CN101652362B - 通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 - Google Patents

通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 Download PDF

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Publication number
CN101652362B
CN101652362B CN2008800103886A CN200880010388A CN101652362B CN 101652362 B CN101652362 B CN 101652362B CN 2008800103886 A CN2008800103886 A CN 2008800103886A CN 200880010388 A CN200880010388 A CN 200880010388A CN 101652362 B CN101652362 B CN 101652362B
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CN
China
Prior art keywords
solvent
formula
phenylfluoroform
toluene
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2008800103886A
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English (en)
Chinese (zh)
Other versions
CN101652362A (zh
Inventor
J·普拉策克
O·彼得罗夫
S·普吕斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
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Schering AG
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Publication date
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Publication of CN101652362A publication Critical patent/CN101652362A/zh
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Publication of CN101652362B publication Critical patent/CN101652362B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2008800103886A 2007-03-30 2008-03-27 通过选择性催化环氧化反应制备埃坡霉素衍生物的方法 Expired - Fee Related CN101652362B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007016046A DE102007016046A1 (de) 2007-03-30 2007-03-30 Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung
DE102007016046.3 2007-03-30
PCT/EP2008/002652 WO2008119563A2 (de) 2007-03-30 2008-03-27 Verfahren zur herstellung von epothilonderivaten durch selektive katalytische epoxidierung

Publications (2)

Publication Number Publication Date
CN101652362A CN101652362A (zh) 2010-02-17
CN101652362B true CN101652362B (zh) 2012-10-10

Family

ID=39551678

Family Applications (1)

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CN2008800103886A Expired - Fee Related CN101652362B (zh) 2007-03-30 2008-03-27 通过选择性催化环氧化反应制备埃坡霉素衍生物的方法

Country Status (13)

Country Link
US (2) US20080242868A1 (https=)
EP (1) EP2142539A2 (https=)
JP (1) JP2010523481A (https=)
KR (1) KR20090125259A (https=)
CN (1) CN101652362B (https=)
AR (1) AR066692A1 (https=)
CA (1) CA2681806A1 (https=)
CL (1) CL2008000901A1 (https=)
DE (1) DE102007016046A1 (https=)
PA (1) PA8773901A1 (https=)
TW (1) TW200902538A (https=)
UY (1) UY30985A1 (https=)
WO (1) WO2008119563A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114539143A (zh) * 2022-01-28 2022-05-27 安徽瑞邦生物科技有限公司 一种4-氰基吡啶的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1122668C (zh) * 1998-12-22 2003-10-01 诺瓦提斯公司 环氧噻酮衍生物，其制备方法及其药物组合物
AR023792A1 (es) 1999-04-30 2002-09-04 Bayer Schering Pharma Ag Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
GB0405898D0 (en) * 2004-03-16 2004-04-21 Novartis Ag Organic compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
F.Cachoux et al..Scaffolds for Microtubule Inhibition through Extensive Modification of the Epothilone Template.《Angew.Chem.Int.Ed》.2005,第44卷第7469-7473页. *
Fritz E. Kuhn et al..Methyltrioxorhenium and its applications in olefin oxidation, metathesis and aldehyde olefination.《Journal of Organometallic Chemistry》.2004,第689卷第4149-4164页. *
FritzE.Kuhnetal..Methyltrioxorheniumanditsapplicationsinolefinoxidation metathesis and aldehyde olefination.《Journal of Organometallic Chemistry》.2004
Klar U et al..Total Synthesis and Antitumor Activity of ZK-EPO:the first fully synthesis epothilone in clinical development.《Angew.Chem.Int.Ed.》.2006,第45卷第7942-7948页. *

Also Published As

Publication number Publication date
TW200902538A (en) 2009-01-16
CA2681806A1 (en) 2008-10-09
US8314248B2 (en) 2012-11-20
EP2142539A2 (de) 2010-01-13
KR20090125259A (ko) 2009-12-04
UY30985A1 (es) 2008-10-31
US20080242868A1 (en) 2008-10-02
PA8773901A1 (es) 2008-11-19
JP2010523481A (ja) 2010-07-15
AR066692A1 (es) 2009-09-09
DE102007016046A1 (de) 2008-10-23
CN101652362A (zh) 2010-02-17
WO2008119563A2 (de) 2008-10-09
WO2008119563A3 (de) 2009-02-12
CL2008000901A1 (es) 2008-10-17
US20120077984A1 (en) 2012-03-29

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