chemical compound C[C@@H](CCC/C(/C)=C\CCC1=CC=C2SC(C)=NC22C1C2)C[C@@H](CC=C)C(C(C)(C)[C@H](CC([O-])=O)O)=O PKIIEHIDVLBDKQ-QJAQHPNASA-M 0.000 description 1
- 0 C[C@@](CCC[C@](C)*CCc(cc1)cc2c1[s]c(C)n2)C[C@@](CC=C)C(C(C)(C)[C@](CC([O-])=O)O)=O Chemical compound C[C@@](CCC[C@](C)*CCc(cc1)cc2c1[s]c(C)n2)C[C@@](CC=C)C(C(C)(C)[C@](CC([O-])=O)O)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007016046A DE102007016046A1 (de) | 2007-03-30 | 2007-03-30 | Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung |
| DE102007016046.3 | 2007-03-30 | ||
| PCT/EP2008/002652 WO2008119563A2 (de) | 2007-03-30 | 2008-03-27 | Verfahren zur herstellung von epothilonderivaten durch selektive katalytische epoxidierung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101652362A CN101652362A (zh) | 2010-02-17 |
| CN101652362B true CN101652362B (zh) | 2012-10-10 |
Family
ID=39551678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800103886A Expired - Fee Related CN101652362B (zh) | 2007-03-30 | 2008-03-27 | 通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20080242868A1 (https=) |
| EP (1) | EP2142539A2 (https=) |
| JP (1) | JP2010523481A (https=) |
| KR (1) | KR20090125259A (https=) |
| CN (1) | CN101652362B (https=) |
| AR (1) | AR066692A1 (https=) |
| CA (1) | CA2681806A1 (https=) |
| CL (1) | CL2008000901A1 (https=) |
| DE (1) | DE102007016046A1 (https=) |
| PA (1) | PA8773901A1 (https=) |
| TW (1) | TW200902538A (https=) |
| UY (1) | UY30985A1 (https=) |
| WO (1) | WO2008119563A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114539143A (zh) * | 2022-01-28 | 2022-05-27 | 安徽瑞邦生物科技有限公司 | 一种4-氰基吡啶的纯化方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1140944E (pt) * | 1998-12-22 | 2004-01-30 | Novartis Pharma Gmbh | Derivados de epotilona e sua utilizacao como agentes antitumorais |
| PE20010116A1 (es) | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
| EP1340498A1 (en) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
| GB0405898D0 (en) * | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
-
2007
- 2007-03-30 DE DE102007016046A patent/DE102007016046A1/de not_active Withdrawn
-
2008
- 2008-03-27 UY UY30985A patent/UY30985A1/es not_active Application Discontinuation
- 2008-03-27 CA CA002681806A patent/CA2681806A1/en not_active Abandoned
- 2008-03-27 CN CN2008800103886A patent/CN101652362B/zh not_active Expired - Fee Related
- 2008-03-27 EP EP08734992A patent/EP2142539A2/de not_active Withdrawn
- 2008-03-27 US US12/056,393 patent/US20080242868A1/en not_active Abandoned
- 2008-03-27 WO PCT/EP2008/002652 patent/WO2008119563A2/de not_active Ceased
- 2008-03-27 JP JP2010500148A patent/JP2010523481A/ja not_active Withdrawn
- 2008-03-27 KR KR1020097020329A patent/KR20090125259A/ko not_active Withdrawn
- 2008-03-28 PA PA20088773901A patent/PA8773901A1/es unknown
- 2008-03-28 TW TW097111589A patent/TW200902538A/zh unknown
- 2008-03-28 AR ARP080101279A patent/AR066692A1/es not_active Application Discontinuation
- 2008-03-28 CL CL200800901A patent/CL2008000901A1/es unknown
-
2011
- 2011-11-30 US US13/308,046 patent/US8314248B2/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| F.Cachoux et al..Scaffolds for Microtubule Inhibition through Extensive Modification of the Epothilone Template.《Angew.Chem.Int.Ed》.2005,第44卷第7469-7473页. * |
| Fritz E. Kuhn et al..Methyltrioxorhenium and its applications in olefin oxidation, metathesis and aldehyde olefination.《Journal of Organometallic Chemistry》.2004,第689卷第4149-4164页. * |
| FritzE.Kuhnetal..Methyltrioxorheniumanditsapplicationsinolefinoxidation metathesis and aldehyde olefination.《Journal of Organometallic Chemistry》.2004 |
| Klar U et al..Total Synthesis and Antitumor Activity of ZK-EPO:the first fully synthesis epothilone in clinical development.《Angew.Chem.Int.Ed.》.2006,第45卷第7942-7948页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090125259A (ko) | 2009-12-04 |
| US20080242868A1 (en) | 2008-10-02 |
| UY30985A1 (es) | 2008-10-31 |
| US8314248B2 (en) | 2012-11-20 |
| JP2010523481A (ja) | 2010-07-15 |
| WO2008119563A3 (de) | 2009-02-12 |
| DE102007016046A1 (de) | 2008-10-23 |
| EP2142539A2 (de) | 2010-01-13 |
| CN101652362A (zh) | 2010-02-17 |
| CL2008000901A1 (es) | 2008-10-17 |
| WO2008119563A2 (de) | 2008-10-09 |
| AR066692A1 (es) | 2009-09-09 |
| CA2681806A1 (en) | 2008-10-09 |
| US20120077984A1 (en) | 2012-03-29 |
| PA8773901A1 (es) | 2008-11-19 |
| TW200902538A (en) | 2009-01-16 |
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