AR066692A1 - Procedimiento para la preparacion de derivados de epotilona por eepoxidacion catalitica selectiva - Google Patents
Procedimiento para la preparacion de derivados de epotilona por eepoxidacion catalitica selectivaInfo
- Publication number
- AR066692A1 AR066692A1 ARP080101279A ARP080101279A AR066692A1 AR 066692 A1 AR066692 A1 AR 066692A1 AR P080101279 A ARP080101279 A AR P080101279A AR P080101279 A ARP080101279 A AR P080101279A AR 066692 A1 AR066692 A1 AR 066692A1
- Authority
- AR
- Argentina
- Prior art keywords
- eepoxidation
- epotilone
- derivatives
- procedure
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
Reivindicacion 1: Procedimiento para preparar el derivado de epotilona de la formula (1) caracterizado porque el dialqueno de la formula (2), se epoxida usando metiltrioxorenio con un agente de epoxidacion en un solvente aprotico de -60°C a -20°C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007016046A DE102007016046A1 (de) | 2007-03-30 | 2007-03-30 | Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066692A1 true AR066692A1 (es) | 2009-09-09 |
Family
ID=39551678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101279A AR066692A1 (es) | 2007-03-30 | 2008-03-28 | Procedimiento para la preparacion de derivados de epotilona por eepoxidacion catalitica selectiva |
Country Status (13)
Country | Link |
---|---|
US (2) | US20080242868A1 (es) |
EP (1) | EP2142539A2 (es) |
JP (1) | JP2010523481A (es) |
KR (1) | KR20090125259A (es) |
CN (1) | CN101652362B (es) |
AR (1) | AR066692A1 (es) |
CA (1) | CA2681806A1 (es) |
CL (1) | CL2008000901A1 (es) |
DE (1) | DE102007016046A1 (es) |
PA (1) | PA8773901A1 (es) |
TW (1) | TW200902538A (es) |
UY (1) | UY30985A1 (es) |
WO (1) | WO2008119563A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114539143A (zh) * | 2022-01-28 | 2022-05-27 | 安徽瑞邦生物科技有限公司 | 一种4-氰基吡啶的纯化方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1122668C (zh) | 1998-12-22 | 2003-10-01 | 诺瓦提斯公司 | 环氧噻酮衍生物,其制备方法及其药物组合物 |
AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
EP1340498A1 (en) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
GB0405898D0 (en) * | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
-
2007
- 2007-03-30 DE DE102007016046A patent/DE102007016046A1/de not_active Withdrawn
-
2008
- 2008-03-27 EP EP08734992A patent/EP2142539A2/de not_active Withdrawn
- 2008-03-27 CN CN2008800103886A patent/CN101652362B/zh not_active Expired - Fee Related
- 2008-03-27 JP JP2010500148A patent/JP2010523481A/ja not_active Withdrawn
- 2008-03-27 US US12/056,393 patent/US20080242868A1/en not_active Abandoned
- 2008-03-27 WO PCT/EP2008/002652 patent/WO2008119563A2/de active Application Filing
- 2008-03-27 CA CA002681806A patent/CA2681806A1/en not_active Abandoned
- 2008-03-27 UY UY30985A patent/UY30985A1/es not_active Application Discontinuation
- 2008-03-27 KR KR1020097020329A patent/KR20090125259A/ko not_active Application Discontinuation
- 2008-03-28 TW TW097111589A patent/TW200902538A/zh unknown
- 2008-03-28 PA PA20088773901A patent/PA8773901A1/es unknown
- 2008-03-28 AR ARP080101279A patent/AR066692A1/es not_active Application Discontinuation
- 2008-03-28 CL CL200800901A patent/CL2008000901A1/es unknown
-
2011
- 2011-11-30 US US13/308,046 patent/US8314248B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2681806A1 (en) | 2008-10-09 |
TW200902538A (en) | 2009-01-16 |
UY30985A1 (es) | 2008-10-31 |
PA8773901A1 (es) | 2008-11-19 |
WO2008119563A2 (de) | 2008-10-09 |
CN101652362A (zh) | 2010-02-17 |
CL2008000901A1 (es) | 2008-10-17 |
DE102007016046A1 (de) | 2008-10-23 |
WO2008119563A3 (de) | 2009-02-12 |
US20120077984A1 (en) | 2012-03-29 |
CN101652362B (zh) | 2012-10-10 |
JP2010523481A (ja) | 2010-07-15 |
US8314248B2 (en) | 2012-11-20 |
KR20090125259A (ko) | 2009-12-04 |
EP2142539A2 (de) | 2010-01-13 |
US20080242868A1 (en) | 2008-10-02 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |